B Diamond

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. pmc Losing your nerves? Maybe it's the antibodies
    Betty Diamond
    The Feinstein Institute for Medical Research, Center of Autoimmune and Musculoskeletal Diseases, 350 Community Drive, Manhasset, New York 110301, USA
    Nat Rev Immunol 9:449-56. 2009
  2. doi request reprint Brain-reactive antibodies and disease
    B Diamond
    Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Annu Rev Immunol 31:345-85. 2013
  3. doi request reprint A model for lupus brain disease
    Betty Diamond
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Immunol Rev 248:56-67. 2012
  4. doi request reprint It takes guts to grow a brain: Increasing evidence of the important role of the intestinal microflora in neuro- and immune-modulatory functions during development and adulthood
    Betty Diamond
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Bioessays 33:588-91. 2011
  5. pmc Moving towards a cure: blocking pathogenic antibodies in systemic lupus erythematosus
    B Diamond
    Autoimmune and Musculoskeletal Disease Center, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Intern Med 269:36-44. 2011
  6. pmc [Neuropsychiatric lupus and autoantibodies against ionotropic glutamate receptor (NMDAR)]
    J F G Cohen-Solal
    Center for Autoimmune and Musculoskeletal Disorders, The Feinstein Institute for Medical Research NS LIJ, 350, Community Drive, Manhasset, NY 11030, USA
    Rev Med Interne 32:130-2. 2011
  7. pmc Glutamate receptor biology and its clinical significance in neuropsychiatric systemic lupus erythematosus
    Cynthia Aranow
    Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Rheum Dis Clin North Am 36:187-201, x-xi. 2010
  8. pmc Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells
    Jie Zhang
    The Center for Autoimmune and Musculoskeletal Disease, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:675-81. 2008
  9. pmc The role of B cells in lupus pathogenesis
    Emil Nashi
    The Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, United States
    Int J Biochem Cell Biol 42:543-50. 2010
  10. pmc Phenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosus
    Annett M Jacobi
    The Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, USA
    PLoS ONE 4:e5776. 2009

Research Grants

  1. Studies of Human and Murine SLE
    Betty Diamond; Fiscal Year: 2006
  2. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2006
  3. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Betty Diamond; Fiscal Year: 2007
  4. Understanding the SELENA trial: Estrogen in Lupus
    Betty Diamond; Fiscal Year: 2007
  5. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2007
  6. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2007
  7. An antigen induced model of SLE
    Betty Diamond; Fiscal Year: 2005
  8. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2009
  9. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2010
  10. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2010

Collaborators

  • Patricio T Huerta
  • Paola Mina-Osorio
  • Kevin Tracey
  • R A Furie
  • Elahna Paul
  • Annett M Jacobi
  • Jie Zhang
  • Cynthia Aranow
  • Meggan Mackay
  • Tao Wang
  • Daisuke Kawabata
  • Jeganathan Venkatesh
  • J F G Cohen-Solal
  • Anne Davidson
  • Emil Nashi
  • Christine M Grimaldi
  • Prameladevi Chinnasamy
  • Sun Jung Kim
  • Weiqing Huang
  • Inaki Sanz
  • Meera Ramanujam
  • Yinghua Wang
  • William Freimuth
  • SunJung Kim
  • Bruce T Volpe
  • Roseann Berlin
  • Xiaonan Xu
  • John Hardin
  • Magi Khalil
  • Zhi Jie Zhou
  • Chuansheng Wang
  • Michele Caton

Detail Information

Publications16

  1. pmc Losing your nerves? Maybe it's the antibodies
    Betty Diamond
    The Feinstein Institute for Medical Research, Center of Autoimmune and Musculoskeletal Diseases, 350 Community Drive, Manhasset, New York 110301, USA
    Nat Rev Immunol 9:449-56. 2009
    ..Under conditions of BBB compromise, and during fetal development, we think that these antibodies can alter brain function in otherwise healthy individuals...
  2. doi request reprint Brain-reactive antibodies and disease
    B Diamond
    Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Annu Rev Immunol 31:345-85. 2013
    ....
  3. doi request reprint A model for lupus brain disease
    Betty Diamond
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Immunol Rev 248:56-67. 2012
    ..We discuss the implications of this model for lupus and for identifying other antibodies that may contribute to brain disease...
  4. doi request reprint It takes guts to grow a brain: Increasing evidence of the important role of the intestinal microflora in neuro- and immune-modulatory functions during development and adulthood
    Betty Diamond
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Bioessays 33:588-91. 2011
    ..These observations necessitate a new look at the many interconnections of the immune system and the brain, suggesting new frontiers for research and new therapeutic strategies for neurodevelopmental diseases...
  5. pmc Moving towards a cure: blocking pathogenic antibodies in systemic lupus erythematosus
    B Diamond
    Autoimmune and Musculoskeletal Disease Center, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Intern Med 269:36-44. 2011
    ..Thus, it might be possible to treat the aspects of autoimmune disease without inducing major immunosuppression and ensuing infectious complications...
  6. pmc [Neuropsychiatric lupus and autoantibodies against ionotropic glutamate receptor (NMDAR)]
    J F G Cohen-Solal
    Center for Autoimmune and Musculoskeletal Disorders, The Feinstein Institute for Medical Research NS LIJ, 350, Community Drive, Manhasset, NY 11030, USA
    Rev Med Interne 32:130-2. 2011
    ..In conclusion, the serum titer of autoantibodies against NR2A/B subunits is an indication of the potential for neuropsychiatric manifestations during the course of the disease...
  7. pmc Glutamate receptor biology and its clinical significance in neuropsychiatric systemic lupus erythematosus
    Cynthia Aranow
    Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Rheum Dis Clin North Am 36:187-201, x-xi. 2010
    ..These studies suggest that an anatomic classification scheme for neuropsychiatric SLE may facilitate research on etiopathogenesis and the design of clinical trials...
  8. pmc Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells
    Jie Zhang
    The Center for Autoimmune and Musculoskeletal Disease, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:675-81. 2008
    ..Moreover, ineffective tolerance checkpoints may exist before and after antigen activation in SLE...
  9. pmc The role of B cells in lupus pathogenesis
    Emil Nashi
    The Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, United States
    Int J Biochem Cell Biol 42:543-50. 2010
    ..Moreover, we discuss how B cell survival and maturation are regulated centrally prior to antigen activation and in the periphery after antigen activation to form the repertoire that generates the spectrum of circulating antibodies...
  10. pmc Phenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosus
    Annett M Jacobi
    The Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, USA
    PLoS ONE 4:e5776. 2009
    ..This methodology enables us to gain insight into the development and fate of DNA-reactive B cells in individual patients with SLE and paves the way ultimately to permit better and more customized therapies...
  11. pmc Enhanced selection of high affinity DNA-reactive B cells following cyclophosphamide treatment in mice
    Daisuke Kawabata
    Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America
    PLoS ONE 5:e8418. 2010
    ..There are significant implications for therapy...
  12. pmc Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential
    Jie Zhang
    The Center for Autoimmune and Musculoskeletal Disease, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
    J Autoimmun 33:270-4. 2009
    ..Thus, the IgM polyreactive repertoire in SLE includes antibodies that may acquire pathogenic function merely by undergoing class-switch recombination to become IgG antibodies...
  13. pmc Selective regulation of autoreactive B cells by FcgammaRIIB
    Jeganathan Venkatesh
    Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Autoimmun 32:149-57. 2009
    ..These data demonstrate that FcgammaRIIB preferentially limits activation of high affinity autoreactive B cells and can influence the activation of DC through an immune complex-mediated mechanism...
  14. pmc Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts
    Sun Jung Kim
    Autoimmune Disease Laboratory, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Exp Med 205:2437-48. 2008
    ..Understanding the factors that regulate antigen-activated B cell differentiation and memory cell formation has implications for both antibody-mediated autoimmune disease and protective antibody responses...
  15. pmc Identification of DNA-reactive B cells in patients with systemic lupus erythematosus
    Jie Zhang
    Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    J Immunol Methods 338:79-84. 2008
    ..This methodology enables us to track the development of autoreactive B cells, which recognize peptide and dsDNA, in individual patients with SLE and permits the isolation of autoreactive B cells for further characterization...
  16. pmc Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study
    Annett M Jacobi
    Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Arthritis Rheum 62:201-10. 2010
    ..To understand the effects of long-term BLyS inhibition in human systemic lupus erythematosus (SLE)...

Research Grants38

  1. Studies of Human and Murine SLE
    Betty Diamond; Fiscal Year: 2006
    ..This effort is based on already existing interactions among the investigators and will be substantially strengthened by the resources provided by the Program Project...
  2. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2006
    ..I.: Michael Lockshin). The overall goal of this collaborative interactive program is to develop the scientific foundation for preventative therapies for cognitive decline in SLE. ..
  3. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Betty Diamond; Fiscal Year: 2007
    ..Finally, the Center will include an administrative core for coordination and implementation of Center activities. ..
  4. Understanding the SELENA trial: Estrogen in Lupus
    Betty Diamond; Fiscal Year: 2007
    ..It cannot be emphasized too much that this study can be performed only in the cohort of patients in the SELENA trial. Another such study will not be performed. ..
  5. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2007
    ..Expertise in immunology, neurology and neuroscience are all critical to this proposal. If this model can be validated, novel approaches to preventing neuropsychiatric symptoms that occur following trauma could be explored. ..
  6. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2007
    ..This application represents a multidisciplinary approach to build on a novel model for neuropsychiatric manifestations of lupus and a novel paradigm for antibody-mediated changes in cognition and behavior. ..
  7. An antigen induced model of SLE
    Betty Diamond; Fiscal Year: 2005
    ..We will determine if an enhanced T cell response alters the repertoire of activated B cells. These studies, in composite, will help us understand how autoreactive B cells can be activated in vivo by antigen exposure. ..
  8. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2009
    ..This application represents a multidisciplinary approach to build on a novel model for neuropsychiatric manifestations of lupus and a novel paradigm for antibody-mediated changes in cognition and behavior. ..
  9. Anti-Microbial Antibodies Induce Neuropsychiatric Syndromes
    Betty Diamond; Fiscal Year: 2010
    ..Expertise in immunology, neurology and neuroscience are all critical to this proposal. If this model can be validated, novel approaches to preventing neuropsychiatric symptoms that occur following trauma could be explored. ..
  10. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2010
    ..This application represents a multidisciplinary approach to build on a novel model for neuropsychiatric manifestations of lupus and a novel paradigm for antibody-mediated changes in cognition and behavior. ..
  11. Instrumentation Grant FACSVantage
    Betty Diamond; Fiscal Year: 2002
    ..abstract_text> ..
  12. FASEB Research Conference on: Autoimmunity
    Betty Diamond; Fiscal Year: 2004
    ..Many investigators consider it to be the premier meeting on autoimmunity. ..
  13. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2004
    ..Ultimately, we hope to develop the scientific foundation for a clinical trial of NR2 receptor antagonists to protect against cognitive decline in SLE. ..
  14. Sex-based Differences in the Immune Response
    Betty Diamond; Fiscal Year: 2005
    ..Finally, we will investigate the differences in B cell responsiveness to estrogen in BALB/c and C57Bl/6 mice to understand what underlies an estrogen mediated breakdown in humoral self- tolerance. ..
  15. Toward a new approach to SLE therapy
    Betty Diamond; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This proposal identifies a non-immunosuppressive strategy for the treatment of systemic lupus. ..