Paul R Hess
Affiliation: North Carolina State University
- Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigenPaul R Hess
Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, 27606, USA
Cancer Immunol Immunother 55:672-83. 2006..Nonetheless, limitations of such vaccines in overcoming tolerance to tumor/self Ag may mandate prior or simultaneous reconstitution of the autoreactive T cell repertoire for this form of immunization to be effective...
- Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporinPaul R Hess
Department of Microbiology and Immunology, Universaity of North Carolina, Chapel Hill, NC, USA
Blood 109:3300-7. 2007..This work demonstrates the therapeutic potential of cytotoxic tetramers to selectively eradicate pathogenic clonotypes while leaving overall T-cell immunity intact...
- Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinctEllen F Young
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
Autoimmunity 42:678-91. 2009..We conclude the underlying immunological processes in both male and female NOD mice are similar while the rates differ and the presence of naïve T cell in the islets may contribute to epitope spreading...
- The use of peptide-major-histocompatibility-complex multimers in type 1 diabetes mellitusGreg S Gojanovich
College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, USA
J Diabetes Sci Technol 6:515-24. 2012....
- Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic miceBenjamin G Vincent
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
J Immunol 184:4196-204. 2010..Finally, we show deletion at 8 wk of age of IGRP(+) CD8(+) T cells, but not dystophia myotonica kinase- or insulin B-reactive cells, significantly delays diabetes in NOD mice...
- Making the most of major histocompatibility complex molecule multimers: applications in type 1 diabetesGreg S Gojanovich
Department of Clinical Sciences and Immunology Program, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA
Clin Dev Immunol 2012:380289. 2012..This paper will provide a brief overview of pMHC multimer usage in defining the role T-cell subsets play in T1D etiology and the therapeutic potential of pMHC for antigen-specific identification and modulation of diabetogenic T cells...
- Evaluation of an in vitro telomeric repeat amplification protocol assay to detect telomerase activity in canine urineAngela L McCleary-Wheeler
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Am J Vet Res 71:1468-74. 2010....