XAIOXIN CHEN

Summary

Affiliation: North Carolina Central University
Country: USA

Publications

  1. pmc Gastroesophageal reflux activates the NF-κB pathway and impairs esophageal barrier function in mice
    Yu Fang
    Department of Cardiovascular and Thoracic Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China
    Am J Physiol Gastrointest Liver Physiol 305:G58-65. 2013
  2. pmc Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice
    Jing Hao
    Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    BMC Gastroenterol 9:59. 2009
  3. ncbi request reprint Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention
    Xiaoxin Chen
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    Curr Cancer Drug Targets 6:613-22. 2006
  4. pmc Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers
    Xiaoxin Chen
    Cancer Research Program, Julius L, Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    BMC Gastroenterol 8:1. 2008
  5. ncbi request reprint Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancer
    Xinyan Zhang
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham 27707, USA, and Gynecological Oncology Center, Peking University People s Hospital, Beijing, P R China
    Gynecol Oncol 103:848-52. 2006
  6. doi request reprint Differential gene expression in normal esophagus and Barrett's esophagus
    Jacob Wang
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    J Gastroenterol 44:897-911. 2009
  7. pmc Identification of arsenic-binding proteins in human breast cancer cells
    Xinyan Zhang
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    Cancer Lett 255:95-106. 2007
  8. pmc Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations
    Robert N Graf
    Duke University, Department of Biomedical Engineering, 136 Hudson Hall, Durham, North Carolina 27708, USA
    J Biomed Opt 14:064030. 2009
  9. ncbi request reprint Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors
    Zheng Sun
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, NC 27707, USA
    Carcinogenesis 27:1902-8. 2006
  10. ncbi request reprint Depletion of beta-arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer
    Sandeep K Raghuwanshi
    Julius L Chambers Biomedical Biotechnology Research Institute, Department of Biology, North Carolina Central University, Durham, NC 27707, USA
    J Immunol 180:5699-706. 2008

Research Grants

  1. Animal Model of Barrett's Esophagus
    Xiaoxin Chen; Fiscal Year: 2003
  2. Chemoprevention of Tobacco-related Oral Carcinogenesis
    Xiaoxin Chen; Fiscal Year: 2005
  3. Mouse Medel of Esophageal Adenocarcinoma
    XAIOXIN CHEN; Fiscal Year: 2007

Collaborators

Detail Information

Publications22

  1. pmc Gastroesophageal reflux activates the NF-κB pathway and impairs esophageal barrier function in mice
    Yu Fang
    Department of Cardiovascular and Thoracic Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China
    Am J Physiol Gastrointest Liver Physiol 305:G58-65. 2013
    ..We conclude that gastroesophageal reflux activates the NF-κB pathway and impairs esophageal barrier function in mice and that targeting the NF-κB pathway may strengthen esophageal barrier function against reflux...
  2. pmc Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice
    Jing Hao
    Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    BMC Gastroenterol 9:59. 2009
    ..However, use of this rat model for mechanistic and chemopreventive studies is limited due to lack of genetically modified rat strains. Therefore, a mouse model of esophageal adenocarcinoma is needed...
  3. ncbi request reprint Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention
    Xiaoxin Chen
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    Curr Cancer Drug Targets 6:613-22. 2006
    ..Inhibition of the 5-lipoxygenase pathways clearly has chemopreventive effects on various cancers, and hence further studies on its enzymes, metabolites and receptors for cancer chemoprevention and therapy are warranted...
  4. pmc Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers
    Xiaoxin Chen
    Cancer Research Program, Julius L, Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    BMC Gastroenterol 8:1. 2008
    ..Invest. 2004;84:753-765). The purpose of this study was to compare the phenotype of rat MLE with human MLE, in order to gain insight into the nature of MLE and its potential role in the development of BE...
  5. ncbi request reprint Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancer
    Xinyan Zhang
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham 27707, USA, and Gynecological Oncology Center, Peking University People s Hospital, Beijing, P R China
    Gynecol Oncol 103:848-52. 2006
    ..The purpose of this study was to develop an immunocytokine for immunotherapy of human ovarian cancer...
  6. doi request reprint Differential gene expression in normal esophagus and Barrett's esophagus
    Jacob Wang
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    J Gastroenterol 44:897-911. 2009
    ..Gene expression profiling with microarray and serial analysis of gene expression (SAGE) may help us understand the potential molecular mechanism of human BE...
  7. pmc Identification of arsenic-binding proteins in human breast cancer cells
    Xinyan Zhang
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    Cancer Lett 255:95-106. 2007
    ..Functional consequence of such binding may depend on whether arsenic binding causes conformational changes or blocks active sites of target proteins...
  8. pmc Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations
    Robert N Graf
    Duke University, Department of Biomedical Engineering, 136 Hudson Hall, Durham, North Carolina 27708, USA
    J Biomed Opt 14:064030. 2009
    ..The structural measurements show a highly statistically significant difference between untreated (normal) and treated (hyperplastic/dysplastic) tissues, indicating the potential utility of this approach as a diagnostic method...
  9. ncbi request reprint Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors
    Zheng Sun
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, NC 27707, USA
    Carcinogenesis 27:1902-8. 2006
    ..In summary, our studies have demonstrated that 5-Lox/LTA4H pathway is one of the major AA-metabolizing pathways involved in DMBA-induced oral carcinogenesis in hamsters, and may be targeted for chemoprevention...
  10. ncbi request reprint Depletion of beta-arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer
    Sandeep K Raghuwanshi
    Julius L Chambers Biomedical Biotechnology Research Institute, Department of Biology, North Carolina Central University, Durham, NC 27707, USA
    J Immunol 180:5699-706. 2008
    ..Altogether, the data suggest that betaarr2 modulates tumorigenesis by regulating inflammation and angiogenesis through activation of CXCR2 and NF-kappaB...
  11. pmc Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of a dual inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 tyrosine kinases
    Zheng Sun
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    Oral Oncol 44:652-7. 2008
    ..GW2974 exerted its chemopreventive effects in part by suppressing aberrant AA metabolism...
  12. ncbi request reprint Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans
    Xiaoxin Chen
    Laboratory for Cancer Research, College of Pharmacy, Rutgers State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 23:123-30. 2002
    ..Since Grp94 is known to inhibit apoptosis by maintaining intracellular Ca(2+) homeostasis, our data suggest a possible correlation between oxidative stress, Grp94 overexpression and apoptosis regulation in esophageal adenocarcinogenesis...
  13. ncbi request reprint Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase
    Jungil Hong
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 25:1671-9. 2004
    ..These activities may contribute to the anti-inflammatory and anticarcinogenic actions of curcumin and its analogs...
  14. ncbi request reprint Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib
    Ning Li
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Clin Cancer Res 11:2089-96. 2005
    ..However, it is unknown whether the 5-lipoxygenase (5-Lox) pathway contributes to oral carcinogenesis, and whether combination of inhibitors of both pathways may have synergistic or additive effects of chemoprevention...
  15. ncbi request reprint Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis
    Xiaoxin Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 10:6703-9. 2004
    ....
  16. ncbi request reprint Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus
    Yinghao Su
    Center for Swallowing and Motility Disorders, VA Boston Healthcare System and Harvard Medical School, Boston, MA 02132, USA
    Lab Invest 84:753-65. 2004
    ..EGDA rats may serve as a useful model to study the pathogenesis, molecular biology, and chemopreventive interventions of human BE and EAC...
  17. ncbi request reprint Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model
    Xiaoxin Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway 08854, USA
    Carcinogenesis 23:2095-102. 2002
    ..Inhibition of tumor formation by sulindac was correlated with lowered levels of PGE2. In conclusion, sulindac exerted its chemopreventive effect against the formation of EAC in the rat EGDA model possibly through its inhibition of Cox...
  18. ncbi request reprint Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin
    Ning Li
    Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 23:1307-13. 2002
    ....
  19. ncbi request reprint Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin
    Xiaoxin Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Natl Cancer Inst 95:1053-61. 2003
    ..We used this model and human EAC and non-tumor tissues to elucidate the expression pattern of LTA4H and to evaluate it as a target for chemoprevention...
  20. ncbi request reprint Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids
    Peiying Yang
    Departments of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
    Prostaglandins Leukot Essent Fatty Acids 75:385-95. 2006
    ....
  21. ncbi request reprint Selection of topically applied non-steroidal anti-inflammatory drugs for oral cancer chemoprevention
    Sandeep Sood
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Oral Oncol 41:562-7. 2005
    ..Both 3% and 6% reduced the incidence of squamous cell carcinoma at the post-initiation stage...
  22. ncbi request reprint Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells
    Tong Liu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 28:488-96. 2007
    ....

Research Grants6

  1. Animal Model of Barrett's Esophagus
    Xiaoxin Chen; Fiscal Year: 2003
    ..Such an animal model would provide a basis for future studies on the mechanism, prevention, and therapy of BE and EAC. ..
  2. Chemoprevention of Tobacco-related Oral Carcinogenesis
    Xiaoxin Chen; Fiscal Year: 2005
    ..Some of the agents and biomarkers studied herein may be used for chemoprevention in individuals with leukoplakia and erythroplakia. ..
  3. Mouse Medel of Esophageal Adenocarcinoma
    XAIOXIN CHEN; Fiscal Year: 2007
    ..This unique model system will lay down a solid foundation for future mechanism-based chemopreventive studies on EAC. ..