Research Topics
Species | Matthew BreenSummaryAffiliation: North Carolina State University Country: USA Publications
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Publications
Canine cytogenetics--from band to basepairM Breen
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, and Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC, USA
Cytogenet Genome Res 120:50-60. 2008..The cytogenetics 'toolbox' for the dog is now loaded. This review aims to provide a summary of some of the recent advancements in canine cytogenetics...- Update on genomics in veterinary oncologyMatthew Breen
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, and Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC 27606, USA
Top Companion Anim Med 24:113-21. 2009..Here, we will review some of the advancements of genomics as they relate to veterinary oncology... 
An integrated 4249 marker FISH/RH map of the canine genomeMatthew Breen
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
BMC Genomics 5:65. 2004..Understanding the genetic basis of both phenotypic variation and disease susceptibility in the dog provides new ways in which to dissect the genetics of human health and biology...
Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans--man and his best friend share more than companionshipMatthew Breen
Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27606, USA
Chromosome Res 16:145-54. 2008..These data suggest that humans and dogs share an ancestrally retained pathogenetic basis for cancer and that cytogenetic evaluation of canine tumors may provide greater insight into the biology of tumorigenesis...- Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcomaRachael Thomas
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Chromosome Res 17:365-77. 2009..These data indicate for the first time that individual genetic backgrounds, as defined by breed in dogs, influence tumor karyotypes in a cancer with extensive genomic instability... - Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomasRachael Thomas
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Chromosome Res 17:987-1000. 2009..Further characterization of these regions may ultimately permit molecular distinction between ISAS and non-ISAS, as a tool for predicting tumor behavior and prognosis, as well as refining means for therapeutic intervention... - Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcoma parallel the human counterpartAndrea Y Angstadt
Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, USA
Genes Chromosomes Cancer 50:859-74. 2011.... - 'Putting our heads together': insights into genomic conservation between human and canine intracranial tumorsRachael Thomas
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Neurooncol 94:333-49. 2009.... 
A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dogRachael Thomas
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
J Hered 98:474-84. 2007..We outline the value of a combined aCGH/FISH approach, together with a well-annotated dog genome assembly, in canine and comparative cancer studies...- Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomasRachael Thomas
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Leuk Lymphoma 52:1321-35. 2011..Our data suggest that gene discovery in NHL may be enhanced through comparative studies exploiting the less complex association between CNAs and tumor pathogenesis in canine patients... - Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumorsRachael Thomas
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Genome Res 15:1831-7. 2005..Here we provide examples of the varied applications of this resource to tumor cytogenetics, in combination with other molecular cytogenetic techniques... - Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomesShannon E Duke Becker
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA
Chromosome Res 19:685-708. 2011..We propose that the complex karyotype rearrangements associated with speciation of the Canidae reflect unstable chromosome regions described by the fragile breakage model... - Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysisRachael Thomas
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC, 27606, USA
Chromosome Res 17:927-34. 2009..These data suggest that the CTVT genome demonstrates a vast degree of both structural and numerical reorganization that is maintained during transmission among the domestic dog population... - Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behaviorBenoit Hedan
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
BMC Cancer 11:201. 2011..This process would identify evolutionarily conserved cytogenetic changes to highlight regions of particular importance to HS biology... - Tackling the characterization of canine chromosomal breakpoints with an integrated in-situ/in-silico approach: the canine PAR and PABAndrea C Young
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Chromosome Res 16:1193-202. 2008..The future application of the approach demonstrated in this study will prove useful when seeking to identify the genomic sequences surrounding recurrent chromosome breakpoints present in canine cancers... - Comparison of regional gene expression differences in the brains of the domestic dog and humanErin Kennerly
Department of Genetics, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA
Hum Genomics 1:435-43. 2004..This study lays the foundation for detailed analysis of the population structure of transcriptional variation as it relates to cognitive and neurological phenotypes in the domestic dog... - Molecular analysis of a spontaneous dystrophin 'knockout' dogS J Schatzberg
College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
Neuromuscul Disord 9:289-95. 1999..This new canine model should further our understanding of the physiological and biochemical processes in Duchenne muscular dystrophy... - FLT3 mutations in canine acute lymphocytic leukemiaSteven E Suter
Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC, USA
BMC Cancer 11:38. 2011..A small percentage of canine acute lymphocytic leukemias (ALL) also exhibit FLT3 ITD mutations... - A novel canine lymphoma cell line: a translational and comparative model for lymphoma researchWilliam C Kisseberth
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Leuk Res 31:1709-20. 2007..This cell line and xenograft represent significant in vitro and in vivo models, respectively, for comparative and translational lymphoma research... - BCR-ABL translocation in a dog with chronic monocytic leukemiaJanice A Cruz Cardona
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
Vet Clin Pathol 40:40-7. 2011..This may have clinical implications for treatment of dogs with chronic leukemias associated with particular genetic mutations. However, more case studies are needed to further characterize this disease... - A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysisR Thomas
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, Raleigh, NC 27606, USA
Cytogenet Genome Res 122:110-21. 2008..This cytogenetically validated, genome integrated BAC clone panel has enormous potential for aiding gene discovery through a comparative approach to molecular oncology... - A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrationsAndrea Y Angstadt
Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA
Cancer Genet 205:572-87. 2012..Such regions of instability may thus have functional significance in the etiology of OS, the most common primary bone tumor in both species... - Integrated cytogenetic BAC map of the genome of the gray, short-tailed opossum, Monodelphis domesticaS E Duke
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, 4700 Hillsborough Street, North Carolina State University, Raleigh, NC 27606, USA
Chromosome Res 15:361-70. 2007.... - Array-based comparative genomic hybridization-guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogsPei Chien Tsai
Department of Molecular Biomedical Science, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Am J Vet Res 73:1335-43. 2012..To identify suitable reference genes for normalization of real-time quantitative PCR (RT-qPCR) assay data for common tumors of dogs... - Cerebellar cortical degeneration in adult American Staffordshire TerriersNatasha Olby
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
J Vet Intern Med 18:201-8. 2004..Many spinocerebellar ataxias in humans are caused by nucleotide repeats, and this genetic aberration merits investigation as a potential cause of the disease in American Staffordshire Terriers... - Microarray analysis of differentially expressed genes of primary tumors in the canine central nervous systemS A M Thomson
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Vet Pathol 42:550-8. 2005..This report represents the first global gene expression analysis of different types of canine brain tumors by cDNA microarrays and might aid in the identification of potential candidate genes involved in tumor formation and progression... - A high-resolution comparative map of canine Chromosome 5q14.3-q33 constructed utilizing the 1.5x canine genome sequenceKenine E Comstock
Clinical and Human Biology Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, D4-100, P.O. Box 19024, Seattle, Washington 98109-1024, USA
Mamm Genome 15:544-51. 2004..Moreover, this study demonstrates the utility of genomic survey sequences when combined with accurate genome maps for rapid mapping of disease susceptibility loci... - The cnm locus, a canine homologue of human autosomal forms of centronuclear myopathy, maps to chromosome 2Laurent Tiret
, , Maisons-Alfort, France
Hum Genet 113:297-306. 2003..To date, no human MTM1 gene member has been mapped to this genetic region. This report thus describes the first spontaneous mammalian model of centronuclear myopathy and defines a new locus for this group of diseases... - A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dogFrode Lingaas
Norwegian School of Veterinary Science, Oslo
Hum Mol Genet 12:3043-53. 2003..Strong evidence is provided that the RCND mutation may have a homozygous lethal effect (P<0.01)... - Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequencesTarjei S Mikkelsen
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 447:167-77. 2007..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation... - The search for a marsupial XIC reveals a break with vertebrate syntenyLance S Davidow
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Chromosome Res 15:137-46. 2007..The latter argues that marsupial XCI does not require XIST and opens the search for alternative mechanisms of dosage compensation... - Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable riskJaime F Modiano
Department of Immunology, AMC Cancer Center, Denver, Colorado 80214, USA
Cancer Res 65:5654-61. 2005..The data show that domestic dogs provide a unique and valuable resource to define factors that mediate risk as well as genes involved in the initiation of B-cell and T-cell LPD... - Genome sequence, comparative analysis and haplotype structure of the domestic dogKerstin Lindblad-Toh
Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, USA
Nature 438:803-19. 2005..The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health... - Canine malignant hemangiosarcoma as a model of primitive angiogenic endotheliumSusan P Fosmire
AMC Cancer Research Center and Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, 80214, USA
Lab Invest 84:562-72. 2004..In summary, these cell lines represent a unique and novel resource to improve our understanding of endothelial cell biology in general and canine HSA in particular... - Interleukin-12 inhibits tumor growth in a novel angiogenesis canine hemangiosarcoma xenograft modelNasim Akhtar
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA
Neoplasia 6:106-16. 2004..The endothelial cell model we have described offers unique opportunities to pursue further investigations with IL-12, as well as other antiangiogenic approaches in cancer therapy... - The dog as a cancer modelChand Khanna
Nat Biotechnol 24:1065-6. 2006
Research Grants
- Canine Brain Tumors - A New Model for Gene DiscoveryMatthew Breen; Fiscal Year: 2006..Characterization of these genetic loci will help to improve the definition of molecular risk and prognosis of human and canine brain tumors, with a potentially major impact on human health. ..
- SPONTANEOUS CANINE MODELS FOR CANCER GENE DISCOVERYMatthew Breen; Fiscal Year: 2007..We propose that Man's best friend will provide the keys to unlocking some of nature's most intriguing puzzles about cancer. ..
- SPONTANEOUS CANINE MODELS FOR CANCER GENE DISCOVERYMatthew Breen; Fiscal Year: 2010..We propose that Man's best friend will provide the keys to unlocking some of nature's most intriguing puzzles about cancer. ..