Research Topics
| XAIOXIN CHENSummaryAffiliation: North Carolina Central University Country: USA Publications
Research Grants
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Detail Information
Publications
Gastroesophageal reflux leads to esophageal cancer in a surgical model with miceJing Hao
Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
BMC Gastroenterol 9:59. 2009..However, use of this rat model for mechanistic and chemopreventive studies is limited due to lack of genetically modified rat strains. Therefore, a mouse model of esophageal adenocarcinoma is needed...- Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markersXiaoxin Chen
Cancer Research Program, Julius L, Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
BMC Gastroenterol 8:1. 2008..Invest. 2004;84:753-765). The purpose of this study was to compare the phenotype of rat MLE with human MLE, in order to gain insight into the nature of MLE and its potential role in the development of BE... 
Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemopreventionXiaoxin Chen
Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
Curr Cancer Drug Targets 6:613-22. 2006..Inhibition of the 5-lipoxygenase pathways clearly has chemopreventive effects on various cancers, and hence further studies on its enzymes, metabolites and receptors for cancer chemoprevention and therapy are warranted...- Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancerXinyan Zhang
Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham 27707, USA, and Gynecological Oncology Center, Peking University People s Hospital, Beijing, P R China
Gynecol Oncol 103:848-52. 2006..The purpose of this study was to develop an immunocytokine for immunotherapy of human ovarian cancer... 
Differential gene expression in normal esophagus and Barrett's esophagusJacob Wang
Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
J Gastroenterol 44:897-911. 2009..Gene expression profiling with microarray and serial analysis of gene expression (SAGE) may help us understand the potential molecular mechanism of human BE...- Identification of arsenic-binding proteins in human breast cancer cellsXinyan Zhang
Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
Cancer Lett 255:95-106. 2007..Functional consequence of such binding may depend on whether arsenic binding causes conformational changes or blocks active sites of target proteins... - Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillationsRobert N Graf
Duke University, Department of Biomedical Engineering, 136 Hudson Hall, Durham, North Carolina 27708, USA
J Biomed Opt 14:064030. 2009..The structural measurements show a highly statistically significant difference between untreated (normal) and treated (hyperplastic/dysplastic) tissues, indicating the potential utility of this approach as a diagnostic method... - Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitorsZheng Sun
Cancer Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, NC 27707, USA
Carcinogenesis 27:1902-8. 2006..In summary, our studies have demonstrated that 5-Lox/LTA4H pathway is one of the major AA-metabolizing pathways involved in DMBA-induced oral carcinogenesis in hamsters, and may be targeted for chemoprevention... - Depletion of beta-arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancerSandeep K Raghuwanshi
Julius L Chambers Biomedical Biotechnology Research Institute, Department of Biology, North Carolina Central University, Durham, NC 27707, USA
J Immunol 180:5699-706. 2008..Altogether, the data suggest that betaarr2 modulates tumorigenesis by regulating inflammation and angiogenesis through activation of CXCR2 and NF-kappaB... - Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of a dual inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 tyrosine kinasesZheng Sun
Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
Oral Oncol 44:652-7. 2008..GW2974 exerted its chemopreventive effects in part by suppressing aberrant AA metabolism... - Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humansXiaoxin Chen
Laboratory for Cancer Research, College of Pharmacy, Rutgers-State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Carcinogenesis 23:123-30. 2002..Since Grp94 is known to inhibit apoptosis by maintaining intracellular Ca(2+) homeostasis, our data suggest a possible correlation between oxidative stress, Grp94 overexpression and apoptosis regulation in esophageal adenocarcinogenesis... - Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical modelXiaoxin Chen
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway 08854, USA
Carcinogenesis 23:2095-102. 2002..Inhibition of tumor formation by sulindac was correlated with lowered levels of PGE2. In conclusion, sulindac exerted its chemopreventive effect against the formation of EAC in the rat EGDA model possibly through its inhibition of Cox... - Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenaseJungil Hong
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Carcinogenesis 25:1671-9. 2004..These activities may contribute to the anti-inflammatory and anticarcinogenic actions of curcumin and its analogs... - Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagusYinghao Su
Center for Swallowing and Motility Disorders, VA Boston Healthcare System and Harvard Medical School, Boston, MA 02132, USA
Lab Invest 84:753-65. 2004..EGDA rats may serve as a useful model to study the pathogenesis, molecular biology, and chemopreventive interventions of human BE and EAC... - Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesisXiaoxin Chen
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Clin Cancer Res 10:6703-9. 2004.... - Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxibNing Li
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers-State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Clin Cancer Res 11:2089-96. 2005..Zileuton and celecoxib prevented oral carcinogenesis at the post-initiation stage through their inhibitory effects on arachidonic acid metabolism... - Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipidsPeiying Yang
Departments of Experimental Therapeutics, The University of Texas, M.D. Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
Prostaglandins Leukot Essent Fatty Acids 75:385-95. 2006.... - Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cellsTong Liu
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Carcinogenesis 28:488-96. 2007.... - Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatinXiaoxin Chen
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
J Natl Cancer Inst 95:1053-61. 2003..We used this model and human EAC and non-tumor tissues to elucidate the expression pattern of LTA4H and to evaluate it as a target for chemoprevention... - Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcuminNing Li
Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Carcinogenesis 23:1307-13. 2002.... - Selection of topically applied non-steroidal anti-inflammatory drugs for oral cancer chemopreventionSandeep Sood
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Oral Oncol 41:562-7. 2005..Both 3% and 6% reduced the incidence of squamous cell carcinoma at the post-initiation stage...
Research Grants
- Animal Model of Barrett's EsophagusXiaoxin Chen; Fiscal Year: 2003..Such an animal model would provide a basis for future studies on the mechanism, prevention, and therapy of BE and EAC. ..
- Chemoprevention of Tobacco-related Oral CarcinogenesisXiaoxin Chen; Fiscal Year: 2005..Some of the agents and biomarkers studied herein may be used for chemoprevention in individuals with leukoplakia and erythroplakia. ..
- Mouse Medel of Esophageal AdenocarcinomaXAIOXIN CHEN; Fiscal Year: 2007..This unique model system will lay down a solid foundation for future mechanism-based chemopreventive studies on EAC. ..