North Carolina State University

..Photostimulation of fully photosensitive hens for a typical production period can occur as early as 24 wk of age. We demonstrated that the conventional age at lighting of 29 to 30 wk of age can be significantly advanced...

..However, the genetic basis of this complex behavior is largely uncharacterized...

..The use of the MF in combination with a classic LFER based on penetrant properties significantly improved the ability to predict dermal absorption of compounds dosed in complex chemical mixtures...

..Thus, our findings do not eliminate the possibility that different strains are in fact 'subspecies' or lower taxa, which may also differ in pathogenic and immunogenic characteristics, environmental tolerance, and other features...

..Concomitant changes in egg weight in the 2 selected lines appear to have resulted in maternal effects that have significantly affected neonatal BW and digestive system maturation...

..Prospective molecular epidemiological studies are necessary to characterize the risk of human Bartonella quintana infection following cat bites...

..Results of this study showed the potential of DRAINMOD-N II for predicting N losses from drained agricultural lands. Further research is needed to test the model for different management practices and soil and climatological conditions...

..Despite increased attention to the role of imported produce in foodborne disease, this study does not support the assumption that domestic produce is of higher microbial quality than Mexican produce...

..To determine the feasibility, safety, and effectiveness of an episcleral or deep scleral lamellar sustained release cyclosporine (CsA) device in a naturally occurring animal model of uveitis...

..Using this method, 4-(dimethylphenylsilyl)nicotine was prepared and oxidized to afford (S)-4-hydroxynicotine...

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..These regions may contain genes involved in the synthesis of cellulose, hemicellulose, and lignin in the leaf-blades and leaf-sheaths of maize...

..9993. The device functions equivalently over a wide range of flow rates. The standard deviation of dilution values averages 0.76% over six flow rates spanning 0.5 to 16 microl min(-1)...

..Either IgE autoreactivity is not associated with moderate to severe AD in dogs, or the methods employed herein were not sensitive enough to permit IgE autoantibody detection...

..Toll-like receptors are the link between the innate and adaptive immune response, and are likely key components of the response of ocular tissue to infectious organisms and in the initiation and perpetuation of autoimmune disease...

..Other candidate genes such as those coding for pheromone binding proteins did not map to this QTL, but there was some genetic evidence of a QTL for response to Z11-16:OH associated with a sensory neuron membrane protein gene...

..To critically review and collate published information on feline degenerative joint disease (DJD) and identify areas in which information is lacking...

..The improvement of quality of life has the potential to benefit the individuals with neurological disabilities and those whose lives overlap and intersect with those individuals...

..05) numbers of coliforms and E. coli were recovered from the dorsal carcass half compared with the ventral half. Bacterial counts of broiler carcasses are affected by both the sampling method used and by carcass location sampled...

..Here we present evidence from nucleotide sequences of six single-copy nuclear protein coding genes used to reconstruct phylogenetic relationships and estimate evolutionary divergence times for all holometabolan orders...

..The absence of threat effects when constraints were minimal provides important boundary information regarding stereotype influences on memory performance...

..This suggests that the primary evolutionary impact of self-incompatibility systems may be to prevent selfing, and prevention of biparental inbreeding might be a beneficial side-effect...

..77 and p = 0.11). Together, these data suggest both COX-2 and 5-LOX are appropriate targets for the management of pain associated with naturally occurring OA...

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..Evolutionary forces causing hybrid sterility or inviability act on the responsible genes while they still are polymorphic, thus we have to study these traits as they arise, before isolation is complete...

..Secondary acute anterior uveitis and hyphema were most likely due to trauma within the primary enclosure...

..The optimal sampling strategy may use 2 sampling methods together in 1 overall sampling plan: limited mark-recapture sampling to estimate survival and detection probabilities and frequent but less expensive transect counts...

..In these cases, eliminating one of these markers from the set to be genotyped in an association study will lead to a reduction in overall power...

..Eight CCR homologous genes were identified in the P. trichocarpa genome and their expression profiling suggests that they may function differentially...

..Although accessible online, analyses of multiple genes are time consuming and are not suitable for analyzing data sets that are proprietary...

..Unlike in humans, there is no correlation between circulating and cell bound IgE. Furthermore, high levels of IgE in the dog may be related to a greater number of B cells in the circulation committed to IgE production...

..Results of this study show that measurement of equine TSH in conjunction with thyroid hormone measurement differentiated normal and hypothyroid horses in this model of equine hypothyroidism...

..The reduction in ammonia emission, though, does not correspond to the reduction in urinary pH but corresponds to the reduction in fecal pH as a result of mixing the urine and feces, in which feces act as a strong buffer...

..Independent analyses based on exon-intron structure suggested that a neighbor-joining tree was more accurate than maximum-likelihood trees obtained using the quartet puzzling algorithm...

..It reviews the important properties of the latest induction and inhalation agents, and stresses the need for continuous monitoring of the anesthetized patient...

..To document the use and clinical outcome of transendoscopic laser techniques for treatment of rostral displacement of the palatopharyngeal arch (RDPA) in horses...

..However, these effects do occur at sufficiently low levels to warrant evaluation of the relative susceptibility of other crustacean species to this previously uncharacterized mode of toxicity...

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..These oligonucleotides demonstrate that modifications have measurable thermodynamic contributions and that loop modifications have global contributions...

..There is evidence that some undesirable behaviors and poor fertility may arise from inadequate rearing nutrition and that nutrition can influence the development of certain behaviors...

..The focus of this review is to put these different mechanisms in perspective and relate them to the drug and skin model system being investigated...

..Self-feeding would reduce the labor costs of hand feeding and could provide backgrounders with a program to expand cattle numbers on a limited land base...

..zea do not originate from cotton-feeding larvae and may be migrants from Mexico. Non-Bt corn in Mexico and the U.S. corn belt appears to serve as an important refuge for H. zea...

..The assessment of percutaneous absorption of phenol found the PEG 400, 70% IPA, and 15-min water treatments significantly (P < 0.05) reduced phenol absorption relative to no treatment...

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..A greater understanding of the molecular mechanisms is clearly needed for designing effective treatment and prevention strategies of catamenial epilepsy in women at risk...

..Altogether, results of these studies provide evidence supporting the hypothesis that canine VCLE is an immunological homologue of subacute cutaneous lupus erythematosus in humans...

..Class I integrons were also common among various serovars...

..The findings further imply that slaughter plant studies based on phenotyping of Salmonella alone (such as serovars) may not reliably indicate the Salmonella status of commercial swine farms...

..These studies provide strong evidence that the PR is not required for the antiseizure effects of progesterone, which mainly occurs through its conversion to the neurosteroid allopregnanolone...

..The approximation in L(p)(micro)(1 < or = p < infinity) space is also discussed. Some experimental results are reported to illustrate our findings...

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..The purpose of this study was to apply nucleic acid sequence-based amplification (NASBA) for the detection of Salmonella enterica serovar Enteritidis (S. Enteritidis) in representative foods...

..We propose that a complete understanding of branching morphogenesis requires measurements of the mechanical aspects...

..Although increases in soy and corn-specific serum IgE concentrations were measured in individual dogs post challenge they were not statistically significant and could not be used to predict clinical hypersensitivity...

..Rather, I have summarized some salient research accomplishments made by our research group over the years in the area of avian macrophage biology and function...

..These observations confirm the modest efficacy of misoprostol for treatment of canine AD and suggest that its mild anti-allergic effects are not associated with either inhibition of inflammatory cell emigration or TNFalpha production...

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..The experiments proposed in this application will help develop a novel animal model for testing specific therapies for catamenial epilepsy, which is not successfully treated currently with conventional seizure control medications. ..

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..parvum infection. The PI is presently in the 3rd year of a 5-year K08 from NIDDK. These studies are anticipated to generate key preliminary data for the PI's first R01 application ..

..Given the evolutionary conservation of function for fundamental traits, such as aggression, genes and pathways discovered in model organisms can be incorporated as candidate genes in human linkage and association studies. ..

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..Identification of new genes affecting Drosophila behaviors will enrich our understanding of the network of genetic interactions required to produce these complex traits. ..

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..The insight into general principles of genotype-phenotype relationships will be applicable to human disease. ..

..Trainees will receive formal training in ethics and professional development, including oral scientific presentation, and will participate in an annual student symposium as part of the training program. ..

..The insight into general principles of genotype-phenotype relationships will be applicable to human disease. ..

..abstract_text> ..

..The insight into general principles of genotype-phenotype relationships will be applicable to human disease. ..

..Given the evolutionary conservation of function for fundamental traits, such as aggression, genes and pathways discovered in model organisms can be incorporated as candidate genes in human linkage and association studies. ..

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..Finally, they shall fine-map QTLs causing response to selection from segregating variation and from new mutations, using a set of overlapping deficiencies covering 70 percent of the Drosophila genome. ..

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..Restriction map variation will be determined for the nine loci, and associations between molecular polymorphisms and phenotypic effects will be examined...

..Associations between phenotypic variation and molecular polymorphisms will be assessed. ..

..This, in turn, should serve to boost well-being in later life. ..

..e., mood regulation) that is maintained with age and that is associated with memory may give insight to factors associated with independent functioning in later life. ..

..e., mood regulation) that is maintained with age and that is associated with memory may give insight to factors associated with independent functioning in later life. ..

..This should also facilitate our ability to structure environments to maximize adaptation to the aging process. ..

..It is hoped that the results of this research will provide a clearer understanding of the cognitive skills of older adults as they pertain to social behavior...