Clement Kleinstreuer

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. ncbi request reprint Fluid-structure interaction analyses of stented abdominal aortic aneurysms
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
    Annu Rev Biomed Eng 9:169-204. 2007
  2. doi request reprint A new catheter for tumor targeting with radioactive microspheres in representative hepatic artery systems. Part I: impact of catheter presence on local blood flow and microsphere delivery
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
    J Biomech Eng 134:051004. 2012
  3. ncbi request reprint Comparison of blood particle deposition models for non-parallel flow domains
    P Worth Longest
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910 3211, Broughton Hall, Raleigh, NC 27695 7910, USA
    J Biomech 36:421-30. 2003
  4. ncbi request reprint Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA
    J Aerosol Med 20:294-309. 2007
  5. doi request reprint Targeted drug-aerosol delivery in the human respiratory system
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
    Annu Rev Biomed Eng 10:195-220. 2008
  6. doi request reprint Computational mechanics of Nitinol stent grafts
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    J Biomech 41:2370-8. 2008
  7. doi request reprint Modeling airflow and particle transport/deposition in pulmonary airways
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    Respir Physiol Neurobiol 163:128-38. 2008
  8. ncbi request reprint Targeted drug aerosol deposition analysis for a four-generation lung airway model with hemispherical tumors
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    J Biomech Eng 125:197-206. 2003
  9. pmc Analysis and computer program for rupture-risk prediction of abdominal aortic aneurysms
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA
    Biomed Eng Online 5:19. 2006
  10. pmc Experimental and theoretical studies of nanofluid thermal conductivity enhancement: a review
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC 27695 7910, USA
    Nanoscale Res Lett 6:229. 2011

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Fluid-structure interaction analyses of stented abdominal aortic aneurysms
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
    Annu Rev Biomed Eng 9:169-204. 2007
    ..Computational fluid-structure interaction simulations provide physical insight into the hemodynamics coupled with multi-wall mechanics' function as an assessment tool for optimal SG placement and improved device design...
  2. doi request reprint A new catheter for tumor targeting with radioactive microspheres in representative hepatic artery systems. Part I: impact of catheter presence on local blood flow and microsphere delivery
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
    J Biomech Eng 134:051004. 2012
    ....
  3. ncbi request reprint Comparison of blood particle deposition models for non-parallel flow domains
    P Worth Longest
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910 3211, Broughton Hall, Raleigh, NC 27695 7910, USA
    J Biomech 36:421-30. 2003
    ..74) and platelets (r2=0.57), given that nano-scale physical and biochemical effects must be greatly approximated in computational simulations involving relatively large-scale geometries and complex flow fields...
  4. ncbi request reprint Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA
    J Aerosol Med 20:294-309. 2007
    ..Using the same human upper airway model, experimentally confirmed computer predictions of controlled particle transport from mouth to generation 3 are provided...
  5. doi request reprint Targeted drug-aerosol delivery in the human respiratory system
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
    Annu Rev Biomed Eng 10:195-220. 2008
    ..To maximize respiratory drug delivery to specific sites, an optimal combination of particle characteristics, inhalation waveform, particle release position, and drug-aerosol dosage has to be achieved...
  6. doi request reprint Computational mechanics of Nitinol stent grafts
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    J Biomech 41:2370-8. 2008
    ..67, which is not acceptable for proper AAA stent-graft design. In summary, a Nitinol stent with PET graft may greatly improve fatigue life, while its compliance is much lower than the NITI-ePTFE combination...
  7. doi request reprint Modeling airflow and particle transport/deposition in pulmonary airways
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    Respir Physiol Neurobiol 163:128-38. 2008
    ..Concerning inhaled therapeutic particles, optimal parameters for mechanical drug-aerosol targeting of predetermined lung areas can be computed, given representative pulmonary airways...
  8. ncbi request reprint Targeted drug aerosol deposition analysis for a four-generation lung airway model with hemispherical tumors
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    J Biomech Eng 125:197-206. 2003
    ..The new concept is generic and hence should be applicable to other regions of the respiratory system as well...
  9. pmc Analysis and computer program for rupture-risk prediction of abdominal aortic aneurysms
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA
    Biomed Eng Online 5:19. 2006
    ..5 cm/year). These criteria may be insufficient for reliable AAA-rupture risk assessment especially when predicting possible rupture of smaller AAAs...
  10. pmc Experimental and theoretical studies of nanofluid thermal conductivity enhancement: a review
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC 27695 7910, USA
    Nanoscale Res Lett 6:229. 2011
    ..Clearly, it will be necessary to consider not only one possible mechanism but combine several mechanisms and compare predictive results to new benchmark experimental data sets...
  11. pmc Experimental and theoretical studies of nanofluid thermal conductivity enhancement: a review
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, NC State University, Raleigh, NC 27695 7910, USA
    Nanoscale Res Lett 6:439. 2011
    ..ABSTRACT: Correction to Kleinstreuer C, Feng Y: Experimental and theoretical studies of nanofluid thermal conductivity enhancement: a review. Nanoscale Research Letters 2011, 6:229...
  12. ncbi request reprint Relation between near-wall residence times of monocytes and early lesion growth in the rabbit aorto-celiac junction
    P Worth Longest
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA
    Ann Biomed Eng 31:53-64. 2003
    ..Results indicate that cell transport and conditions for hemodyamically induced surface reactivity are necessary components in formulating an effective model for monocyte adhesion in complex three-dimensional vessel configurations...
  13. ncbi request reprint Particle-hemodynamics modeling of the distal end-to-side femoral bypass: effects of graft caliber and graft-end cut
    P Worth Longest
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, 3211 Broughton Hall, Raleigh, NC 27695 7910, USA
    Med Eng Phys 25:843-58. 2003
    ..These results illustrate the need for alternative anastomotic designs with the intent of reducing critical hemodynamic wall parameters and mitigating regions of significant particle-wall interactions...
  14. ncbi request reprint Blood flow and structure interactions in a stented abdominal aortic aneurysm model
    Zhonghua Li
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, 3198 Broughton Hall, Raleigh, NC 27695 7910, USA
    Med Eng Phys 27:369-82. 2005
    ..The time-varying drag force on the EVG exerted by physiological blood flow is unavoidable, where for patients with severe hypertension the risk of EVG migration is very high...
  15. doi request reprint Experimental microsphere targeting in a representative hepatic artery system
    Andrew L Richards
    Department of Mechanical Engineering, North Carolina State University, Raleigh, NC 27695, USA
    IEEE Trans Biomed Eng 59:198-204. 2012
    ..Individual branch targeting was possible for each of the five outputs. The experimental results validate the simulation methodology for achieving targeted microsphere distributions in a known geometry under constant flow conditions...
  16. ncbi request reprint Numerical simulation of wall shear stress conditions and platelet localization in realistic end-to-side arterial anastomoses
    P Worth Longest
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Box 7910, Raleigh, NC 27695 7910, USA
    J Biomech Eng 125:671-81. 2003
    ....
  17. doi request reprint Airflow and nanoparticle deposition in a 16-generation tracheobronchial airway model
    Zhe Zhang
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
    Ann Biomed Eng 36:2095-110. 2008
    ..Furthermore, the deposition efficiencies at each individual bifurcation in the TB region can be well correlated as a function of an effective diffusion parameter...
  18. ncbi request reprint Fluid-structure interaction effects on sac-blood pressure and wall stress in a stented aneurysm
    Z Li
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    J Biomech Eng 127:662-71. 2005
    ..All simulation results are in agreement with experimental data and clinical observations...
  19. ncbi request reprint Effects of major endoleaks on a stented abdominal aortic aneurysm
    Z Li
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    J Biomech Eng 128:59-68. 2006
    ..Interestingly enough, the net downward force acting on the implant is significantly reduced; thus, in the presence of endoleaks, the risk of stent-graft migration may be mitigated...
  20. ncbi request reprint Particle hemodynamics analysis of Miller cuff arterial anastomosis
    P Worth Longest
    Department of Mechanical and Aerospace Engineering, North Carolina State University, 2309 Woodrow Drive, Raleigh, NC 27609, USA
    J Vasc Surg 38:1353-62. 2003
    ..We hypothesize that particle hemodynamic conditions are a biophysical mechanism potentially responsible for the clinically observed shift in intimal hyperplasia localization associated with better patency of the Miller configuration...
  21. ncbi request reprint Isotonic and hypertonic saline droplet deposition in a human upper airway model
    Zhe Zhang
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695 7910, USA
    J Aerosol Med 19:184-98. 2006
    ..However, solute concentrations below 10% may not have a very pronounced effect on droplet deposition in the human upper airways...
  22. ncbi request reprint Computational analysis of type II endoleaks in a stented abdominal aortic aneurysm model
    Z Li
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    J Biomech 39:2573-82. 2006
    ..In contrast, the stent-graft migration force is reduced by type II endoleaks because it greatly depends on the pressure difference between the stent-graft and the aneurysm cavity...
  23. ncbi request reprint Analysis of biomechanical factors affecting stent-graft migration in an abdominal aortic aneurysm model
    Z Li
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA
    J Biomech 39:2264-73. 2006
    ..A comprehensive FSI analysis of the coupled SG-AAA dynamics provides physical insight for evaluating the luminal hemodynamics, and maximum AAA-stresses as well as biomechanical factors leading potentially to SG migration...
  24. ncbi request reprint Computational analysis of biomechanical contributors to possible endovascular graft failure
    Z Li
    Department of Mechanical and Aerospace Engineering and Department of Biomedical Engineering, North Carolina State University, Raleigh, USA
    Biomech Model Mechanobiol 4:221-34. 2005
    ..AAA-neck angle, iliac bifurcation angle, neck aorta-to-iliac diameter ratio, EVG size, aorto-uni-iliac EVG, and hypertension play important roles in generating forces potentially leading to EVG migration...
  25. doi request reprint Computational analysis of non-spherical particle transport and deposition in shear flow with application to lung aerosol dynamics--a review
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    J Biomech Eng 135:021008. 2013
    ....
  26. doi request reprint Computer modeling of controlled microsphere release and targeting in a representative hepatic artery system
    Christopher A Basciano
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    Ann Biomed Eng 38:1862-79. 2010
    ..g., those connected to tumors) under transient flow conditions in realistic geometries via a novel drug-particle targeting methodology...
  27. doi request reprint Deposition of naphthalene and tetradecane vapors in models of the human respiratory system
    Zhe Zhang
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
    Inhal Toxicol 23:44-57. 2011
    ..The different deposition patterns of naphthalene and tetradecane vapors in the human respiratory system may indicate different toxic and hence health effects of these toxic jet-fuel components...
  28. ncbi request reprint Effects of blood flow and vessel geometry on wall stress and rupture risk of abdominal aortic aneurysms
    Z Li
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh 27695 7910, USA
    J Med Eng Technol 30:283-97. 2006
    ..The most likely rupture site is located near the anterior distal side for the anterior-posterior asymmetric AAA and the left distal side in the lateral asymmetric AAA...
  29. ncbi request reprint Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta
    J R Buchanan
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, 3211 Broughton Hall, Raleigh, NC 27695 7910, USA
    J Biomech 36:1185-96. 2003
    ..These results suggest that the transport and deposition pattern of monocytes to arterial endothelium plays a significant role in the localization of lesions...
  30. ncbi request reprint A new wall stress equation for aneurysm-rupture prediction
    Z Li
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    Ann Biomed Eng 33:209-13. 2005
    ..It can be readily used for AAA-rupture predictions or can be integrated into more elaborate AAA-assessment models...
  31. pmc Lung deposition analyses of inhaled toxic aerosols in conventional and less harmful cigarette smoke: a review
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
    Int J Environ Res Public Health 10:4454-85. 2013
    ....
  32. doi request reprint An adjustable triple-bifurcation unit model for air-particle flow simulations in human tracheobronchial airways
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, and Department of Biomedical Engineering, North Carolina State University, Raleigh NC 27695 7910, USA
    J Biomech Eng 131:021007. 2009
    ..The present study revealed that turbulent air-particle flow may propagate to G5 for the assumed inhalation flow rate. Geometry and upstream effects are more pronounced for micron particle deposition than for nanoparticle deposition...
  33. doi request reprint Invariant-based anisotropic constitutive models of the healthy and aneurysmal abdominal aortic wall
    C A Basciano
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    J Biomech Eng 131:021009. 2009
    ..A streamlined implementation is also possible for future numerical investigations of fluid-structure interactions in abdominal aortic aneurysms...
  34. ncbi request reprint Aerosol transport and deposition in sequentially bifurcating airways
    J K Comer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh 27695 7910, USA
    J Biomech Eng 122:152-8. 2000
    ....
  35. ncbi request reprint Transport and uptake of MTBE and ethanol vapors in a human upper airway model
    Zhe Zhang
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA
    Inhal Toxicol 18:169-84. 2006
    ....
  36. ncbi request reprint Hemodynamic parameters and early intimal thickening in branching blood vessels
    C Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh 27695-7910, USA
    Crit Rev Biomed Eng 29:1-64. 2001
    ..Suggested redesigns reduce several hemodynamic parameters (i.e., the WSSG, WSSAG, and normal pressure gradient [NPG]), thereby reducing the likelihood of restenosis, especially near the critical toe region...
  37. ncbi request reprint Computational particle-hemodynamics analysis and geometric reconstruction after carotid endarterectomy
    S Hyun
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, 3211 Broughton Hall, Raleigh, NC 27695-7910, USA
    Comput Biol Med 31:365-84. 2001
    ....
  38. ncbi request reprint Laminar airflow and nanoparticle or vapor deposition in a human nasal cavity model
    H Shi
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    J Biomech Eng 128:697-706. 2006
    ....
  39. ncbi request reprint Computational analysis of a human inhalation test chamber for dosimetry-and-health effect studies
    S Hyun
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, USA
    Appl Occup Environ Hyg 17:561-72. 2002
    ....
  40. ncbi request reprint Numerical simulation of wall shear stress and particle-based hemodynamic parameters in pre-cuffed and streamlined end-to-side anastomoses
    P Worth Longest
    Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, VA, 23284 3015, USA
    Ann Biomed Eng 33:1752-66. 2005
    ..Further testing will be necessary to determine if the observed elevated particle-wall interactions in a pre-cuffed anastomosis provide the stimulus responsible for the reported high failure rates of these grafts...
  41. ncbi request reprint Computational analysis of effects of external carotid artery flow and occlusion on adverse carotid bifurcation hemodynamics
    Sinjae Hyun
    Department of Biomedical Engineering, Mercer University, USA
    J Vasc Surg 37:1248-54. 2003
    ..Both local and area-averaged hemodynamic wall parameters were computed for the distal common carotid artery (CCA) and the proximal ICA...