Research Topics
Genomes and Genes | James C BonnerSummaryAffiliation: North Carolina State University Country: USA Publications
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Publications
Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophagesJong Kwon Lee
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA
Part Fibre Toxicol 9:14. 2012....- Carbon nanotubes as delivery systems for respiratory disease: do the dangers outweigh the potential benefits?James C Bonner
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
Expert Rev Respir Med 5:779-87. 2011..However, functionalization of CNTs to modulate aspect ratio, biodegradability and to remove residual metals could allow for safe design of CNTs for use in drug delivery in certain circumstances... - Nanoparticles as a potential cause of pleural and interstitial lung diseaseJames C Bonner
Department of Environmental and Molecular Toxicology, Campus Box 7633, Raleigh, NC 27695 7633, USA
Proc Am Thorac Soc 7:138-41. 2010.... - Mesenchymal cell survival in airway and interstitial pulmonary fibrosisJames C Bonner
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
Fibrogenesis Tissue Repair 3:15. 2010..Understanding the mechanisms that regulate the survival or death of mesenchymal cells is central to ultimately developing therapeutic strategies for lung fibrosis... - Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesisDianne M Walters
CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, NC 27709, USA
Am J Pathol 167:1221-9. 2005.... - Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosisJames W Voltz
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Am J Respir Cell Mol Biol 39:45-52. 2008..Sex differences should be carefully considered when designing and interpreting experimental models of pulmonary fibrosis in mice... 
Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblastsJennifer L Ingram
CIIT Centers for Health Research, Research Triangle Park, Durham, NC 27709, USA
J Immunol 177:4141-8. 2006..This novel mechanism could aid in identifying molecular targets for the treatment of chronic airway remodeling and fibrosis in asthma...- STAT-1 signaling in human lung fibroblasts is induced by vanadium pentoxide through an IFN-beta autocrine loopAurita Antao-Menezes
Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
J Immunol 180:4200-7. 2008..This mechanism is postulated to counterbalance profibrogenic mechanisms that follow V(2)O(5) injury... - Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinaseYi-Zhe Wang
Laboratory of Pulmonary Pathobiology, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 35:845-55. 2003..Moreover, p38 MAPK and EGF receptor activation are required for V2O5-induced STAT-1 activation... - Respiratory syncytial virus infection reduces lung inflammation and fibrosis in mice exposed to vanadium pentoxideElizabeth A Turpin
The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Respir Res 11:20. 2010..It is unknown whether individuals with pre-existing respiratory viral infection are susceptible to V2O5-induced bronchitis. We hypothesized that respiratory viral infection will exacerbate vanadium-induced lung fibrosis... - IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-RalphaJennifer L Ingram
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
FASEB J 18:1132-4. 2004..Our findings indicate that IL-13 acts in synergy with IL-1beta to stimulate growth by coordinately up-regulating PDGF-AA and the PDGF-Ralpha, respectively... - Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthmaJessica P Ryman-Rasmussen
North Carolina State University, Box 7633, Raleigh, NC 27695, USA
Am J Respir Cell Mol Biol 40:349-58. 2009..These data indicate that inhaled MWCNT require pre-existing inflammation to cause airway fibrosis. Our findings suggest that individuals with pre-existing allergic inflammation may be susceptible to airway fibrosis from inhaled MWCNT... - Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosisJeffrey W Card
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
Am J Respir Cell Mol Biol 37:300-8. 2007..Collectively, these data suggest an important regulatory role for COX-2 in the maintenance of lung function in the setting of lung fibrosis, but not in the progression of the fibrotic process per se... - Regulation of PDGF and its receptors in fibrotic diseasesJames C Bonner
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Cytokine Growth Factor Rev 15:255-73. 2004..This review summarizes the literature on the role of PDGF and its receptors in the development of fibrosis in a variety of organ systems, including lung, liver, kidney, and skin... - Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitisJennifer L Ingram
The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Respir Res 8:34. 2007.... - Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinasesJennifer L Ingram
Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Am J Physiol Lung Cell Mol Physiol 284:L774-82. 2003..The induction of HB-EGF is not related to a burst of H(2)O(2) in V(2)O(5) treated cells, yet the action of V(2)O(5) in upregulating HB-EGF is oxidant dependent and could be due to the reaction of V(2)O(5) with endogenous H(2)O(2)... - Lung fibrotic responses to particle exposureJames C Bonner
Respiratory Biology Program, Division of Biological Sciences, CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
Toxicol Pathol 35:148-53. 2007.... - Bacterial lipopolysaccharide enhances PDGF signaling and pulmonary fibrosis in rats exposed to carbon nanotubesMark F Cesta
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, 27695 7633, USA
Am J Respir Cell Mol Biol 43:142-51. 2010..Our findings also suggest that individuals with pre-existing pulmonary inflammation are at greater risk for the potential adverse effects of MWCNT... - Nickel nanoparticles enhance platelet-derived growth factor-induced chemokine expression by mesothelial cells via prolonged mitogen-activated protein kinase activationEllen E Glista-Baker
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695 7633, USA
Am J Respir Cell Mol Biol 47:552-61. 2012..These data indicate that NiNPs enhance the activity of PDGF in regulating chemokine production in NRM2 cells through a mechanism involving reactive oxygen species generation and prolonged activation of ERK-1,2... - Over-expression of human endosulfatase-1 exacerbates cadmium-induced injury to transformed human lung cells in vitroHuiying Zhang
Department of Molecular Biomedical Sciences, Center for Comparative Molecular Translational Research, College of Veterinary Medicine, NC State University, Raleigh, NC 27607, USA
Toxicol Appl Pharmacol 265:27-42. 2012.... - ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposureBernard M Fischer
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
FASEB J 19:1374-6. 2005..1 microM), an ErbB2-neutralizing antibody, blocked thymidine incorporation only in NE-treated cells. These results suggest ErbB2 is a critical factor for epithelial recovery following NE exposure... - EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseasesJennifer L Ingram
Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27709, USA
Curr Mol Med 6:409-21. 2006..A full understanding of the complex mechanisms involving these receptors and ligands should lead to therapeutic strategies for the treatment of a wide range of fibroproliferative lung diseases... - p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblastsAnnette B Rice
Airway Inflammation Group, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
Am J Respir Cell Mol Biol 27:759-65. 2002..Collectively, these data demonstrate that p38 MAP kinase activation negatively regulates PDGF- and EGF-mediated growth responses by directly interacting with ERK1/2 and suppressing its phosphorylation... - Inhaled carbon nanotubes reach the subpleural tissue in miceJessica P Ryman-Rasmussen
Department of Environmental and Molecular Toxicology, College of Agricultural and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA
Nat Nanotechnol 4:747-51. 2009..This work suggests that minimizing inhalation of nanotubes during handling is prudent until further long-term assessments are conducted... - Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: a possible mechanism for the development of airway fibrosis in asthmaJennifer L Ingram
Laboratory of Pulmonary Pathobiology (Drs. Ingram and Bonner, Ms. Rice, and Ms. Geisenhoffer, National Institute of Environmental Health Science, Research Triangle Park, NC 27709, USA
Chest 123:422S-4S. 2003 - Proliferation of the airway epithelium in asthma: are inflammatory cells required?Brian W Booth
North Carolina State University, Raleigh, NC 27606, USA
Chest 123:384S-5S. 2003 - Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesisJames C Bonner
Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
Am J Pathol 161:459-70. 2002..These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation...