Slavko Komarnytsky

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. pmc Anabolic effect of plant brassinosteroid
    Debora Esposito
    Biotech Center, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, USA
    FASEB J 25:3708-19. 2011
  2. pmc Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model
    Slavko Komarnytsky
    Plants for Human Health Institute, North Carolina State University, Kannapolis, North Carolina 28081, United States
    J Agric Food Chem 61:1841-9. 2013
  3. pmc Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells
    Slavko Komarnytsky
    Biotech Center, SEBS, Rutgers University, New Brunswick, NJ, USA
    J Cell Physiol 228:1120-6. 2013
  4. pmc Hypoglycemic effects of brassinosteroid in diet-induced obese mice
    Debora Esposito
    Biotech Center, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, USA
    Am J Physiol Endocrinol Metab 303:E652-8. 2012
  5. pmc Acceleration of cutaneous wound healing by brassinosteroids
    Debora Esposito
    Biotech Center, Rutgers University, New Brunswick, New Jersey Department of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey
    Wound Repair Regen 21:688-96. 2013
  6. pmc 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model
    Pablo Kizelsztein
    Rutgers University, 59 Dudley Rd, New Brunswick, NJ 08901, USA
    Am J Physiol Endocrinol Metab 296:E433-9. 2009
  7. pmc Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells
    Debora Esposito
    Biotech Center, SEBS, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901, United States
    J Med Chem 54:4057-66. 2011
  8. ncbi request reprint Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography
    Christopher Okunji
    Biotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901 8520, USA
    J Chromatogr A 1151:45-50. 2007
  9. pmc Cosecretion of protease inhibitor stabilizes antibodies produced by plant roots
    Slavko Komarnytsky
    Biotech Center, Rutgers University, New Brunswick, New Jersey 08901, USA
    Plant Physiol 141:1185-93. 2006
  10. ncbi request reprint Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line
    Dmitry Govorko
    Rutgers University, Biotech Center, 59 Dudley Road, New Brunswick, NJ 08901, USA
    Am J Physiol Endocrinol Metab 293:E1503-10. 2007

Collaborators

Detail Information

Publications15

  1. pmc Anabolic effect of plant brassinosteroid
    Debora Esposito
    Biotech Center, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, USA
    FASEB J 25:3708-19. 2011
    ..These findings suggest that oral application of HB triggers selective anabolic response with minimal or no androgenic side-effects and begin to elucidate the putative cellular targets for plant brassinosteroids in mammals...
  2. pmc Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model
    Slavko Komarnytsky
    Plants for Human Health Institute, North Carolina State University, Kannapolis, North Carolina 28081, United States
    J Agric Food Chem 61:1841-9. 2013
    ..These results support the multimodal effects of pregnane glycosides on feeding regulation, which depends on the activity of the melanocortin signaling pathway and BDNF...
  3. pmc Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells
    Slavko Komarnytsky
    Biotech Center, SEBS, Rutgers University, New Brunswick, NJ, USA
    J Cell Physiol 228:1120-6. 2013
    ....
  4. pmc Hypoglycemic effects of brassinosteroid in diet-induced obese mice
    Debora Esposito
    Biotech Center, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, USA
    Am J Physiol Endocrinol Metab 303:E652-8. 2012
    ..These results indicate the antidiabetic effects of brassinosteroids and begin to elucidate their putative cellular targets both in vitro and in vivo...
  5. pmc Acceleration of cutaneous wound healing by brassinosteroids
    Debora Esposito
    Biotech Center, Rutgers University, New Brunswick, New Jersey Department of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey
    Wound Repair Regen 21:688-96. 2013
    ..Targeting this signaling pathway with brassinosteroids may represent a promising approach to the therapy of delayed wound healing. ..
  6. pmc 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model
    Pablo Kizelsztein
    Rutgers University, 59 Dudley Rd, New Brunswick, NJ 08901, USA
    Am J Physiol Endocrinol Metab 296:E433-9. 2009
    ..These studies demonstrate the anti-obesity and anti-diabetic effects of 20HE and begin to elucidate its putative cellular targets both in vitro and in vivo...
  7. pmc Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells
    Debora Esposito
    Biotech Center, SEBS, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901, United States
    J Med Chem 54:4057-66. 2011
    ..Plant brassinosteroids and their synthetic derivatives may offer a novel therapeutic strategy for promoting growth, repair, and maintenance of skeletal muscles...
  8. ncbi request reprint Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography
    Christopher Okunji
    Biotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901 8520, USA
    J Chromatogr A 1151:45-50. 2007
    ..Compound (4) was the most potent (IC(50) 582 microM) and compared favorably with a reference tyrosinase inhibitor (kojic acid, IC(50) 130 microM)...
  9. pmc Cosecretion of protease inhibitor stabilizes antibodies produced by plant roots
    Slavko Komarnytsky
    Biotech Center, Rutgers University, New Brunswick, New Jersey 08901, USA
    Plant Physiol 141:1185-93. 2006
    ....
  10. ncbi request reprint Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line
    Dmitry Govorko
    Rutgers University, Biotech Center, 59 Dudley Road, New Brunswick, NJ 08901, USA
    Am J Physiol Endocrinol Metab 293:E1503-10. 2007
    ..These results indicate that the isolated compounds may be responsible for much of the glucose-lowering activity of the Artemisia dracunculus extract...
  11. doi request reprint Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro
    Debora Esposito
    Department of Plant Biology and Pathology, Rutgers The State University of New Jersey, 59 Dudley Road, New Brunswick, New Jersey 08901, USA
    J Ethnopharmacol 148:433-40. 2013
    ..Preparations derived from bulbs of various Lilium species have been used to promote the healing of skin abrasions, sores and burns and to aid in healing wounds in Traditional Chinese and Greco-Roman Medicine...
  12. doi request reprint Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex
    Pablo Kizelsztein
    Biotech Center, SEBS, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, USA
    J Neuroimmunol 217:28-37. 2009
    ..These effects might be explained by the increase in Hsp70 levels driven by triptolide and stabilization of the NF-kappaB/IkappaBalpha complex leading to an attenuated inflammatory response...
  13. ncbi request reprint Plants and human health in the twenty-first century
    Ilya Raskin
    Biotech Center, Foran Hall, 59 Dudley Road, Cook College, Rutgers University, New Brunswick, NJ 08901 8520, USA
    Trends Biotechnol 20:522-31. 2002
    ..This review discusses the history, future, scientific background and regulatory issues related to botanical therapeutics...
  14. ncbi request reprint Protease inhibitors and their peptidomimetic derivatives as potential drugs
    Georgie Fear
    Biotech Center, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, USA
    Pharmacol Ther 113:354-68. 2007
    ..It remains to be seen which second generation agents will evolve into approved drugs or complementary therapies...
  15. ncbi request reprint Functional analysis of promoter elements in plants
    Slavko Komarnytsky
    Biotech Center, Cook College, Rutgers University, 59 Dudley Rd, New Brunswick, NJ 08901 8520, USA
    Genet Eng (N Y) 25:113-41. 2003