Research Topics
| Ronald BaynesSummaryAffiliation: North Carolina State University Country: USA Publications
Research Grants
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Detail Information
Publications
Challenges obtaining a biowaiver for topical veterinary dosage formsR Baynes
College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
J Vet Pharmacol Ther 35:103-14. 2012....
In vitro dermal disposition of abamectin (avermectin B(1)) in livestockRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Res Vet Sci 76:235-42. 2004....- A preliminary survey of antibiotic residues and viable bacteria in milk from three Caribbean Basin countriesR E Baynes
Department of Anatomy, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
J Food Prot 62:177-80. 1999..The presence of beta-lactam residues in some of these samples suggests the appropriateness of testing milk prior to processing for consumption... - NDELA and nickel modulation of triazine disposition in skinRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
Toxicol Ind Health 21:197-205. 2005..Workers should therefore not only be concerned about dermatotoxicity of these contaminants, but also the modulated dermal disposition of cutting fluid additives when these contaminants are present in cutting fluid formulations... - Partitioning behavior of aromatic components in jet fuel into diverse membrane-coated fibersRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
J Toxicol Environ Health A 70:1879-87. 2007..This information may be incorporated into physiologically based pharmacokinetic (PBPK) models to provide a more accurate assessment of tissue dosimetry of related toxicants... - Pharmacokinetics of melamine in pigs following intravenous administrationRonald E Baynes
Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
Food Chem Toxicol 46:1196-200. 2008.... - Quantification of chemical mixture interactions modulating dermal absorption using a multiple membrane fiber arrayRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
Chem Res Toxicol 21:591-9. 2008.... - A solvatochromatic approach to quantifying formulation effects on dermal permeabilityR E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
SAR QSAR Environ Res 19:615-30. 2008.... - Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamineRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, United States
Food Chem Toxicol 48:2542-6. 2010.... - Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixturesRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Ind Health 18:237-48. 2002..In summary, physicochemical interactions in these mixtures influenced availability of LAS for absorption and distribution in skin, and could ultimately influence toxicological responses in skin... - Effect of chemical interactions in pentachlorophenol mixtures on skin and membrane transportRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, Department of Food Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Toxicol Sci 69:295-305. 2002.... - Mixture effects of JP-8 additives on the dermal disposition of jet fuel componentsR E Baynes
Center for Cutaneous Toxicology and Residue Pharmacology, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Appl Pharmacol 175:269-81. 2001..More importantly, products of two-factor interactions were not predictable from single-factor exposures and, by extension, cannot be extrapolated to three-factor interactions... - Analysis of N,N-diethyl-m-toluamide in porcine skin perfusates using solid-phase extraction disks and reversed-phase high-performance liquid chromatographyRonald E Baynes
North Carolina State University College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics, 4700 Hillsborough St, Raleigh, NC 27606, USA
J Chromatogr B Analyt Technol Biomed Life Sci 780:45-52. 2002..1%. This method was used to analyze perfusate samples from skin (n=4) topically exposed to DEET-ethanol formulations. The data from these analyses determined that DEET permeability in porcine skin was 2.55 x 10(-5)+/-0.54 x 10(-5) cm/h... - Dermatotoxicity of cutting fluid mixtures:in vitro and in vivo studiesNancy A Monteiro-Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
Cutan Ocul Toxicol 25:235-47. 2006..These findings will however require further clinical studies to validate these acute dermal effects as well as human cumulative irritation following exposure to similar cutting fluid formulations in the workplace... - Dermal permeation of biocides and aromatic chemicals in three generic formulations of metalworking fluidsVikrant Vijay
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 8401, USA
J Toxicol Environ Health A 72:832-41. 2009..The dilution of these MWF formulations with water may increase dermal permeability of biocides, allowing for an enhanced risk for systemic toxicological effects and dermatitis potential... 
Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swineJennifer Buur
Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, NC 27606, USA
Antimicrob Agents Chemother 50:2344-51. 2006..These models can be used to calculate the parameters required by FDA and explore those conditions where the established withdrawal time may not be sufficient...- An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber arrayXin Rui Xia
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Appl Pharmacol 221:320-8. 2007..It is an experimentally based, high throughput approach that provides high prediction confidence and does not require literature data nor molecular structure information in contrast to the existing predictive models... - Membrane-coated fiber array approach for predicting skin permeability of chemical mixtures from different vehiclesJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Toxicol Sci 99:153-61. 2007..These results suggested that the experimentally based MCF array approach can be used to predict skin absorption from chemical mixtures in different vehicles or formulations... - Sulfamethazine water medication pharmacokinetics and contamination in a commercial pig production unitSharon E Mason
Department of Population Health and Pathobiology, Center for Chemical Toxicology and Research Pharmacokinetics, North Carolina State University, Raleigh 27606, USA
J Food Prot 71:584-9. 2008..These results are of concern for producers and veterinarians, because in commercial farms, the entire barn is often treated,and environmental contamination could result in residues of an unknown duration... - Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approachVikrant Vijay
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, CCTRP CVM, 4700 Hillsborough Street, Raleigh, NC 27606, United States
Toxicol Lett 175:34-43. 2007..89 and 0.84, respectively. In conclusion, the LSER approach adequately predicted the dermal permeability of four biocides in commercial cutting fluids and also shed light on the chemical interactions resulting in reduced permeability... - Pyridostigmine bromide modulates the dermal disposition of [14C]permethrinRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, Raleigh 27606, USA
Toxicol Appl Pharmacol 181:164-73. 2002.... - Gulf War related exposure factors influencing topical absorption of 14C-permethrinJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Lett 135:61-71. 2002..The toxicologic significance of this moderate increase in permethrin absorption remains unclear... - Application of linear solvation energy relationships to a custom-made polyaniline solid-phase microextraction fiber and three commercial fibersJames L Yeatts
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
J Chromatogr A 1188:108-17. 2008..The PANI fiber may offer greater flexibility in the choice of fibers to use for solid-phase microextraction... - Percutaneous absorption of topical N,N-diethyl-m-toluamide (DEET): effects of exposure variables and coadministered toxicantsJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
J Toxicol Environ Health A 66:133-51. 2003.... - A compartment model for the membrane-coated fiber technique used for determining the absorption parameters of chemicals into lipophilic membranesXin Rui Xia
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Pharm Res 21:1345-52. 2004..The purpose of this work was to develop a compartment model for the membrane-coated fiber (MCF) technique for determining the absorption parameters of chemicals into lipophilic membranes... - A novel in-vitro technique for studying percutaneous permeation with a membrane-coated fiber and gas chromatography/mass spectrometry: part I. Performances of the technique and determination of the permeation rates and partition coefficients of chemical mXin-Rui Xia
Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP, College of Veterinary Medicine, Campus Box 8401, 4700 Hillsborough Street, North Carolina State University, Raleigh, North Carolina 27606, USA
Pharm Res 20:275-82. 2003..The initial permeation rate and equilibrium time can be obtained for each compound, which could serve as characteristic parameters regarding the skin permeability of the compound... - Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skinNancy A Monteiro-Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicology 183:15-28. 2003..In conclusion, these studies suggest that systemic exposure to PB suppressed IL-8 release at multiple time points in two skin model systems. This interaction merits further study... - Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazineRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
Toxicol Lett 159:252-60. 2005.... - Analysis of diltiazem in Lipoderm transdermal gel using reversed-phase high-performance liquid chromatography applied to homogenization and stability studiesJennifer L Buur
North Carolina State University, College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics, 4700 Hillsborough St Raleigh, NC 27606, USA
J Pharm Biomed Anal 38:60-5. 2005..Diltiazem was stable at a concentration of 246 mg/ml for 30 days and at a concentration of 99.6 mg/ml for 60 days no matter the storage conditions explored in this study... - Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber techniqueXin-Rui Xia
Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Eur J Pharm Sci 24:15-23. 2005..It was demonstrated that the MCF technique could be used to determine the partition, diffusion and permeation coefficients, as well as the thickness of the boundary layer in a lipophilic membrane/water system... - Regression method of the hydrophobicity ruler approach for determining octanol/water partition coefficients of very hydrophobic compoundsXiang Q Kong
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27606, USA
Chemosphere 66:1086-93. 2007..The critical experimental factors, the merits of the regression method were discussed... - Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cowsGeof W Smith
Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Am Vet Med Assoc 224:1827-30. 2004..Elimination of ceftiofur may be correlated with milk production, and cows producing smaller volumes of milk may have prolonged withdrawal times... - Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic modelJennifer L Buur
Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough St Raleigh, NC 27606, USA
Regul Toxicol Pharmacol 51:324-31. 2008..PBPK models, such as this one, provide evidence of the usefulness in species extrapolation over a range of dosing scenarios and can be used to protect the food supply after accidental exposure in the face of little in the target species... - Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattleGeof W Smith
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Am Vet Med Assoc 234:245-8. 2009..To determine elimination kinetics of tilmicosin in milk following intramammary administration in lactating dairy cattle... - Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissuesJennifer L Buur
Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
Am J Vet Res 66:1686-93. 2005..CONCLUSIONS AND CLINICAL RELEVANCE: Use of this model enabled accurate prediction of sulfamethazine pharmacokinetics in swine and has applications for food safety and prediction of drug residues in edible tissues... - Extrapolated withdrawal-interval estimator (EWE) algorithm: a quantitative approach to establishing extralabel withdrawal timesTomas Martin-Jimenez
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802, USA
Regul Toxicol Pharmacol 36:131-7. 2002..Population models could be fitted to fragmentary data to predict residue concentrations in tissues, validate the EWE estimates, and obtain WDI estimates... - Drugs approved for small ruminantsAlistair I Webb
Food Animal Residue Avoidance Databank, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
J Am Vet Med Assoc 224:520-3. 2004 - Multivariate meta-analysis of pharmacokinetic studies of ampicillin trihydrate in cattleRonette Gehring
Center for Chemical Toxicology Research and Pharmacokinetics, Food Animal Residue Avoidance Databank, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Am J Vet Res 66:108-12. 2005..Accurate estimates of pharmacokinetic parameters are important for the calculation of dosages and extended withdrawal intervals after extralabel drug administration... - Current update on drugs for game bird speciesMartha L Needham
Food Animal Residue Avoidance Databank, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Am Vet Med Assoc 231:1506-8. 2007 - Evaluation of the advisory services provided by the Food Animal Residue Avoidance DatabankJiming Wang
Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Am Vet Med Assoc 223:1596-8. 2003
Research Grants
- Influence of Metal-Working Fluid Formulations on Dermal Absorption of BiocidesRonald E Baynes; Fiscal Year: 2010..Ultimately, the products of this research will help inform the development and risk assessment of formulations that afford greater protection. ..
- DERMAL ABSORPTION OF CUTTING FLUID MIXTURESRonald Baynes; Fiscal Year: 2003..This experimental approach allows interaction models to be built which can be used to assess other workplace mixtures. ..
- Mixture Effects on the Dermal Absorption of BiocidesRonald Baynes; Fiscal Year: 2005..Comparative analysis of interaction coefficients between the MCF and biological systems will provide some insight into dominant physicochemical interactions influencing dermal absorption of biocides in chemical mixtures. ..
- Mixture Effects on the Dermal Absorption of BiocidesRonald Baynes; Fiscal Year: 2007..Comparative analysis of interaction coefficients between the MCF and biological systems will provide some insight into dominant physicochemical interactions influencing dermal absorption of biocides in chemical mixtures. ..