Mary Ann Lila


Affiliation: North Carolina State University
Country: USA


  1. request reprint
    Grace M, Esposito D, Timmers M, Xiong J, Yousef G, Komarnytsky S, et al. In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents. Food Funct. 2016;7:4285-4298 pubmed
    ..SP and KP were the most potent to inhibit the expression of COX2. The SNP had the strongest effect in decreasing non-mitochondrial oxidative burst associated with inflammatory response in macrophages. ..
  2. Lila M, Burton Freeman B, Grace M, Kalt W. Unraveling Anthocyanin Bioavailability for Human Health. Annu Rev Food Sci Technol. 2016;7:375-93 pubmed publisher
    ..We argue that the persistence of anthocyanin metabolites suggests enterohepatic recycling, leading to prolonged residence time, and supports the notion that anthocyanins are far more bioavailable than previously suggested. ..
  3. Plundrich N, Cook B, Maleki S, Fourches D, Lila M. Binding of peanut allergen Ara h 2 with Vaccinium fruit polyphenols. Food Chem. 2019;284:287-295 pubmed publisher
    ..These results suggest that certain polyphenols can inhibit IgE recognition of Ara h 2 by obstructing linear IgE epitopes. ..
  4. Hoskin R, Xiong J, Esposito D, Lila M. Blueberry polyphenol-protein food ingredients: The impact of spray drying on the in vitro antioxidant activity, anti-inflammatory markers, glucose metabolism and fibroblast migration. Food Chem. 2019;280:187-194 pubmed publisher
    ..The data suggests that spray drying is a convenient and cost-effective technique to produce blueberry-polyphenol food ingredients with preserved phytochemicals with biological activities. ..
  5. Grace M, Xiong J, Esposito D, Ehlenfeldt M, Lila M. Simultaneous LC-MS quantification of anthocyanins and non-anthocyanin phenolics from blueberries with widely divergent profiles and biological activities. Food Chem. 2019;277:336-346 pubmed publisher
  6. Nieman D, Kay C, Rathore A, Grace M, Strauch R, Stephan E, et al. Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following Two Weeks of Flavonoid Supplementation. Nutrients. 2018;10: pubmed publisher
  7. Lila M, Schneider M, Devlin A, Plundrich N, LASTER S, Foegeding E. Polyphenol-enriched berry extracts naturally modulate reactive proteins in model foods. Food Funct. 2017;8:4760-4767 pubmed publisher
    ..Cytokine and chemokine production characteristic of allergic reactions were blocked by the polyphenols, allowing for the potential creation of hypoallergenic protein-berry polyphenol enriched foods. ..
  8. McOliver C, Camper A, Doyle J, Eggers M, Ford T, Lila M, et al. Community-based research as a mechanism to reduce environmental health disparities in american Indian and alaska native communities. Int J Environ Res Public Health. 2015;12:4076-100 pubmed publisher
  9. Plundrich N, White B, Dean L, Davis J, Foegeding E, Lila M. Stability and immunogenicity of hypoallergenic peanut protein-polyphenol complexes during in vitro pepsin digestion. Food Funct. 2015;6:2145-54 pubmed publisher
    ..These results suggest that peanut protein-polyphenol complexes may be less immunoreactive passing through the digestive tract in vivo, contributing to their attenuated allergenicity. ..

More Information


  1. Grace M, Esposito D, Timmers M, Xiong J, Yousef G, Komarnytsky S, et al. Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts. Food Chem. 2016;210:85-95 pubmed publisher
    ..Moreover, the P extract significantly decreased the non-mitochondrial oxidative burst associated with inflammatory response in macrophages. ..
  2. Xiong J, Grace M, Esposito D, Komarnytsky S, Wang F, Lila M. Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities. Chin J Nat Med. 2017;15:816-824 pubmed publisher
    ..4 ?g·mL-1). Moreover, B extract, at 25 µg·mL-1, significantly decreased the non-mitochondrial oxidative burst that is often associated with inflammatory response in human monocytic macrophages. ..
  3. OVERALL J, Bonney S, Wilson M, Beermann A, Grace M, Esposito D, et al. Metabolic Effects of Berries with Structurally Diverse Anthocyanins. Int J Mol Sci. 2017;18: pubmed publisher
    ..Further work is needed to understand mechanisms that lead to nearly anoxic conditions in the gut lumens, including the relative contributions of host, diet and/or microbial oxidative activity, and their implication to human health. ..
  4. de Rus Jacquet A, Timmers M, Ma S, Thieme A, McCabe G, Vest J, et al. Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms. J Ethnopharmacol. 2017;206:408-425 pubmed publisher
  5. Plundrich N, Bansode R, Foegeding E, Williams L, Lila M. Protein-bound Vaccinium fruit polyphenols decrease IgE binding to peanut allergens and RBL-2H3 mast cell degranulation in vitro. Food Funct. 2017;8:1611-1621 pubmed publisher
    ..Future trials are warranted to investigate the immunomodulatory mechanisms of these protein-polyphenol complexes and the role of quercetin in their hypoallergenic potential. ..
  6. Correia R, Grace M, Esposito D, Lila M. Wild blueberry polyphenol-protein food ingredients produced by three drying methods: Comparative physico-chemical properties, phytochemical content, and stability during storage. Food Chem. 2017;235:76-85 pubmed publisher
    ..Overall, spray drying the blueberry extracts complexed with protein proved to be an environment-friendly strategy to produce stable functional ingredients with multiple applications for the food industry. ..