Paul R Hess

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. ncbi Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen
    Paul R Hess
    Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, 27606, USA
    Cancer Immunol Immunother 55:672-83. 2006
  2. ncbi Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin
    Paul R Hess
    Department of Microbiology and Immunology, Universaity of North Carolina, Chapel Hill, NC, USA
    Blood 109:3300-7. 2007
  3. ncbi Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct
    Ellen F Young
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    Autoimmunity 42:678-91. 2009
  4. ncbi The use of peptide-major-histocompatibility-complex multimers in type 1 diabetes mellitus
    Greg S Gojanovich
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, USA
    J Diabetes Sci Technol 6:515-24. 2012
  5. ncbi Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice
    Benjamin G Vincent
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 184:4196-204. 2010
  6. ncbi Making the most of major histocompatibility complex molecule multimers: applications in type 1 diabetes
    Greg S Gojanovich
    Department of Clinical Sciences and Immunology Program, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA
    Clin Dev Immunol 2012:380289. 2012
  7. ncbi Evaluation of an in vitro telomeric repeat amplification protocol assay to detect telomerase activity in canine urine
    Angela L McCleary-Wheeler
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Am J Vet Res 71:1468-74. 2010

Collaborators

Detail Information

Publications7

  1. ncbi Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen
    Paul R Hess
    Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, 27606, USA
    Cancer Immunol Immunother 55:672-83. 2006
    ..Nonetheless, limitations of such vaccines in overcoming tolerance to tumor/self Ag may mandate prior or simultaneous reconstitution of the autoreactive T cell repertoire for this form of immunization to be effective...
  2. ncbi Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin
    Paul R Hess
    Department of Microbiology and Immunology, Universaity of North Carolina, Chapel Hill, NC, USA
    Blood 109:3300-7. 2007
    ..This work demonstrates the therapeutic potential of cytotoxic tetramers to selectively eradicate pathogenic clonotypes while leaving overall T-cell immunity intact...
  3. ncbi Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct
    Ellen F Young
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    Autoimmunity 42:678-91. 2009
    ..We conclude the underlying immunological processes in both male and female NOD mice are similar while the rates differ and the presence of naïve T cell in the islets may contribute to epitope spreading...
  4. ncbi The use of peptide-major-histocompatibility-complex multimers in type 1 diabetes mellitus
    Greg S Gojanovich
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, USA
    J Diabetes Sci Technol 6:515-24. 2012
    ....
  5. ncbi Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice
    Benjamin G Vincent
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 184:4196-204. 2010
    ..Finally, we show deletion at 8 wk of age of IGRP(+) CD8(+) T cells, but not dystophia myotonica kinase- or insulin B-reactive cells, significantly delays diabetes in NOD mice...
  6. ncbi Making the most of major histocompatibility complex molecule multimers: applications in type 1 diabetes
    Greg S Gojanovich
    Department of Clinical Sciences and Immunology Program, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA
    Clin Dev Immunol 2012:380289. 2012
    ..This paper will provide a brief overview of pMHC multimer usage in defining the role T-cell subsets play in T1D etiology and the therapeutic potential of pMHC for antigen-specific identification and modulation of diabetogenic T cells...
  7. ncbi Evaluation of an in vitro telomeric repeat amplification protocol assay to detect telomerase activity in canine urine
    Angela L McCleary-Wheeler
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Am J Vet Res 71:1468-74. 2010
    ....