IRWIN L KLEIN

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. ncbi request reprint Thyroid hormone and cardiac contractility
    Irwin Klein
    Division of Endocrinology, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA
    Am J Cardiol 91:1331-2. 2003
  2. ncbi request reprint Evaluation of the therapeutic efficacy of different levothyroxine preparations in the treatment of human thyroid disease
    Irwin Klein
    School of Medicine, New York, New York 11030, USA
    Thyroid 13:1127-32. 2003
  3. ncbi request reprint Thyroid disease and the heart
    Irwin Klein
    Department of Medicine and the Feinstein Institute for Medical Research, North Shore University Hospital, 350 Community Dr, Manhasset, NY 11030, USA
    Circulation 116:1725-35. 2007
  4. ncbi request reprint Thyroid hormone-regulated cardiac gene expression and cardiovascular disease
    Sara Danzi
    Division of Endocrinology and The Department of Medicine, North Shore University Hospital NYU School of Medicine, Manhasset, New York, USA
    Thyroid 12:467-72. 2002
  5. pmc Differential regulation of the myosin heavy chain genes alpha and beta in rat atria and ventricles: role of antisense RNA
    Sara Danzi
    Feinstein Institute for Medical Research and the Department of Medicine, North Shore University Hospital, Manhasset, New York 11030, USA
    Thyroid 18:761-8. 2008
  6. ncbi request reprint Recent considerations in the treatment of hypothyroidism
    Sara Danzi
    North Shore University Hospital, Department of Medicine and the Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Curr Opin Investig Drugs 9:357-62. 2008
  7. ncbi request reprint Potential uses of T3 in the treatment of human disease
    Sara Danzi
    Department of Medicine, North Shore University Hospital, Manhasset, New York, USA
    Clin Cornerstone 7:S9-15. 2005
  8. ncbi request reprint Effect of serum triiodothyronine on regulation of cardiac gene expression: role of histone acetylation
    Sara Danzi
    North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Am J Physiol Heart Circ Physiol 289:H1506-11. 2005
  9. ncbi request reprint Low T3 syndrome in a patient with acute myocarditis
    Matvey Brokhin
    North Shore University Hospital, Manhasset, New York, USA
    Clin Cornerstone 7:S28-9. 2005
  10. ncbi request reprint Posttranscriptional regulation of myosin heavy chain expression in the heart by triiodothyronine
    Sara Danzi
    Division of Endocrinology and Department of Medicine, North Shore University Hospital New York University School of Medicine and North Shore LIJ Research Institute, Manhasset, New York, USA
    Am J Physiol Heart Circ Physiol 288:H455-60. 2005

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Thyroid hormone and cardiac contractility
    Irwin Klein
    Division of Endocrinology, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA
    Am J Cardiol 91:1331-2. 2003
  2. ncbi request reprint Evaluation of the therapeutic efficacy of different levothyroxine preparations in the treatment of human thyroid disease
    Irwin Klein
    School of Medicine, New York, New York 11030, USA
    Thyroid 13:1127-32. 2003
    ..These are relevant to the physician and patient because small differences in the efficacy can produce unwanted effects of either underreplacement or overreplacement...
  3. ncbi request reprint Thyroid disease and the heart
    Irwin Klein
    Department of Medicine and the Feinstein Institute for Medical Research, North Shore University Hospital, 350 Community Dr, Manhasset, NY 11030, USA
    Circulation 116:1725-35. 2007
    ..We also review the alterations in thyroid hormone metabolism that accompany chronic congestive heart failure and the approach to the management of patients with amiodarone-induced alterations in thyroid function tests...
  4. ncbi request reprint Thyroid hormone-regulated cardiac gene expression and cardiovascular disease
    Sara Danzi
    Division of Endocrinology and The Department of Medicine, North Shore University Hospital NYU School of Medicine, Manhasset, New York, USA
    Thyroid 12:467-72. 2002
    ..T(3) replacement therapy for hypothyroidism restores normal expression of these T(3) regulated genes and recent experiments suggest that the diseased human heart in congestive failure would benefit from similar T(3) replacement therapy...
  5. pmc Differential regulation of the myosin heavy chain genes alpha and beta in rat atria and ventricles: role of antisense RNA
    Sara Danzi
    Feinstein Institute for Medical Research and the Department of Medicine, North Shore University Hospital, Manhasset, New York 11030, USA
    Thyroid 18:761-8. 2008
    ..To further our understanding of the potential mechanisms involved, we determined the T3 responsiveness of the MHC genes, alpha and beta, and the beta-MHC antisense (AS) gene in the rat ventricles and atria...
  6. ncbi request reprint Recent considerations in the treatment of hypothyroidism
    Sara Danzi
    North Shore University Hospital, Department of Medicine and the Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Curr Opin Investig Drugs 9:357-62. 2008
    ..This review summarizes recent considerations in the field of thyroidology to address the potential for improvement in the treatment of patients. The goal of these improvements should be to achieve both clinical and chemical euthyroidism...
  7. ncbi request reprint Potential uses of T3 in the treatment of human disease
    Sara Danzi
    Department of Medicine, North Shore University Hospital, Manhasset, New York, USA
    Clin Cornerstone 7:S9-15. 2005
    ..Further developmental work is needed to refine T3 therapy in a way to enhance efficacy and lower the potential for unwanted effects...
  8. ncbi request reprint Effect of serum triiodothyronine on regulation of cardiac gene expression: role of histone acetylation
    Sara Danzi
    North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Am J Physiol Heart Circ Physiol 289:H1506-11. 2005
    ....
  9. ncbi request reprint Low T3 syndrome in a patient with acute myocarditis
    Matvey Brokhin
    North Shore University Hospital, Manhasset, New York, USA
    Clin Cornerstone 7:S28-9. 2005
  10. ncbi request reprint Posttranscriptional regulation of myosin heavy chain expression in the heart by triiodothyronine
    Sara Danzi
    Division of Endocrinology and Department of Medicine, North Shore University Hospital New York University School of Medicine and North Shore LIJ Research Institute, Manhasset, New York, USA
    Am J Physiol Heart Circ Physiol 288:H455-60. 2005
    ..beta-MHC antisense RNA is present in euthyroid myocytes, but levels are not significant in hypothyroid myocytes. This differential expression may explain some of the effects of T3 on MHC posttranscriptional regulation...
  11. ncbi request reprint Thyroid hormone and blood pressure regulation
    Sara Danzi
    Division of Endocrinology and The Department of Medicine, North Shore University Hospital NYU School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    Curr Hypertens Rep 5:513-20. 2003
    ..In this paper, we review the direct and indirect thyroid hormone-mediated effects on blood pressure...
  12. doi request reprint Effects of amiodarone therapy on thyroid function
    Janna Cohen-Lehman
    Department of Medicine, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Nat Rev Endocrinol 6:34-41. 2010
    ....
  13. ncbi request reprint Effect of triiodothyronine on gene transcription during cardiopulmonary bypass in infants with ventricular septal defect
    Sara Danzi
    Division of Endocrinology, Department of Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, New York, USA
    Am J Cardiol 95:787-9. 2005
    ..To our knowledge, a novel heteronuclear assay demonstrated for the first time in human heart that rapid change in T3 levels altered the adenine nucleotide translocase-1 transcription rate during cardiopulmonary bypass...
  14. ncbi request reprint Interleukin-6 and thyroid hormone metabolism in pediatric cardiac surgery patients
    Clarie K McMahon
    Department of Pediatric, North Shore LIJ Health System, NYU School of Medicine, Manhasset, New York, USA
    Thyroid 13:301-4. 2003
    ....