Research Topics
Genomes and GenesSpecies | Katherine E BurdickSummaryAffiliation: North Shore University Hospital Country: USA Publications
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Publications
The MATRICS consensus cognitive battery in patients with bipolar I disorderKatherine E Burdick
Department of Psychiatry, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 36:1587-92. 2011..Additional studies should address important psychometric features such as repeatability and potential practice and/or ceiling effects...
Pharmacogenetic approaches to cognitive enhancement in schizophreniaKatherine E Burdick
Albert Einstein College of Medicine, USA
Harv Rev Psychiatry 19:102-8. 2011..In this review, we discuss the potential use of cognition as a primary outcome measure of interest in future pharmacogenetic trials of schizophrenia...- Genetic variation in the DAOA gene complex: impact on susceptibility for schizophrenia and on cognitive performanceCarolin Opgen-Rhein
Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, United States
Schizophr Res 103:169-77. 2008..Our aim in this study was to investigate the relationship between DAOA variation and schizophrenia, and the influence of DAOA on cognitive performance... - DTNBP1 genotype influences cognitive decline in schizophreniaKatherine E Burdick
Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, United States
Schizophr Res 89:169-72. 2007..The current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1)... - Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive abilityKatherine E Burdick
Hillside Hospital, North Shore Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, NY 11004, USA
Am J Psychiatry 167:436-43. 2010..Thus, MET may be of particular interest as a candidate gene for neuropsychiatric diseases with a developmental etiology, including schizophrenia... - Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive bindingKatherine E Burdick
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Hum Mol Genet 17:2462-73. 2008..These data suggest that NDEL1 significantly influences risk for SZ via an interaction with DISC1. We propose a model where NDEL1 and NDE1 compete for binding with DISC1... 
Disrupted in schizophrenia 1 genotype and positive symptoms in schizophreniaPamela DeRosse
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Biol Psychiatry 61:1208-10. 2007....- COMT genotype increases risk for bipolar I disorder and influences neurocognitive performanceKatherine E Burdick
Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Bipolar Disord 9:370-6. 2007..A large body of evidence suggests that COMT is associated with cognitive performance in patients with schizophrenia and in healthy volunteers but there have been no reports of its relationship to cognition in BPD... - Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?Terry E Goldberg
Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
Arch Gen Psychiatry 64:1115-22. 2007..However, none of these studies included healthy controls undergoing repeated testing to assess the possibility that improvements might reflect simple practice effects... - COMT genotype and manic symptoms in schizophreniaPamela DeRosse
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, and Harvard Partners Center for Genetics and Genomics, Boston, MA, United States
Schizophr Res 87:28-31. 2006..These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ... - Runs of homozygosity reveal highly penetrant recessive loci in schizophreniaTodd Lencz
Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Proc Natl Acad Sci U S A 104:19942-7. 2007..Other risk ROHs feature haplotypes that are also common in healthy individuals, possibly indicating a source of balancing selection... - Dysbindin genotype and negative symptoms in schizophreniaPamela DeRosse
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Am J Psychiatry 163:532-4. 2006.... - Emotional modulation of response inhibition in stable patients with bipolar I disorder: a comparison with healthy and schizophrenia subjectsChaya B Gopin
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Bipolar Disord 13:164-72. 2011..We examined the pattern of affective processing in stable BD patients and compared their profile to that of healthy controls (HC) and patients diagnosed with schizophrenia (SZ)... - A schizophrenia risk gene, ZNF804A, influences neuroanatomical and neurocognitive phenotypesTodd Lencz
Department of Psychiatry, Division of Research, The Zucker Hillside Hospital Division of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 35:2284-91. 2010..05). The risk allele dosage also predicted impairments on a timed visuomotor performance task (trails A). Results support a role of ZNF804A in phenotypes reflecting altered neural connectivity... - Neurocognitive profile analysis in obsessive-compulsive disorderKatherine E Burdick
Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
J Int Neuropsychol Soc 14:640-5. 2008..Findings of specific abnormalities on tasks of motor and processing speed are consistent with a hypothesized role of thalamocortical and basal ganglia regions in the pathogenesis of OCD... - Cognitive and symptomatic predictors of functional disability in schizophreniaSyed Shamsi
Department of Psychiatry, Division of Psychiatry Research, Glen Oaks, NY 11004, United States
Schizophr Res 126:257-64. 2011..Few studies have assessed the relationship between functional outcomes and the MATRICS consensus cognition battery (MCCB), which will be central to future clinical trials of cognitive enhancing agents... - Deficits in memory strategy use are related to verbal memory impairments in adolescents with schizophrenia-spectrum disordersDavid Roofeh
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Schizophr Res 85:201-12. 2006..To assess the nature of learning and verbal memory deficits in adolescents with schizophrenia-spectrum disorders (SzS) (i.e., schizophrenia, schizoaffective disorder, and schizophreniform disorder)... - Iowa gambling task in schizophrenia: a review and new data in patients with schizophrenia and co-occurring cannabis use disordersSerge Sevy
Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY, 11004, USA
Schizophr Res 92:74-84. 2007..To test this hypothesis, we compared schizophrenia patients with (SCZ((+))) or without (SCZ((-))) cannabis use disorders, to healthy subjects, on measures of cognition and IGT performance... - Genetic variation in DTNBP1 influences general cognitive abilityKatherine E Burdick
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA
Hum Mol Genet 15:1563-8. 2006..These data suggest that DTNBP1 genetic variation influences human intelligence... - Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypesTodd Lencz
The Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, New York 11004, USA
Br J Psychiatry 194:313-8. 2009..Brain-derived neurotrophic factor variants may help clarify the status of schizoaffective disorder... - Clinical and cognitive correlates of suicide attempts in bipolar disorder: is suicide predictable?Alison M Gilbert
Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
J Clin Psychiatry 72:1027-33. 2011..We conducted a retrospective investigation of potential clinical, demographic, and neuropsychological risk factors for suicide attempts in patients diagnosed with bipolar disorder... - Neurocognitive deficits in adolescents with schizophrenia: longitudinal stability and predictive utility for short-term functional outcomeKelly L Cervellione
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
J Am Acad Child Adolesc Psychiatry 46:867-78. 2007..Here, the authors examined the longitudinal stability of neuropsychological deficits in adolescents with EOS relative to HCS and the associations of these deficits with short-term functional outcome in patients... - Attention and psychomotor functioning in bipolar depressionKatherine E Burdick
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System and Albert Einstein College of Medicine, Glen Oaks, NY, USA
Psychiatry Res 166:192-200. 2009..Associations among indices of attention deficits and psychomotor slowing may be indicative of similarities in the underlying neurobiology of these frequently co-occurring symptom domains in depressed individuals with bipolar disorder... - Volumetric and shape analysis of the thalamus in first-episode schizophreniaDenise M Coscia
The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
Hum Brain Mapp 30:1236-45. 2009..Our findings suggest that thalamic abnormalities are evident at the onset of a first episode of schizophrenia prior to extensive pharmacologic intervention and that these abnormalities have neuropsychological correlates... - Neurocognition as a stable endophenotype in bipolar disorder and schizophreniaKatherine E Burdick
Bipolar Disorders Research Program, Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA
J Nerv Ment Dis 194:255-60. 2006..These preliminary findings suggest that neurocognitive domains appear longitudinally stable across broad domains in schizophrenia. In contrast, stable functioning may be more limited to attentional domains in bipolar disorder... - Ziprasidone-induced cognitive enhancement in schizophrenia: specificity or pseudospecificity?Anil K Malhotra
Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, and Albert Einstein College of Medicine, United States
Schizophr Res 87:181-4. 2006..We tested the hypothesis that ziprasidone improves cognition in the absence of clinical improvement... - Early-onset schizophrenia is associated with impaired adolescent development of attentional capacity using the identical pairs continuous performance testEmily Thaden
The Zucker Hillside Hospital, Department of Psychiatry Research 75 59 263rd Street, Glen Oaks, NY 11004, USA
Schizophr Res 81:157-66. 2006.... - DISC1 and neurocognitive function in schizophreniaKatherine E Burdick
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
Neuroreport 16:1399-402. 2005..These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia... - Decision-making impairments in adolescents with early-onset schizophreniaHana M Kester
Department of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
Schizophr Res 85:113-23. 2006..These findings have potential implications for understanding the increased vulnerability for the development of substance abuse in adolescents with schizophrenia... - A role for white matter abnormalities in the pathophysiology of bipolar disorderKatie Mahon
Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
Neurosci Biobehav Rev 34:533-54. 2010..Taken together, the evidence supports and clarifies a model of BD that involves disconnectivity in regions implicated in emotion generation and regulation... - Cognitive dysfunction in bipolar disorder: future place of pharmacotherapyKatherine E Burdick
Department of Psychiatry, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
CNS Drugs 21:971-81. 2007..Finally, psychosocial intervention and/or cognitive remediation should be considered as alternatives to medications, although these techniques will also require additional systematic study... - Meta-analysis of genetic variation in DTNBP1 and general cognitive abilityJian Ping Zhang
The Zucker Hillside Hospital, Glen Oaks, New York, USA
Biol Psychiatry 68:1126-33. 2010..We examined the relationship between DTNBP1 SNPs and general cognitive ability in nonpsychiatric healthy samples via meta-analysis... - Neurocognitive profile in adolescents with early-onset schizophrenia: clinical correlatesJoseph P Rhinewine
Department of Psychiatry Research Zucker Hillside Hospital, Glen Oaks, New York 11004, USA
Biol Psychiatry 58:705-12. 2005..The overall pattern is similar to that observed in severely ill first-episode adult patients. The impairments across multiple neurocognitive domains suggest widespread brain dysfunction in EOS... - A voxel-based diffusion tensor imaging study of white matter in bipolar disorderKatie Mahon
Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 34:1590-600. 2009..Our findings are consistent with models of bipolar disorder that implicate dysregulation of cortico-subcortical and cerebellar regions in the disorder and may have relevance for phenomenology... - Lack of an inverse relationship between duration of untreated psychosis and cognitive function in first episode schizophreniaTerry E Goldberg
Psychiatry Research, Zucker Hillside Hospital, United States
Schizophr Res 107:262-6. 2009..Furthermore, assuming that cognition is a core symptom of schizophrenia, the notion that ongoing psychosis is somehow toxic for a variety of information processing domains appears questionable... - Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorderRaphael J Braga
The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, NY, USA
Psychiatry Res 200:242-5. 2012..Interestingly, bipolar patients with history of CUD had better neurocognitive performance as compared to patients with no history of CUD... - Assessing cognitive deficits in bipolar disorder: are self-reports valid?Katherine E Burdick
Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Psychiatry Res 136:43-50. 2005..Such discrepancies could relate to impaired insight, efforts to conceal deficits, or to subthreshold affective symptoms... - Preliminary randomized, double-blind, placebo-controlled trial of pramipexole added to mood stabilizers for treatment-resistant bipolar depressionJoseph F Goldberg
Department of Psychiatry, Weill Medical College of Cornell University, New York, NY, USA
Am J Psychiatry 161:564-6. 2004..The authors conducted a preliminary randomized, placebo-controlled trial to determine the safety and antidepressant efficacy of pramipexole in treatment-resistant bipolar depression...