Research Topics
Species | Greg GibsonSummaryAffiliation: North Carolina State University Country: USA Publications
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Publications
Evolution. The synthesis and evolution of a supermodelGreg Gibson
Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
Science 307:1890-1. 2005- Mutation accumulation of the transcriptomeGreg Gibson
Nat Genet 37:458-60. 2005 - The quantitative genetics of transcriptionGreg Gibson
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 37695 7614, USA
Trends Genet 21:616-23. 2005..The implications of these findings for genotype-phenotype mapping and modeling the evolution of transcription are discussed... - Evolution: the plastic transcriptomeGreg Gibson
Department of Genetics, North Carolina State University, Raleigh, 27695 7614, USA
Curr Biol 16:R285-7. 2006.... 
A gene expression signature of confinement in peripheral blood of red wolves (Canis rufus)Erin Kennerly
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 27695 7614, USA
Mol Ecol 17:2782-91. 2008....
Mixture modeling of transcript abundance classes in natural populationsWen Ping Hsieh
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
Genome Biol 8:R98. 2007..Here, we explore the distributions of cis-acting and trans-acting factors and their relative contributions to expression of transcripts that exhibit two or more classes of abundance among individuals within populations...
Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypesPierre R Bushel
National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
BMC Syst Biol 1:15. 2007..The inability of clustering algorithms to incorporate biological data in the grouping process can limit proper interpretation of the data and its underlying biology...- Human genetics: the hidden text of genome-wide associationsGreg Gibson
Department of Genetics, North Carolina State University, Gardner Hall, Raleigh, North Carolina 27695 7614, USA
Curr Biol 17:R929-32. 2007..Several challenges lie ahead, including translation of the findings into practical public health outcomes, and integrating genetic analysis with broader biological understanding... - Human evolution: thrifty genes and the dairy queenGreg Gibson
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Curr Biol 17:R295-6. 2007..Two new studies of genes that have experienced positive selection since the origin of pastoral agriculture help explain the incidence of lactose tolerance and diabetes, but cast considerable doubt on the popular thrifty genes hypothesis... - Nucleotide variation in the Egfr locus of Drosophila melanogasterArnar Palsson
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27513 7614, USA
Genetics 167:1199-212. 2004..The effect of sample size on inference of the roles of population structure, uneven recombination, and weak selection in patterning nucleotide variation in the locus is discussed... - Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogasterIan Dworkin
Department of Genetics, North Carolina State University, Raleigh, 27695 7614, USA
Genetics 169:2115-25. 2005..These results are discussed both within the framework of future association-mapping studies and within the context of the evolutionary dynamics of alleles in populations... - Genomic consequences of background effects on scalloped mutant expressivity in the wing of Drosophila melanogasterIan Dworkin
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 181:1065-76. 2009.... - Geographical genomics of human leukocyte gene expression variation in southern MoroccoYoussef Idaghdour
Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
Nat Genet 42:62-7. 2010..No evidence of large-effect trans-acting mediators of the pervasive environmental influence was found; instead, genetic and environmental factors acted in a largely additive manner... - Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphologyArnar Palsson
Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
BMC Genet 6:44. 2005..This re-evaluation utilized different genetic testcrosses to generate heterozygous individuals with a variety of genetic backgrounds as well as sampling of new alleles from Kenyan stocks... - The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogasterIan Dworkin
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 187:1171-84. 2011..We discuss these results in the light of possible attractor states of gene expression and how this would affect interpretation of covariation between transcriptional profiles and other phenotypes... - Association of orthodenticle with natural variation for early embryonic patterning in Drosophila melanogasterLisa M Goering
Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
J Exp Zool B Mol Dev Evol 312:841-54. 2009.... - Extensive sex-specific nonadditivity of gene expression in Drosophila melanogasterGreg Gibson
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 167:1791-9. 2004..Strikingly, while 25% of all genes differ between the two parents, 33% differ between both F1's and the parents, averaged across sexes. However, only 5% of genes show overdominance, suggesting that heterosis for expression is rare... - Association between nucleotide variation in Egfr and wing shape in Drosophila melanogasterArnar Palsson
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 167:1187-98. 2004..However, these features severely limit the ability of linkage disequilibrium mapping in Drosophila to resolve quantitative effects to single nucleotides... - Quantitative trait transcripts for nicotine resistance in Drosophila melanogasterGisele Passador-Gurgel
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Nat Genet 39:264-8. 2007..Differences between populations from North Carolina and California suggest that the resistance mechanism may be an evolved response to environmental exposure... - Impact of population structure on genetic diversity of a potential vaccine target in the canine hookworm (Ancylostoma caninum)Jennifer M Moser
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
J Parasitol 93:796-805. 2007..3-kilobase stretch of sequence. Evidence for gene flow among geographically distinct samples suggests that the mobility of hosts of A. caninum is an important contributing factor to the population structure of the parasite... - Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogasterIan Dworkin
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 173:1417-31. 2006..These results provide an entry point into the genetics of wing shape and are discussed within the framework of the dissection of complex phenotypes... - Comparison of regional gene expression differences in the brains of the domestic dog and humanErin Kennerly
Department of Genetics, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA
Hum Genomics 1:435-43. 2004..This study lays the foundation for detailed analysis of the population structure of transcriptional variation as it relates to cognitive and neurological phenotypes in the domestic dog... - Use of regression methods to identify motifs that modulate germline transcription in Drosophila melanogasterEmily Honeycutt
Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27695 7566, USA
Genet Res 83:177-88. 2004..In our case, this grouping of motifs suggests binding sites for cooperating factors in sex-specific expression, as well as a way of combining smaller motifs into larger binding sites... - Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogasterIan Dworkin
Department of Genetics, North Carolina State University, Raleigh 27695, USA
Curr Biol 13:1888-93. 2003..A tendency for the rarer alleles to have more disrupted eye development suggests that mutation-selection balance is a possible mechanism contributing to maintaining cryptic variation for Egfr... - Microarray analysis: genome-scale hypothesis scanningGreg Gibson
Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
PLoS Biol 1:E15. 2003 - Population genomics: finding the variants of mass disruptionGreg Gibson
Department of Genetics, North Carolina State University, Raleigh, NC 27695-76214, USA
Curr Biol 13:R901-3. 2003 - Pharmacogenetic association study of 30 genes with phenobarbital drug response in epileptic dogsErin M Kennerly
Department of Genetics, Gardner Hall, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
Pharmacogenet Genomics 19:911-22. 2009..Exploration of the genetic mechanisms involved in drug response may provide better treatment options for epileptic patients... - Uncovering cryptic genetic variationGreg Gibson
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
Nat Rev Genet 5:681-90. 2004.... - Cross-species comparison of genome-wide expression patternsXianghong Jasmine Zhou
Department of Genetics, North Carolina State University, Raleigh, NC 27695-7614, USA
Genome Biol 5:232. 2004..Recent studies have used cross-species comparisons of expression profiles to annotate gene functions, to draw evolutionary inferences concerning specific biological processes and to study the global properties of expression networks... - A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan AmazighsYoussef Idaghdour
North Carolina State University, Raleigh, North Carolina, United States of America
PLoS Genet 4:e1000052. 2008.... - Genotype-by-diet interactions drive metabolic phenotype variation in Drosophila melanogasterLaura K Reed
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 185:1009-19. 2010..Changes in metabolic trait mean and variance in response to diet indicates that shifts in both population mean and variance in underlying traits could contribute to increases in complex disease... - Genetic variation for dorsal-ventral patterning of the Drosophila melanogaster eggshellLisa M Goering
Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
Evol Dev 7:81-8. 2005..Therefore, we conclude that the polymorphisms we have identified in Egfr do not contribute to variation in DAS, and further work is required to understand the genetic architecture of this trait... - Mixed-model reanalysis of primate data suggests tissue and species biases in oligonucleotide-based gene expression profilesWen-Ping Hsieh
Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 165:747-57. 2003..A small subset of genes that are candidates for adaptive divergence may be identified on the basis of a high ratio of interspecific to intraspecific divergence... - Merging ecology, molecular evolution, and functional geneticsMichael Purugganan
Department of Genetics, North Carolina State University, Gardner Hall, Raleigh, NC 27695-7614, USA
Mol Ecol 12:1109-12. 2003 - Enabling population and quantitative genomicsGreg Gibson
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 27695 7614, USA
Genet Res 80:1-6. 2002..Here we discuss the set of community-wide genetic and molecular resources, including panels of specific types of inbred lines and high density resequencing and SNP detection, that will facilitate such studies... - Microarrays in ecology and evolution: a previewGreg Gibson
Department of Genetics, North Carolina State University, Gardner Hall, Raleigh, NC 27695 7614, USA
Mol Ecol 11:17-24. 2002.... - Developmental evolution: getting robust about robustnessGreg Gibson
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
Curr Biol 12:R347-9. 2002..A new mode of theoretical modeling of genetic networks holds great promise for increasing our understanding of both the quantitative mechanisms of robustness and its evolutionary impact... - Greg GibsonGreg Gibson
Department of Genetics, North Carolina State University, Gardner Hall, Raleigh, North Carolina 27695-7614, USA
Curr Biol 15:R531-2. 2005 - Gene expression profiles associated with the transition to parasitism in Ancylostoma caninum larvaeJennifer M Moser
Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
Mol Biochem Parasitol 143:39-48. 2005..Comparison of two strains of A. caninum from North Carolina and Maryland only identified a single gene, one of the members of the ASP family, that was differentially repressed upon serum stimulation... - Analysis of variance of microarray dataJulien F Ayroles
Department of Genetics, North Carolina State University, Raleigh, NC, USA
Methods Enzymol 411:214-33. 2006..Commercial and open-source software for performing ANOVA is widely available... - Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in DrosophilaRebecca M Riley
Department of Genetics, North Carolina State University, Raleigh, NC 27695 7614, USA
Mol Ecol 12:1315-23. 2003.... - Unusual genetic architecture of natural variation affecting drug resistance in Drosophila melanogasterRoland Carrillo
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 27695-7614, USA
Genet Res 80:205-13. 2002.... - A genetic attack on the defense complexGreg Gibson
Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 27695 7614, USA
Bioessays 24:487-9. 2002..This species has undergone rapid and parallel morphological and behavioral evolution, and there is now hope that some of the genes responsible for the divergence may soon be identified... - The evolution of developmental regulatory pathwaysGreg Gibson
Bioinformatic Research Center, Partners II Bldg, Centennial Campus, North Carolina State University, Raleigh North Carolina, 27695 7566, USA
Curr Opin Genet Dev 12:695-700. 2002.... - Failure to replicate effect of Kibra on human memory in two large cohorts of European originAnna C Need
Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina 27710, USA
Am J Med Genet B Neuropsychiatr Genet 147:667-8. 2008..These results suggest that Kibra does not have a strong and general effect on human memory... - Evolution of genes and genomes on the Drosophila phylogenyAndrew G Clark
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Nature 450:203-18. 2007..These may prove to underlie differences in the ecology and behaviour of these diverse species... - Perspective: Evolution and detection of genetic robustnessJ Arjan G M de Visser
Department of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
Evolution 57:1959-72. 2003.... - Anomalies in the expression profile of interspecific hybrids of Drosophila melanogaster and Drosophila simulansJose M Ranz
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genome Res 14:373-9. 2004..The net result of the multiple incompatibilities is that the gene-expression profiles of the parental females are more similar to each other than either is to that of the hybrid... - Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogasterLisa A McGraw
Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
Curr Biol 14:1509-14. 2004..The mating-dependent genes that we have identified contribute to many biological processes including metabolism, immune defense, and protein modification... - Effects of population structure and sex on association between serotonin receptors and Drosophila heart rateNaruo Nikoh
University of the Air, Chiba City 261 8586, Japan
Genetics 168:1963-74. 2004.... - The environmental contribution to gene expression profilesGreg Gibson
School of Integrative Biology, The University of Queensland, Goddard Building, St Lucia Campus, Brisbane, Queensland 4072, Australia
Nat Rev Genet 9:575-81. 2008..Incorporating estimates of genetic relationships into study designs will facilitate genomic analysis of environmental plasticity by aiding the identification of major regulatory loci in natural populations...