Benedict Law

Summary

Affiliation: North Dakota State University
Country: USA

Publications

  1. pmc Protease-sensitive fluorescent nanofibers
    Benedict Law
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Bioconjug Chem 18:1701-4. 2007
  2. doi request reprint Proteolysis: a biological process adapted in drug delivery, therapy, and imaging
    Benedict Law
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58105, USA
    Bioconjug Chem 20:1683-95. 2009
  3. doi request reprint Structural modification of protease inducible preprogrammed nanofiber precursor
    Benedict Law
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biomacromolecules 9:421-5. 2008
  4. doi request reprint Polymeric nanoparticles with sequential and multiple FRET cascade mechanisms for multicolor and multiplexed imaging
    Anil Wagh
    Department of Pharmaceutical Sciences, College of Pharmacy, Nursing and Allied Sciences, North Dakota State University, Department 2665, PO Box 6050, Fargo, ND 58108 6050, USA
    Small 9:2129-39. 2013
  5. ncbi request reprint In-vivo imaging of tumor associated urokinase-type plasminogen activator activity
    Jong Kai Hsiao
    Massachusetts General Hospital, Harvard Medical School, Center for Molecular Imaging Research, Charlestown, 02129, USA
    J Biomed Opt 11:34013. 2006
  6. doi request reprint A short circulating peptide nanofiber as a carrier for tumoral delivery
    Anil Wagh
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA
    Nanomedicine 9:449-57. 2013
  7. pmc The first characterization of free radicals formed from cellular COX-catalyzed peroxidation
    Yan Gu
    Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND 58105, USA
    Free Radic Biol Med 57:49-60. 2013
  8. doi request reprint Liposome-mediated amplified detection of cell-secreted matrix metalloproteinase-9
    Jayati Banerjee
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58105, USA
    Chem Commun (Camb) 46:3209-11. 2010
  9. ncbi request reprint Peptide-based biomaterials for protease-enhanced drug delivery
    Benedict Law
    Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biomacromolecules 7:1261-5. 2006
  10. ncbi request reprint Mechanism-based fluorescent reporter for protein kinase A detection
    Benedict Law
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Chembiochem 6:1361-7. 2005

Collaborators

Detail Information

Publications21

  1. pmc Protease-sensitive fluorescent nanofibers
    Benedict Law
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Bioconjug Chem 18:1701-4. 2007
    ..These protease-sensitive nanofibers may have considerable biomedical applications as diagnostic sensors or for protease-assisted drug deliveries...
  2. doi request reprint Proteolysis: a biological process adapted in drug delivery, therapy, and imaging
    Benedict Law
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58105, USA
    Bioconjug Chem 20:1683-95. 2009
    ..This review focuses on various proteolysis-dependent approaches to drug delivery, therapy, and imaging. References are selected to illustrate the concepts and demonstrate the potentials of these enzyme-responsive strategies...
  3. doi request reprint Structural modification of protease inducible preprogrammed nanofiber precursor
    Benedict Law
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biomacromolecules 9:421-5. 2008
    ....
  4. doi request reprint Polymeric nanoparticles with sequential and multiple FRET cascade mechanisms for multicolor and multiplexed imaging
    Anil Wagh
    Department of Pharmaceutical Sciences, College of Pharmacy, Nursing and Allied Sciences, North Dakota State University, Department 2665, PO Box 6050, Fargo, ND 58108 6050, USA
    Small 9:2129-39. 2013
    ..Using an animal model subcutaneously implanted with the particles, it is further demonstrated that the developed platform could be useful for in vivo multiplexed imaging...
  5. ncbi request reprint In-vivo imaging of tumor associated urokinase-type plasminogen activator activity
    Jong Kai Hsiao
    Massachusetts General Hospital, Harvard Medical School, Center for Molecular Imaging Research, Charlestown, 02129, USA
    J Biomed Opt 11:34013. 2006
    ..Our results suggest a direct detection method for uPA activity in vivo and the approach can be used for monitoring tumor growth and development...
  6. doi request reprint A short circulating peptide nanofiber as a carrier for tumoral delivery
    Anil Wagh
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA
    Nanomedicine 9:449-57. 2013
    ..Overall, our data suggested a new paradigm in drug delivery via using a short circulating NFP, rather than a long circulating 3D nanoparticle, as a delivery cargo...
  7. pmc The first characterization of free radicals formed from cellular COX-catalyzed peroxidation
    Yan Gu
    Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND 58105, USA
    Free Radic Biol Med 57:49-60. 2013
    ..Our results indicate that free radicals generated from the distinct radical reactions in COX-catalyzed peroxidation may represent the novel metabolites of AA and DGLA that correspond to their contrasting bioactivity...
  8. doi request reprint Liposome-mediated amplified detection of cell-secreted matrix metalloproteinase-9
    Jayati Banerjee
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58105, USA
    Chem Commun (Camb) 46:3209-11. 2010
    ..A liposome-based amplified detection system is presented for the cancer cell secreted pathogenic enzyme matrix metalloproteinase-9 which does not require the use of biological antibodies...
  9. ncbi request reprint Peptide-based biomaterials for protease-enhanced drug delivery
    Benedict Law
    Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biomacromolecules 7:1261-5. 2006
    ..Our results suggest that this type of material may have far-reaching applications for functionally targeted drug delivery...
  10. ncbi request reprint Mechanism-based fluorescent reporter for protein kinase A detection
    Benedict Law
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Chembiochem 6:1361-7. 2005
    ..The remaining peptide sequence, which acts as an inhibitor, is attached covalently to the enzyme. Our results suggest that this type of sensors could have far-reaching applications in the molecular sensing of enzymes...
  11. ncbi request reprint Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples
    Benedict Law
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Anal Biochem 338:151-8. 2005
    ..We were able to directly measure uPA activities in different cancer cell lines. This newly developed technique could be expanded to nearly all proteases, including the ones that cannot be analyzed by traditional zymography...
  12. pmc Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells
    Michael D Scott
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58108 6050, USA
    Analyst 137:5487-90. 2012
    ..These polymers differentiate at a post-translation level possibly due to their ability to interact with extracellular enzymes that are over-expressed in cancerous conditions...
  13. doi request reprint Cell penetrating peptide tethered bi-ligand liposomes for delivery to brain in vivo: Biodistribution and transfection
    Gitanjali Sharma
    Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND 58108 6050, USA
    J Control Release 167:1-10. 2013
    ....
  14. doi request reprint Design and synthesis of a near-infrared fluorescent nanofiber precursor for detecting cell-secreted urokinase activity
    Ruchi Malik
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USA
    Anal Biochem 412:26-33. 2011
    ..Fluorescence changes were uPA dependent, as confirmed with both Western blot analysis and enzyme activity assay. Our data suggest that an optimized preparation may be useful for imaging uPA activity in vivo...
  15. ncbi request reprint Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter
    Benedict Law
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Chem Biol 11:99-106. 2004
    ..No activation with negative control compounds and uPA inhibitors could be measured. These data indicate that the optimized preparation should be useful for imaging uPA in cancer...
  16. pmc Release of liposomal contents by cell-secreted matrix metalloproteinase-9
    Jayati Banerjee
    Department of Pharmaceutical Sciences, Department of Chemistry, Biochemistry and Molecular Biology, North Dakota State University, Fargo, North Dakota 58108, USA
    Bioconjug Chem 20:1332-9. 2009
    ..Metastatic cancer cells (MCF7) secreting high levels of the enzyme rapidly release the encapsulated contents from the liposomes...
  17. ncbi request reprint A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicity
    Benedict Law
    Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, 02129, USA
    Mol Cancer Ther 5:1944-9. 2006
    ..Our results suggested that r7-kla is an apoptosis inducer and can be potentially used as an antitumor agent, especially when combined with the appropriate systemic delivery systems...
  18. doi request reprint The receptor for advanced glycation end products influences the expression of its S100 protein ligands in melanoma tumors
    Varsha Meghnani
    Department of Pharmaceutical Sciences, North Dakota State University, Dept 2665, PO Box 6050, Fargo, ND 58108, United States
    Int J Biochem Cell Biol 57:54-62. 2014
    ..We further demonstrate that the anti-RAGE antibody treatment significantly enhanced the efficacy of the alkylating drug dacarbazine in reducing the growth rate of RAGE overexpressing tumors. ..
  19. doi request reprint Development of biocompatible polymeric nanoparticles for in vivo NIR and FRET imaging
    Anil Wagh
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58108 6050, United States
    Bioconjug Chem 23:981-92. 2012
    ..Additional animal phantom studies demonstrated that the FRET imaging platform developed could have far-reaching applications in optical imaging. ..
  20. doi request reprint Methods for conjugating antibodies to nanocarriers
    Anil Wagh
    Department of Pharmaceutical Sciences, College of Pharmacy, Nursing and Allied Sciences, North Dakota State University, Fargo, ND, USA
    Methods Mol Biol 1045:249-66. 2013
    ..The advantages and limitations are described herein. Specific examples are selected to demonstrate the experimental procedures and to illustrate the potential for applying to other nanocarrier system. ..
  21. pmc LC/ESR/MS study of pH-dependent radical generation from 15-LOX-catalyzed DPA peroxidation
    Preeti Purwaha
    Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND 58105, USA
    Free Radic Biol Med 51:1461-70. 2011
    ..This pH-dependent alteration of radical formation and oxygenation pattern may have significant implications and provide a basis for our ongoing investigations of LOXs as well as fatty acids in cancer biology...