EDWARD ZIFF

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity
    Yafell Serulle
    Program in Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA
    Channels (Austin) 2:230-2. 2008
  2. pmc Getting to synaptic complexes through systems biology
    Bryen A Jordan
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Genome Biol 7:214. 2006
  3. ncbi request reprint TARPs and the AMPA receptor trafficking paradox
    Edward B Ziff
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Neuron 53:627-33. 2007
  4. ncbi request reprint Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein AMPA receptor-binding protein complexes
    Joshua B Silverman
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:8505-16. 2007
  5. ncbi request reprint PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking
    Wei Lu
    Program in Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:407-21. 2005
  6. ncbi request reprint Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons
    Bryen A Jordan
    Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Nat Neurosci 10:427-35. 2007
  7. ncbi request reprint Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters
    Sunita DeSouza
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 22:3493-503. 2002
  8. ncbi request reprint NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex
    Jonathan G Hanley
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Neuron 34:53-67. 2002
  9. pmc A GluR1-cGKII interaction regulates AMPA receptor trafficking
    Yafell Serulle
    Program in Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA
    Neuron 56:670-88. 2007
  10. ncbi request reprint Intracellular membrane targeting and suppression of Ser880 phosphorylation of glutamate receptor 2 by the linker I-set II domain of AMPA receptor-binding protein
    Jie Fu
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 23:7592-601. 2003

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity
    Yafell Serulle
    Program in Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA
    Channels (Austin) 2:230-2. 2008
    ..Moreover, our study indicates that the interaction of cGKII with GluR1, which is under the regulation of the NMDAR and NO, plays an important role in hippocampal plasticity...
  2. pmc Getting to synaptic complexes through systems biology
    Bryen A Jordan
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Genome Biol 7:214. 2006
    ....
  3. ncbi request reprint TARPs and the AMPA receptor trafficking paradox
    Edward B Ziff
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Neuron 53:627-33. 2007
    ..This review considers how transmembrane AMPAR regulatory proteins (TARPs), a novel family of AMPAR auxiliary subunits, have changed our view of AMPAR transport and raised some perplexing questions...
  4. ncbi request reprint Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein AMPA receptor-binding protein complexes
    Joshua B Silverman
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:8505-16. 2007
    ..Thus, the interaction of scaffolding proteins with cadherin-NPRAP complexes may anchor diverse signaling and adhesion molecules at cadherins...
  5. ncbi request reprint PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking
    Wei Lu
    Program in Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:407-21. 2005
    ..We suggest that the PICK1 interaction with ABP/GRIP is a critical step in controlling GluR2 trafficking...
  6. ncbi request reprint Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons
    Bryen A Jordan
    Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Nat Neurosci 10:427-35. 2007
    ..We propose that AIDA-1d mediates a link between synaptic activity and control of protein biosynthetic capacity by regulating nucleolar assembly...
  7. ncbi request reprint Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters
    Sunita DeSouza
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 22:3493-503. 2002
    ..We suggest that pABP-L and ABP-L provide, respectively, synaptic and intracellular sites for the anchorage of AMPA receptors during receptor trafficking to and from the synapse...
  8. ncbi request reprint NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex
    Jonathan G Hanley
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Neuron 34:53-67. 2002
    ..This demonstrates that the previously reported synaptic stabilization of AMPARs by NSF involves disruption of GluR2-PICK1 interactions. Furthermore, we are reporting a non-SNARE substrate for NSF disassembly activity...
  9. pmc A GluR1-cGKII interaction regulates AMPA receptor trafficking
    Yafell Serulle
    Program in Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA
    Neuron 56:670-88. 2007
    ..This work identifies a pathway, downstream from the NMDA receptor (NMDAR) and nitric oxide (NO), which stimulates GluR1 accumulation in the plasma membrane and plays an important role in synaptic plasticity...
  10. ncbi request reprint Intracellular membrane targeting and suppression of Ser880 phosphorylation of glutamate receptor 2 by the linker I-set II domain of AMPA receptor-binding protein
    Jie Fu
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 23:7592-601. 2003
    ..Receptors in such a pool may contribute to receptor endocytotic and exocytotic trafficking and recycling...
  11. pmc Stable synaptic retention of serine-880-phosphorylated GluR2 in hippocampal neurons
    Bradley A States
    Department of Biochemistry, NYU School of Medicine, NY, USA
    Mol Cell Neurosci 38:189-202. 2008
    ..Our results demonstrate a population of hippocampal AMPARs which do not require interaction with GRIP/ABP for synaptic anchorage...
  12. ncbi request reprint Membrane localization of membrane type 5 matrix metalloproteinase by AMPA receptor binding protein and cleavage of cadherins
    Sara Monea
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 26:2300-12. 2006
    ....
  13. ncbi request reprint NMDA receptor regulation of nNOS phosphorylation and induction of neuron death
    Gerald A Rameau
    Department of Biochemistry, Howard Hughes Medical Institute, NYU School of Medicine, New York, NY 10016, USA
    Neurobiol Aging 24:1123-33. 2003
    ..We conclude that NMDA receptor activation induces death of neurons by a cell autonomous pathway involving nNOS dephosphorylation by a calcineurin-dependent mechanism...
  14. pmc Regulation of synaptic structure and function by palmitoylated AMPA receptor binding protein
    Charu Misra
    Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell Neurosci 43:341-52. 2010
    ..Thus postsynaptic pABP-L induces pre and postsynaptic changes that are dependent on palmitoylation and likely achieved through ABP association with a multi-molecular cell surface signaling complex...
  15. ncbi request reprint RNA editing at arg607 controls AMPA receptor exit from the endoplasmic reticulum
    Ingo H Greger
    Howard Hughes Medical Institute, Department of Biochemistry, NYU School of Medicine, New York 10016, USA
    Neuron 34:759-72. 2002
    ..Therefore, Arg607 is a central regulator. In addition to channel gating, it also controls ER exit and may thereby ensure the availability of GluR2 for assembly into AMPARs...
  16. ncbi request reprint Receptor trafficking and the plasticity of excitatory synapses
    Michael F Barry
    Howard Hughes Medical Institute, Department of Biochemistry, New York University Medical Center, New York, New York 10016, USA
    Curr Opin Neurobiol 12:279-86. 2002
    ..Moreover, phosphorylation may play an important role in receptor transport and synaptic turnover...
  17. ncbi request reprint Identification and verification of novel rodent postsynaptic density proteins
    Bryen A Jordan
    Department of Biochemistry, New York University, School of Medicine, NY 10016, USA
    Mol Cell Proteomics 3:857-71. 2004
    ..These results suggest new mechanisms by which the PSD helps regulate synaptic strength and transmission...
  18. ncbi request reprint Bidirectional regulation of neuronal nitric-oxide synthase phosphorylation at serine 847 by the N-methyl-D-aspartate receptor
    Gerald A Rameau
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 279:14307-14. 2004
    ..These mechanisms may share pathways, respectively, with NMDA receptor-induced forms of synaptic plasticity and excitotoxicity...
  19. ncbi request reprint AMPA receptor tetramerization is mediated by Q/R editing
    Ingo H Greger
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Neuron 40:763-74. 2003
    ..Therefore, a single amino acid residue affects channel composition and, in turn, controls ion conduction through the majority of AMPARs in the brain...
  20. ncbi request reprint AMPA receptors do the electric slide
    Sunita DeSouza
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Sci STKE 2002:pe45. 2002
    ....
  21. pmc Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development
    Yukio Akaneya
    Department of Biochemistry, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e12486. 2010
    ..Members of the ephrin-A family are glycosyl-phosphatidylinositol-anchored to the cell surface and activate EphA receptors, which are receptor tyrosine kinases...
  22. ncbi request reprint Ca2+-dependent formation of a dynamin-synaptophysin complex: potential role in synaptic vesicle endocytosis
    Christopher Daly
    Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical Center, New York, New York 10016, USA
    J Biol Chem 277:9010-5. 2002
    ..GTP binding releases dynamin from synaptophysin, possibly serving to regulate dynamin selfassembly during endocytosis. Our results suggest that synaptophysin plays a role in SV recycling by recruiting dynamin to the vesicle membrane...
  23. ncbi request reprint Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death
    Gerald A Rameau
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 27:3445-55. 2007
    ..These findings suggest a critical role for a kinetically complex and novel series of regulatory nNOS phosphorylations induced by the NMDA receptor for the in vivo control of nNOS...
  24. ncbi request reprint Developmentally regulated, combinatorial RNA processing modulates AMPA receptor biogenesis
    Ingo H Greger
    Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Neuron 51:85-97. 2006
    ..Therefore, RNA editing sites, located at strategic subunit interfaces, shape AMPA-R assembly and trafficking in a developmentally regulated manner...
  25. ncbi request reprint Molecular determinants of AMPA receptor subunit assembly
    Ingo H Greger
    MRC Laboratory of Molecular Biology, Neurobiology Division, Cambridge CB2 2QH, UK
    Trends Neurosci 30:407-16. 2007
    ..These processes ultimately determine the size and shape of the postsynaptic response, and are the subject of this review...
  26. ncbi request reprint Analysis of human neuropeptide FF gene expression
    Johanna M Nystedt
    Department of Biology, Abo Akademi University, BioCity, Turku, Finland
    J Neurochem 82:1330-42. 2002
    ..We postulate that control of human NPFF gene expression is the result of both positive and negative regulatory elements and the use of multiple transcription initiation sites...
  27. ncbi request reprint Association of the AMPA receptor-related postsynaptic density proteins GRIP and ABP with subsets of glutamate-sensitive neurons in the rat retina
    Robert Gabriel
    Department of General Zoology and Neurobiology, University of Pecs, H 7604 Pécs, Hungary
    J Comp Neurol 449:129-40. 2002
    ..Our results show that ABP and GRIP colocalize with GluR2/3 in particular subsets of retinal neuron, as was previously established for certain neurons in the brain...
  28. ncbi request reprint EphB2 gets a GRIP on the dendritic arbor
    Charu Misra
    Nat Neurosci 8:848-50. 2005

Research Grants2

  1. AMPA Receptor Trafficking and Signaling Complexes
    EDWARD ZIFF; Fiscal Year: 2007
    ..These studies are pertinent to normal mechanisms of learning and to learning disabilities that occur during aging or as a result of neural degeneration or genetic mutation. ..