Paul R Hess

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. pmc Making the most of major histocompatibility complex molecule multimers: applications in type 1 diabetes
    Greg S Gojanovich
    Department of Clinical Sciences and Immunology Program, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA
    Clin Dev Immunol 2012:380289. 2012
  2. ncbi request reprint Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen
    Paul R Hess
    Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, 27606, USA
    Cancer Immunol Immunother 55:672-83. 2006
  3. pmc Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin
    Paul R Hess
    Department of Microbiology and Immunology, Universaity of North Carolina, Chapel Hill, NC, USA
    Blood 109:3300-7. 2007
  4. pmc Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance
    Sabrina M Hess
    Immunology Program, Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA
    Transpl Immunol 29:138-45. 2013
  5. pmc Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct
    Ellen F Young
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    Autoimmunity 42:678-91. 2009
  6. pmc Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris)
    Gregory S Gojanovich
    Immunology Program, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
    Dev Comp Immunol 41:578-86. 2013
  7. pmc The use of peptide-major-histocompatibility-complex multimers in type 1 diabetes mellitus
    Greg S Gojanovich
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, USA
    J Diabetes Sci Technol 6:515-24. 2012
  8. pmc Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K
    Jennifer C Holmes
    Immunology Program, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA
    Immunogenetics 65:675-89. 2013
  9. pmc Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice
    Benjamin G Vincent
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 184:4196-204. 2010
  10. doi request reprint Comparison of automated versus manual neutrophil counts for the detection of cellular abnormalities in dogs receiving chemotherapy: 50 cases (May to June 2008)
    Michelle C Cora
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 242:1539-43. 2013

Collaborators

Detail Information

Publications12

  1. pmc Making the most of major histocompatibility complex molecule multimers: applications in type 1 diabetes
    Greg S Gojanovich
    Department of Clinical Sciences and Immunology Program, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA
    Clin Dev Immunol 2012:380289. 2012
    ..This paper will provide a brief overview of pMHC multimer usage in defining the role T-cell subsets play in T1D etiology and the therapeutic potential of pMHC for antigen-specific identification and modulation of diabetogenic T cells...
  2. ncbi request reprint Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen
    Paul R Hess
    Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh, 27606, USA
    Cancer Immunol Immunother 55:672-83. 2006
    ..Nonetheless, limitations of such vaccines in overcoming tolerance to tumor/self Ag may mandate prior or simultaneous reconstitution of the autoreactive T cell repertoire for this form of immunization to be effective...
  3. pmc Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin
    Paul R Hess
    Department of Microbiology and Immunology, Universaity of North Carolina, Chapel Hill, NC, USA
    Blood 109:3300-7. 2007
    ..This work demonstrates the therapeutic potential of cytotoxic tetramers to selectively eradicate pathogenic clonotypes while leaving overall T-cell immunity intact...
  4. pmc Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance
    Sabrina M Hess
    Immunology Program, Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA
    Transpl Immunol 29:138-45. 2013
    ..Toxic tetramers conceivably could be used in combination to dissect manipulate CD8(+) T-cell immunodominance hierarchies, and to prevent the induction of donor-specific, minor H antigen CTL responses in allotransplantation. ..
  5. pmc Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct
    Ellen F Young
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    Autoimmunity 42:678-91. 2009
    ..We conclude the underlying immunological processes in both male and female NOD mice are similar while the rates differ and the presence of naïve T cell in the islets may contribute to epitope spreading...
  6. pmc Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris)
    Gregory S Gojanovich
    Immunology Program, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
    Dev Comp Immunol 41:578-86. 2013
    ..This data should prove useful in investigating the association of specific TAP defects or alleles with immunity to intracellular pathogens and cancer in dogs. ..
  7. pmc The use of peptide-major-histocompatibility-complex multimers in type 1 diabetes mellitus
    Greg S Gojanovich
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, USA
    J Diabetes Sci Technol 6:515-24. 2012
    ....
  8. pmc Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K
    Jennifer C Holmes
    Immunology Program, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA
    Immunogenetics 65:675-89. 2013
    ..As predicted, FLAI-E, FLAI-H, and FLAI-K fulfill the major criteria of class Ia genes. These data represent a necessary prerequisite for studying epitope-specific antiviral CD8+ T-cell responses in cats...
  9. pmc Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice
    Benjamin G Vincent
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 184:4196-204. 2010
    ..Finally, we show deletion at 8 wk of age of IGRP(+) CD8(+) T cells, but not dystophia myotonica kinase- or insulin B-reactive cells, significantly delays diabetes in NOD mice...
  10. doi request reprint Comparison of automated versus manual neutrophil counts for the detection of cellular abnormalities in dogs receiving chemotherapy: 50 cases (May to June 2008)
    Michelle C Cora
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 242:1539-43. 2013
    ....
  11. pmc A cell-based MHC stabilization assay for the detection of peptide binding to the canine classical class I molecule, DLA-88
    Peter Ross
    Immunology Program, Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA
    Vet Immunol Immunopathol 150:206-12. 2012
    ..This work demonstrates the potential to use RMA-S cells transfected with canine alleles as a tool for CTL epitope discovery in this species...
  12. doi request reprint Evaluation of an in vitro telomeric repeat amplification protocol assay to detect telomerase activity in canine urine
    Angela L McCleary-Wheeler
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Am J Vet Res 71:1468-74. 2010
    ....