Samuel L Jones

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. ncbi request reprint Protein kinase A regulates beta2 integrin avidity in neutrophils
    Samuel L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Leukoc Biol 71:1042-8. 2002
  2. ncbi request reprint Neutrophils increase paracellular permeability of restituted ischemic-injured porcine ileum
    J mai Gayle
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Surgery 132:461-70. 2002
  3. ncbi request reprint A retrospective analysis of hepatic injury in horses with proximal enteritis (1984-2002)
    Jennifer L Davis
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Vet Intern Med 17:896-901. 2003
  4. pmc Neutrophils do not mediate the pathophysiological sequelae of Cryptosporidium parvum infection in neonatal piglets
    Leah M Zadrozny
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Infect Immun 74:5497-505. 2006
  5. ncbi request reprint Predisposing factors for small colon impaction in horses and outcome of medical and surgical treatment: 44 cases (1999-2004)
    Lisa M Frederico
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 229:1612-6. 2006
  6. ncbi request reprint Asymmetrical protein kinase A activity establishes neutrophil cytoskeletal polarity and enables chemotaxis
    Samuel L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, 27606, USA
    J Leukoc Biol 78:248-58. 2005
  7. ncbi request reprint The future of antiinflammatory therapy
    S L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Vet Clin North Am Equine Pract 17:245-62, vi. 2001
  8. doi request reprint Detection of Bartonella henselae in the blood of 2 adult horses
    S L Jones
    Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA
    J Vet Intern Med 22:495-8. 2008
  9. ncbi request reprint Role of the enteric nervous system in the pathophysiology of secretory diarrhea
    Samuel L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, USA
    J Vet Intern Med 16:222-8. 2002
  10. ncbi request reprint Signaling mechanism for equine neutrophil activation by immune complexes
    S L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Vet Immunol Immunopathol 82:87-100. 2001

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Protein kinase A regulates beta2 integrin avidity in neutrophils
    Samuel L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Leukoc Biol 71:1042-8. 2002
    ..These data demonstrate that PKA appears to have a dual role in the mechanism regulating alphaMbeta2 integrin avidity and adhesion...
  2. ncbi request reprint Neutrophils increase paracellular permeability of restituted ischemic-injured porcine ileum
    J mai Gayle
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Surgery 132:461-70. 2002
    ..However, we noted marked neutrophil infiltration 6 to 18 hours after ischemia during mucosal repair. We postulated such neutrophil infiltration would disrupt restituting epithelium...
  3. ncbi request reprint A retrospective analysis of hepatic injury in horses with proximal enteritis (1984-2002)
    Jennifer L Davis
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Vet Intern Med 17:896-901. 2003
    ....
  4. pmc Neutrophils do not mediate the pathophysiological sequelae of Cryptosporidium parvum infection in neonatal piglets
    Leah M Zadrozny
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Infect Immun 74:5497-505. 2006
    ..These studies are the first to demonstrate that neutrophilic inflammation arising in response to infection by a noninvasive epithelial pathogen results in physiologic rather than pathological effects in vivo...
  5. ncbi request reprint Predisposing factors for small colon impaction in horses and outcome of medical and surgical treatment: 44 cases (1999-2004)
    Lisa M Frederico
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 229:1612-6. 2006
    ..To identify factors associated with development of small colon impaction in horses and with selection of medical versus surgical treatment and to determine the prognosis for affected horses following medical or surgical management...
  6. ncbi request reprint Asymmetrical protein kinase A activity establishes neutrophil cytoskeletal polarity and enables chemotaxis
    Samuel L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, 27606, USA
    J Leukoc Biol 78:248-58. 2005
    ..These data suggest that asymmetrical PKA activity is necessary and sufficient for actin cytoskeletal polarization and migration during neutrophil chemotaxis. In addition, our data suggest PI-3K is an effector of PKA during chemotaxis...
  7. ncbi request reprint The future of antiinflammatory therapy
    S L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Vet Clin North Am Equine Pract 17:245-62, vi. 2001
    ..These areas of antiinflammatory research are rapidly yielding drugs with diverse future applications in equine medicine...
  8. doi request reprint Detection of Bartonella henselae in the blood of 2 adult horses
    S L Jones
    Department of Clinical Sciences, North Carolina State University, Raleigh, NC, USA
    J Vet Intern Med 22:495-8. 2008
    ..Bartonella sp. infection has been identified in a growing number of animal species, including cats, rodents, porpoises, and canids, but has not been reported in horses...
  9. ncbi request reprint Role of the enteric nervous system in the pathophysiology of secretory diarrhea
    Samuel L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, USA
    J Vet Intern Med 16:222-8. 2002
    ..New approaches targeting the enteric nervous system show promise for the treatment of secretory diarrhea...
  10. ncbi request reprint Signaling mechanism for equine neutrophil activation by immune complexes
    S L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Vet Immunol Immunopathol 82:87-100. 2001
    ..These data demonstrate that like in human PMN, IC-induced activation of beta 2 integrins and beta 2 integrin-dependent functions in equine PMN is dependent on PI3K activity...
  11. ncbi request reprint Treatment of acute and chronic gastrointestinal inflammation
    Samuel L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vet Clin North Am Equine Pract 19:697-714. 2003
    ....
  12. doi request reprint p38 mitogen-activated kinase (MAPK) is essential for equine neutrophil migration
    Rachael E Eckert
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, United States
    Vet Immunol Immunopathol 129:181-91. 2009
    ..These findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38 MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis...
  13. ncbi request reprint Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1beta- and COX-2-dependent mechanism
    Donnie E Shifflett
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Am J Physiol Gastrointest Liver Physiol 287:G50-7. 2004
    ..We concluded that PMNs augment recovery of TER in ischemia-injured ileal mucosa via IL-1beta-dependent upregulation of COX-2...
  14. pmc Myristoylated alanine-rich C-kinase substrate (MARCKS) protein regulation of human neutrophil migration
    Rachael E Eckert
    Department of Clinical Sciences, College of Veterinary Medicine, North Caroline State University, Raleigh, North Carolina, USA
    Am J Respir Cell Mol Biol 42:586-94. 2010
    ..MANS did not alter fMLF-induced increases in surface beta2 integrin expression. These results suggest that MARCKS, via its myristoylated aminoterminus, is a key regulator of neutrophil migration and adhesion...
  15. doi request reprint Tonic protein kinase A activity maintains inactive beta2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase
    Clayton D Chilcoat
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Leukoc Biol 83:964-71. 2008
    ..These findings demonstrate that tonic PKA activity prevents activation of beta2 integrins and adhesion by inhibiting MLC phosphorylation via a MLCK-dependent but ROCK-independent pathway...
  16. doi request reprint The effect of lidocaine on in vitro adhesion and migration of equine neutrophils
    Vanessa L Cook
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Vet Immunol Immunopathol 129:137-42. 2009
    ..In conclusion, lidocaine did not inhibit neutrophil migration or adhesion in vitro at therapeutic concentrations, and increased migration and adhesion at higher concentrations...
  17. ncbi request reprint Mitogen-activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum
    Donnie E Shifflett
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Am J Physiol Gastrointest Liver Physiol 286:G906-13. 2004
    ..COX-2 expression appears to be positively and negatively regulated by the p38 MAPK and the JNK pathways, respectively. Alternatively, ERK1/2 appear to be involved in COX-2-independent reparative events that remain to be defined...
  18. ncbi request reprint Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant
    Rachael E Eckert
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Leukoc Biol 82:1311-21. 2007
    ..Adhesion does not appear to be an important regulator of the state of VASP Ser 157 phosphorylation in chemoattractant-stimulated neutrophils...
  19. pmc A myristoylated alanine-rich C kinase substrate-related peptide suppresses cytokine mRNA and protein expression in LPS-activated canine neutrophils
    Jingjing Li
    Comparative Biomedical Sciences Graduate Program, North Carolina State University, Raleigh, NC 27606, USA
    Am J Respir Cell Mol Biol 48:314-21. 2013
    ....
  20. ncbi request reprint PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum
    Dianne Little
    Department of Clinical Sciences, North Carolina State University, Raleigh 27606, USA
    Am J Physiol Gastrointest Liver Physiol 284:G46-56. 2003
    ..These experiments suggest that PGs stimulate recovery of paracellular resistance via a mechanism involving transepithelial osmotic gradients and PI3K-dependent restoration of tight junction protein distribution...
  21. ncbi request reprint Cyclooxygenase (COX) inhibitors and the intestine
    Dianne Little
    Colic and Digestive Disease Program, Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA
    J Vet Intern Med 21:367-77. 2007
    ....
  22. ncbi request reprint The effects of cAMP modulation upon the adhesion and respiratory burst activity of immune complex-stimulated equine neutrophils
    Clayton D Chilcoat
    Department of Clinical Sciences, North Carolina College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Vet Immunol Immunopathol 88:65-77. 2002
    ..Importantly, co-treatment of equine PMN with rolipram and either beta(2) adrenergic agonist synergistically inhibited both the adhesion of equine PMN to IC as well as the subsequent respiratory burst activity...
  23. doi request reprint Role of p38 MAPK in LPS induced pro-inflammatory cytokine and chemokine gene expression in equine leukocytes
    Laura E Neuder
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, United States
    Vet Immunol Immunopathol 129:192-9. 2009
    ..This study provides evidence for the use of selective p38 MAPK inhibitors as potential therapeutics for the treatment of equine endotoxemia...
  24. ncbi request reprint The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes
    Rachael E Eckert
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
    Vet Immunol Immunopathol 118:294-303. 2007
    ..We concluded that p38 MAPK is essential for LPS-induced COX-2 expression suggesting that p38 MAPK is a potential target for anti-inflammatory therapy during equine endotoxemia...
  25. ncbi request reprint Restoration of barrier function in injured intestinal mucosa
    Anthony T Blikslager
    Department of Clinical Science, North Carolina State University, Raleigh 27606, USA
    Physiol Rev 87:545-64. 2007
    ..The net result of reparative mechanisms is remarkably rapid closure of mucosal wounds in mammalian tissues to prevent the onset of sepsis...
  26. ncbi request reprint Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes
    J L Davis
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Vet Pharmacol Ther 25:99-104. 2002
    ..The PMN half-life was 49.2 h. Dosage of 10 mg/kg of azithromycin p.o. once daily for foals with R. equi pneumonia is recommended for further study...
  27. pmc Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein
    Teresa D Green
    Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA
    J Leukoc Biol 92:633-9. 2012
    ..These results suggest that MARCKS is involved in directed migration of macrophages via a process involving its phosphorylation, cytoplasmic translocation, and interaction with actin...
  28. ncbi request reprint Red maple (Acer rubrum) leaf toxicosis in horses: a retrospective study of 32 cases
    Ashley Alward
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Vet Intern Med 20:1197-201. 2006
    ..Ingestion of wilted red maple leaves by horses can result in severe hemolytic anemia and methemoglobinemia. Little is known about what factors influence the outcome of red maple leaf toxicosis in horses...
  29. ncbi request reprint Suppurative cholangiohepatitis and enteritis in adult horses
    Jennifer L Davis
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Vet Intern Med 17:583-7. 2003
  30. ncbi request reprint Moxifloxacin pharmacokinetics in horses and disposition into phagocytes after oral dosing
    S Y Gardner
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Vet Pharmacol Ther 27:57-60. 2004
  31. ncbi request reprint Hypomagnesemia in hospitalized horses
    Anna M Johansson
    Department of Clinical Science, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    J Vet Intern Med 17:860-7. 2003
    ..53, 95% CI: 0.30-0.95). Among horses that survived, hypomagnesemia at admission was associated with a longer hospitalization period (OR: 1.45, 95% CI: 1.00-2.11)...
  32. ncbi request reprint Percutaneous retrieval of a jugular catheter fragment from the pulmonary artery of a foal
    Dianne Little
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27616, USA
    J Am Vet Med Assoc 220:212-4, 184. 2002
    ..To our knowledge, this is the first report of successful retrieval of a catheter fragment from the pulmonary artery in a horse...
  33. ncbi request reprint Ultrasonographic findings in horses with right dorsal colitis: five cases (2000-2001)
    Samuel L Jones
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 222:1248-51. 2003
    ..To determine whether ultrasonography would be useful in the diagnosis of right dorsal colitis in horses...
  34. ncbi request reprint Use of an insect cell culture growth medium to isolate bacteria from horses with effusive, fibrinous pericarditis: a preliminary study
    Samuel L Jones
    Intracellular Pathogens Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vet Microbiol 121:177-81. 2007
    ..and Pseudomonas rhodesiae from pericardial fluid samples. A similar or novel caterpillar-associated bacteria was not identified; however, use of an ICCGM might enhance isolation of bacteria from equine pericardial fluid...
  35. ncbi request reprint The effects of cyclo-oxygenase inhibitors on bile-injured and normal equine colon
    N B Campbell
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Equine Vet J 34:493-8. 2002
    ..Alternatively, selective inhibition of COX-2 may reduce the incidence of adverse effects in horses requiring NSAID therapy...
  36. ncbi request reprint Nasal adenocarcinoma with diffuse metastases involving the orbit, cerebrum, and multiple cranial nerves in a horse
    Jennifer L Davis
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 221:1460-3, 1420. 2002
    ..No evidence of direct involvement of the right facial and left vestibulocochlear nerves was found, suggesting the possibility of paraneoplastic peripheral neuropathy...
  37. doi request reprint Two Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Paralogs are Required for Normal Development in Zebrafish
    Laura E Ott
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606
    Anat Rec (Hoboken) 294:1511-24. 2011
    ..These results demonstrate that Marcksa and Marcksb are required for normal zebrafish development and suggest that zebrafish are a suitable model to further study MARCKS function. Anat Rec, 2011. © 2011 Wiley-Liss, Inc. ..
  38. doi request reprint Use of ultrasound to evaluate outcome following colic surgery for equine large colon volvulus
    M K Sheats
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Equine Vet J 42:47-52. 2010
    ..The post operative response of the large colon wall after a surgically corrected large colon volvulus (LCV) has not been investigated...
  39. ncbi request reprint Neodymium:yttrium-aluminum-garnet laser ablation of a urethral web to relieve urinary outflow obstruction in a horse
    A T Blikslager
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Am Vet Med Assoc 218:1970-2, 1937. 2001
    ..The proximal location of the urethral lesion in this horse would have made use of traditional surgical methods problematic, whereas transendoscopic laser photoablation was easy and effective...
  40. pmc Protective role of neutrophils in mice experimentally infected with Rhodococcus equi
    Ronald J Martens
    Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, 77843, USA
    Infect Immun 73:7040-2. 2005
    ..equi resulted in more severe disease and significantly increased tissue concentrations of R. equi...