ROBERT ANHOLT

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. doi request reprint Modulation of Feeding Behavior by Odorant-Binding Proteins in Drosophila melanogaster
    Shilpa Swarup
    Department of Biological Sciences and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
    Chem Senses 39:125-32. 2014
  2. pmc A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein response
    Robert R H Anholt
    Department of Biological Sciences and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695 7617, USA Electronic address
    Trends Mol Med 19:586-93. 2013
  3. doi request reprint Genetics of aggression
    Robert R H Anholt
    Department of Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Annu Rev Genet 46:145-64. 2012
  4. pmc The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks
    Tatiana V Morozova
    Department of Biology, Box 7617, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 13:239. 2012
  5. pmc Transcriptional response to alcohol exposure in Drosophila melanogaster
    Tatiana V Morozova
    WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 7:R95. 2006
  6. pmc Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster
    Tatiana V Morozova
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 8:R231. 2007
  7. pmc The soluble proteome of the Drosophila antenna
    Robert R H Anholt
    Department of Biology, North Carolina State University, Raleigh, NC 27695 7617, USA
    Chem Senses 35:21-30. 2010
  8. ncbi request reprint The genetic architecture of odor-guided behavior in Drosophila melanogaster
    R R Anholt
    Department of Zoology, North Carolina State University, Raleigh 27695, USA
    Behav Genet 31:17-27. 2001
  9. ncbi request reprint Quantitative genetic analyses of complex behaviours in Drosophila
    Robert R H Anholt
    Department of Zoology, W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Nat Rev Genet 5:838-49. 2004
  10. ncbi request reprint The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome
    Robert R H Anholt
    The Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Genet 35:180-4. 2003

Research Grants

  1. Molecular Genetics of Olfaction in Drosophilia
    ROBERT ANHOLT; Fiscal Year: 2009
  2. Molecular Genetics of Olfaction in Drosophilia
    Robert R H Anholt; Fiscal Year: 2010
  3. Comparative Genomics of Glaucoma
    ROBERT ANHOLT; Fiscal Year: 2007
  4. MOLECULAR GENETICS OF OLFACTION IN DROSOPHILA
    ROBERT ANHOLT; Fiscal Year: 2006
  5. MOLECULAR GENETICS OF OLFACTION IN DROSOPHILA
    ROBERT ANHOLT; Fiscal Year: 2002
  6. Molecular Genetics of Olfaction in Drosophilia
    ROBERT ANHOLT; Fiscal Year: 2009

Collaborators

Detail Information

Publications33

  1. doi request reprint Modulation of Feeding Behavior by Odorant-Binding Proteins in Drosophila melanogaster
    Shilpa Swarup
    Department of Biological Sciences and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
    Chem Senses 39:125-32. 2014
    ....
  2. pmc A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein response
    Robert R H Anholt
    Department of Biological Sciences and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695 7617, USA Electronic address
    Trends Mol Med 19:586-93. 2013
    ..This mechanism of POAG is reminiscent of other age-dependent neurodegenerative diseases that involve accumulation of protein aggregates. ..
  3. doi request reprint Genetics of aggression
    Robert R H Anholt
    Department of Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Annu Rev Genet 46:145-64. 2012
    ..Comparative genomic analyses based on the principle of evolutionary conservation are needed to enable a complete dissection of the neurogenetic underpinnings of this universal fitness trait...
  4. pmc The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks
    Tatiana V Morozova
    Department of Biology, Box 7617, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 13:239. 2012
    ..Alcoholism is a significant public health problem. A picture of the genetic architecture underlying alcohol-related phenotypes is emerging from genome-wide association studies and work on genetically tractable model organisms...
  5. pmc Transcriptional response to alcohol exposure in Drosophila melanogaster
    Tatiana V Morozova
    WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 7:R95. 2006
    ....
  6. pmc Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster
    Tatiana V Morozova
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 8:R231. 2007
    ..Furthermore, flies exposed to ethanol undergo physiological and behavioral changes that resemble human alcohol intoxication, including loss of postural control, sedation, and development of tolerance...
  7. pmc The soluble proteome of the Drosophila antenna
    Robert R H Anholt
    Department of Biology, North Carolina State University, Raleigh, NC 27695 7617, USA
    Chem Senses 35:21-30. 2010
    ..The procedure described here opens the way for precise quantification of any target protein in the Drosophila antenna and should be readily applicable to antennae from other insects...
  8. ncbi request reprint The genetic architecture of odor-guided behavior in Drosophila melanogaster
    R R Anholt
    Department of Zoology, North Carolina State University, Raleigh 27695, USA
    Behav Genet 31:17-27. 2001
    ....
  9. ncbi request reprint Quantitative genetic analyses of complex behaviours in Drosophila
    Robert R H Anholt
    Department of Zoology, W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Nat Rev Genet 5:838-49. 2004
    ..Recent advances in quantitative genetic and functional genomic approaches now enable the extensive characterization of complex genetic networks that mediate behaviours in this important model organism...
  10. ncbi request reprint The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome
    Robert R H Anholt
    The Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Genet 35:180-4. 2003
    ....
  11. pmc Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster
    Deepa Sambandan
    W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 179:1079-88. 2008
    ....
  12. pmc Scribble is essential for olfactory behavior in Drosophila melanogaster
    Indrani Ganguly
    The W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
    Genetics 164:1447-57. 2003
    ..Expression of Scrib is widespread in olfactory organs and the central nervous system. Finally, alternative splicing of scrib generates transcripts that differ in the number of leucine-rich repeats and PDZ domains...
  13. ncbi request reprint Pinocchio, a novel protein expressed in the antenna, contributes to olfactory behavior in Drosophila melanogaster
    Stephanie M Rollmann
    Department of Zoology, North Carolina State University, Raleigh, 27695 7617, USA
    J Neurobiol 63:146-58. 2005
    ..Furthermore, in situ hybridization reveals CG4710 expression in the third antennal segment. We have named this gene of previously unknown function and its product "Pinocchio (Pino)"...
  14. pmc Alcohol sensitivity in Drosophila: translational potential of systems genetics
    Tatiana V Morozova
    Department of Biology, W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
    Genetics 183:733-45, 1SI-12SI. 2009
    ....
  15. pmc Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster
    Deepa Sambandan
    Department of Genetics, The W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh 27695 7617, USA
    Genetics 174:1349-63. 2006
    ..Our results show that the manifestation of epistatic networks dynamically changes with alterations in the environment...
  16. pmc Plasticity of the chemoreceptor repertoire in Drosophila melanogaster
    Shanshan Zhou
    Department of Biology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS Genet 5:e1000681. 2009
    ..This finely pixilated modular organization of the chemosensory subgenome enables fine tuning of the expression of the chemoreceptor repertoire in response to ecologically relevant environmental and physiological conditions...
  17. pmc The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila
    Stephanie M Rollmann
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 176:947-56. 2007
    ..Our results demonstrate how hypomorphic mutation of an early developmental gene results in genomewide transcriptional consequences and alterations in brain structure accompanied by profound impairment of adult behavior...
  18. pmc Association of polymorphisms in odorant-binding protein genes with variation in olfactory response to benzaldehyde in Drosophila
    Ping Wang
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 177:1655-65. 2007
    ..Model predictions of alternative pre-mRNA secondary structures associated with polymorphic sites suggest that alterations in Obp mRNA structure could contribute to phenotypic variation in olfactory behavior...
  19. ncbi request reprint Genetic modules and networks for behavior: lessons from Drosophila
    Robert R H Anholt
    WM Keck Center for Behavioral Biology and Departments of Zoology and Genetics, North Carolina State University, Raleigh, NC 27695 7617, USA
    Bioessays 26:1299-306. 2004
    ..Such networks are exquisitely sensitive to genetic background and sex effects. This review describes how Drosophila can serve as a model for uncovering fundamental principles of the genetic architecture of behavior...
  20. ncbi request reprint Ain't misbehavin' ? Genotype-environment interactions and the genetics of behavior
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Trends Genet 23:311-4. 2007
    ..This report, together with studies from Drosophila, stresses the importance of understanding genotype-environment interactions...
  21. ncbi request reprint Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster
    Stephanie M Rollmann
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Nat Genet 38:824-9. 2006
    ..Transposon-induced sex-specific and sex-antagonistic effects further accentuate the complex influences that intergenic transposable elements can contribute to quantitative trait phenotypes...
  22. ncbi request reprint Of flies and man: Drosophila as a model for human complex traits
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, 27695, USA
    Annu Rev Genomics Hum Genet 7:339-67. 2006
    ....
  23. pmc Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure
    Stephanie M Rollmann
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Genetics 179:1327-36. 2008
    ....
  24. ncbi request reprint Impaired olfactory behavior in mice deficient in the alpha subunit of G(o)
    Alice H Luo
    W M Keck Center for Behavioral Biology, North Carolina State University, Box 7617, Raleigh, NC 27695 7617, USA
    Brain Res 941:62-71. 2002
    ..Thus, Galpha(o) is necessary for the expression of olfactory behavior under normal conditions and dependent on genetic background, but is not essential for the formation and maintenance of glomeruli...
  25. pmc Natural variation in odorant recognition among odorant-binding proteins in Drosophila melanogaster
    Ping Wang
    Department of Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 184:759-67. 2010
    ..Thus, dual olfactory recognition where OBPs regulate odorant access to receptors may enhance olfactory discrimination...
  26. pmc The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila melanogaster
    Nalini H Kulkarni
    The W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 161:1507-16. 2002
    ..These results indicate that the DSC1 channel contributes to processing of olfactory information during the olfactory avoidance response...
  27. pmc Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior
    Juan José Fanara
    W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh 27695, USA
    Genetics 162:1321-8. 2002
    ....
  28. pmc Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster
    Akihiko Yamamoto
    Department of Biology, North Carolina State University, Raleigh, NC, USA
    Genet Res (Camb) 91:373-82. 2009
    ....
  29. pmc Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster
    Akihiko Yamamoto
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Proc Natl Acad Sci U S A 105:12393-8. 2008
    ..We find that behavioral and neuroanatomical phenotypes are determined by a common set of genes that are organized as partially overlapping genetic networks...
  30. pmc Systems genetics of complex traits in Drosophila melanogaster
    Julien F Ayroles
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Genet 41:299-307. 2009
    ..Overlapping transcripts in modules associated with different traits provide insight into the molecular basis of pleiotropy between complex traits...
  31. doi request reprint Understanding the neurogenetics of sleep: progress from Drosophila
    Susan T Harbison
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Trends Genet 25:262-9. 2009
    ..Advances in systems genetics coupled with the ability to target specific brain regions enable the characterization of transcriptional networks and neural circuits contributing to phenotypic variation in sleep...
  32. pmc Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma
    Mary Anna Carbone
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
    PLoS ONE 4:e4216. 2009
    ..Among several hypotheses, activation of the unfolded protein response (UPR) has emerged as a possible disease mechanism...
  33. pmc Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC)
    TERESA BORRAS
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 163:637-45. 2003
    ..Our observations establish the Drosophila eye as an advantageous system for the discovery of genes that are associated with glaucoma...

Research Grants17

  1. Molecular Genetics of Olfaction in Drosophilia
    ROBERT ANHOLT; Fiscal Year: 2009
    ..abstract_text> ..
  2. Molecular Genetics of Olfaction in Drosophilia
    Robert R H Anholt; Fiscal Year: 2010
    ....
  3. Comparative Genomics of Glaucoma
    ROBERT ANHOLT; Fiscal Year: 2007
    ..abstract_text> ..
  4. MOLECULAR GENETICS OF OLFACTION IN DROSOPHILA
    ROBERT ANHOLT; Fiscal Year: 2006
    ..The completion of these specific aims will lead to a greater, more comprehensive understanding of the genetic architecture of olfactory behavior. ..
  5. MOLECULAR GENETICS OF OLFACTION IN DROSOPHILA
    ROBERT ANHOLT; Fiscal Year: 2002
    ..The isolated gene will be expressed in the baculovirus system and if the gene resembles a receptor, the odorant-induced, second messengers will be examined in the Sf9 cells that are used to express the gene in baculovirus. ..
  6. Molecular Genetics of Olfaction in Drosophilia
    ROBERT ANHOLT; Fiscal Year: 2009
    ....