Research Topics
| John Michael CullenSummaryAffiliation: North Carolina State University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic diseaseTracey N Gillespie
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 222:47-51, 35. 2003..Identification of Bartonella DNA in these dogs indicates the need for future prospective studies to determine the clinical relevance of Bartonella spp infection in dogs with hepatic disease...
Summary of the World Small Animal Veterinary Association standardization committee guide to classification of liver disease in dogs and catsJohn M Cullen
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Vet Clin North Am Small Anim Pract 39:395-418. 2009..The aim is to find a sound scientific basis of diagnostic and treatment protocols for hepatobiliary diseases. This article provides an overview of that monograph...- Effects of Kupffer cell depletion on acute alpha-naphthylisothiocyanate-induced liver toxicity in male miceJohn M Cullen
College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
Toxicol Pathol 41:7-17. 2013..These findings suggest that Kupffer cell reduction increases hepatobiliary damage due to ANIT treatment... 
Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behaviorBenoit Hedan
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
BMC Cancer 11:201. 2011..This process would identify evolutionarily conserved cytogenetic changes to highlight regions of particular importance to HS biology...- H-ras consensus sequence and mutations in primary hepatocellular carcinomas of lemurs and lorisesJ M Cullen
College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Vet Pathol 48:868-74. 2011..There were 4 silent mutations that did not contain changes in the encoded amino acids, 2 of which were found in nonneoplastic regions of tumor-bearing liver... - Time course gene expression using laser capture microscopy-extracted bile ducts, but not hepatic parenchyma, reveals acute alpha-naphthylisothiocyanate toxicityJohn Michael Cullen
North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina 27606, USA
Toxicol Pathol 38:715-29. 2010.... - Aflatoxin B1 and/or hepatitis B virus induced tumor spectrum in a genetically engineered hepatitis B virus expression and Trp53 haploinsufficient mouse model system for hepatocarcinogenesisJohn M Cullen
College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Toxicol Pathol 37:333-42. 2009..In this model system, HBV expression affected only hepatocellular neoplasia in association with both aflatoxin B1 initiation and p53 haploinsufficiency... - Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax)J M Cullen
College of Veterinary Medicine, NCSU, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
J Zoo Wildl Med 39:263-5. 2008..These data indicate that WHV is present in central North Carolina at rates approaching those seen in endemic areas, such as the mid-Atlantic region of the United States... - Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucksJ M Cullen
College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA
Antimicrob Agents Chemother 45:2740-5. 2001..No histologic evidence of liver injury was apparent in the biopsies. Under the conditions of this study, adefovir dipivoxil was an effective antihepadnaviral agent... - The role of pathology in the identification of drug-induced hepatic toxicityJohn M Cullen
North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Expert Opin Drug Metab Toxicol 2:241-7. 2006..All pathologists have the responsibility to effectively and accurately communicate their findings and interpretations to the appropriate audiences... - Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporinPaul R Hess
Department of Microbiology and Immunology, Universaity of North Carolina, Chapel Hill, NC, USA
Blood 109:3300-7. 2007..This work demonstrates the therapeutic potential of cytotoxic tetramers to selectively eradicate pathogenic clonotypes while leaving overall T-cell immunity intact... - Mechanistic classification of liver injuryJohn M Cullen
College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Toxicol Pathol 33:6-8. 2005..A classification of liver injury is presented as a means to better understand the spectrum of known mechanisms of liver injury and to assist in discovering novel pathways of toxic liver injury... - Imaging diagnosis--Neuronal ceroid lipofuscinosis with a chronic subdural hematomaMidori Goto Asakawa
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
Vet Radiol Ultrasound 51:155-8. 2010..We hypothesize that rapid brain atrophy contributed to the subdural hematoma formation, a complication not described previously in dogs with neuronal lipofuscinosis... - Spontaneous hepatocellular carcinoma in captive prosimiansL M Zadrozny
North Carolina State University, College of Veterinary Medicine, Department of Population Health and Pathobiology, Raleigh, NC 27606, USA
Vet Pathol 47:306-11. 2010..In conclusion, hepatocellular neoplasia is relatively common in captive prosimians, although previously suspected etiologies seem unlikely... - Woodchuck interleukin-6 gene: structure, characterization, and biologic activityDaniel H Li
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 W Campus Drive, CCSR Building 2230, Stanford, CA 94305 5166, USA
Gene 342:157-64. 2004..Cloning of the woodchuck IL-6 gene and demonstrating biologic activity of the gene product will facilitate studies of human hepatitis B virus using the woodchuck model... - Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virusYuao Zhu
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Virology 327:26-40. 2004.... - Helicobacter marmotae sp. nov. isolated from livers of woodchucks and intestines of catsJames G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Clin Microbiol 40:2513-9. 2002..nov. for these organisms. Further studies are required to ascertain if this novel Helicobacter sp. plays a tumor promotion role in hepadnavirus-associated tumors in woodchucks or causes enterohepatic disease in cats... - The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphologyChunxiao Xu
Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Virology 359:283-94. 2007..We hypothesize that a common event is loss of the ability to express WHV, allowing these hepatocytes to escape immune mediated cell death and to undergo clonal expansion to form distinct foci...