B Diamond

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. pmc Losing your nerves? Maybe it's the antibodies
    Betty Diamond
    The Feinstein Institute for Medical Research, Center of Autoimmune and Musculoskeletal Diseases, 350 Community Drive, Manhasset, New York 110301, USA
    Nat Rev Immunol 9:449-56. 2009
  2. pmc Phenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosus
    Annett M Jacobi
    The Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, USA
    PLoS ONE 4:e5776. 2009
  3. pmc Enhanced selection of high affinity DNA-reactive B cells following cyclophosphamide treatment in mice
    Daisuke Kawabata
    Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America
    PLoS ONE 5:e8418. 2010
  4. pmc Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts
    Sun Jung Kim
    Autoimmune Disease Laboratory, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Exp Med 205:2437-48. 2008
  5. pmc Tolerogenic function of Blimp-1 in dendritic cells
    Sun Jung Kim
    Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Exp Med 208:2193-9. 2011
  6. pmc Female mouse fetal loss mediated by maternal autoantibody
    Li Wang
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Northshore Long Island Jewish Health System, Manhasset, NY 11030, USA
    J Exp Med 209:1083-9. 2012
  7. pmc Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus
    Ji Y Lee
    Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, NY 10461, USA
    Nat Med 15:91-6. 2009
  8. doi request reprint Brain-reactive antibodies and disease
    B Diamond
    Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Annu Rev Immunol 31:345-85. 2013
  9. doi request reprint A model for lupus brain disease
    Betty Diamond
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Immunol Rev 248:56-67. 2012
  10. pmc Moving towards a cure: blocking pathogenic antibodies in systemic lupus erythematosus
    B Diamond
    Autoimmune and Musculoskeletal Disease Center, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Intern Med 269:36-44. 2011

Research Grants

  1. Toward a new approach to SLE therapy
    Betty Diamond; Fiscal Year: 2010
  2. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2005
  3. Sex-based Differences in the Immune Response
    Betty Diamond; Fiscal Year: 2004
  4. Studies of Human and Murine SLE
    Betty Diamond; Fiscal Year: 2006
  5. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2007
  6. An antigen induced model of SLE
    Betty Diamond; Fiscal Year: 2005
  7. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2009
  8. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2010
  9. An antigen induced model of SLE
    Betty Diamond; Fiscal Year: 2005
  10. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2003

Collaborators

Detail Information

Publications38

  1. pmc Losing your nerves? Maybe it's the antibodies
    Betty Diamond
    The Feinstein Institute for Medical Research, Center of Autoimmune and Musculoskeletal Diseases, 350 Community Drive, Manhasset, New York 110301, USA
    Nat Rev Immunol 9:449-56. 2009
    ..Under conditions of BBB compromise, and during fetal development, we think that these antibodies can alter brain function in otherwise healthy individuals...
  2. pmc Phenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosus
    Annett M Jacobi
    The Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, USA
    PLoS ONE 4:e5776. 2009
    ..This methodology enables us to gain insight into the development and fate of DNA-reactive B cells in individual patients with SLE and paves the way ultimately to permit better and more customized therapies...
  3. pmc Enhanced selection of high affinity DNA-reactive B cells following cyclophosphamide treatment in mice
    Daisuke Kawabata
    Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America
    PLoS ONE 5:e8418. 2010
    ..There are significant implications for therapy...
  4. pmc Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts
    Sun Jung Kim
    Autoimmune Disease Laboratory, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Exp Med 205:2437-48. 2008
    ..Understanding the factors that regulate antigen-activated B cell differentiation and memory cell formation has implications for both antibody-mediated autoimmune disease and protective antibody responses...
  5. pmc Tolerogenic function of Blimp-1 in dendritic cells
    Sun Jung Kim
    Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Exp Med 208:2193-9. 2011
    ..This study is of particular interest because a polymorphism of Blimp-1 associates with SLE...
  6. pmc Female mouse fetal loss mediated by maternal autoantibody
    Li Wang
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Northshore Long Island Jewish Health System, Manhasset, NY 11030, USA
    J Exp Med 209:1083-9. 2012
    ....
  7. pmc Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus
    Ji Y Lee
    Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, NY 10461, USA
    Nat Med 15:91-6. 2009
    ..These data support a paradigm in which in utero exposure to neurotoxic autoantibodies causes abnormal brain development with long-term consequences. This paradigm may apply to multiple congenital neuropsychiatric disorders...
  8. doi request reprint Brain-reactive antibodies and disease
    B Diamond
    Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Annu Rev Immunol 31:345-85. 2013
    ....
  9. doi request reprint A model for lupus brain disease
    Betty Diamond
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Immunol Rev 248:56-67. 2012
    ..We discuss the implications of this model for lupus and for identifying other antibodies that may contribute to brain disease...
  10. pmc Moving towards a cure: blocking pathogenic antibodies in systemic lupus erythematosus
    B Diamond
    Autoimmune and Musculoskeletal Disease Center, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Intern Med 269:36-44. 2011
    ..Thus, it might be possible to treat the aspects of autoimmune disease without inducing major immunosuppression and ensuing infectious complications...
  11. doi request reprint It takes guts to grow a brain: Increasing evidence of the important role of the intestinal microflora in neuro- and immune-modulatory functions during development and adulthood
    Betty Diamond
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Bioessays 33:588-91. 2011
    ..These observations necessitate a new look at the many interconnections of the immune system and the brain, suggesting new frontiers for research and new therapeutic strategies for neurodevelopmental diseases...
  12. ncbi request reprint Cutting edge: expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus
    C M Grimaldi
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 167:1886-90. 2001
    ..Thus, a sustained increase in E2 alters B cell development, leading to the survival, expansion, and activation of a population of autoreactive marginal zone B cells implicating this B cell subset in autoimmunity...
  13. ncbi request reprint Autoimmune myocarditis does not require B cells for antigen presentation
    S Malkiel
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 163:5265-8. 1999
    ..Either anatomic sequestration of cardiac myosin peptide-MHC complexes or subthreshold presentation of cardiac myosin peptides by conventional APC can explain the survival of these autoreactive T cells...
  14. ncbi request reprint Molecular analysis of the autoantibody response in peptide-induced autoimmunity
    C Putterman
    Division of Rheumatology, Department of Medicine, and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 164:2542-9. 2000
    ..Furthermore, the recovery of an Ab with the heavy and light chain combination of the Ab originally used to isolate the immunizing peptide confirms the utility of phage display peptide libraries in generating true molecular mimics...
  15. ncbi request reprint T cell studies in a peptide-induced model of systemic lupus erythematosus
    M Khalil
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 166:1667-74. 2001
    ..Despite the fact that tissue injury is mediated by Ab, the critical initiating T cell response is Th1...
  16. pmc T-Cell-dependent antibody response to the dominant epitope of streptococcal polysaccharide, N-acetyl-glucosamine, is cross-reactive with cardiac myosin
    S Malkiel
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 68:5803-8. 2000
    ..We speculate that the pathogenic antibody response in rheumatic carditis may reflect the conversion of a T-cell-independent response to GlcNAc to a T-cell-dependent cross-reactive response to GlcNAc and myosin...
  17. doi request reprint Hormonal regulation of B-cell function and systemic lupus erythematosus
    J F G Cohen-Solal
    The Center of Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, USA
    Lupus 17:528-32. 2008
    ..Finally, we will discuss the relevance and implications of these results for human disease...
  18. ncbi request reprint A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus
    L A DeGiorgio
    Department of Neurology and Neuroscience, The Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, New York, USA
    Nat Med 7:1189-93. 2001
    ..These observations indicate that lupus antibodies cross-react with DNA and NMDA receptors, gain access to cerebrospinal fluid and may mediate non-thrombotic and non-vasculitic abnormalities of the central nervous system...
  19. pmc Peptide mimic of phosphorylcholine, a dominant epitope found on Streptococcus pneumoniae
    S L Harris
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 68:5778-84. 2000
    ..This idiotype-derived mimotope of PC is a useful tool for understanding immunologic cross-reactivity and learning to design T-cell-dependent vaccines for S. pneumoniae...
  20. ncbi request reprint Sex hormones and SLE: influencing the fate of autoreactive B cells
    J F G Cohen-Solal
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Curr Top Microbiol Immunol 305:67-88. 2006
    ..We describe how estrogen and prolactin influence B cell maturation and selection, permitting B cells to mature to immunocompetence. Finally, we discuss the relevance and implications of these data for human disease...
  21. ncbi request reprint Speculations on the immunogenicity of self proteins
    B Diamond
    Department of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol (Basel) 112:29-34. 2003
    ..This review first reviews aspects of B cell tolerance and activation and then presents a model to try to explain the auto-immune response to therapeutic proteins...
  22. ncbi request reprint Identification of a new V kappa gene family that is highly expressed in hybridomas from an autoimmune mouse strain
    R Shefner
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461
    J Immunol 145:1609-14. 1990
    ..Because this family was first identified in an autoantibody, we studied its expression in an autoimmune mouse strain. This V kappa family is expressed in 20% of hybridomas from NZB mice...
  23. ncbi request reprint The anti-DNA-associated idiotype 8.12 is encoded by the V lambda II gene family and maps to the vicinity of L chain CDR1
    E Paul
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461
    J Immunol 149:3588-95. 1992
    ..The sequences of several 8.12+ and 8.12- V lambda II genes are reported here and are used to map the 8.12 Id to the vicinity of CDR1, as well as to further characterize the large and polymorphic V lambda II gene family...
  24. ncbi request reprint Randomized controlled phase II trial of glatiramer acetate in ALS
    P H Gordon
    Department of Neurology, Columbia University, NY, USA
    Neurology 66:1117-9. 2006
    ..01). Treated patients showed enhanced lymphocyte proliferation (p = 0.02). The safety profile and immune effects support conducting larger trials of dose selection and efficacy...
  25. ncbi request reprint Block and tackle: CTLA4Ig takes on lupus
    A Davidson
    Department of Medicine, Columbia University, New York, NY, USA
    Lupus 14:197-203. 2005
    ..We discuss the preclinical use of CTLA4Ig in murine SLE models and the rationale for a clinical trial in SLE patients...
  26. ncbi request reprint The immune tolerance network and rheumatic disease: immune tolerance comes to the clinic
    B Diamond
    Albert Einstein College of Medicine, Department of Microbiology and Immunology and Medicine, Bronx, New York 10461, USA
    Arthritis Rheum 44:1730-5. 2001
    ..If the ITN succeeds in linking basic research into the mechanisms of autoimmunity with clinical trials of promising new therapies, it can be expected to play a critical role in advancing the practice of clinical rheumatology...
  27. ncbi request reprint Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies
    A P Kuan
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunogenetics 49:79-85. 1999
    ..Future studies will determine whether the genetic factors identified in this study are also involved in susceptibility to rheumatic fever...
  28. ncbi request reprint Using peptide mimetopes to elucidate anti-polysaccharide and anti-nucleic acid humoral responses
    M Caton
    Albert Einstein College of Medicine, Dept of Microbiology and Immunology, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell Mol Biol (Noisy-le-grand) 49:255-62. 2003
    ..Both of these peptide mimetopes for PC provide useful information regarding the requirements of a protective antibody response against pneumococcal infection, and define a critical role for adjuvant and carrier as well as mimetope...
  29. pmc Molecular analysis of the human immunoglobulin V lambda II gene family
    M Irigoyen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461
    J Clin Invest 94:532-8. 1994
    ..8.12 negative V lambda II encoded light chains also derive from a limited number of V lambda II genes, suggesting that only a subset of the apparently available V lambda II genes are commonly expressed...
  30. pmc [Neuropsychiatric lupus and autoantibodies against ionotropic glutamate receptor (NMDAR)]
    J F G Cohen-Solal
    Center for Autoimmune and Musculoskeletal Disorders, The Feinstein Institute for Medical Research NS LIJ, 350, Community Drive, Manhasset, NY 11030, USA
    Rev Med Interne 32:130-2. 2011
    ..In conclusion, the serum titer of autoantibodies against NR2A/B subunits is an indication of the potential for neuropsychiatric manifestations during the course of the disease...
  31. doi request reprint Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder
    L Brimberg
    Center for Autoimmune and Musculoskeletal Diseases, Manhasset, NY, USA
    Mol Psychiatry 18:1171-7. 2013
    ..The detailed characterization of the specificity of these antibodies will provide practical benefits for the management and prevention of this disorder. ..
  32. pmc Glutamate receptor biology and its clinical significance in neuropsychiatric systemic lupus erythematosus
    Cynthia Aranow
    Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Rheum Dis Clin North Am 36:187-201, x-xi. 2010
    ..These studies suggest that an anatomic classification scheme for neuropsychiatric SLE may facilitate research on etiopathogenesis and the design of clinical trials...
  33. pmc The role of B cells in lupus pathogenesis
    Emil Nashi
    The Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, United States
    Int J Biochem Cell Biol 42:543-50. 2010
    ..Moreover, we discuss how B cell survival and maturation are regulated centrally prior to antigen activation and in the periphery after antigen activation to form the repertoire that generates the spectrum of circulating antibodies...
  34. pmc Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells
    Jie Zhang
    The Center for Autoimmune and Musculoskeletal Disease, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:675-81. 2008
    ..Moreover, ineffective tolerance checkpoints may exist before and after antigen activation in SLE...
  35. pmc Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study
    Annett M Jacobi
    Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Arthritis Rheum 62:201-10. 2010
    ..To understand the effects of long-term BLyS inhibition in human systemic lupus erythematosus (SLE)...
  36. pmc Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential
    Jie Zhang
    The Center for Autoimmune and Musculoskeletal Disease, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
    J Autoimmun 33:270-4. 2009
    ..Thus, the IgM polyreactive repertoire in SLE includes antibodies that may acquire pathogenic function merely by undergoing class-switch recombination to become IgG antibodies...
  37. pmc Selective regulation of autoreactive B cells by FcgammaRIIB
    Jeganathan Venkatesh
    Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Autoimmun 32:149-57. 2009
    ..These data demonstrate that FcgammaRIIB preferentially limits activation of high affinity autoreactive B cells and can influence the activation of DC through an immune complex-mediated mechanism...
  38. pmc Identification of DNA-reactive B cells in patients with systemic lupus erythematosus
    Jie Zhang
    Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    J Immunol Methods 338:79-84. 2008
    ..This methodology enables us to track the development of autoreactive B cells, which recognize peptide and dsDNA, in individual patients with SLE and permits the isolation of autoreactive B cells for further characterization...

Research Grants38

  1. Toward a new approach to SLE therapy
    Betty Diamond; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This proposal identifies a non-immunosuppressive strategy for the treatment of systemic lupus. ..
  2. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2005
    ..I.: Michael Lockshin). The overall goal of this collaborative interactive program is to develop the scientific foundation for preventative therapies for cognitive decline in SLE. ..
  3. Sex-based Differences in the Immune Response
    Betty Diamond; Fiscal Year: 2004
    ..Finally, we will investigate the differences in B cell responsiveness to estrogen in BALB/c and C57Bl/6 mice to understand what underlies an estrogen mediated breakdown in humoral self- tolerance. ..
  4. Studies of Human and Murine SLE
    Betty Diamond; Fiscal Year: 2006
    ..This effort is based on already existing interactions among the investigators and will be substantially strengthened by the resources provided by the Program Project...
  5. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2007
    ..Expertise in immunology, neurology and neuroscience are all critical to this proposal. If this model can be validated, novel approaches to preventing neuropsychiatric symptoms that occur following trauma could be explored. ..
  6. An antigen induced model of SLE
    Betty Diamond; Fiscal Year: 2005
    ..We will determine if an enhanced T cell response alters the repertoire of activated B cells. These studies, in composite, will help us understand how autoreactive B cells can be activated in vivo by antigen exposure. ..
  7. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2009
    ..Expertise in immunology, neurology and neuroscience are all critical to this proposal. If this model can be validated, novel approaches to preventing neuropsychiatric symptoms that occur following trauma could be explored. ..
  8. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2010
    ..Expertise in immunology, neurology and neuroscience are all critical to this proposal. If this model can be validated, novel approaches to preventing neuropsychiatric symptoms that occur following trauma could be explored. ..
  9. An antigen induced model of SLE
    Betty Diamond; Fiscal Year: 2005
    ..We will determine if an enhanced T cell response alters the repertoire of activated B cells. These studies, in composite, will help us understand how autoreactive B cells can be activated in vivo by antigen exposure. ..
  10. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2003
    ..I.: Michael Lockshin). The overall goal of this collaborative interactive program is to develop the scientific foundation for preventative therapies for cognitive decline in SLE. ..
  11. Instrumentation Grant FACSVantage
    Betty Diamond; Fiscal Year: 2002
    ..abstract_text> ..
  12. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2004
    ..I.: Michael Lockshin). The overall goal of this collaborative interactive program is to develop the scientific foundation for preventative therapies for cognitive decline in SLE. ..
  13. An antigen induced model of SLE
    Betty Diamond; Fiscal Year: 2003
    ..We will determine if an enhanced T cell response alters the repertoire of activated B cells. These studies, in composite, will help us understand how autoreactive B cells can be activated in vivo by antigen exposure. ..
  14. Sex-based Differences in the Immune Response
    Betty Diamond; Fiscal Year: 2003
    ..Finally, we will investigate the differences in B cell responsiveness to estrogen in BALB/c and C57Bl/6 mice to understand what underlies an estrogen mediated breakdown in humoral self- tolerance. ..
  15. An antigen induced model of SLE
    Betty Diamond; Fiscal Year: 2004
    ..We will determine if an enhanced T cell response alters the repertoire of activated B cells. These studies, in composite, will help us understand how autoreactive B cells can be activated in vivo by antigen exposure. ..
  16. Sex-based Differences in the Immune Response
    Betty Diamond; Fiscal Year: 2004
    ..Finally, we will investigate the differences in B cell responsiveness to estrogen in BALB/c and C57Bl/6 mice to understand what underlies an estrogen mediated breakdown in humoral self- tolerance. ..
  17. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2002
    ..I.: Michael Lockshin). The overall goal of this collaborative interactive program is to develop the scientific foundation for preventative therapies for cognitive decline in SLE. ..
  18. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2007
    ..This application represents a multidisciplinary approach to build on a novel model for neuropsychiatric manifestations of lupus and a novel paradigm for antibody-mediated changes in cognition and behavior. ..
  19. An antigen induced model of SLE
    Betty Diamond; Fiscal Year: 2002
    ..We will determine if an enhanced T cell response alters the repertoire of activated B cells. These studies, in composite, will help us understand how autoreactive B cells can be activated in vivo by antigen exposure. ..
  20. Sex-based Differences in the Immune Response
    Betty Diamond; Fiscal Year: 2002
    ..Finally, we will investigate the differences in B cell responsiveness to estrogen in BALB/c and C57Bl/6 mice to understand what underlies an estrogen mediated breakdown in humoral self- tolerance. ..
  21. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2009
    ..This application represents a multidisciplinary approach to build on a novel model for neuropsychiatric manifestations of lupus and a novel paradigm for antibody-mediated changes in cognition and behavior. ..
  22. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2010
    ..This application represents a multidisciplinary approach to build on a novel model for neuropsychiatric manifestations of lupus and a novel paradigm for antibody-mediated changes in cognition and behavior. ..
  23. Understanding the SELENA trial: Estrogen in Lupus
    Betty Diamond; Fiscal Year: 2004
    ..It cannot be emphasized too much that this study can be performed only in the cohort of patients in the SELENA trial. Another such study will not be performed. ..
  24. Understanding the SELENA trial: Estrogen in Lupus
    Betty Diamond; Fiscal Year: 2007
    ..It cannot be emphasized too much that this study can be performed only in the cohort of patients in the SELENA trial. Another such study will not be performed. ..
  25. Sex-based Differences in the Immune Response
    Betty Diamond; Fiscal Year: 2005
    ..Finally, we will investigate the differences in B cell responsiveness to estrogen in BALB/c and C57Bl/6 mice to understand what underlies an estrogen mediated breakdown in humoral self- tolerance. ..
  26. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2004
    ..Ultimately, we hope to develop the scientific foundation for a clinical trial of NR2 receptor antagonists to protect against cognitive decline in SLE. ..
  27. Understanding the SELENA trial: Estrogen in Lupus
    Betty Diamond; Fiscal Year: 2005
    ..It cannot be emphasized too much that this study can be performed only in the cohort of patients in the SELENA trial. Another such study will not be performed. ..
  28. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2004
    ..I.: Michael Lockshin). The overall goal of this collaborative interactive program is to develop the scientific foundation for preventative therapies for cognitive decline in SLE. ..
  29. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Betty Diamond; Fiscal Year: 2006
    ..Finally, the Center will include an administrative core for coordination and implementation of Center activities. ..
  30. FASEB Research Conference on: Autoimmunity
    Betty Diamond; Fiscal Year: 2004
    ..Many investigators consider it to be the premier meeting on autoimmunity. ..
  31. Understanding the SELENA trial: Estrogen in Lupus
    Betty Diamond; Fiscal Year: 2006
    ..It cannot be emphasized too much that this study can be performed only in the cohort of patients in the SELENA trial. Another such study will not be performed. ..
  32. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2006
    ..I.: Michael Lockshin). The overall goal of this collaborative interactive program is to develop the scientific foundation for preventative therapies for cognitive decline in SLE. ..
  33. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Betty Diamond; Fiscal Year: 2007
    ..Finally, the Center will include an administrative core for coordination and implementation of Center activities. ..
  34. An antigen induced model of SLE
    Betty Diamond; Fiscal Year: 2001
    ..We will determine if an enhanced T cell response alters the repertoire of activated B cells. These studies, in composite, will help us understand how autoreactive B cells can be activated in vivo by antigen exposure. ..