Seth D Norrholm

Summary

Country: USA

Publications

  1. pmc Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters
    Dennis K Miller
    College of Pharmacy, University of Kentucky, Lexington, KY, 40536 0082, USA
    J Pharmacol Exp Ther 310:1035-45. 2004
  2. pmc Tailoring therapeutic strategies for treating posttraumatic stress disorder symptom clusters
    Seth D Norrholm
    Atlanta VA Medical Center, Mental Health Service Line, Decatur, GA, USA
    Neuropsychiatr Dis Treat 6:517-32. 2010
  3. pmc Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder
    Seth Davin Norrholm
    Mental Health Service Line, Atlanta VA Medical Center Decatur, GA, USA Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine Atlanta, GA, USA
    Front Behav Neurosci 7:30. 2013
  4. pmc Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Learn Mem 13:681-5. 2006
  5. pmc The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes
    Seth D Norrholm
    College of Pharmacy, Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536 0082, USA
    Neuropharmacology 53:982-9. 2007
  6. pmc Timing of extinction relative to acquisition: a parametric analysis of fear extinction in humans
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Behav Neurosci 122:1016-30. 2008
  7. pmc Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA
    Cortex 49:1884-91. 2013
  8. pmc Childhood abuse is associated with increased startle reactivity in adulthood
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Depress Anxiety 26:1018-26. 2009
  9. pmc Dark-enhanced startle responses and heart rate variability in a traumatized civilian sample: putative sex-specific correlates of posttraumatic stress disorder
    Asante Kamkwalala
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
    Psychosom Med 74:153-9. 2012
  10. pmc Posttraumatic stress disorder may be associated with impaired fear inhibition: relation to symptom severity
    Tanja Jovanovic
    Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Psychiatry Res 167:151-60. 2009

Collaborators

Detail Information

Publications29

  1. pmc Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters
    Dennis K Miller
    College of Pharmacy, University of Kentucky, Lexington, KY, 40536 0082, USA
    J Pharmacol Exp Ther 310:1035-45. 2004
    ....
  2. pmc Tailoring therapeutic strategies for treating posttraumatic stress disorder symptom clusters
    Seth D Norrholm
    Atlanta VA Medical Center, Mental Health Service Line, Decatur, GA, USA
    Neuropsychiatr Dis Treat 6:517-32. 2010
    ..Finally, the review will also address potential genetic approaches to treatment as another form of individualized treatment...
  3. pmc Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder
    Seth Davin Norrholm
    Mental Health Service Line, Atlanta VA Medical Center Decatur, GA, USA Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine Atlanta, GA, USA
    Front Behav Neurosci 7:30. 2013
    ....
  4. pmc Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Learn Mem 13:681-5. 2006
    ..This is the first demonstration of fear extinction and reinstatement in humans using startle measures...
  5. pmc The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes
    Seth D Norrholm
    College of Pharmacy, Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536 0082, USA
    Neuropharmacology 53:982-9. 2007
    ..These findings have important implications regarding the analysis of monoaminergic reuptake in brain regions exhibiting heterogeneous transporter expression...
  6. pmc Timing of extinction relative to acquisition: a parametric analysis of fear extinction in humans
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Behav Neurosci 122:1016-30. 2008
    ..Thus, the results remain inconclusive regarding spontaneous recovery and the timing of extinction and are discussed in terms of performing translational studies of fear in humans...
  7. pmc Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA
    Cortex 49:1884-91. 2013
    ..The current study aimed to see whether neural activation during inhibition was reduced in a highly traumatized civilian population, and whether atypical activation was associated with impaired fear inhibition...
  8. pmc Childhood abuse is associated with increased startle reactivity in adulthood
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Depress Anxiety 26:1018-26. 2009
    ..The acoustic startle response (ASR) is a subcortical reflex modulated by neural systems implicated in posttraumatic stress disorder (PTSD). The ASR is conserved across species and is increased in rodent models of developmental stress...
  9. pmc Dark-enhanced startle responses and heart rate variability in a traumatized civilian sample: putative sex-specific correlates of posttraumatic stress disorder
    Asante Kamkwalala
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
    Psychosom Med 74:153-9. 2012
    ..5 times larger in men than in women...
  10. pmc Posttraumatic stress disorder may be associated with impaired fear inhibition: relation to symptom severity
    Tanja Jovanovic
    Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Psychiatry Res 167:151-60. 2009
    ..However, the high-symptom PTSD group did not show fear inhibition: these subjects had significantly greater fear potentiation on the AB trials than both the controls and the low-symptom PTSD patients...
  11. pmc Tools for translational neuroscience: PTSD is associated with heightened fear responses using acoustic startle but not skin conductance measures
    EBONY M GLOVER
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Depress Anxiety 28:1058-66. 2011
    ..However, many PTSD studies using the skin conductance response (SCR) report no group differences in fear acquisition...
  12. pmc Fear potentiation is associated with hypothalamic-pituitary-adrenal axis function in PTSD
    Tanja Jovanovic
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, United States
    Psychoneuroendocrinology 35:846-57. 2010
    ..These results suggest that impaired fear inhibition and associated alterations in HPA feedback may reflect amygdala hyperactivity in subjects with PTSD...
  13. pmc Fear extinction in traumatized civilians with posttraumatic stress disorder: relation to symptom severity
    Seth D Norrholm
    Atlanta Veterans Affairs Medical Center, Mental Health Service Line, Decatur, Georgia, USA
    Biol Psychiatry 69:556-63. 2011
    ..On the basis of our earlier findings, we employed an established fear extinction paradigm to further explore fear dysregulation in a civilian traumatized population...
  14. pmc Contingency awareness and fear inhibition in a human fear-potentiated startle paradigm
    Tanja Jovanovic
    Mental Health Service 116A, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Behav Neurosci 120:995-1004. 2006
    ..A response keypad was used to assess contingency awareness on a trial-by-trial basis. Both aware and unaware subjects showed fear-potentiated startle. However, awareness was related to stimulus discrimination and fear inhibition...
  15. pmc Acute stress disorder versus chronic posttraumatic stress disorder: inhibition of fear as a function of time since trauma
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Depress Anxiety 30:217-24. 2013
    ..This is the first study to use a conditioned inhibition paradigm with traumatized individuals within a month of trauma exposure. We hypothesized that impaired fear inhibition would be evident in PTSD, but not ASD...
  16. pmc Cortisol suppression by dexamethasone reduces exaggerated fear responses in posttraumatic stress disorder
    Tanja Jovanovic
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, United States
    Psychoneuroendocrinology 36:1540-52. 2011
    ..46, p=0.01. These results suggest that transient suppression of HPA function via dexamethasone suppression may reduce exaggerated fear in patients with PTSD...
  17. pmc Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters
    Marhaba Hojahmat
    College of Pharmacy, University of Kentucky, Rose Street, Lexington, KY 40536 0082, USA
    Bioorg Med Chem 18:640-9. 2010
    ..5-fold selectivity for VMAT2 over alpha4beta2 nAChRs. Thus, esterification of the lobeline molecule may be a useful structural modification for the development of lobeline analogs with improved selectivity at VMAT2...
  18. pmc Altered resting psychophysiology and startle response in Croatian combat veterans with PTSD
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30303, USA
    Int J Psychophysiol 71:264-8. 2009
    ..Startle habituation and baseline heart-rate appear to offer the most reliable psychophysiological indices of PTSD. This finding replicates trends in the literature in a new population of PTSD patients...
  19. pmc Impaired fear inhibition is a biomarker of PTSD but not depression
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303
    Depress Anxiety 27:244-51. 2010
    ..Given the high comorbidity between PTSD and depression, our goal was to see whether this impairment is specific to PTSD, or a non-specific symptom associated with both disorders...
  20. pmc Estrogen levels are associated with extinction deficits in women with posttraumatic stress disorder
    EBONY M GLOVER
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Biol Psychiatry 72:19-24. 2012
    ..Low estrogen in naturally cycling women is associated with deficits in fear extinction. On the basis of these findings, we have now examined the influence of estrogen levels on fear extinction in women with and without PTSD...
  21. pmc Physiological markers of anxiety are increased in children of abused mothers
    Tanja Jovanovic
    Emory University School of Medicine, Dept of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, USA
    J Child Psychol Psychiatry 52:844-52. 2011
    ..The current study employed psychophysiological methods to describe biomarkers of anxiety in children of traumatized mothers...
  22. pmc Inhibition of fear is differentially associated with cycling estrogen levels in women
    EBONY M GLOVER
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    J Psychiatry Neurosci 38:341-8. 2013
    ....
  23. pmc Acoustic startle reduction in cocaine dependence persists for 1 year of abstinence
    Sarah Corcoran
    Mental Health Service, Atlanta VA Medical Center, Decatur, GA 30033, USA
    Psychopharmacology (Berl) 215:93-103. 2011
    ....
  24. pmc PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus
    Jennifer Strafford Stevens
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 111:3158-63. 2014
    ..Individual differences in ADCYAP1R1 genotype may contribute to dysregulated fear circuitry known to play a central role in PTSD and other anxiety disorders. ..
  25. pmc meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release
    David B Horton
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    J Pharmacol Exp Ther 336:940-51. 2011
    ....
  26. pmc Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter
    Guangrong Zheng
    College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    J Med Chem 48:5551-60. 2005
    ....
  27. pmc Differences in startle reflex and prepulse inhibition in European-Americans and African-Americans
    Wendy Hasenkamp
    Atlanta Department of Veterans Affairs Medical Center, Atlanta, Georgia, USA
    Psychophysiology 45:876-82. 2008
    ..These findings support the idea of racial differences in startle response. Implications for study design are highlighted, and possible environmental and genetic influences are considered...
  28. pmc Versatility of fear-potentiated startle paradigms for assessing human conditioned fear extinction and return of fear
    Seth D Norrholm
    Trauma Recovery Program, Mental Health Service Line, Atlanta Veterans Affairs Medical Center Decatur, GA, USA
    Front Behav Neurosci 5:77. 2011
    ..We discuss the current results as they relate to future investigations of PTSD-related impairments in fear processing in populations with diverse medical and psychiatric histories...
  29. pmc PTSD and gene variants: new pathways and new thinking
    Kelly Skelton
    Atlanta VA Medical Center, 1670 Clairmont Rd, Decatur, GA 30033, USA
    Neuropharmacology 62:628-37. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...