Research Topics
| A ZychlinskySummaryAffiliation: New York University Country: USA Publications
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Detail Information
Publications
Apoptosis as a proinflammatory event: what can we learn from bacteria-induced cell death?A Zychlinsky
Dept of Microbiology, New York University School of Medicine, NY 10016, USA
Trends Microbiol 5:201-4. 1997..Bacteria-induced apoptosis appears to promote an inflammatory response that causes tissue damage and further bacterial colonization. Shigella pathogenesis offers a paradigm for the role of apoptosis in bacterial infections...- Toll-like receptor-2 transduces signals for NF-kappa B activation, apoptosis and reactive oxygen species productionA O Aliprantis
Skirball Institute and Department of Microbiology, New York University School of Medicine, New York 10016, USA
J Endotoxin Res 7:287-91. 2001..We propose that Toll-like receptor-2 fulfils multiple roles in the genesis of the immune response to bacterial pathogens... - Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2A O Aliprantis
Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Science 285:736-9. 1999..Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms... 
In vivo apoptosis in Shigella flexneri infectionsA Zychlinsky
The Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
Infect Immun 64:5357-65. 1996..Macrophages, T cells, and B cells are shown to undergo apoptosis in vivo. These results indicate that apoptosis may play a crucial role in the pathogenesis of shigellosis...- Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosisH Hilbi
The Skirball Institute, Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, New York, New York 10016, USA
Infect Immun 68:5502-8. 2000..TPPII was also found to be involved in apoptosis induced by ATP and the protein kinase inhibitor staurosporine. We propose that TPPII participates in apoptotic pathways... - How bacteria initiate inflammation: aspects of the emerging storyD Hersh
Department of Microbiology, The Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
Curr Opin Microbiol 1:43-8. 1998..There is therefore much greater diversity in the class of molecules and mechanisms by which bacteria engage the host immune system than previously appreciated... - The apoptotic signaling pathway activated by Toll-like receptor-2A O Aliprantis
Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 1001, USA
EMBO J 19:3325-36. 2000..These results indicate that caspase activation is an innate immune response to microbial pathogens, culminating in apoptosis and cytokine production... - The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneriJ E Moss
Skirball Institute and Department of Microbiology, New York University Medical Center, NY 10016, USA
Cell Microbiol 2:443-52. 2000..PhoP appears to regulate Shigella susceptibility to PMNs and antimicrobial molecules that are important for the late stages of infection with this enteric bacterium... - Release of Toll-like receptor-2-activating bacterial lipoproteins in Shigella flexneri culture supernatantsA O Aliprantis
Skirball Institute and Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
Infect Immun 69:6248-55. 2001..The activation of apoptosis by BLP shed from S. flexneri is discussed as a novel aspect of the interaction of bacteria with the host... - A bacterial invasin induces macrophage apoptosis by binding directly to ICEY Chen
Skirball Institute, Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
EMBO J 15:3853-60. 1996..We found that IpaB binds directly to ICE and this enzyme is activated during S. flexneri infection. Furthermore, specific inhibitors of ICE prevented Shigella-induced apoptosis... - The selC-associated SHI-2 pathogenicity island of Shigella flexneriJ E Moss
Skirball Institute, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
Mol Microbiol 33:74-83. 1999..flexneri strains tested and parts of the island were also found in other Shigella species. SHI-2 may allow Shigella survival in stressful environments, such as those encountered during infection... - IpaB, a Shigella flexneri invasin, colocalizes with interleukin-1 beta-converting enzyme in the cytoplasm of macrophagesK Thirumalai
The Skirball Institute, New York University School of Medicine, New York 10016, USA
Infect Immun 65:787-93. 1997..In double-labeling experiments, we show that IpaB and ICE colocalize in the cytoplasm of the macrophage, suggesting that soon after secretion, IpaB binds to ICE to initiate apoptosis and to promote the cleavage of IL-1 beta... - Pathogenicity islands of ShigellaM Ingersoll
Skirball Institute and Department of Microbiology, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
Curr Top Microbiol Immunol 264:49-65. 2002 - The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1D Hersh
Skirball Institute, Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Proc Natl Acad Sci U S A 96:2396-401. 1999..Taken together, the data demonstrate that SipB functions as an analog of the Shigella invasin IpaB... - Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaBH Hilbi
Skirball Institute, Department of Microbiology and Kaplan Cancer Center, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 273:32895-900. 1998..Taken together these data indicate that Shigella-induced apoptosis is distinct from other forms of apoptosis and seems uniquely dependent on Casp-1...