Research Topics
Genomes and Genes | Hua ZhuSummaryAffiliation: New Jersey Country: USA Publications
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Publications
Caveolae/caveolin-1 are important modulators of store-operated calcium entry in Hs578/T breast cancer cellsHua Zhu
The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick 08901, USA
J Pharmacol Sci 106:287-94. 2008..Our results suggest alteration of SOCE by caveolin-1 expression changes could be one of the mechanisms contributing to the progression of breast cancer...
Involvement of Caveolin-1 in repair of DNA damage through both homologous recombination and non-homologous end joiningHua Zhu
Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, United States of America
PLoS ONE 5:e12055. 2010..By acting as a scaffolding protein, Cav-1 plays crucial roles in the regulation of various physiologic and patho-physiologic processes including oncogenic transformation and tumorigenesis, and tumor invasion and metastasis...- Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repairPeihui Lin
Department of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
FASEB J 26:1875-83. 2012..Together, our data reveal NM-IIA as a key cytoskeleton motor protein that facilitates vesicle trafficking during MG53-mediated cell membrane repair... 
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophyNoah Weisleder
Department of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Sci Transl Med 4:139ra85. 2012..Our data support the concept of targeted cell membrane repair in regenerative medicine, and present MG53 protein as an attractive biological reagent for restoration of membrane repair defects in human diseases...- Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagyHao Wu
Department of Pharmacology, Neural and Behavioral Sciences, and the Penn State Cancer Institute, Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
Cancer Res 69:2453-60. 2009.... - ORF7 of varicella-zoster virus is a neurotropic factorAnca Selariu
Department of Microbiology and Molecular Genetics, UMDNJ New Jersey Medical School, Newark, New Jersey, USA
J Virol 86:8614-24. 2012.... - Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repairHua Zhu
Department of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Biol Chem 286:12820-4. 2011..Our data suggest that membrane-delimited interaction between MG53 and PTRF contributes to initiation of cell membrane repair, which can be an attractive target for treatment or prevention of tissue injury in human diseases... - Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cellsHua Zhu
Department of Pharmacology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, United States
Biochem Pharmacol 76:582-8. 2008.... - Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factorZhen Zhang
Department of Microbiology and Molecular Genetics, UMNDJ Newark, Newark, New Jersey, United States of America
PLoS Pathog 6:e1000971. 2010..The global profiling of the VZV genome gives further insights into the replication and pathogenesis of this virus, which can lead to improved prevention and therapy of chicken pox and shingles... - Suppression of P-glycoprotein gene expression in Hs578T/Dox by the overexpression of caveolin-1Hua Zhu
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Dantun Road 15, Chaoyang District, Beijing 100101, China
FEBS Lett 576:369-74. 2004..Taken together, our results indicate that such suppression of P-gp in the transfectants overexpressing caveolin-1 may occur at the transcriptional level... - Overexpression of caveolin-1 increases plasma membrane fluidity and reduces P-glycoprotein function in Hs578T/DoxChuanxi Cai
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Biochem Biophys Res Commun 320:868-74. 2004..Our data demonstrate for the first time that the reduction of the plasma membrane cholesterol level induced by overexpressing caveolin-1 may indirectly inhibit P-gp transport activity by increasing plasma membrane fluidity... - Growth suppression of MCF-7 cancer cell-derived xenografts in nude mice by caveolin-1Ping Wu
Center for Systems Biology, Institute of Biophysics, Chinese Academy of Sciences, Datun Road 15, Chaoyang District, Beijing 100101, China
Biochem Biophys Res Commun 376:215-20. 2008..Our current findings provide for the first time in vivo evidence that caveolin-1 can indeed function as a tumor suppressor in human breast adenocarcinoma derived from MCF-7 cells rather than as a tumor promoter... - [Screening of highly effective siRNA sequence targeting to HIV-1 vif and the lentiviral-mediated antiviral research in vitro]Tao Zhang
National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen 361005, China
Bing Du Xue Bao 24:88-95. 2008..These results showed that RNAi has great potential as an antiviral gene therapy approach and supports the efforts to develop treatment for HIV-1-infected individuals... - Suppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1Ping Wu
Center for Systems Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Cancer Lett 256:64-72. 2007.... - Genetic analysis of varicella-zoster virus ORF0 to ORF4 by use of a novel luciferase bacterial artificial chromosome systemZhen Zhang
Department of Microbiology and Molecular Genetics, UMDNJ New Jersey Medical School, 225 Warren Street, Newark, NJ 07101 1709, USA
J Virol 81:9024-33. 2007..This work has validated and justified the use of the novel luciferase VZV BAC system to efficiently generate recombinant VZV variants and ease subsequent viral growth kinetic analysis both in vitro and in vivo... - Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease modelQiang Liu
State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Academia Sinica, Beijing, China
FASEB J 21:61-73. 2007..The dissected signaling pathway of nicotine-mediated neuroprotection in the present study provides a mechanistic basis for the potential development of drug targets for treating AD... - Tissue factor-dependent coagulation is preferentially up-regulated within arterial branching areas in a baboon model of Escherichia coli sepsisCristina Lupu
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13 St, Oklahoma City, OK 73104, USA
Am J Pathol 167:1161-72. 2005..These data suggest that site-dependent endothelial heterogeneity and rheological factors contribute to focal procoagulant responses to E. coli... - Effect of interleukin-7 gene transfection into ovarian carcinoma cell line SKOV3 in vitro and in vivoXing Xie
Department of Gynecologic Oncology, School of Medicine, Women s Hospital, Zhejiang University, Hangzhou 310006, China
Gynecol Oncol 92:578-85. 2004..To investigate the effect of interleukin-7 (IL-7) gene transfection into an established ovarian carcinoma cell line (SKOV3) in vitro and evaluate the tumorigenicity of SKOV3-IL-7 in severe combined immunodeficient (SCID) mice... - Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatmentHelen V Yarovoi
The Children's Hospital of Philadelphia, 1 Civic Center, ARC, Rm 317, Philadelphia, PA 19104, USA
Blood 102:4006-13. 2003..Our studies also suggest that platelet-released factor VIII is at least as potent as an equivalent plasma level and perhaps even more potent in an arterial thrombosis model...