Ronald Baynes

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. pmc Risks associated with melamine and related triazine contamination of food
    Re Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Emerg Health Threats J 3:e5. 2010
  2. doi request reprint Challenges obtaining a biowaiver for topical veterinary dosage forms
    R Baynes
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    J Vet Pharmacol Ther 35:103-14. 2012
  3. ncbi request reprint A preliminary survey of antibiotic residues and viable bacteria in milk from three Caribbean Basin countries
    R E Baynes
    Department of Anatomy, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Food Prot 62:177-80. 1999
  4. doi request reprint Pharmacokinetics of melamine in pigs following intravenous administration
    Ronald E Baynes
    Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
    Food Chem Toxicol 46:1196-200. 2008
  5. ncbi request reprint In vitro dermal disposition of abamectin (avermectin B(1)) in livestock
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Res Vet Sci 76:235-42. 2004
  6. doi request reprint Quantification of chemical mixture interactions modulating dermal absorption using a multiple membrane fiber array
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Chem Res Toxicol 21:591-9. 2008
  7. ncbi request reprint Partitioning behavior of aromatic components in jet fuel into diverse membrane-coated fibers
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Toxicol Environ Health A 70:1879-87. 2007
  8. ncbi request reprint Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Ind Health 18:237-48. 2002
  9. ncbi request reprint A solvatochromatic approach to quantifying formulation effects on dermal permeability
    R E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
    SAR QSAR Environ Res 19:615-30. 2008
  10. ncbi request reprint Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamine
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, United States
    Food Chem Toxicol 48:2542-6. 2010

Research Grants

Collaborators

Detail Information

Publications42

  1. pmc Risks associated with melamine and related triazine contamination of food
    Re Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Emerg Health Threats J 3:e5. 2010
    ....
  2. doi request reprint Challenges obtaining a biowaiver for topical veterinary dosage forms
    R Baynes
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    J Vet Pharmacol Ther 35:103-14. 2012
    ....
  3. ncbi request reprint A preliminary survey of antibiotic residues and viable bacteria in milk from three Caribbean Basin countries
    R E Baynes
    Department of Anatomy, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Food Prot 62:177-80. 1999
    ..The presence of beta-lactam residues in some of these samples suggests the appropriateness of testing milk prior to processing for consumption...
  4. doi request reprint Pharmacokinetics of melamine in pigs following intravenous administration
    Ronald E Baynes
    Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
    Food Chem Toxicol 46:1196-200. 2008
    ....
  5. ncbi request reprint In vitro dermal disposition of abamectin (avermectin B(1)) in livestock
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Res Vet Sci 76:235-42. 2004
    ....
  6. doi request reprint Quantification of chemical mixture interactions modulating dermal absorption using a multiple membrane fiber array
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Chem Res Toxicol 21:591-9. 2008
    ....
  7. ncbi request reprint Partitioning behavior of aromatic components in jet fuel into diverse membrane-coated fibers
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Toxicol Environ Health A 70:1879-87. 2007
    ..This information may be incorporated into physiologically based pharmacokinetic (PBPK) models to provide a more accurate assessment of tissue dosimetry of related toxicants...
  8. ncbi request reprint Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Ind Health 18:237-48. 2002
    ..In summary, physicochemical interactions in these mixtures influenced availability of LAS for absorption and distribution in skin, and could ultimately influence toxicological responses in skin...
  9. ncbi request reprint A solvatochromatic approach to quantifying formulation effects on dermal permeability
    R E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
    SAR QSAR Environ Res 19:615-30. 2008
    ....
  10. ncbi request reprint Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamine
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, United States
    Food Chem Toxicol 48:2542-6. 2010
    ....
  11. ncbi request reprint Analysis of N,N-diethyl-m-toluamide in porcine skin perfusates using solid-phase extraction disks and reversed-phase high-performance liquid chromatography
    Ronald E Baynes
    North Carolina State University College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics, 4700 Hillsborough St, Raleigh, NC 27606, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 780:45-52. 2002
    ..1%. This method was used to analyze perfusate samples from skin (n=4) topically exposed to DEET-ethanol formulations. The data from these analyses determined that DEET permeability in porcine skin was 2.55 x 10(-5)+/-0.54 x 10(-5) cm/h...
  12. ncbi request reprint Effect of chemical interactions in pentachlorophenol mixtures on skin and membrane transport
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Food Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Toxicol Sci 69:295-305. 2002
    ....
  13. ncbi request reprint Mixture effects of JP-8 additives on the dermal disposition of jet fuel components
    R E Baynes
    Center for Cutaneous Toxicology and Residue Pharmacology, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 175:269-81. 2001
    ..More importantly, products of two-factor interactions were not predictable from single-factor exposures and, by extension, cannot be extrapolated to three-factor interactions...
  14. ncbi request reprint NDELA and nickel modulation of triazine disposition in skin
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
    Toxicol Ind Health 21:197-205. 2005
    ..Workers should therefore not only be concerned about dermatotoxicity of these contaminants, but also the modulated dermal disposition of cutting fluid additives when these contaminants are present in cutting fluid formulations...
  15. ncbi request reprint Dermatotoxicity of cutting fluid mixtures:in vitro and in vivo studies
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    Cutan Ocul Toxicol 25:235-47. 2006
    ..These findings will however require further clinical studies to validate these acute dermal effects as well as human cumulative irritation following exposure to similar cutting fluid formulations in the workplace...
  16. ncbi request reprint Dermal permeation of biocides and aromatic chemicals in three generic formulations of metalworking fluids
    Vikrant Vijay
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 8401, USA
    J Toxicol Environ Health A 72:832-41. 2009
    ..The dilution of these MWF formulations with water may increase dermal permeability of biocides, allowing for an enhanced risk for systemic toxicological effects and dermatitis potential...
  17. pmc Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine
    Jennifer Buur
    Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, NC 27606, USA
    Antimicrob Agents Chemother 50:2344-51. 2006
    ..These models can be used to calculate the parameters required by FDA and explore those conditions where the established withdrawal time may not be sufficient...
  18. ncbi request reprint Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approach
    Vikrant Vijay
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, CCTRP CVM, 4700 Hillsborough Street, Raleigh, NC 27606, United States
    Toxicol Lett 175:34-43. 2007
    ..89 and 0.84, respectively. In conclusion, the LSER approach adequately predicted the dermal permeability of four biocides in commercial cutting fluids and also shed light on the chemical interactions resulting in reduced permeability...
  19. ncbi request reprint Membrane-coated fiber array approach for predicting skin permeability of chemical mixtures from different vehicles
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 99:153-61. 2007
    ..These results suggested that the experimentally based MCF array approach can be used to predict skin absorption from chemical mixtures in different vehicles or formulations...
  20. ncbi request reprint An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 221:320-8. 2007
    ..It is an experimentally based, high throughput approach that provides high prediction confidence and does not require literature data nor molecular structure information in contrast to the existing predictive models...
  21. ncbi request reprint Sulfamethazine water medication pharmacokinetics and contamination in a commercial pig production unit
    Sharon E Mason
    Department of Population Health and Pathobiology, Center for Chemical Toxicology and Research Pharmacokinetics, North Carolina State University, Raleigh 27606, USA
    J Food Prot 71:584-9. 2008
    ..These results are of concern for producers and veterinarians, because in commercial farms, the entire barn is often treated,and environmental contamination could result in residues of an unknown duration...
  22. doi request reprint Application of linear solvation energy relationships to a custom-made polyaniline solid-phase microextraction fiber and three commercial fibers
    James L Yeatts
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Chromatogr A 1188:108-17. 2008
    ..The PANI fiber may offer greater flexibility in the choice of fibers to use for solid-phase microextraction...
  23. ncbi request reprint Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber technique
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Eur J Pharm Sci 24:15-23. 2005
    ..It was demonstrated that the MCF technique could be used to determine the partition, diffusion and permeation coefficients, as well as the thickness of the boundary layer in a lipophilic membrane/water system...
  24. ncbi request reprint Percutaneous absorption of topical N,N-diethyl-m-toluamide (DEET): effects of exposure variables and coadministered toxicants
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Toxicol Environ Health A 66:133-51. 2003
    ....
  25. ncbi request reprint Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skin
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicology 183:15-28. 2003
    ..In conclusion, these studies suggest that systemic exposure to PB suppressed IL-8 release at multiple time points in two skin model systems. This interaction merits further study...
  26. ncbi request reprint A compartment model for the membrane-coated fiber technique used for determining the absorption parameters of chemicals into lipophilic membranes
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Pharm Res 21:1345-52. 2004
    ..The purpose of this work was to develop a compartment model for the membrane-coated fiber (MCF) technique for determining the absorption parameters of chemicals into lipophilic membranes...
  27. ncbi request reprint Gulf War related exposure factors influencing topical absorption of 14C-permethrin
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 135:61-71. 2002
    ..The toxicologic significance of this moderate increase in permethrin absorption remains unclear...
  28. ncbi request reprint Pyridostigmine bromide modulates the dermal disposition of [14C]permethrin
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, Raleigh 27606, USA
    Toxicol Appl Pharmacol 181:164-73. 2002
    ....
  29. ncbi request reprint Analysis of diltiazem in Lipoderm transdermal gel using reversed-phase high-performance liquid chromatography applied to homogenization and stability studies
    Jennifer L Buur
    North Carolina State University, College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics, 4700 Hillsborough St Raleigh, NC 27606, USA
    J Pharm Biomed Anal 38:60-5. 2005
    ..Diltiazem was stable at a concentration of 246 mg/ml for 30 days and at a concentration of 99.6 mg/ml for 60 days no matter the storage conditions explored in this study...
  30. ncbi request reprint Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Toxicol Lett 159:252-60. 2005
    ....
  31. ncbi request reprint A novel in-vitro technique for studying percutaneous permeation with a membrane-coated fiber and gas chromatography/mass spectrometry: part I. Performances of the technique and determination of the permeation rates and partition coefficients of chemical m
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, Campus Box 8401, 4700 Hillsborough Street, North Carolina State University, Raleigh, North Carolina 27606, USA
    Pharm Res 20:275-82. 2003
    ..To develop a novel in-vitro technique for rapid assessment of percutaneous absorption of chemical mixtures...
  32. ncbi request reprint Regression method of the hydrophobicity ruler approach for determining octanol/water partition coefficients of very hydrophobic compounds
    Xiang Q Kong
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27606, USA
    Chemosphere 66:1086-93. 2007
    ..The critical experimental factors, the merits of the regression method were discussed...
  33. ncbi request reprint Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows
    Geof W Smith
    Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 224:1827-30. 2004
    ..To determine the elimination kinetics of ceftiofur hydrochloride in milk after intramammary administration in lactating dairy cows...
  34. ncbi request reprint Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues
    Jennifer L Buur
    Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Am J Vet Res 66:1686-93. 2005
    ..To develop a flow-limited, physiologic-based pharmacokinetic model for use in estimating concentrations of sulfamethazine after IV administration to swine...
  35. doi request reprint Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle
    Geof W Smith
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 234:245-8. 2009
    ..To determine elimination kinetics of tilmicosin in milk following intramammary administration in lactating dairy cattle...
  36. ncbi request reprint Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model
    Jennifer L Buur
    Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough St Raleigh, NC 27606, USA
    Regul Toxicol Pharmacol 51:324-31. 2008
    ..PBPK models, such as this one, provide evidence of the usefulness in species extrapolation over a range of dosing scenarios and can be used to protect the food supply after accidental exposure in the face of little in the target species...
  37. doi request reprint Tetracycline residues in porcine stomach after administration via drinking water on a swine farm
    Danielle Lindquist
    Center for Chemical Toxicology and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Food Prot 77:122-6. 2014
    ..These residue levels may explain why stomach tissues tested in Russia and Europe show positive residues for tetracycline, even though the meat may pass inspection here in the United States prior to export. ..
  38. ncbi request reprint Drugs approved for small ruminants
    Alistair I Webb
    Food Animal Residue Avoidance Databank, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
    J Am Vet Med Assoc 224:520-3. 2004
  39. ncbi request reprint Extrapolated withdrawal-interval estimator (EWE) algorithm: a quantitative approach to establishing extralabel withdrawal times
    Tomas Martin-Jimenez
    Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802, USA
    Regul Toxicol Pharmacol 36:131-7. 2002
    ..Population models could be fitted to fragmentary data to predict residue concentrations in tissues, validate the EWE estimates, and obtain WDI estimates...
  40. ncbi request reprint Current update on drugs for game bird species
    Martha L Needham
    Food Animal Residue Avoidance Databank, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Am Vet Med Assoc 231:1506-8. 2007
  41. ncbi request reprint Multivariate meta-analysis of pharmacokinetic studies of ampicillin trihydrate in cattle
    Ronette Gehring
    Center for Chemical Toxicology Research and Pharmacokinetics, Food Animal Residue Avoidance Databank, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Am J Vet Res 66:108-12. 2005
    ....
  42. ncbi request reprint Evaluation of the advisory services provided by the Food Animal Residue Avoidance Databank
    Jiming Wang
    Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 223:1596-8. 2003

Research Grants7

  1. Influence of Metal-Working Fluid Formulations on Dermal Absorption of Biocides
    Ronald E Baynes; Fiscal Year: 2010
    ..Ultimately, the products of this research will help inform the development and risk assessment of formulations that afford greater protection. ..
  2. DERMAL ABSORPTION OF CUTTING FLUID MIXTURES
    Ronald Baynes; Fiscal Year: 2001
    ..This experimental approach allows interaction models to be built which can be used to assess other workplace mixtures. ..
  3. DERMAL ABSORPTION OF CUTTING FLUID MIXTURES
    Ronald Baynes; Fiscal Year: 2002
    ..This experimental approach allows interaction models to be built which can be used to assess other workplace mixtures. ..
  4. DERMAL ABSORPTION OF CUTTING FLUID MIXTURES
    Ronald Baynes; Fiscal Year: 2003
    ..This experimental approach allows interaction models to be built which can be used to assess other workplace mixtures. ..
  5. Mixture Effects on the Dermal Absorption of Biocides
    Ronald Baynes; Fiscal Year: 2005
    ..Comparative analysis of interaction coefficients between the MCF and biological systems will provide some insight into dominant physicochemical interactions influencing dermal absorption of biocides in chemical mixtures. ..
  6. Mixture Effects on the Dermal Absorption of Biocides
    Ronald Baynes; Fiscal Year: 2007
    ..Comparative analysis of interaction coefficients between the MCF and biological systems will provide some insight into dominant physicochemical interactions influencing dermal absorption of biocides in chemical mixtures. ..