John M Kane

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. pmc Assessing the comparative effectiveness of long-acting injectable vs. oral antipsychotic medications in the prevention of relapse provides a case study in comparative effectiveness research in psychiatry
    John M Kane
    The Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, 75 59 263 St, Glen Oaks, NY 11004, USA
    J Clin Epidemiol 66:S37-41. 2013
  2. doi request reprint Aripiprazole intramuscular depot as maintenance treatment in patients with schizophrenia: a 52-week, multicenter, randomized, double-blind, placebo-controlled study
    John M Kane
    The Zucker Hillside Hospital and The Hofstra North Shore LIJ School of Medicine, Glen Oaks, NY 11004 1100, USA
    J Clin Psychiatry 73:617-24. 2012
  3. doi request reprint Lurasidone: a clinical overview
    John M Kane
    The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY, USA
    J Clin Psychiatry 72:24-8. 2011
  4. pmc DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia
    Philip R Szeszko
    Feinstein Institute for Medical Research, Manhasset, NY, USA
    Biol Psychol 79:103-10. 2008
  5. doi request reprint A multicenter, randomized, double-blind, placebo-controlled, 16-week study of adjunctive aripiprazole for schizophrenia or schizoaffective disorder inadequately treated with quetiapine or risperidone monotherapy
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004 1150, USA
    J Clin Psychiatry 70:1348-57. 2009
  6. ncbi request reprint Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?
    Terry E Goldberg
    Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 64:1115-22. 2007
  7. pmc Patterns of stress in schizophrenia
    Julia D Betensky
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Psychiatry Res 160:38-46. 2008
  8. ncbi request reprint Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain
    Anil K Malhotra
    Psychiatry Research, Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 69:904-12. 2012
  9. pmc The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia
    Pamela DeRosse
    Center for Translational Psychiatry, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Schizophr Bull 34:1047-53. 2008
  10. ncbi request reprint Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials
    John M Kane
    The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    J Psychopharmacol 24:1019-29. 2010

Detail Information

Publications79

  1. pmc Assessing the comparative effectiveness of long-acting injectable vs. oral antipsychotic medications in the prevention of relapse provides a case study in comparative effectiveness research in psychiatry
    John M Kane
    The Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, 75 59 263 St, Glen Oaks, NY 11004, USA
    J Clin Epidemiol 66:S37-41. 2013
    ..To date, many studies comparing LAIs and oral antipsychotics have been conducted; however, the results are mixed, and careful interpretation of the data is required...
  2. doi request reprint Aripiprazole intramuscular depot as maintenance treatment in patients with schizophrenia: a 52-week, multicenter, randomized, double-blind, placebo-controlled study
    John M Kane
    The Zucker Hillside Hospital and The Hofstra North Shore LIJ School of Medicine, Glen Oaks, NY 11004 1100, USA
    J Clin Psychiatry 73:617-24. 2012
    ..To evaluate the efficacy and tolerability of a once-monthly intramuscular (IM) depot formulation of the dopamine partial agonist aripiprazole as maintenance treatment in adults meeting DSM-IV-TR schizophrenia criteria...
  3. doi request reprint Lurasidone: a clinical overview
    John M Kane
    The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY, USA
    J Clin Psychiatry 72:24-8. 2011
    ..Lurasidone may be particularly helpful for patients with schizophrenia who are overweight or have endocrine problems (diabetes, dyslipidemia) or comorbid cardiovascular conditions...
  4. pmc DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia
    Philip R Szeszko
    Feinstein Institute for Medical Research, Manhasset, NY, USA
    Biol Psychol 79:103-10. 2008
    ..Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology...
  5. doi request reprint A multicenter, randomized, double-blind, placebo-controlled, 16-week study of adjunctive aripiprazole for schizophrenia or schizoaffective disorder inadequately treated with quetiapine or risperidone monotherapy
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004 1150, USA
    J Clin Psychiatry 70:1348-57. 2009
    ..Combining antipsychotics is common practice in the treatment of schizophrenia. This study investigated aripiprazole adjunctive to risperidone or quetiapine for treating schizophrenia and schizoaffective disorder...
  6. ncbi request reprint Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?
    Terry E Goldberg
    Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 64:1115-22. 2007
    ..However, none of these studies included healthy controls undergoing repeated testing to assess the possibility that improvements might reflect simple practice effects...
  7. pmc Patterns of stress in schizophrenia
    Julia D Betensky
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Psychiatry Res 160:38-46. 2008
    ....
  8. ncbi request reprint Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain
    Anil K Malhotra
    Psychiatry Research, Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 69:904-12. 2012
    ..Unfortunately, SGAs are often associated with substantial weight gain, with no means to predict which patients are at greatest risk...
  9. pmc The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia
    Pamela DeRosse
    Center for Translational Psychiatry, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Schizophr Bull 34:1047-53. 2008
    ..We examined these chromosomal regions for association to positive, negative, and disorganized symptom clusters, using a dense set of single-nucleotide polymorphisms (SNPs)...
  10. ncbi request reprint Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials
    John M Kane
    The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    J Psychopharmacol 24:1019-29. 2010
    ..In conclusion, akathisia with aripiprazole occurred early in treatment, was mild-to-moderate in severity, led to few study discontinuations, and did not compromise therapeutic efficacy...
  11. pmc Does antipsychotic polypharmacy increase the risk for metabolic syndrome?
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, United States
    Schizophr Res 89:91-100. 2007
    ..To determine whether the coprescribing of two or more antipsychotics, a relatively frequent practice with little data to support its safety and efficacy, is associated with an increased prevalence of metabolic syndrome...
  12. ncbi request reprint Symptomatic remission in schizophrenia patients treated with aripiprazole or haloperidol for up to 52 weeks
    John M Kane
    The Zucker Hillside Hospital, 75 59 263 St, Glen Oaks, NY 11004, USA
    Schizophr Res 95:143-50. 2007
    ..This analysis examined symptomatic remission in acutely ill patients with schizophrenia receiving either aripiprazole or haloperidol for one year...
  13. pmc Predictors of remission, schizophrenia, and bipolar disorder in adolescents with brief psychotic disorder or psychotic disorder not otherwise specified considered at very high risk for schizophrenia
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    J Child Adolesc Psychopharmacol 18:475-90. 2008
    ....
  14. pmc Differentiation in the preonset phases of schizophrenia and mood disorders: evidence in support of a bipolar mania prodrome
    Christoph U Correll
    Albert Einstein College of Medicine, Department of Psychiatry, Bronx, NY, USA
    Schizophr Bull 33:703-14. 2007
    ..The presence and specificity of a bipolar prodrome remains questioned. We aimed to characterize the prodrome prior to a first psychotic and nonpsychotic mania and to examine the phenotypic proximity to the schizophrenia prodrome...
  15. ncbi request reprint White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study
    Philip R Szeszko
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 162:602-5. 2005
    ..The goal of this study was to investigate brain white matter abnormalities by using diffusion tensor imaging in patients with schizophrenia or schizoaffective disorder close to illness onset...
  16. ncbi request reprint Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 33:976-84. 2008
    ..These abnormalities have clinical and neuropsychological correlates, which may be useful in further characterizing structure-function relations in schizophrenia and constraining neurobiological models of the disorder...
  17. pmc Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive ability
    Katherine E Burdick
    Hillside Hospital, North Shore Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, NY 11004, USA
    Am J Psychiatry 167:436-43. 2010
    ..Thus, MET may be of particular interest as a candidate gene for neuropsychiatric diseases with a developmental etiology, including schizophrenia...
  18. pmc Past and present progress in the pharmacologic treatment of schizophrenia
    John M Kane
    Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 71:1115-24. 2010
    ....
  19. ncbi request reprint Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia
    Pamela DeRosse
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Biol Psychiatry 61:1208-10. 2007
    ....
  20. pmc Quantifying clinical relevance in the treatment of schizophrenia
    Christoph U Correll
    Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
    Clin Ther 33:B16-39. 2011
    ..While in research studies, the use of quantitative assessments is ubiquitous, this is not the case in routine clinical practice, creating an important translational practice gap...
  21. pmc Time to treatment response in first-episode schizophrenia: should acute treatment trials last several months?
    Juan A Gallego
    The Zucker Hillside Hospital, NY 11004, USA
    J Clin Psychiatry 72:1691-6. 2011
    ..This analysis explored trial duration with first-episode patients and asked whether early limited improvement predicts ultimate lack of treatment response with first-episode patients as it does with multiepisode patients...
  22. pmc Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents
    Christoph U Correll
    Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, 75 59 263rd St, Glen Oaks, NY 11004, USA
    JAMA 302:1765-73. 2009
    ..Cardiometabolic effects of second-generation antipsychotic medications are concerning but have not been sufficiently studied in pediatric and adolescent patients naive to antipsychotic medication...
  23. pmc Obesity and coronary risk in patients treated with second-generation antipsychotics
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY, 11004, USA
    Eur Arch Psychiatry Clin Neurosci 261:417-23. 2011
    ..Obesity does not appear to be an independent predictor for the 10-year risk of coronary heart disease events in patients without metabolic syndrome treated with second-generation antipsychotics...
  24. ncbi request reprint DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients
    Todd Lencz
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 163:529-31. 2006
    ....
  25. doi request reprint The efficacy of aripiprazole in the treatment of multiple symptom domains in patients with acute schizophrenia: a pooled analysis of data from the pivotal trials
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, New York, NY, USA
    Schizophr Res 105:208-15. 2008
    ..To examine the efficacy of aripiprazole across symptoms in patients with acute exacerbation of schizophrenia or schizoaffective disorder...
  26. pmc DRD2 promoter region variation predicts antipsychotic-induced weight gain in first episode schizophrenia
    Todd Lencz
    Division of Psychiatry Research, The Zucker Hillside Hospital, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Pharmacogenet Genomics 20:569-72. 2010
    ..Given earlier evidence that deletion carriers show reduced symptom response to medication, additional study of appropriate treatment options for these patients seems warranted...
  27. doi request reprint Medical outcome of patients with dementia in a free-standing psychiatric hospital
    Peter Manu
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Geriatr Psychiatry Neurol 26:29-33. 2013
    ..The hospital outcome of patients with dementia is significantly worse than that of cognitively intact persons of the same age admitted to medical or surgical units but has not been investigated in psychiatric settings...
  28. pmc Magnetic resonance imaging predictors of treatment response in first-episode schizophrenia
    Philip R Szeszko
    Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA
    Schizophr Bull 38:569-78. 2012
    ....
  29. pmc Antipsychotic drug administration does not correlate with prolonged rate-corrected QT interval in children and adolescents: results from a nested case-control study
    Christoph U Correll
    North Shore Long Island Jewish Health System, The Zucker Hillside Hospital, Glen Oaks, New York 11004, USA
    J Child Adolesc Psychopharmacol 21:365-8. 2011
    ..The rate-corrected QT interval (QTc) prolongation is a risk factor for sudden cardiac death and may be induced by antipsychotic drugs...
  30. ncbi request reprint Dysbindin genotype and negative symptoms in schizophrenia
    Pamela DeRosse
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 163:532-4. 2006
    ....
  31. pmc Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia
    Todd Lencz
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Proc Natl Acad Sci U S A 104:19942-7. 2007
    ..Other risk ROHs feature haplotypes that are also common in healthy individuals, possibly indicating a source of balancing selection...
  32. doi request reprint Adjunctive armodafinil for negative symptoms in adults with schizophrenia: a double-blind, placebo-controlled study
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, 75 59 263rd Street, Kaufmann Bldg, Suite 103, Glen Oaks, NY 11004 1150, USA
    Schizophr Res 135:116-22. 2012
    ..This study investigated the efficacy and tolerability of adjunctive armodafinil for treatment of negative symptoms in adults with schizophrenia receiving antipsychotic medications...
  33. ncbi request reprint Aripiprazole for treatment-resistant schizophrenia: results of a multicenter, randomized, double-blind, comparison study versus perphenazine
    John M Kane
    Zucker Hillside Hospital and The Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 68:213-23. 2007
    ..Treatment-resistant schizophrenia poses a major therapeutic challenge. This multicenter, double-blind, randomized study compared the efficacy and safety of aripiprazole and perphenazine in treatment-resistant patients with schizophrenia...
  34. ncbi request reprint COMT genotype and manic symptoms in schizophrenia
    Pamela DeRosse
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, and Harvard Partners Center for Genetics and Genomics, Boston, MA, United States
    Schizophr Res 87:28-31. 2006
    ..These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ...
  35. ncbi request reprint Randomized comparison of olanzapine versus risperidone for the treatment of first-episode schizophrenia: 4-month outcomes
    Delbert G Robinson
    Department of Psychiatry, The Zucker Hillside Hospital of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 163:2096-102. 2006
    ..The authors compared 4-month treatment outcomes for olanzapine versus risperidone in patients with first-episode schizophrenia spectrum disorders...
  36. ncbi request reprint Ziprasidone-induced cognitive enhancement in schizophrenia: specificity or pseudospecificity?
    Anil K Malhotra
    Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, and Albert Einstein College of Medicine, United States
    Schizophr Res 87:181-4. 2006
    ..We tested the hypothesis that ziprasidone improves cognition in the absence of clinical improvement...
  37. ncbi request reprint White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study
    Sanjiv Kumra
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 44:934-41. 2005
    ..To investigate abnormalities in the structural integrity of brain white matter as suggested by diffusion tensor imaging in adolescents with early-onset schizophrenia (onset of psychosis by age 18)...
  38. pmc Safety and tolerability of antipsychotic polypharmacy
    Juan A Gallego
    The Zucker Hillside Hospital, Psychiatry Research, North Shore LIJ Health System, Glen Oaks, NY 11004, USA
    Expert Opin Drug Saf 11:527-42. 2012
    ..Prior reviews have focused on the efficacy of APP, but no systematic review exists regarding the safety and tolerability of this practice...
  39. ncbi request reprint Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis
    Taro Kishi
    Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Hum Psychopharmacol 27:63-9. 2012
    ..We sought to assess the relationship between genotype alterations in 5-HT6 receptors and schizophrenia both in a case-control study and a meta-analysis...
  40. pmc Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes
    Todd Lencz
    The Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, New York 11004, USA
    Br J Psychiatry 194:313-8. 2009
    ..Brain-derived neurotrophic factor variants may help clarify the status of schizoaffective disorder...
  41. ncbi request reprint Review of treatments that can ameliorate nonadherence in patients with schizophrenia
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 67:9-14. 2006
    ....
  42. ncbi request reprint Early identification and high-risk strategies for bipolar disorder
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Bipolar Disord 9:324-38. 2007
    ..To describe and compare the relative merits of different identification strategies for individuals at risk for bipolar disorder (BPD)...
  43. pmc Antipsychotic polypharmacy: a Japanese survey of prescribers' attitudes and rationales
    Taishiro Kishimoto
    Keio University School of Medicine, Department of Neuropsychiatry, Shinjuku, Tokyo, Japan The Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA Hofstra North Shore LIJ School of Medicine, Hempstead, NY, USA The Feinstein Institute for Medical Research, Manhasset, NY, USA Electronic address
    Psychiatry Res 209:406-11. 2013
    ..64, 95% CI: 0.44-0.92, p=0.017) (r(2)=0.111, p=0.001). High and low APP prescribers shared a comparable degree of justifications and concerns. Future research should examine the impact of cultural determinants on APP. ..
  44. pmc Hospitalisation rates in patients switched from oral anti-psychotics to aripiprazole once-monthly for the management of schizophrenia
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital and The Hofstra North Shore LIJ School of Medicine, Glen Oaks, NY, USA
    J Med Econ 16:917-25. 2013
    ..To report the design and preliminary results of a mirror-image study comparing total psychiatric hospitalisation rates pre- and post-switch to aripiprazole once-monthly, an extended release injectable solution...
  45. doi request reprint Lessons learned in the conduct of a global, large simple trial of treatments indicated for schizophrenia
    Francesca M Kolitsopoulos
    Epidemiology, Worldwide Safety Strategy, Pfizer, Inc, New York, NY, USA
    Contemp Clin Trials 34:239-47. 2013
    ....
  46. doi request reprint Insulin secretion in patients receiving clozapine, olanzapine, quetiapine and risperidone
    Peter Manu
    Zucker Hillside Hospital, Glen Oaks, NY, United States
    Schizophr Res 143:358-62. 2013
    ..An independent effect of SGAs on insulin secretion has been suggested in animal models, but has not been demonstrated in clinical samples...
  47. pmc Effectiveness of a cognitive behavioral weight management intervention in obese patients with psychotic disorders compared to patients with nonpsychotic disorders or no psychiatric disorders: results from a 12-month, real-world study
    Jian Ping Zhang
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychopharmacol 32:458-64. 2012
    ..Therefore, we compared the effect of a cognitive-behavioral weight loss intervention in obese subjects with psychotic disorders, other psychiatric diagnoses, and without psychiatric disorders...
  48. ncbi request reprint Atypical antipsychotics: sedation versus efficacy
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 69:18-31. 2008
    ....
  49. doi request reprint Armodafinil as adjunctive therapy in adults with cognitive deficits associated with schizophrenia: a 4-week, double-blind, placebo-controlled study
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004 1150, USA
    J Clin Psychiatry 71:1475-81. 2010
    ..To evaluate the efficacy and tolerability of armodafinil, the longer-lasting isomer of modafinil, as adjunctive therapy in patients with schizophrenia...
  50. pmc QT interval duration and dispersion in children and adolescents treated with ziprasidone
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 72:854-60. 2011
    ..To assess the incidence of symptoms (palpitations, syncope) and electrocardiographic signs (increased QT duration and dispersion) of an increased risk of torsades de pointes in youth treated with ziprasidone...
  51. doi request reprint A randomized placebo-controlled trial of asenapine for the prevention of relapse of schizophrenia after long-term treatment
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, 75 59 263rd St, Kaufmann Bldg, Ste 103, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 72:349-55. 2011
    ..Long-term efficacy of asenapine in preventing schizophrenia relapse was assessed in a 26-week double-blind, placebo-controlled trial that followed 26 weeks of open-label treatment...
  52. ncbi request reprint Oral ziprasidone in the treatment of schizophrenia: a review of short-term trials
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 64:19-25. 2003
    ..Available clinical data support rapid titration to > or = 120 mg/day for optimal efficacy in patients with acute exacerbation of schizophrenia...
  53. doi request reprint The QTc interval and its dispersion in patients receiving two atypical antipsychotics
    Christoph U Correll
    Medical Services, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Eur Arch Psychiatry Clin Neurosci 259:23-7. 2009
    ..Polytherapy with atypical antipsychotics is becoming common, but the effect of this practice on the QTc has not been explored in detail...
  54. ncbi request reprint Clinical insights into pharmacogenetics and schizophrenia, part 2
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA
    J Clin Psychiatry 69:1006-13. 2008
  55. doi request reprint Equally increased risk for metabolic syndrome in patients with bipolar disorder and schizophrenia treated with second-generation antipsychotics
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Bipolar Disord 10:788-97. 2008
    ..We compared bipolar disorder and schizophrenia patients receiving SGAs to determine whether MetS prevalence is influenced by the primary psychiatric diagnosis or concomitant mood stabilizer treatment...
  56. ncbi request reprint A 28-week, randomized, double-blind study of olanzapine versus aripiprazole in the treatment of schizophrenia
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004 1150, USA
    J Clin Psychiatry 70:572-81. 2009
    ..To evaluate the effectiveness of olanzapine versus aripiprazole in patients with schizophrenia...
  57. ncbi request reprint Metabolic syndrome and the risk of coronary heart disease in 367 patients treated with second-generation antipsychotic drugs
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 67:575-83. 2006
    ....
  58. ncbi request reprint Genetic variation in DTNBP1 influences general cognitive ability
    Katherine E Burdick
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA
    Hum Mol Genet 15:1563-8. 2006
    ..These data suggest that DTNBP1 genetic variation influences human intelligence...
  59. ncbi request reprint Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 160:2190-7. 2003
    ..The authors investigated volumetric alterations of the anterior hippocampal formation in patients experiencing a first episode of schizophrenia relative to healthy comparison subjects...
  60. ncbi request reprint Reduced frontal white matter integrity in early-onset schizophrenia: a preliminary study
    Sanjiv Kumra
    Department of Research, Zucker Hillside Hospital, Glen Oaks, New York 11004, USA
    Biol Psychiatry 55:1138-45. 2004
    ..Diffusion tensor imaging provides a relatively new approach for quantifying possible connectivity of WM in vivo...
  61. doi request reprint Medical outcome of psychiatric inpatients with admission hyponatremia
    Peter Manu
    Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, United States
    Psychiatry Res 198:24-7. 2012
    ..Admission hyponatremia is associated with an increased rate of significant medical deteriorations of psychiatric inpatients and should trigger enhanced clinical monitoring to identify and treat somatic disorders...
  62. doi request reprint A double-blind, randomized study comparing the efficacy and safety of sertindole and risperidone in patients with treatment-resistant schizophrenia
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 72:194-204. 2011
    ..The objective of this study was to examine the efficacy and safety of sertindole, compared to risperidone, in this patient population...
  63. ncbi request reprint Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder
    John M Kane
    Zucker Hillside Hospital, Glen Oaks, NY, USA
    J Clin Psychiatry 63:763-71. 2002
    ..Aripiprazole is an investigational agent for treating schizophrenia that has a novel pharmacologic profile. The present study investigated the efficacy, safety, and tolerability of aripiprazole and haloperidol compared with placebo...
  64. pmc Incidence of tardive dyskinesia with risperidone or olanzapine in the elderly: results from a 2-year, prospective study in antipsychotic-naïve patients
    Margaret G Woerner
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Neuropsychopharmacology 36:1738-46. 2011
    ..This information is relevant for all patients receiving antipsychotics, not just the especially sensitive elderly...
  65. ncbi request reprint Identification of high-risk coronary heart disease patients receiving atypical antipsychotics: single low-density lipoprotein cholesterol threshold or complex national standard?
    Christoph U Correll
    Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 69:578-83. 2008
    ..The study was performed in patients receiving second-generation antipsychotics (SGAs), a medication class associated with CHD risk...
  66. ncbi request reprint DISC1 and neurocognitive function in schizophrenia
    Katherine E Burdick
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
    Neuroreport 16:1399-402. 2005
    ..These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia...
  67. ncbi request reprint Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Br J Psychiatry 190:230-6. 2007
    ..Despite the high prevalence of cannabis use in schizophrenia, few studies have examined the potential relationship between cannabis exposure and brain structural abnormalities in schizophrenia...
  68. doi request reprint Olanzapine long-acting injection: a 24-week, randomized, double-blind trial of maintenance treatment in patients with schizophrenia
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 167:181-9. 2010
    ..The purpose of the present study was to evaluate the efficacy and tolerability of olanzapine long-acting injection for maintenance treatment of schizophrenia...
  69. ncbi request reprint Efficacy and tolerability of ziprasidone in patients with treatment-resistant schizophrenia
    John M Kane
    The Zucker Hillside Hospital and The Albert Einstein College of Medicine, Glen Oaks, New York, USA
    Int Clin Psychopharmacol 21:21-8. 2006
    ..Ziprasidone was associated with a greater decrease in median prolactin levels and a lower incidence of clinically significant weight change. Neither agent caused any clinically important changes in QTc interval...
  70. pmc Antipsychotic combinations vs monotherapy in schizophrenia: a meta-analysis of randomized controlled trials
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, New York, NY 11004, USA
    Schizophr Bull 35:443-57. 2009
    ..Despite lacking evidence for its safety and efficacy, antipsychotic cotreatment is common in schizophrenia. Objective: To evaluate therapeutic and adverse effects of antipsychotic cotreatment vs monotherapy in schizophrenia...
  71. doi request reprint Comparative utility of aripiprazole and haloperidol in schizophrenia: post hoc analysis of two 52-week, randomized, controlled trials
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, New York 11004, USA
    Appl Health Econ Health Policy 7:109-19. 2009
    ..Since their introduction, second-generation antipsychotics (SGAs) have become the drugs of choice for the treatment of schizophrenia. However, recent findings have questioned the benefits of SGAs over first-generation antipsychotics (FGAs)...
  72. ncbi request reprint Genomics and the future of pharmacotherapy in psychiatry
    Anil K Malhotra
    Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Int Rev Psychiatry 19:523-30. 2007
    ..These increasingly comprehensive approaches should provide informative data on the genes associated with psychotropic drug response, a critical step towards the ultimate goal of 'personalized' medicine...
  73. pmc Antipsychotic polypharmacy: a survey study of prescriber attitudes, knowledge and behavior
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Schizophr Res 131:58-62. 2011
    ..Although common in psychiatric practice, reasons for antipsychotic polypharmacy (APP) have remained unclear...
  74. ncbi request reprint Low-density lipoprotein cholesterol in patients treated with atypical antipsychotics: missed targets and lost opportunities
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Schizophr Res 92:103-7. 2007
    ..Lowering low-density lipoprotein-cholesterol (LDL-C) to individualized targets of 100, 130 or 160 mg/dl reduces the risk of CHD. We determined the prevalence of above-target LDL-C and its management during psychiatric hospitalization...
  75. ncbi request reprint Long-acting injectable risperidone: efficacy and safety of the first long-acting atypical antipsychotic
    John M Kane
    The Zucker Hillside Hospital, New York, NY 11004, USA
    Am J Psychiatry 160:1125-32. 2003
    ..The authors assessed the efficacy and safety of the first long-acting atypical antipsychotic (long-acting injectable risperidone) in patients with schizophrenia...
  76. ncbi request reprint Clozapine as a first treatment for schizophrenia
    Margaret G Woerner
    Department of Psychiatry, Zucker Hillside Hospital of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 160:1514-6. 2003
    ..The authors' goal was to explore whether clozapine given as the first antipsychotic treatment favorably affects the course of schizophrenia...
  77. ncbi request reprint Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies
    Christoph U Correll
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Schneider Children s Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 161:414-25. 2004
    ..This hypothesis was examined in a systematic review of studies involving open or controlled treatment with any second-generation antipsychotic...
  78. ncbi request reprint Strategies for improving compliance in treatment of schizophrenia by using a long-acting formulation of an antipsychotic: clinical studies
    John M Kane
    Albert Einstein College of Medicine, Bronx, NY, USA
    J Clin Psychiatry 64:34-40. 2003
    ....
  79. ncbi request reprint Cost-effective screening for the metabolic syndrome in patients treated with second-generation antipsychotic medications
    David Straker
    Department of Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Am J Psychiatry 162:1217-21. 2005
    ..The authors' goal was to explore the relationship between second-generation antipsychotics and the metabolic syndrome...