John Michael Cullen

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. ncbi request reprint Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease
    Tracey N Gillespie
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 222:47-51, 35. 2003
  2. doi request reprint Summary of the World Small Animal Veterinary Association standardization committee guide to classification of liver disease in dogs and cats
    John M Cullen
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vet Clin North Am Small Anim Pract 39:395-418. 2009
  3. doi request reprint Effects of Kupffer cell depletion on acute alpha-naphthylisothiocyanate-induced liver toxicity in male mice
    John M Cullen
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
    Toxicol Pathol 41:7-17. 2013
  4. pmc Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior
    Benoit Hedan
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    BMC Cancer 11:201. 2011
  5. doi request reprint H-ras consensus sequence and mutations in primary hepatocellular carcinomas of lemurs and lorises
    J M Cullen
    College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vet Pathol 48:868-74. 2011
  6. doi request reprint Time course gene expression using laser capture microscopy-extracted bile ducts, but not hepatic parenchyma, reveals acute alpha-naphthylisothiocyanate toxicity
    John Michael Cullen
    North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina 27606, USA
    Toxicol Pathol 38:715-29. 2010
  7. doi request reprint Aflatoxin B1 and/or hepatitis B virus induced tumor spectrum in a genetically engineered hepatitis B virus expression and Trp53 haploinsufficient mouse model system for hepatocarcinogenesis
    John M Cullen
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Pathol 37:333-42. 2009
  8. ncbi request reprint Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax)
    J M Cullen
    College of Veterinary Medicine, NCSU, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    J Zoo Wildl Med 39:263-5. 2008
  9. pmc Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks
    J M Cullen
    College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA
    Antimicrob Agents Chemother 45:2740-5. 2001
  10. ncbi request reprint The role of pathology in the identification of drug-induced hepatic toxicity
    John M Cullen
    North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Expert Opin Drug Metab Toxicol 2:241-7. 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease
    Tracey N Gillespie
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 222:47-51, 35. 2003
    ..Identification of Bartonella DNA in these dogs indicates the need for future prospective studies to determine the clinical relevance of Bartonella spp infection in dogs with hepatic disease...
  2. doi request reprint Summary of the World Small Animal Veterinary Association standardization committee guide to classification of liver disease in dogs and cats
    John M Cullen
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vet Clin North Am Small Anim Pract 39:395-418. 2009
    ..The aim is to find a sound scientific basis of diagnostic and treatment protocols for hepatobiliary diseases. This article provides an overview of that monograph...
  3. doi request reprint Effects of Kupffer cell depletion on acute alpha-naphthylisothiocyanate-induced liver toxicity in male mice
    John M Cullen
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
    Toxicol Pathol 41:7-17. 2013
    ..These findings suggest that Kupffer cell reduction increases hepatobiliary damage due to ANIT treatment...
  4. pmc Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior
    Benoit Hedan
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    BMC Cancer 11:201. 2011
    ..This process would identify evolutionarily conserved cytogenetic changes to highlight regions of particular importance to HS biology...
  5. doi request reprint H-ras consensus sequence and mutations in primary hepatocellular carcinomas of lemurs and lorises
    J M Cullen
    College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vet Pathol 48:868-74. 2011
    ..There were 4 silent mutations that did not contain changes in the encoded amino acids, 2 of which were found in nonneoplastic regions of tumor-bearing liver...
  6. doi request reprint Time course gene expression using laser capture microscopy-extracted bile ducts, but not hepatic parenchyma, reveals acute alpha-naphthylisothiocyanate toxicity
    John Michael Cullen
    North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina 27606, USA
    Toxicol Pathol 38:715-29. 2010
    ....
  7. doi request reprint Aflatoxin B1 and/or hepatitis B virus induced tumor spectrum in a genetically engineered hepatitis B virus expression and Trp53 haploinsufficient mouse model system for hepatocarcinogenesis
    John M Cullen
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Pathol 37:333-42. 2009
    ..In this model system, HBV expression affected only hepatocellular neoplasia in association with both aflatoxin B1 initiation and p53 haploinsufficiency...
  8. ncbi request reprint Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax)
    J M Cullen
    College of Veterinary Medicine, NCSU, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    J Zoo Wildl Med 39:263-5. 2008
    ..These data indicate that WHV is present in central North Carolina at rates approaching those seen in endemic areas, such as the mid-Atlantic region of the United States...
  9. pmc Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks
    J M Cullen
    College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA
    Antimicrob Agents Chemother 45:2740-5. 2001
    ..No histologic evidence of liver injury was apparent in the biopsies. Under the conditions of this study, adefovir dipivoxil was an effective antihepadnaviral agent...
  10. ncbi request reprint The role of pathology in the identification of drug-induced hepatic toxicity
    John M Cullen
    North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Expert Opin Drug Metab Toxicol 2:241-7. 2006
    ..All pathologists have the responsibility to effectively and accurately communicate their findings and interpretations to the appropriate audiences...
  11. pmc Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin
    Paul R Hess
    Department of Microbiology and Immunology, Universaity of North Carolina, Chapel Hill, NC, USA
    Blood 109:3300-7. 2007
    ..This work demonstrates the therapeutic potential of cytotoxic tetramers to selectively eradicate pathogenic clonotypes while leaving overall T-cell immunity intact...
  12. ncbi request reprint Mechanistic classification of liver injury
    John M Cullen
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Pathol 33:6-8. 2005
    ..A classification of liver injury is presented as a means to better understand the spectrum of known mechanisms of liver injury and to assist in discovering novel pathways of toxic liver injury...
  13. ncbi request reprint Imaging diagnosis--Neuronal ceroid lipofuscinosis with a chronic subdural hematoma
    Midori Goto Asakawa
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Vet Radiol Ultrasound 51:155-8. 2010
    ..We hypothesize that rapid brain atrophy contributed to the subdural hematoma formation, a complication not described previously in dogs with neuronal lipofuscinosis...
  14. doi request reprint Spontaneous hepatocellular carcinoma in captive prosimians
    L M Zadrozny
    North Carolina State University, College of Veterinary Medicine, Department of Population Health and Pathobiology, Raleigh, NC 27606, USA
    Vet Pathol 47:306-11. 2010
    ..In conclusion, hepatocellular neoplasia is relatively common in captive prosimians, although previously suspected etiologies seem unlikely...
  15. ncbi request reprint Woodchuck interleukin-6 gene: structure, characterization, and biologic activity
    Daniel H Li
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 W Campus Drive, CCSR Building 2230, Stanford, CA 94305 5166, USA
    Gene 342:157-64. 2004
    ..Cloning of the woodchuck IL-6 gene and demonstrating biologic activity of the gene product will facilitate studies of human hepatitis B virus using the woodchuck model...
  16. ncbi request reprint Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus
    Yuao Zhu
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Virology 327:26-40. 2004
    ....
  17. pmc Helicobacter marmotae sp. nov. isolated from livers of woodchucks and intestines of cats
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 40:2513-9. 2002
    ..nov. for these organisms. Further studies are required to ascertain if this novel Helicobacter sp. plays a tumor promotion role in hepadnavirus-associated tumors in woodchucks or causes enterohepatic disease in cats...
  18. pmc The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphology
    Chunxiao Xu
    Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Virology 359:283-94. 2007
    ..We hypothesize that a common event is loss of the ability to express WHV, allowing these hepatocytes to escape immune mediated cell death and to undergo clonal expansion to form distinct foci...