David Eidelberg

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. pmc Network correlates of disease severity in multiple system atrophy
    K L Poston
    Stanford University Medical Center, Stanford, CA, USA
    Neurology 78:1237-44. 2012
  2. ncbi Impaired sequence learning in carriers of the DYT1 dystonia mutation
    Maria Felice Ghilardi
    Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, New York, NY 11030, USA
    Ann Neurol 54:102-9. 2003
  3. pmc Early Parkinson's disease: longitudinal changes in brain activity during sequence learning
    Maren Carbon
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Neurobiol Dis 37:455-60. 2010
  4. pmc Metabolic brain networks in neurodegenerative disorders: a functional imaging approach
    David Eidelberg
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY, USA
    Trends Neurosci 32:548-57. 2009
  5. pmc Brain networks in Huntington disease
    David Eidelberg
    Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    J Clin Invest 121:484-92. 2011
  6. ncbi The assessment of neurological systems with functional imaging
    David Eidelberg
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Brain Lang 102:192-9. 2007
  7. ncbi Caudate nucleus: influence of dopaminergic input on sequence learning and brain activation in Parkinsonism
    Maren Carbon
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, New York, NY 11030, USA
    Neuroimage 21:1497-507. 2004
  8. ncbi Network modulation in the treatment of Parkinson's disease
    Kotaro Asanuma
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Brain 129:2667-78. 2006
  9. ncbi Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease
    Maja Trost
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Neuroimage 31:301-7. 2006
  10. doi Improved sequence learning with subthalamic nucleus deep brain stimulation: evidence for treatment-specific network modulation
    Hideo Mure
    Center for Neurosciences, The Feinstein Institute for Medical Research, NY, USA
    J Neurosci 32:2804-13. 2012

Research Grants

Detail Information

Publications100

  1. pmc Network correlates of disease severity in multiple system atrophy
    K L Poston
    Stanford University Medical Center, Stanford, CA, USA
    Neurology 78:1237-44. 2012
    ..Nonetheless, the potential utility of this pattern as a MSA biomarker is contingent upon its specificity for this disorder and its relationship to clinical disability in individual patients...
  2. ncbi Impaired sequence learning in carriers of the DYT1 dystonia mutation
    Maria Felice Ghilardi
    Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, New York, NY 11030, USA
    Ann Neurol 54:102-9. 2003
    ..Although localized increases in neural activity may enable normal movement execution in these subjects, this mechanism may not compensate for their defect in sequence learning...
  3. pmc Early Parkinson's disease: longitudinal changes in brain activity during sequence learning
    Maren Carbon
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Neurobiol Dis 37:455-60. 2010
    ..005) was present in the subjects with high learning performance over time. The findings are consistent with a decline in learning-related neural activity in cortical areas with prominent Lewy body formation...
  4. pmc Metabolic brain networks in neurodegenerative disorders: a functional imaging approach
    David Eidelberg
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY, USA
    Trends Neurosci 32:548-57. 2009
    ..Ongoing developments in network applications are likely to enhance the role of functional imaging in the investigation of neurodegenerative disorders...
  5. pmc Brain networks in Huntington disease
    David Eidelberg
    Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    J Clin Invest 121:484-92. 2011
    ..Quantifying metabolic progression at the systems level may identify network biomarkers to aid in the objective assessment of new disease-modifying therapies and identify new regions that merit mechanistic study in HD models...
  6. ncbi The assessment of neurological systems with functional imaging
    David Eidelberg
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Brain Lang 102:192-9. 2007
    ..Functional changes in the relevant neural systems are likely to underlie the behavioral abnormalities observed in a variety of disease and treatment conditions...
  7. ncbi Caudate nucleus: influence of dopaminergic input on sequence learning and brain activation in Parkinsonism
    Maren Carbon
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, New York, NY 11030, USA
    Neuroimage 21:1497-507. 2004
    ..Despite minimal reductions in nigro-caudate input, PD patients demonstrate a loss of this coupling early in the disease...
  8. ncbi Network modulation in the treatment of Parkinson's disease
    Kotaro Asanuma
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Brain 129:2667-78. 2006
    ..The modulation of pathological brain networks is a critical feature of the treatment response in parkinsonism...
  9. ncbi Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease
    Maja Trost
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Neuroimage 31:301-7. 2006
    ..These findings indicate that suppression of abnormal network activity is a feature of both STN stimulation and lesioning. Nonetheless, these two interventions may differ metabolically at a regional level...
  10. doi Improved sequence learning with subthalamic nucleus deep brain stimulation: evidence for treatment-specific network modulation
    Hideo Mure
    Center for Neurosciences, The Feinstein Institute for Medical Research, NY, USA
    J Neurosci 32:2804-13. 2012
    ..Selective modulation of overactive SMA-STN projection pathways may underlie the improvement in learning found with stimulation...
  11. pmc Increased sensorimotor network activity in DYT1 dystonia: a functional imaging study
    Maren Carbon
    Centre for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Brain 133:690-700. 2010
    ..Lastly, quantification of normal motor-related activation pattern expression in individual cases may have utility as an objective descriptor of therapeutic response in trials of new treatments for dystonia and related disorders...
  12. pmc Impaired sequence learning in dystonia mutation carriers: a genotypic effect
    Maren Carbon
    Centre for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Brain 134:1416-27. 2011
    ..The close relationship between reduced cerebellar pathway integrity and increased learning-related activation of the premotor cortex is compatible with the view of DYT1 dystonia as a neurodevelopmental circuit disorder...
  13. pmc Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomes
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Nucl Med 51:7-15. 2010
    ..Nonetheless, clinical improvement was significant only in younger (age < or = 60 y) transplant recipients, as indicated by a reduction in Unified Parkinson's Disease Rating Scale (UPDRS) motor scores...
  14. ncbi Changes in network activity with the progression of Parkinson's disease
    Chaorui Huang
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Brain 130:1834-46. 2007
    ..Potential disease-modifying therapies may alter the time course of one or both of these abnormal networks...
  15. pmc Parkinson's disease: increased motor network activity in the absence of movement
    Ji Hyun Ko
    Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Neurosci 33:4540-9. 2013
    ..22). Thus, the resting state in PD is characterized by changes in the activity of normal as well as pathological brain networks...
  16. doi Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis
    Chris C Tang
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Lancet Neurol 9:149-58. 2010
    ..We aimed to assess whether metabolic brain imaging combined with spatial covariance analysis could accurately discriminate patients with parkinsonism who had different underlying disorders...
  17. ncbi Neuroimaging in human dystonia
    Kotaro Asanuma
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, and Department of Neurology, North Shore University Hospital, New York, NY, USA
    J Med Invest 52:272-9. 2005
    ..This presentation will focus on an integrated approach to understanding the pathophysiology of this genetic and biochemically diverse disorder...
  18. pmc Cerebellothalamocortical connectivity regulates penetrance in dystonia
    Miklos Argyelan
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    J Neurosci 29:9740-7. 2009
    ..Overall, these findings point to a novel mechanism to explain differences in clinical expression in carriers of genes for brain disease...
  19. ncbi Learning networks in health and Parkinson's disease: reproducibility and treatment effects
    Maren Carbon
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    Hum Brain Mapp 19:197-211. 2003
    ..Network quantification can provide an objective means of assessing the effects of therapy on cognitive functioning in neurodegenerative disorders...
  20. pmc Serotonin modulation of cerebral glucose metabolism in depressed older adults
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York, USA
    Biol Psychiatry 66:259-66. 2009
    ..The hypothesis was tested that smaller decreases in metabolism would be observed in cortical and limbic regions in depressed older adults relative to control subjects...
  21. pmc Early registration of diffusion tensor images for group tractography of dystonia patients
    An Vo
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Magn Reson Imaging 37:67-75. 2013
    ..We propose using an early registration method that produces sharper group images and enables us to do group tractography...
  22. pmc Abnormal network topographies and changes in global activity: absence of a causal relationship
    Vijay Dhawan
    Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Neuroimage 63:1827-32. 2012
    ..In aggregate, the data demonstrate that abnormal PDRP expression is not induced by reductions in global activity. Moreover, significant declines in GMR are not associated with the appearance of PDRP-like spatial topographies...
  23. ncbi Functional imaging of sequence learning in Parkinson's disease
    Maren Carbon
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    J Neurol Sci 248:72-7. 2006
    ..These observations support hypotheses on disease-stage and task-specific effects within the different cortico-striato-pallido-thalamocortical loops and the mesocortical system in PD...
  24. doi Dopaminergic suppression of brain deactivation responses during sequence learning
    Miklos Argyelan
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore University Hospital, Manhasset, New York 11030, USA
    J Neurosci 28:10687-95. 2008
    ..002) and with the val(158)met catechol-O-methyltransferase genotype. Our findings suggest that dopamine can influence prefrontal deactivation during learning, and that these changes are linked to baseline performance and genotype...
  25. pmc Metabolic changes in DYT11 myoclonus-dystonia
    Maren Carbon
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Neurology 80:385-91. 2013
    ....
  26. ncbi The metabolic pathology of dopa-responsive dystonia
    Kotaro Asanuma
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, NY, USA
    Ann Neurol 57:596-600. 2005
    ..This pattern was not expressed in mutation carriers for primary torsion dystonia. Dopa-responsive dystonia has a unique metabolic architecture that differs from other inherited forms of dystonia...
  27. ncbi Increased cerebellar activation during sequence learning in DYT1 carriers: an equiperformance study
    Maren Carbon
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, New York, New York 11030, USA
    Brain 131:146-54. 2008
    ..The inability to recruit the appropriate set of neocortical areas because of altered fronto-striatal connectivity may have led to the shift to cerebellar processing...
  28. doi Differential diagnosis of parkinsonian syndromes using PCA-based functional imaging features
    Phoebe G Spetsieris
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Neuroimage 45:1241-52. 2009
    ..Results illustrate that highly accurate diagnosis can often be achieved by simple comparison of scores utilizing optimized patterns...
  29. pmc Abnormalities in metabolic network activity precede the onset of motor symptoms in Parkinson's disease
    Chris C Tang
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore University Hospital, Manhasset, New York 11030, USA
    J Neurosci 30:1049-56. 2010
    ..The timing and laterality of symptom onset relates to focal asymmetric metabolic changes at the putamenal node of this network...
  30. pmc Parkinson's disease cognitive network correlates with caudate dopamine
    Martin Niethammer
    Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Neuroimage 78:204-9. 2013
    ..These baseline measures likely function in concert to determine the cognitive effects of dopaminergic therapy in PD...
  31. ncbi Metabolic brain networks associated with cognitive function in Parkinson's disease
    Chaorui Huang
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Department of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, NY 11030, USA
    Neuroimage 34:714-23. 2007
    ..Because PDCP expression is not altered by routine antiparkinsonian treatment, this measure of network activity may prove useful in clinical trials targeting the progression of non-motor manifestations of this disorder...
  32. ncbi Regional metabolic changes in parkinsonian patients with normal dopaminergic imaging
    Thomas Eckert
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    Mov Disord 22:167-73. 2007
    ..The results suggest that parkinsonian subjects with normal dopaminergic imaging do not have evidence of classical PD or an atypical parkinsonian syndrome...
  33. pmc Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease
    Andrew Feigin
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 104:19559-64. 2007
    ..Network biomarkers may be used as physiological assays in early-phase trials of experimental therapies for PD and other neurodegenerative disease...
  34. doi Selective serotonin reuptake inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Synapse 63:1-6. 2009
    ....
  35. pmc Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's disease
    Shigeki Hirano
    The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Neurosci 28:4201-9. 2008
    ..These findings suggest that flow-metabolism dissociation is a distinctive feature of LD treatment. This phenomenon may be especially pronounced in patients with LD-induced dyskinesia...
  36. doi Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography
    Serge Sevy
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, NY 11004, USA
    Psychopharmacology (Berl) 197:549-56. 2008
    ....
  37. pmc Metabolic network as a progression biomarker of premanifest Huntington's disease
    Chris C Tang
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Clin Invest 123:4076-88. 2013
    ..Here we used a computational approach to identify a functional brain network associated with the progression of preclinical Huntington's disease (HD)...
  38. pmc Functional neuroimaging in Parkinson's disease
    Martin Niethammer
    The Feinstein Institute for Medical Research, Manhasset, New York, USA
    Cold Spring Harb Perspect Med 2:a009274. 2012
    ....
  39. ncbi Early stage Parkinson's disease patients and normal volunteers: comparative mechanisms of sequence learning
    Marc J Mentis
    Functional Brain Imaging Laboratory, Center for Neurosciences, North Shore Long Island Jewish Research Institute, North Shore University Hospital and New York University School of Medicine, Manhasset, New York, USA
    Hum Brain Mapp 20:246-58. 2003
    ..However, when a difficult task would normally require bilateral activation, PD(es) patients fail to learn because information processing within the network is impaired. Hum. Brain Mapp. 20:246-258, 2003...
  40. ncbi L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease
    M Felice Ghilardi
    Department of Physiology and Pharmacology, CUNY Medical School at City College, City University of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
    Parkinsonism Relat Disord 13:146-51. 2007
    ..Motor performance was assessed with simple motor tasks. L-Dopa improved motor scores and movement speed, but had no beneficial effect on either type of sequence learning...
  41. doi Metabolic correlates of subthalamic nucleus activity in Parkinson's disease
    Tanya P Lin
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Brain 131:1373-80. 2008
    ..These pathways are likely to mediate the clinical benefit that is seen following targeted STN interventions for this disease...
  42. ncbi Thalamic stimulation for parkinsonian tremor: correlation between regional cerebral blood flow and physiological tremor characteristics
    Masafumi Fukuda
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    Neuroimage 21:608-15. 2004
    ..05, uncorrected). Our results suggest that Vim DBS for PD tremor modulates the activity of cerebello-thalamo-cortical pathways. Specific tremor characteristics relate to activity in different nodes of this system...
  43. doi Assessing the microlesion effect of subthalamic deep brain stimulation surgery with FDG PET
    Michael Pourfar
    Departments of Neurology and Medicine, North Shore University Hospital, Manhasset, New York 11030, USA
    J Neurosurg 110:1278-82. 2009
    ..The authors investigated whether the insertion of deep brain stimulation electrodes into the subthalamic nucleus can alter regional brain metabolism in the absence of stimulation...
  44. doi Metabolic networks for assessment of therapy and diagnosis in Parkinson's disease
    Shigeki Hirano
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    Mov Disord 24:S725-31. 2009
    ..These disease-related patterns can potentially be used in an automated imaging-based algorithm to classify patients with these disorders...
  45. ncbi Assessment of disease progression in parkinsonism
    Kotaro Asanuma
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    J Neurol 251:vII4-8. 2004
    ..The interim results indicate the evolution of abnormal metabolic brain networks and activation responses occurring in parallel with presynaptic nigrostriatal dopamine dysfunction in early PD...
  46. ncbi Abnormal brain networks in primary torsion dystonia
    Maren Carbon
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, New York, USA
    Adv Neurol 94:155-61. 2004
  47. pmc Parkinson's disease tremor-related metabolic network: characterization, progression, and treatment effects
    Hideo Mure
    The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Neuroimage 54:1244-53. 2011
    ..Quantification of treatment-mediated changes in both PDTP and PDRP scores can provide an objective means of evaluating the differential effects of novel antiparkinsonian interventions on the different motor features of the disorder...
  48. pmc The functional neuroanatomy of geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York, USA
    Int J Geriatr Psychiatry 24:798-808. 2009
    ....
  49. pmc Basal ganglia and kinematics modulation: insights from Parkinson's and Huntington's diseases
    Clara Moisello
    Department of Physiology and Pharmacology, CUNY Medical School, 160 Convent Avenue, New York, NY 10031, USA
    Parkinsonism Relat Disord 17:642-4. 2011
    ..The opposite trends in Parkinson's and Huntington's disease suggest that such regulation might depend on the balance between the outputs of direct and indirect pathways...
  50. pmc Learning and consolidation of visuo-motor adaptation in Parkinson's disease
    Lucio Marinelli
    Department of Physiology and Pharmacology, CUNY Medical School, New York, NY 100031, USA
    Parkinsonism Relat Disord 15:6-11. 2009
    ..This lack of consolidation, which is present in the early stages of the disease and is independent from therapy, may be due to abnormal homeostatic processes that occur during sleep...
  51. pmc Preclinical Huntington's disease: compensatory brain responses during learning
    Andrew Feigin
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Ann Neurol 59:53-9. 2006
    ..Nonetheless, this mechanism may not be sufficient to sustain a normal level of task performance, even during the presymptomatic stage of the disease...
  52. pmc Abnormal metabolic network activity in REM sleep behavior disorder
    Florian Holtbernd
    From the Center for Neurosciences F H, Y M, C C T, A F, V D, D E, The Feinstein Institute for Medical Research, Manhasset, NY Center for Advanced Research in Sleep Medicine J F G, R B P, M V, J M, Hôpital du Sacré Coeur de Montréal Department of Psychology J F G, M V, Université du Québec à Montréal Department of Neurology R B P, Montreal General Hospital Montreal Neurological Institute J P S, McGill University and Department of Psychiatry J M, University of Montreal, Montreal, Canada
    Neurology 82:620-7. 2014
    ....
  53. ncbi Microstructural white matter changes in carriers of the DYT1 gene mutation
    Maren Carbon
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    Ann Neurol 56:283-6. 2004
    ..Abnormal anatomical connectivity of the supplementary motor area may contribute to the susceptibility of DYT1 carriers to develop clinical manifestations of dystonia...
  54. ncbi Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibility
    Yilong Ma
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    J Cereb Blood Flow Metab 27:597-605. 2007
    ..The quantification of PDRP expression in PD patients can serve as a potential biomarker in PET intervention studies for this disorder...
  55. ncbi Quantification of Parkinson's disease-related network expression with ECD SPECT
    Thomas Eckert
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Eur J Nucl Med Mol Imaging 34:496-501. 2007
    ..In the current study, we utilized a new, fully automated voxel-based method to quantify network expression in ECD SPECT images from patients with classical PD, patients with multiple system atrophy (MSA), and healthy control subjects...
  56. pmc Abnormal regional brain function in Parkinson's disease: truth or fiction?
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Neuroimage 45:260-6. 2009
    ..Moreover, stability of the normalized measurements, particularly at the network level, makes these metabolic indices suitable as imaging biomarkers of PD progression and the treatment response...
  57. ncbi Anticholinesterase effect on motor kinematic measures and brain activation in Parkinson's disease
    Marc J Mentis
    Center for Neurosciences, North Shore LIJ Health System, New Hyde Park, NY 11030, USA
    Mov Disord 21:549-55. 2006
    ..Furthermore, movement integrity while on donepezil was maintained without compensatory brain activity. Donepezil 10 mg/day can be given for nonmotor symptoms in PD without adverse motor effects or compensatory brain activity...
  58. doi Abnormal metabolic brain networks in Parkinson's disease from blackboard to bedside
    Chris C Tang
    Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, USA
    Prog Brain Res 184:161-76. 2010
    ..Using multiple disease-related networks for PD, MSA, and PSP, we have developed a novel, fully automated algorithm for accurate classification at the single-patient level, even at early disease stages...
  59. ncbi Imaging markers of mild cognitive impairment: multivariate analysis of CBF SPECT
    Chaorui Huang
    Center for Neurosciences, North Shore Long Island Jewish Health System, New York University School of Medicine, New York, NY, USA
    Neurobiol Aging 28:1062-9. 2007
    ..SPECT and neuropsychological testing can be used objectively for both baseline diagnosis and to monitor changes in brain function during very early AD...
  60. ncbi Functional brain imaging in Parkinson's disease
    Maren Carbon
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Movement Disorders Center, North Shore University Hospital, Manhasset, New York, USA
    Adv Neurol 91:175-81. 2003
  61. ncbi New strategies for automated differential diagnosis of degenerative brain disorders
    Phoebe G Spetsieris
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:3421-5. 2007
    ..It is shown that the extraction of exclusive sub-networks that stem from contrasting image features between conditions can be an effective tool for optimization that does not require expert knowledge...
  62. ncbi An examination of executive dysfunction associated with frontostriatal circuitry in Parkinson's disease
    Dennis J Zgaljardic
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Research Institute, Manhasset, NY, USA
    J Clin Exp Neuropsychol 28:1127-44. 2006
    ..In conclusion, our findings suggest that nondemented patients with PD exhibit greater impairment on neuropsychological measures associated with DLPFC than with ACC or OFC circuit function...
  63. ncbi Tc-99m ethylene cysteinate dimer SPECT in the differential diagnosis of parkinsonism
    Andrew Feigin
    Center for Neuroscience, North Shore University Hospital, Manhasset, New York and New York University School of Medicine, New York, New York, USA
    Mov Disord 17:1265-70. 2002
    ..Because of significant individual subject overlap between groups, however, the clinical utility of this method in the differential diagnosis of Parkinsonism remains uncertain...
  64. ncbi Radiosynthesis of [18F] N-(3-Fluoropropyl)-2-beta-Carbomethoxy-3-beta-(4-Bromophenyl) Nortropane and the regional brain uptake in non human primate using PET
    Thomas Chaly
    Department of Medicine, North Shore University Hospital, NYU Medical College, PET Research, Manhasset, NY 11030, USA
    Nucl Med Biol 31:125-31. 2004
    ..18F]FPCBT displayed good brain uptake and its high target to non target ratio indicate that it is a potential candidate for DAT imaging...
  65. ncbi The metabolic topography of posthypoxic myoclonus
    Steven J Frucht
    Department of Neurology, Columbia Presbyterian Medical Center, New York, NY, USA
    Neurology 62:1879-81. 2004
    ..Interventions such as deep brain stimulation that interrupt networks that involve these structures may be useful in patients with severe PHM...
  66. pmc Parkinson's disease spatial covariance pattern: noninvasive quantification with perfusion MRI
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Cereb Blood Flow Metab 30:505-9. 2010
    ..01) in patients scanned with either modality, and the two values were highly intercorrelated (P<0.0001). Perfusion MRI methods can be used for accurate quantification of disease-related covariance patterns...
  67. ncbi Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial
    Michael G Kaplitt
    Department of Neurological Surgery, Weill Medical College of Cornell University, New York, NY, USA
    Lancet 369:2097-105. 2007
    ..We aimed to measure the safety, tolerability, and potential efficacy of transfer of glutamic acid decarboxylase (GAD) gene with adeno-associated virus (AAV) into the subthalamic nucleus of patients with Parkinson's disease...
  68. doi Correlation of laparoscopic experience with differential functional brain activation: a positron emission tomography study with oxygen 15-labeled water
    Brian Duty
    Smith Institute for Urology, North Shore Long Island Jewish Health System, New Hyde Park, NY 11042, USA
    Arch Surg 147:627-32. 2012
    ..Regions of functional brain activation differ between novice and expert laparoscopists...
  69. pmc Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Cereb Blood Flow Metab 32:633-42. 2012
    ..Network quantification may provide a useful biomarker for the evaluation of new therapeutic agents in preclinical models of PD...
  70. ncbi Dyskinesia after fetal cell transplantation for parkinsonism: a PET study
    Yilong Ma
    Center for Neurosciences, North Shore Long Island Jewish Research Institute and Department of Neurology, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Ann Neurol 52:628-34. 2002
    ..These findings suggest that unbalanced increases in dopaminergic function can complicate the outcome of neuronal transplantation for parkinsonism...
  71. ncbi The differential effect of PD and normal aging on early explicit sequence learning
    Maria Felice Ghilardi
    Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 60:1313-9. 2003
    ..However, it is not known whether this defect is present during the earliest stages of the illness or whether it reflects specific limitations in dividing attention between cognitive and motor requirements...
  72. ncbi Primary dystonia: is abnormal functional brain architecture linked to genotype?
    Maja Trost
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Ann Neurol 52:853-6. 2002
    ..The findings suggest that the DYT1 metabolic topography is not genotype specific and may be present in carriers of other dystonia mutations...
  73. ncbi Microstructural white matter changes in primary torsion dystonia
    Maren Carbon
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    Mov Disord 23:234-9. 2008
    ..Our data thus support the possibility of a disturbance in cerebello-thalamo-cortical pathways as a cause of the clinical manifestations of PTD...
  74. doi Network biomarkers for the diagnosis and treatment of movement disorders
    Kathleen L Poston
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Neurobiol Dis 35:141-7. 2009
    ..Finally, the application of network analysis to the study of inherited movement disorders such as Huntington's disease can aid in the assessment of disease-modifying therapies in pre-symptomatic gene mutation carriers...
  75. ncbi Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease
    Yilong Ma
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, New York University School of Medicine, Manhasset, NY, USA
    Mol Imaging Biol 9:223-33. 2007
    ..In particular, we present data to validate the reproducibility and reliability of unique spatial covariance patterns related with PD and HD...
  76. ncbi Relationships among the metabolic patterns that correlate with mnemonic, visuospatial, and mood symptoms in Parkinson's disease
    Marc J Mentis
    Center for Neuroscience, North Shore Long Island Jewish Research Institute, Manhasset, NY, USA
    Am J Psychiatry 159:746-54. 2002
    ..A multivariate analysis of baseline brain metabolism was used to investigate the relationships among pathophysiological mechanisms responsible for cognitive dysfunction and dysphoria in nondemented patients with Parkinson's disease...
  77. pmc Scaled subprofile modeling of resting state imaging data in Parkinson's disease: methodological issues
    Phoebe G Spetsieris
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Neuroimage 54:2899-914. 2011
    ..g. cerebellum) that may be required in univariate analytical approaches is obviated in SSM. We discuss deviations of the methodology that may yield erroneous or confounding factors...
  78. pmc Hereditary dystonia as a neurodevelopmental circuit disorder: Evidence from neuroimaging
    Martin Niethammer
    The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Neurobiol Dis 42:202-9. 2011
    ..Abnormal expression of this network is reduced by successful treatment with deep brain stimulation. This article is part of a Special Issue entitled "Advances in dystonia"...
  79. doi Seizure propagation in a patient with musicogenic epilepsy
    Ashesh D Mehta
    Department of Neurosurgery, North Shore Long Island Jewish Health System, New Hyde Park, NY 11040, USA
    Epilepsy Behav 14:421-4. 2009
    ..Right temporal lobectomy resulted in Engel class 1 outcome...
  80. ncbi Correlates of movement initiation and velocity in Parkinson's disease: A longitudinal PET study
    Maren Carbon
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, New York, NY 11030, USA
    Neuroimage 34:361-70. 2007
    ..Our data suggest that with advancing PD, motor performance is associated with the recruitment of brain regions normally involved in the execution of more complex tasks...
  81. ncbi Dosimetry of the dopamine transporter radioligand 18F-FPCIT in human subjects
    William Robeson
    Center for Neurosciences, North Shore University Hospital, Manhasset, New York, USA
    J Nucl Med 44:961-6. 2003
    ..The goal was to determine a limiting dose consistent with accepted guidelines for use in clinical studies and to compare the radiation burden with other agents such as (123)I-FPCIT, (18)F-fluorodopa, and (18)F-FDG...
  82. doi Three-fold cross-validation of parkinsonian brain patterns
    Phoebe G Spetsieris
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore LIJ, Health System, Manhasset, NY 11030, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:2906-9. 2010
    ..Combined accuracy for each of the three folds ranged from 82% to 93% in the training set and was approximately 81% for prospective test subjects...
  83. ncbi Comparative analysis of striatal FDOPA uptake in Parkinson's disease: ratio method versus graphical approach
    Vijay Dhawan
    Center for Neuroscience, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Nucl Med 43:1324-30. 2002
    ..CONCLUSION: These results suggest that SOR determined from a single 10-min scan at 95 min is as accurate as K(i)(occ) in separating PD patients from healthy subjects and in predicting clinical measures of disease severity...
  84. ncbi Woman with a 26-year history of parkinsonism, supranuclear ophthalmoplegia, and loss of postural reflexes
    Paul H Gordon
    Department of Neurology, Division of Movement Disorders, Columbia Presbyterian Medical Center, New York, New York 10032, USA
    Mov Disord 19:950-61. 2004
    ..A woman who had her first serious fall at age 48 years subsequently developed neurological symptoms. Her case is described, differential diagnoses are presented, pathology is discussed, and a final diagnosis is reached...
  85. pmc Neuroimaging and therapeutics in movement disorders
    Thomas Eckert
    Department of Neurology II and Psychiatry, University of Magdeburg, Germany
    NeuroRx 2:361-71. 2005
    ..Both imaging strategies have provided novel insights into the mechanisms underlying a variety of pharmacological and stereotaxic surgical treatment strategies for PD and other movement disorders...
  86. ncbi Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease
    Dennis J Zgaljardic
    Transitional Learning Center at Galveston, Galveston, TX 77550, USA
    Cogn Behav Neurol 20:184-92. 2007
    ..The prevalence of apathy was assessed across select cognitive and psychiatric variables in 32 nondemented patients with Parkinson disease (PD) and 29 demographically matched healthy control participants...
  87. ncbi Testing a test for Alzheimer disease
    Randall J Bateman
    Neurology 68:482-3. 2007
  88. doi Abnormal metabolic networks in atypical parkinsonism
    Thomas Eckert
    Department of Neurology II, University of Magdeburg, Germany
    Mov Disord 23:727-33. 2008
    ..These disease-related networks can potentially be used in conjunction with functional brain imaging as quantifiable biomarkers for the assessment of these pathological conditions...
  89. ncbi Executive processes in Parkinson's disease: FDG-PET and network analysis
    Catherine Lozza
    INSERM U 320, Centre Cyceron, Caen, France
    Hum Brain Mapp 22:236-45. 2004
    ..According to these findings, the networks subserving bradykinesia and executive dysfunction in PD seems to be topographically distinct and to involve different aspects of subcortico-cortical processing...
  90. ncbi Preoperative response to levodopa is the best predictor of transplant outcome
    Curt R Freed
    Ann Neurol 55:896; author reply 896-7. 2004
  91. ncbi The role of functional neuroimaging in the differential diagnosis of idiopathic Parkinson's disease and multiple system atrophy
    Thomas Eckert
    Dept of Neurology II, University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Clin Auton Res 14:84-91. 2004
    ..The following paper provides a review of different PET imaging methods for the differential diagnosis of PD and MSA patients...
  92. ncbi Effects of serotonin transporter promoter polymorphisms on serotonin function
    Gwenn S Smith
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 29:2226-34. 2004
    ....
  93. ncbi Serotonin modulation of cerebral glucose metabolism in normal aging
    Sara Goldberg
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neurobiol Aging 25:167-74. 2004
    ..These results suggest different compensatory processes in anterior compared to posterior brain regions secondary to the age-related loss of serotonin innervation...
  94. ncbi Evolving metabolic changes during the first postoperative year after subthalamotomy
    Maja Trost
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, USA
    J Neurosurg 99:872-8. 2003
    ..In this study positron emission tomography (PET) scanning was used to assess these changes and their relation to long-term benefits of subthalamotomy...
  95. ncbi Differential cortical and subcortical activations in learning rotations and gains for reaching: a PET study
    John W Krakauer
    Department of Neurology and Department of Neurobiology and Behavior, Columbia University, New York 10032, USA
    J Neurophysiol 91:924-33. 2004
    ..In contrast, early gain adaptation involves only subcortical structures, which we suggest reflects a more automatic process of contextual recalibration of a scaling factor...
  96. ncbi Brain networks and clinical penetrance: lessons from hyperkinetic movement disorders
    David Eidelberg
    Curr Opin Neurol 16:471-4. 2003
  97. ncbi Can imaging distinguish PSP from other neurodegenerative disorders?
    David Eidelberg
    Neurology 58:997-8. 2002
  98. ncbi A new approach to spatial covariance modeling of functional brain imaging data: ordinal trend analysis
    Christian Habeck
    Cognitive Neuroscience Division, Taub Institute, and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neural Comput 17:1602-45. 2005
    ..In sum, OrT has potential applications to not only studies of young adults and their cognitive abilities, but also studies of normal aging and neurological and psychiatric disease...
  99. ncbi Chemotherapy-induced parkinsonism responsive to levodopa: an underrecognized entity
    Cathy Chuang
    The Neurological Institute, Columbia Presbyterian Medical Center, New York, NY, USA
    Mov Disord 18:328-31. 2003
    ..All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated...
  100. ncbi Modulation of regional brain function by deep brain stimulation: studies with positron emission tomography
    Maren Carbon
    Curr Opin Neurol 15:451-5. 2002

Research Grants17

  1. Brain and Behavior in Dystonia: A Multicenter Study
    David Eidelberg; Fiscal Year: 2006
    ..Together, these studies will provide important information about the physiological mechanisms that underlie primary torsion dystonia, and the possible therapeutic effect of deep brain stimulation. ..
  2. Brain and Behavior in Dystonia: A Multicenter Study
    David Eidelberg; Fiscal Year: 2005
    ..Together, these studies will provide important information about the physiological mechanisms that underlie primary torsion dystonia, and the possible therapeutic effect of deep brain stimulation. ..
  3. Brain and Behavior in Dystonia: A Multicenter Study
    David Eidelberg; Fiscal Year: 2004
    ..Together, these studies will provide important information about the physiological mechanisms that underlie primary torsion dystonia, and the possible therapeutic effect of deep brain stimulation. ..
  4. ASSESSMENT OF DISEASE PROGRESSION IN PARKINSONISM
    David Eidelberg; Fiscal Year: 2003
    ..He will also provide structured training in the fundamentals of experimental neurological research in using new functional brain imaging techniques. ..
  5. PET IN PARKINSONISM: A MULTICENTER COLLABORATIVE STUDY
    David Eidelberg; Fiscal Year: 2003
    ..abstract_text> ..
  6. PET IN PARKINSONISM: A MULTICENTER COLLABORATIVE STUDY
    David Eidelberg; Fiscal Year: 2002
    ..abstract_text> ..
  7. PET IN HYPERKINETIC DISORDERS--A MULTICENTER STUDY
    David Eidelberg; Fiscal Year: 2001
    ..This approach may have great utility in evaluating new interventions for the treatment of the hyperkinetic movement disorders. ..
  8. PET IN PARKINSONISM: A MULTICENTER COLLABORATIVE STUDY
    David Eidelberg; Fiscal Year: 2001
    ..abstract_text> ..
  9. PET IN PARKINSONISM: A MULTICENTER COLLABORATIVE STUDY
    David Eidelberg; Fiscal Year: 2000
    ..abstract_text> ..
  10. PET IN HYPERKINETIC DISORDERS--A MULTICENTER STUDY
    David Eidelberg; Fiscal Year: 2000
    ..This approach may have great utility in evaluating new interventions for the treatment of the hyperkinetic movement disorders. ..
  11. PET IN HYPERKINETIC DISORDERS--A MULTICENTER STUDY
    David Eidelberg; Fiscal Year: 1999
    ..This approach may have great utility in evaluating new interventions for the treatment of the hyperkinetic movement disorders. ..
  12. PET IN PARKINSONISM--A MULTICENTER COLLABORATIVE STUDY
    David Eidelberg; Fiscal Year: 1999
    ..This approach may have great utility in evaluating new therapies for PD and related disorders. ..
  13. Brain and Behavior in Dystonia: A Multicenter Study
    David Eidelberg; Fiscal Year: 2007
    ..Together, these studies will provide important information about the physiological mechanisms that underlie primary torsion dystonia, and the possible therapeutic effect of deep brain stimulation. ..