Research Topics
Species | ROBERT ANHOLTSummaryAffiliation: North Carolina State University Country: USA Publications
Research Grants
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Detail Information
Publications
Genetics of aggressionRobert R H Anholt
Department of Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
Annu Rev Genet 46:145-64. 2012..Comparative genomic analyses based on the principle of evolutionary conservation are needed to enable a complete dissection of the neurogenetic underpinnings of this universal fitness trait...
The genetic basis of alcoholism: multiple phenotypes, many genes, complex networksTatiana V Morozova
Department of Biology, Box 7617, North Carolina State University, Raleigh, NC 27695, USA
Genome Biol 13:239. 2012..Alcoholism is a significant public health problem. A picture of the genetic architecture underlying alcohol-related phenotypes is emerging from genome-wide association studies and work on genetically tractable model organisms...- Transcriptional response to alcohol exposure in Drosophila melanogasterTatiana V Morozova
WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
Genome Biol 7:R95. 2006.... - Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogasterTatiana V Morozova
Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
Genome Biol 8:R231. 2007..Furthermore, flies exposed to ethanol undergo physiological and behavioral changes that resemble human alcohol intoxication, including loss of postural control, sedation, and development of tolerance... - The soluble proteome of the Drosophila antennaRobert R H Anholt
Department of Biology, North Carolina State University, Raleigh, NC 27695 7617, USA
Chem Senses 35:21-30. 2010..The procedure described here opens the way for precise quantification of any target protein in the Drosophila antenna and should be readily applicable to antennae from other insects... 
The genetic architecture of odor-guided behavior in Drosophila melanogasterR R Anholt
Department of Zoology, North Carolina State University, Raleigh 27695, USA
Behav Genet 31:17-27. 2001....- Quantitative genetic analyses of complex behaviours in DrosophilaRobert R H Anholt
Department of Zoology, W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
Nat Rev Genet 5:838-49. 2004..Recent advances in quantitative genetic and functional genomic approaches now enable the extensive characterization of complex genetic networks that mediate behaviours in this important model organism... - The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptomeRobert R H Anholt
The Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
Nat Genet 35:180-4. 2003.... - Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogasterDeepa Sambandan
W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 179:1079-88. 2008.... - Scribble is essential for olfactory behavior in Drosophila melanogasterIndrani Ganguly
The W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
Genetics 164:1447-57. 2003..Expression of Scrib is widespread in olfactory organs and the central nervous system. Finally, alternative splicing of scrib generates transcripts that differ in the number of leucine-rich repeats and PDZ domains... - Pinocchio, a novel protein expressed in the antenna, contributes to olfactory behavior in Drosophila melanogasterStephanie M Rollmann
Department of Zoology, North Carolina State University, Raleigh, 27695 7617, USA
J Neurobiol 63:146-58. 2005..Furthermore, in situ hybridization reveals CG4710 expression in the third antennal segment. We have named this gene of previously unknown function and its product "Pinocchio (Pino)"... - Plasticity of the chemoreceptor repertoire in Drosophila melanogasterShanshan Zhou
Department of Biology, North Carolina State University, Raleigh, North Carolina, United States of America
PLoS Genet 5:e1000681. 2009..This finely pixilated modular organization of the chemosensory subgenome enables fine tuning of the expression of the chemoreceptor repertoire in response to ecologically relevant environmental and physiological conditions... - Alcohol sensitivity in Drosophila: translational potential of systems geneticsTatiana V Morozova
Department of Biology, W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
Genetics 183:733-45, 1SI-12SI. 2009.... - Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogasterDeepa Sambandan
Department of Genetics, the W.M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh 27695-7617, USA
Genetics 174:1349-63. 2006..Our results show that the manifestation of epistatic networks dynamically changes with alterations in the environment... - The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult DrosophilaStephanie M Rollmann
Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 176:947-56. 2007..Our results demonstrate how hypomorphic mutation of an early developmental gene results in genomewide transcriptional consequences and alterations in brain structure accompanied by profound impairment of adult behavior... - Association of polymorphisms in odorant-binding protein genes with variation in olfactory response to benzaldehyde in DrosophilaPing Wang
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 177:1655-65. 2007..Model predictions of alternative pre-mRNA secondary structures associated with polymorphic sites suggest that alterations in Obp mRNA structure could contribute to phenotypic variation in olfactory behavior... - Ain't misbehavin' ? Genotype-environment interactions and the genetics of behaviorTrudy F C Mackay
Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
Trends Genet 23:311-4. 2007..This report, together with studies from Drosophila, stresses the importance of understanding genotype-environment interactions... - Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogasterStephanie M Rollmann
Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
Nat Genet 38:824-9. 2006..Transposon-induced sex-specific and sex-antagonistic effects further accentuate the complex influences that intergenic transposable elements can contribute to quantitative trait phenotypes... - Genetic modules and networks for behavior: lessons from DrosophilaRobert R H Anholt
WM Keck Center for Behavioral Biology and Departments of Zoology and Genetics, North Carolina State University, Raleigh, NC 27695 7617, USA
Bioessays 26:1299-306. 2004..Such networks are exquisitely sensitive to genetic background and sex effects. This review describes how Drosophila can serve as a model for uncovering fundamental principles of the genetic architecture of behavior... - Of flies and man: Drosophila as a model for human complex traitsTrudy F C Mackay
Department of Genetics, North Carolina State University, Raleigh, North Carolina, 27695, USA
Annu Rev Genomics Hum Genet 7:339-67. 2006.... - Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structureStephanie M Rollmann
Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
Genetics 179:1327-36. 2008.... - Impaired olfactory behavior in mice deficient in the alpha subunit of G(o)Alice H Luo
W M Keck Center for Behavioral Biology, North Carolina State University, Box 7617, Raleigh, NC 27695 7617, USA
Brain Res 941:62-71. 2002..Thus, Galpha(o) is necessary for the expression of olfactory behavior under normal conditions and dependent on genetic background, but is not essential for the formation and maintenance of glomeruli... - Natural variation in odorant recognition among odorant-binding proteins in Drosophila melanogasterPing Wang
Department of Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 184:759-67. 2010..Thus, dual olfactory recognition where OBPs regulate odorant access to receptors may enhance olfactory discrimination... - The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila melanogasterNalini H Kulkarni
The W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
Genetics 161:1507-16. 2002..These results indicate that the DSC1 channel contributes to processing of olfactory information during the olfactory avoidance response... - Systems genetics of complex traits in Drosophila melanogasterJulien F Ayroles
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Nat Genet 41:299-307. 2009..Overlapping transcripts in modules associated with different traits provide insight into the molecular basis of pleiotropy between complex traits... - Neurogenetic networks for startle-induced locomotion in Drosophila melanogasterAkihiko Yamamoto
Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
Proc Natl Acad Sci U S A 105:12393-8. 2008..We find that behavioral and neuroanatomical phenotypes are determined by a common set of genes that are organized as partially overlapping genetic networks... - Vanaso is a candidate quantitative trait gene for Drosophila olfactory behaviorJuan José Fanara
W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh 27695, USA
Genetics 162:1321-8. 2002.... - Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogasterAkihiko Yamamoto
Department of Biology, North Carolina State University, Raleigh, NC, USA
Genet Res (Camb) 91:373-82. 2009.... - Understanding the neurogenetics of sleep: progress from DrosophilaSusan T Harbison
Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
Trends Genet 25:262-9. 2009..Advances in systems genetics coupled with the ability to target specific brain regions enable the characterization of transcriptional networks and neural circuits contributing to phenotypic variation in sleep... - Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucomaMary Anna Carbone
Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
PLoS ONE 4:e4216. 2009..This process could occur at a late age with wild-type MYOC, but might be accelerated by MYOC mutants to account for juvenile onset glaucoma... - Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC)TERESA BORRAS
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Genetics 163:637-45. 2003..Our observations establish the Drosophila eye as an advantageous system for the discovery of genes that are associated with glaucoma...
Research Grants
- Molecular Genetics of Olfaction in DrosophiliaROBERT ANHOLT; Fiscal Year: 2009..abstract_text> ..
- Molecular Genetics of Olfaction in DrosophiliaRobert R H Anholt; Fiscal Year: 2010....
- Comparative Genomics of GlaucomaROBERT ANHOLT; Fiscal Year: 2007..abstract_text> ..
- MOLECULAR GENETICS OF OLFACTION IN DROSOPHILAROBERT ANHOLT; Fiscal Year: 2006..The completion of these specific aims will lead to a greater, more comprehensive understanding of the genetic architecture of olfactory behavior. ..
- MOLECULAR GENETICS OF OLFACTION IN DROSOPHILAROBERT ANHOLT; Fiscal Year: 2002..The isolated gene will be expressed in the baculovirus system and if the gene resembles a receptor, the odorant-induced, second messengers will be examined in the Sf9 cells that are used to express the gene in baculovirus. ..
- Molecular Genetics of Olfaction in DrosophiliaROBERT ANHOLT; Fiscal Year: 2009....