Nicholas Chiorazzi

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. pmc Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
    Bradley T Messmer
    North Shore LIJ Research Institute, 350 Community Dr, Manhasset, NY 11030, USA
    J Exp Med 200:519-25. 2004
  2. pmc Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification
    Carmela Gurrieri
    Division of Molecular Immunology, Department of Pathology, Cornell University Weill Medical College, New York, NY 10021, USA
    J Exp Med 196:629-39. 2002
  3. pmc Chronic lymphocytic leukemia: a tale of one or two signals?
    Nicholas Chiorazzi
    Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Hofstra North Shore LIJ School of Medicine, 350 Community Drive, Manhasset, NY 10030, USA
    Cell Res 23:182-5. 2013
  4. doi Implications of new prognostic markers in chronic lymphocytic leukemia
    Nicholas Chiorazzi
    The Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Hematology Am Soc Hematol Educ Program 2012:76-87. 2012
  5. pmc Enhanced expression of mRNA for nuclear factor kappaB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritis
    Shunsei Hirohata
    Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173 8605, Japan
    Arthritis Res Ther 8:R54. 2006
  6. ncbi B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor
    Nicholas Chiorazzi
    North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    Annu Rev Immunol 21:841-94. 2003
  7. pmc Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities
    Nicholas Chiorazzi
    Feinstein Institute for Medical Research and Department of Medicine, North Shore University Hospital and Albert Einstein College of Medicine, Manhasset, NY 11030, USA
    Blood 117:1781-91. 2011
  8. ncbi Cell proliferation and death: forgotten features of chronic lymphocytic leukemia B cells
    Nicholas Chiorazzi
    The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Best Pract Res Clin Haematol 20:399-413. 2007
  9. ncbi Chronic lymphocytic leukemia
    Nicholas Chiorazzi
    Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    N Engl J Med 352:804-15. 2005
  10. ncbi B-cell chronic lymphocytic leukemia, a clonal disease of B lymphocytes with receptors that vary in specificity for (auto)antigens
    Nicholas Chiorazzi
    Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Ann N Y Acad Sci 1062:1-12. 2005

Research Grants

  1. B-cell repertoires in chronic lymphocytic leukemia
    Nicholas Chiorazzi; Fiscal Year: 2010
  2. B-cell repertoires in chronic lymphocytic leukemia
    Nicholas Chiorazzi; Fiscal Year: 2009
  3. GENERAL CLINICAL RESEARCH CENTER
    Nicholas Chiorazzi; Fiscal Year: 2006
  4. B CLL SUBGROUPS--MATURATION STAGE AND GENE EXPRESSION
    Nicholas Chiorazzi; Fiscal Year: 2004
  5. B CELL REPERTOIRES IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Nicholas Chiorazzi; Fiscal Year: 2004
  6. B CELL REPERTOIRES IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Nicholas Chiorazzi; Fiscal Year: 2001
  7. B CELL REPERTOIRES IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Nicholas Chiorazzi; Fiscal Year: 2003
  8. B CLL SUBGROUPS--MATURATION STAGE AND GENE EXPRESSION
    Nicholas Chiorazzi; Fiscal Year: 2001
  9. IRB Oversight and Educational Enhancement Program
    Nicholas Chiorazzi; Fiscal Year: 2002
  10. B CELL REPERTOIRES IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Nicholas Chiorazzi; Fiscal Year: 2002

Detail Information

Publications62

  1. pmc Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
    Bradley T Messmer
    North Shore LIJ Research Institute, 350 Community Dr, Manhasset, NY 11030, USA
    J Exp Med 200:519-25. 2004
    ..These shared, stereotyped Ig molecules may be valuable probes for antigen identification and important targets for cross-reactive idiotypic therapy...
  2. pmc Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification
    Carmela Gurrieri
    Division of Molecular Immunology, Department of Pathology, Cornell University Weill Medical College, New York, NY 10021, USA
    J Exp Med 196:629-39. 2002
    ..These data indicate that a somatic mutation mechanism remains functional in CLL cells and could play a role in the evolution of the clone...
  3. pmc Chronic lymphocytic leukemia: a tale of one or two signals?
    Nicholas Chiorazzi
    Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Hofstra North Shore LIJ School of Medicine, 350 Community Drive, Manhasset, NY 10030, USA
    Cell Res 23:182-5. 2013
    ..These findings are discussed in the context of available information about the antigen reactivity of CLL B cells and its potential role in clonal survival and drive...
  4. doi Implications of new prognostic markers in chronic lymphocytic leukemia
    Nicholas Chiorazzi
    The Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Hematology Am Soc Hematol Educ Program 2012:76-87. 2012
    ..These and other biology-based indicators of patient clinical course and outcome can be used as starting points from which to understand and treat CLL...
  5. pmc Enhanced expression of mRNA for nuclear factor kappaB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritis
    Shunsei Hirohata
    Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173 8605, Japan
    Arthritis Res Ther 8:R54. 2006
    ..These results indicate that the enhanced expression of NFkappaB1 mRNA in bone marrow CD34+ cells plays a pivotal role in their abnormal responses to TNF-alpha and, thus, in the pathogenesis of RA...
  6. ncbi B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor
    Nicholas Chiorazzi
    North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    Annu Rev Immunol 21:841-94. 2003
    ..Finally, we discuss current and emerging views of the cellular origin of B-CLL cells and the differentiation pathways down which we believe these cells progress...
  7. pmc Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities
    Nicholas Chiorazzi
    Feinstein Institute for Medical Research and Department of Medicine, North Shore University Hospital and Albert Einstein College of Medicine, Manhasset, NY 11030, USA
    Blood 117:1781-91. 2011
    ....
  8. ncbi Cell proliferation and death: forgotten features of chronic lymphocytic leukemia B cells
    Nicholas Chiorazzi
    The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Best Pract Res Clin Haematol 20:399-413. 2007
    ..Therefore, CLL is a disease of both proliferation and accumulation in which a homeostatic balance exists in patients with stable lymphocyte counts or an imbalance exists in patients with rising lymphocyte counts...
  9. ncbi Chronic lymphocytic leukemia
    Nicholas Chiorazzi
    Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    N Engl J Med 352:804-15. 2005
  10. ncbi B-cell chronic lymphocytic leukemia, a clonal disease of B lymphocytes with receptors that vary in specificity for (auto)antigens
    Nicholas Chiorazzi
    Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Ann N Y Acad Sci 1062:1-12. 2005
    ..Thus, B-CLL appears to be a disease of B-cell clones that have undergone various types of receptor reconfiguration and yet retain inappropriate antigen-binding properties...
  11. pmc In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia
    Carlo Calissano
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Blood 114:4832-42. 2009
    ....
  12. pmc Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells
    Carlo Calissano
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York, United States of America
    Mol Med 17:1374-82. 2011
    ..Finally, the study lays the groundwork for future analyses that might provide a more robust understanding of the development and clonal evolution of this currently incurable disease...
  13. pmc IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions
    Piers E M Patten
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Blood 120:4802-11. 2012
    ..Furthermore, AID protein was associated with worse patient outcome and adverse cytogenetics. We conclude that the production of fully functional AID protein by U-CLL and M-CLL cells could be involved in clonal evolution of the disease...
  14. pmc Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia
    Fabio Ghiotto
    Department of Medicine, North Shore University Hospital, Manhasset, NY, USA
    Mol Med 12:300-8. 2006
    ..These similarities and differences between the IgH and IgL V gene repertoires expressed in B-CLL suggest some novel features while also reinforcing concepts derived from studies of the IgH repertoire...
  15. pmc Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin
    Charles C Chu
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish LIJ Health System, Manhasset, NY 11030, USA
    Blood 115:3907-15. 2010
    ..Taken together, our data indicate that a large proportion of CLL clones emerge from natural antibody-producing cells expressing immunoglobulins that recognize MEACs, and that this reactivity is associated with poor clinical outcome...
  16. pmc T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic lymphocytic leukemia patients
    Rajendra N Damle
    Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    Blood 120:2438-49. 2012
    ..These findings provide an understanding of how BCR-mediated signals impact telomerase modulation in IGHV mutation-based subgroups of B-CLL and normal B cells...
  17. pmc Dendritic cells from chronic lymphocytic leukemia patients are normal regardless of Ig V gene mutation status
    Davorka Messmer
    The Laboratory of Experimental Immunology, Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York, USA
    Mol Med 10:96-103. 2004
    ..Our data show that DCs generated from the B-CLL subgroup with unmutated Ig V genes are functionally normal. These results are very promising for the use of DCs from patients with poor prognosis for immunotherapy...
  18. pmc CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells
    Rajendra N Damle
    Laboratory of Experimental Immunology, The Feinstein Institute for Medical Research, North Shore Long Island Jewish LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Blood 110:3352-9. 2007
    ..These findings may help explain why high percentages of CD38(+) cells within clones are associated with poor clinical outcome...
  19. pmc Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
    Charles C Chu
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish LIJ Health System, Manhasset, NY, USA
    Blood 112:5122-9. 2008
    ..Binding of CLL mAb to MYHIIA could promote the development, survival, and expansion of these leukemic cells...
  20. ncbi Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations
    Rajendra N Damle
    North Shore Long Island Jewish Research Institute, 350 Community Dr, Manhasset, NY 11030, USA
    Blood 103:375-82. 2004
    ..In addition, they reinforce the concept that B-CLL is not simply an accumulative disease of slowly dividing B lymphocytes but possibly one of B cells with extensive proliferative histories...
  21. ncbi B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
    Rajendra N Damle
    North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    Blood 99:4087-93. 2002
    ....
  22. pmc Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia
    Xiao Jie Yan
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Blood 118:5201-10. 2011
    ..These findings indicate the value of multicytokine analyses for prognosis and suggest therapeutic strategies in CLL aimed at reducing CL1 and increasing CL2/CL3 cytokines...
  23. ncbi Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone
    Emilia Albesiano
    North Shore Long Island Jewish Research Institute, 350 Community Dr, Manhasset, NY 11030, USA
    Blood 102:3333-9. 2003
    ..These data suggest that AID-mediated DNA alterations may occur in a variably sized, minor subset of B-CLL cells at any given time...
  24. pmc A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion
    Hyunjoo Lee
    Laboratory of B Cell Biology, Karches Center for Chronic Lymphocytic Leukemia Research, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 188:6093-108. 2012
    ....
  25. pmc Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells
    Till Seiler
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish LIJ Health System, Manhasset, NY 11030, USA
    Blood 114:3615-24. 2009
    ....
  26. pmc A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
    Davide Bagnara
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Blood 117:5463-72. 2011
    ....
  27. doi Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades
    Xiao Jie Yan
    The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Clin Immunol 131:481-94. 2009
    ..Our studies suggest immunological mechanisms by which I3C ameliorates SLE in mice and provide a rationale for its use as an adjunctive therapy for human lupus...
  28. pmc Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia
    Fabio Ghiotto
    Department of Medicine, North Shore University Hospital and New York University School of Medicine, Manhasset, New York, USA
    J Clin Invest 113:1008-16. 2004
    ....
  29. pmc Surface expression of Bcl-2 in chronic lymphocytic leukemia and other B-cell leukemias and lymphomas without a breakpoint t(14;18)
    Brian A McCarthy
    Laboratory of Experimental Immunology, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Mol Med 14:618-27. 2008
    ..It is not clear if this surface membrane expression is a passive consequence of the apoptotic process or an active attempt by the B cell to abort cell death by stabilizing the plasma membrane...
  30. pmc Effects of prostaglandin E2 on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansion
    Shabirul Haque
    1Laboratory of B Cell Biology, Karches Center for CLL Research and Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA
    FASEB J 28:627-43. 2014
    ..8 × 10(-4)). We conclude that, devoid of the repressive influences of Bcl-6, dividing B lymphoblasts in inflamed tissues should display heightened p53 transcription and increased risk of p53 mutagenesis...
  31. pmc Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity
    Maxime Hervé
    Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, New York, New York 10021, USA
    J Clin Invest 115:1636-43. 2005
    ..We concluded that both UM-CLLs and M-CLLs originate from self-reactive B cell precursors and that SHM plays an important role in the development of the disease by altering original BCR autoreactivity...
  32. ncbi Dendritic cell activating peptides induce distinct cytokine profiles
    Gloria Telusma
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    Int Immunol 18:1563-73. 2006
    ..These DC-activating peptides could serve as an adjuvant in immunotherapeutic or vaccine context and the selective activity of these different peptides suggests a means to customize the functional properties of DCs...
  33. pmc Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling
    Shih Shih Chen
    Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 110:E1500-7. 2013
    ..This transferrable, antigenic-specific murine B-cell clone (TCL1-192) provides a platform to study the types and sites of antigen-BCR interactions and genetic alterations that result and may have relevance to patients...
  34. pmc In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
    Bradley T Messmer
    Institute for Medical Research, North Shore LIJ Research Institute, Manhasset, New York 11030, USA
    J Clin Invest 115:755-64. 2005
    ..A correlation between birth rates and disease activity and progression appears to exist, which may help identify patients at risk for worsening disease in advance of clinical deterioration...
  35. ncbi High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization
    Davorka Messmer
    Laboratory of Experimental Immunology, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    J Immunol 173:307-13. 2004
    ..HMGB1 released by necrotic cells may be a signal of tissue or cellular injury that, when sensed by DCs, induces and/or enhances an immune reaction...
  36. ncbi The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process
    Bradley T Messmer
    North Shore Long Island Jewish Research Institute, 350 Community Dr, Manhasset, NY 11030, USA
    Blood 103:3490-5. 2004
    ..60; framework region [FR] R/S, 1.72). These results are consistent with the notion that V(H) mutations in B-CLL cells result from canonical SHM and select for altered, structurally sound antigen receptors...
  37. pmc Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation
    Rosa Catera
    Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:665-74. 2008
    ..These data suggest that CLL may derive from normal B cells whose function is to remove cellular debris, and also to provide a first line of defense against pathogens...
  38. pmc Peptides that bind specifically to an antibody from a chronic lymphocytic leukemia clone expressing unmutated immunoglobulin variable region genes
    Yun Liu
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 19:245-52. 2013
    ..This information may be of value in identifying and targeting B lymphocytes expressing specific BCRs in CLL patients and healthy subjects with monoclonal B lymphocytosis...
  39. pmc Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion
    Yasushi Miura
    Center for Immunology and Inflammation, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    Mol Med 9:166-74. 2003
    ..Thus, nucleotide insertion/deletion can lead to B-cell receptor diversification in B lymphocytes that clonally expand in synovial tissues of patients with rheumatoid arthritis...
  40. pmc Torque teno virus 10 isolated by genome amplification techniques from a patient with concomitant chronic lymphocytic leukemia and polycythemia vera
    Charles C Chu
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish LIJ Health System, Manhasset, New York, United States of America
    Mol Med 17:1338-48. 2011
    ..These results prove that this method identifies infectious agents and provides an experimental methodology to test correlation with disease...
  41. pmc Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells
    Rajendra N Damle
    The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Best Pract Res Clin Haematol 23:33-45. 2010
    ....
  42. doi A cyclooxygenase-2/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells
    Hyunjoo Lee
    Laboratory of B Cell Biology, Karches Center for Chronic Lymphocytic Leukemia Research, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 185:5300-14. 2010
    ..Taken together, the results suggest that a PGE(2) feed-forward mechanism for augmenting COX-2 pathway proteins promotes progressively increased levels of AID mRNA, protein, and function...
  43. pmc Analysis of single nucleotide polymorphisms in the promoter region of interleukin-10 by denaturing high-performance liquid chromatography
    Dorothy Guzowski
    North Shore LIJ Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    J Biomol Tech 16:154-66. 2005
    ..Once distinct chromatograms were established for each of the SNPs and the nucleotide changes confirmed by sequencing, genotype and haplotype frequencies were tabulated for the groups studied...
  44. ncbi Lifespan is prolonged in autoimmune-prone (NZB/NZW) F1 mice fed a diet supplemented with indole-3-carbinol
    Karen J Auborn
    North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Nutr 133:3610-3. 2003
    ..The estrogen urinary metabolite ratio of 2- to 16alpha-hydroxyestrone was increased in I3C-fed mice. These findings demonstrate a profound effect of dietary I3C in experimental SLE...
  45. pmc B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia
    Xiao Jie Yan
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 103:11713-8. 2006
    ..This (auto)antigen-driven mouse model reliably captures the BCR characteristics of aggressive, treatment-resistant human B-CLL...
  46. pmc Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance
    Preetesh Jain
    The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Haematologica 97:599-607. 2012
    ..The objective of this study was to quantify blood and tissue levels of Th17 and other interleukin-17-producing cells in patients with this disease and correlate blood levels with clinical outcome...
  47. ncbi The global transcriptional maturation program and stimuli-specific gene expression profiles of human myeloid dendritic cells
    Davorka Messmer
    Laboratory of Experimental Immunology, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    Int Immunol 15:491-503. 2003
    ..Since some of these genes have down-regulatory functions in other settings, they may have a regulatory role in DC maturation and immune response generation...
  48. ncbi TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells
    Jidong Shan
    Department of Molecular Oncology, North Shore Long Island Jewish Research Institute, New York University School of Medicine, Manhasset, New York 11030, USA
    Cancer Res 62:290-4. 2002
    ....
  49. ncbi Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody-producing cell lines
    Julia Kurth
    Institute for Genetics and Department of Internal Medicine I, University of Cologne, Cologne, Germany
    Eur J Immunol 32:3785-92. 2002
    ..We conclude that CD95 gene mutations play little if any role in the generation of the pool of PB in SLE patients and that mutations in the CD95 gene are rare among autoantibody-producing B cells in SLE and rheumatoid arthritis...
  50. pmc CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice
    Juergen Foell
    Department of Surgery and Emory Vaccine Center, School of Medicine, School of Public Health, Emory University, Atlanta, Georgia, USA
    J Clin Invest 111:1505-18. 2003
    ..Our data support the hypothesis that CD137-mediated signaling anergized CD4(+) T cells during priming at the DC interface...
  51. ncbi B lymphocytes in humans express ZAP-70 when activated in vivo
    Giovanna Cutrona
    Division of Medical Oncology C, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova, Italy
    Eur J Immunol 36:558-69. 2006
    ..B-CLL cells are activated cells and their ZAP-70 expression reflects a normal property of activated B cells populations rather than a neoplastic aberration...
  52. pmc FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia
    Fu Jun Li
    Division of Hematology Oncology, Department of Medicine, University of Alabama at Birmingham, AL 35294 2182, USA
    Blood 112:179-87. 2008
    ..75 years for FCRL2-low patients. Our studies indicate that FCRL2 has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in CLL...
  53. pmc The CD38 ectoenzyme family: advances in basic science and clinical practice
    Fortunato Morabito
    Unità Operativa di Ematologia, Azienda Ospedaliera di Cosenza, Cosenza, Italy
    Mol Med 12:342-4. 2006
    ....
  54. ncbi CD5+ B cells with the features of subepithelial B cells found in human tonsils
    Mariella Dono
    S C Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 37:2138-47. 2007
    ..These data are discussed considering the present views on the origin of B cell subset populations and the relationships between MZ and B1 cells...
  55. ncbi Clonal heterogeneity in chronic lymphocytic leukemia cells: superior response to surface IgM cross-linking in CD38, ZAP-70-positive cells
    Giovanna Cutrona
    PhD Divisione di Oncologia Medica C Istituto Nazionale per la Ricerca sul Cancro, IST, L go Rosanna Benzi, 10 16132 Genoa, Italy
    Haematologica 93:413-22. 2008
    ..We studied whether cells expressing CD38 and ZAP-70 are more susceptible to stimulation through B-cell receptors than are cells that do not express CD38 and ZAP-70...
  56. ncbi Maintenance of B lymphocyte-related clones in the cerebrospinal fluid of multiple sclerosis patients
    Monica Colombo
    U O Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 33:3433-8. 2003
    ....
  57. ncbi The human marginal zone B cell
    Mariella Dono
    Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova, Italy
    Ann N Y Acad Sci 987:117-24. 2003
    ..If the current distinction into B1 and B2 cells has to be maintained also for humans, it is likely that only these CD5-positive cells rather than the FM B cells should be called B1 cells...
  58. ncbi Determining the clinical course and outcome in chronic lymphocytic leukemia
    Kanti R Rai
    N Engl J Med 348:1797-9. 2003
  59. ncbi Recent advances in the molecular biology and immunobiology of chronic lymphocytic leukemia
    Manlio Ferrarini
    Division of Medical Oncology C, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Semin Hematol 41:207-23. 2004
    ..The difference in the ability to respond to antigen as a full-fledged B-CLL probably accounts for the different biological features and clinical outcomes of the patients in these subgroups...
  60. pmc Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen
    Jason S Weinstein
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Immunol 181:3259-67. 2008
    ..This has implications for understanding the strong association of humoral autoimmunity with lymphoid neogenesis, which may be associated with deficient censoring of autoreactive cells...
  61. ncbi Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells
    Elizabeth P Ryan
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Clin Immunol 120:76-90. 2006
    ..It will therefore be important to evaluate drugs that inhibit Cox-2 as potential therapeutic agents in B-CLL in vivo...

Research Grants19

  1. B-cell repertoires in chronic lymphocytic leukemia
    Nicholas Chiorazzi; Fiscal Year: 2010
    ..The studies lay the groundwork for future therapies which will target the stimulants or the molecules on the leukemia cells that the stimulants bind. ..
  2. B-cell repertoires in chronic lymphocytic leukemia
    Nicholas Chiorazzi; Fiscal Year: 2009
    ..The studies lay the groundwork for future therapies which will target the stimulants or the molecules on the leukemia cells that the stimulants bind. ..
  3. GENERAL CLINICAL RESEARCH CENTER
    Nicholas Chiorazzi; Fiscal Year: 2006
    ..The Interfacility Transport Division provides transportation of patients from hospital ..
  4. B CLL SUBGROUPS--MATURATION STAGE AND GENE EXPRESSION
    Nicholas Chiorazzi; Fiscal Year: 2004
    ..Hopefully, these differences will provide important basic and clinical insights into this disease and suggest future prognostic and therapeutic approaches to it. ..
  5. B CELL REPERTOIRES IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Nicholas Chiorazzi; Fiscal Year: 2004
    ..We anticipate that these studies will support a clonal evolution model proceeding from antigenically overexpanded normal aging B cells to a leukemic CCL clone. ..
  6. B CELL REPERTOIRES IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Nicholas Chiorazzi; Fiscal Year: 2001
    ..We anticipate that these studies will support a clonal evolution model proceeding from antigenically overexpanded normal aging B cells to a leukemic CCL clone. ..
  7. B CELL REPERTOIRES IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Nicholas Chiorazzi; Fiscal Year: 2003
    ..We anticipate that these studies will support a clonal evolution model proceeding from antigenically overexpanded normal aging B cells to a leukemic CCL clone. ..
  8. B CLL SUBGROUPS--MATURATION STAGE AND GENE EXPRESSION
    Nicholas Chiorazzi; Fiscal Year: 2001
    ..Hopefully, these differences will provide important basic and clinical insights into this disease and suggest future prognostic and therapeutic approaches to it. ..
  9. IRB Oversight and Educational Enhancement Program
    Nicholas Chiorazzi; Fiscal Year: 2002
    ..The new database will also keep track of education and training information and permit cross-referencing of serious adverse events. ..
  10. B CELL REPERTOIRES IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Nicholas Chiorazzi; Fiscal Year: 2002
    ..We anticipate that these studies will support a clonal evolution model proceeding from antigenically overexpanded normal aging B cells to a leukemic CCL clone. ..
  11. B CLL SUBGROUPS--MATURATION STAGE AND GENE EXPRESSION
    Nicholas Chiorazzi; Fiscal Year: 2003
    ..Hopefully, these differences will provide important basic and clinical insights into this disease and suggest future prognostic and therapeutic approaches to it. ..
  12. B CLL SUBGROUPS--MATURATION STAGE AND GENE EXPRESSION
    Nicholas Chiorazzi; Fiscal Year: 2002
    ..Hopefully, these differences will provide important basic and clinical insights into this disease and suggest future prognostic and therapeutic approaches to it. ..
  13. B CLL SUBGROUPS--MATURATION STAGE AND GENE EXPRESSION
    Nicholas Chiorazzi; Fiscal Year: 2004
    ..Hopefully, these differences will provide important basic and clinical insights into this disease and suggest future prognostic and therapeutic approaches to it. ..
  14. B CELL REPERTOIRES IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Nicholas Chiorazzi; Fiscal Year: 2000
    ..We anticipate that these studies will support a clonal evolution model proceeding from antigenically overexpanded normal aging B cells to a leukemic CCL clone. ..