L Zhang

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc Molecular mechanism governing heme signaling in yeast: a higher-order complex mediates heme regulation of the transcriptional activator HAP1
    L Zhang
    Department of Biochemistry, NYU Medical Center, New York, New York 10016, USA
    Mol Cell Biol 18:3819-28. 1998
  2. pmc Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection
    L A Chakrabarti
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 74:1209-23. 2000
  3. pmc The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme
    T Hon
    Department of Biochemistry, NYU School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 21:7923-32. 2001
  4. ncbi request reprint The coiled coil dimerization element of the yeast transcriptional activator Hap1, a Gal4 family member, is dispensable for DNA binding but differentially affects transcriptional activation
    A Hach
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 275:248-54. 2000
  5. ncbi request reprint Molecular mechanism of heme signaling in yeast: the transcriptional activator Hap1 serves as the key mediator
    L Zhang
    Department of Biochemistry, NYU Medical Center, New York, New York 10016, USA
    Cell Mol Life Sci 56:415-26. 1999
  6. ncbi request reprint Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha
    Y Y Tang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 275:39579-88. 2000
  7. ncbi request reprint The yeast heme-responsive transcriptional activator Hap1 is a preexisting dimer in the absence of heme
    T Hon
    Department of Biochemistry, New York University Medical Center, New York, New York 10016, USA
    J Biol Chem 274:22770-4. 1999
  8. ncbi request reprint Effect of HIV-1 infection on lymphocyte proliferation in gut-associated lymphoid tissue
    A H Talal
    Aaron Diamond AIDS Research Center, New York City, New York, USA
    J Acquir Immune Defic Syndr 26:208-17. 2001
  9. pmc Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1
    L Zhang
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 72:9307-12. 1998
  10. ncbi request reprint Age-dependent changes in T cell homeostasis and SIV load in sooty mangabeys
    L A Chakrabarti
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Med Primatol 29:158-65. 2000

Detail Information

Publications76

  1. pmc Molecular mechanism governing heme signaling in yeast: a higher-order complex mediates heme regulation of the transcriptional activator HAP1
    L Zhang
    Department of Biochemistry, NYU Medical Center, New York, New York 10016, USA
    Mol Cell Biol 18:3819-28. 1998
    ..Our studies provide significant insights into the molecular events leading to heme activation of HAP1 and may shed light on molecular mechanisms of various heme-controlled biological processes in diverse organisms...
  2. pmc Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection
    L A Chakrabarti
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 74:1209-23. 2000
    ..Normal T-cell turnover in SIV-infected mangabeys provides an explanation for the long-term maintenance of a functional immune system in these hosts...
  3. pmc The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme
    T Hon
    Department of Biochemistry, NYU School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 21:7923-32. 2001
    ..Our results suggest that Ssa-Ydj1 and Sro9 act together to mediate Hap1 repression in the absence of heme and that molecular chaperones promote heme regulation of Hap1 by a mechanism distinct from the mechanism of steroid signaling...
  4. ncbi request reprint The coiled coil dimerization element of the yeast transcriptional activator Hap1, a Gal4 family member, is dispensable for DNA binding but differentially affects transcriptional activation
    A Hach
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 275:248-54. 2000
    ....
  5. ncbi request reprint Molecular mechanism of heme signaling in yeast: the transcriptional activator Hap1 serves as the key mediator
    L Zhang
    Department of Biochemistry, NYU Medical Center, New York, New York 10016, USA
    Cell Mol Life Sci 56:415-26. 1999
    ....
  6. ncbi request reprint Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha
    Y Y Tang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 275:39579-88. 2000
    ..These data refine the structural analyses and further support the hypothesis that CBFbeta enhances DNA binding by inducing a conformational change in the Runt domain...
  7. ncbi request reprint The yeast heme-responsive transcriptional activator Hap1 is a preexisting dimer in the absence of heme
    T Hon
    Department of Biochemistry, New York University Medical Center, New York, New York 10016, USA
    J Biol Chem 274:22770-4. 1999
    ..Our data suggest that in the absence of heme, Hap1 exists as a dimer, and the two subunits act cooperatively in DNA binding. Hap1 repression is caused, at least in part, by inhibition of the DNA binding activity of the preexisting dimer...
  8. ncbi request reprint Effect of HIV-1 infection on lymphocyte proliferation in gut-associated lymphoid tissue
    A H Talal
    Aaron Diamond AIDS Research Center, New York City, New York, USA
    J Acquir Immune Defic Syndr 26:208-17. 2001
    ..To determine the change in the percentage of proliferative and activated lymphocytes in gut-associated lymphoid tissue (GALT) in HIV-1-infected subjects compared with that in uninfected controls...
  9. pmc Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1
    L Zhang
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 72:9307-12. 1998
    ....
  10. ncbi request reprint Age-dependent changes in T cell homeostasis and SIV load in sooty mangabeys
    L A Chakrabarti
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Med Primatol 29:158-65. 2000
    ..Thus, the number of susceptible target cells may be a limiting factor in natural SIV infection...
  11. ncbi request reprint Open-label phase II trial of amprenavir, abacavir, and fixed-dose zidovudine/lamivudine in newly and chronically HIV-1--infected patients
    R G Kost
    The Aaron Diamond AIDS Research Center, New York, New York 10016, USA
    J Acquir Immune Defic Syndr 26:332-9. 2001
    ..Patient intolerance may limit the efficacy of this combination...
  12. ncbi request reprint Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes
    S M Mense
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Physiol Genomics 25:435-49. 2006
    ..These results provide a global view of the signaling and regulatory network mediating oxygen regulation in human astrocytes...
  13. ncbi request reprint Anti-HIV agent MAP30 modulates the expression profile of viral and cellular genes for proliferation and apoptosis in AIDS-related lymphoma cells infected with Kaposi's sarcoma-associated virus
    Y Sun
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 287:983-94. 2001
    ..These results provide valuable insight into the molecular mechanisms of MAP30 anti-KS action and suggest its utility as a therapeutic agent against AIDS-related tumors...
  14. doi request reprint Feasibility of immunocytochemical detection of tumor markers (XIAP, phosphohistone H1 and p63) in FNA cellblock samples from head and neck squamous cell carcinoma
    M Wu
    Department of Pathology, Mount Sinai School of Medicine, New York, New York, USA
    Diagn Cytopathol 36:797-800. 2008
    ..p-H1 and XIAP may be useful for monitoring actions of cyclin-dependent kinase inhibitors, XIAP-lowering, and/or apoptosis-inducing drugs, respectively. Future studies will focus on the impact of therapies upon these staining profiles...
  15. ncbi request reprint Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model
    X M Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
    J Allergy Clin Immunol 108:639-46. 2001
    ..CONCLUSION: FAHF-1 protected peanut-sensitized mice from anaphylactic reactions and significantly reversed established IgE-mediated peanut allergy. This suggests that FAHF-1 might prove valuable for the treatment of peanut allergy...
  16. pmc Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo
    L Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 71:2555-61. 1997
    ..e., that transmission does not reset the evolutionary clock...
  17. ncbi request reprint An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen
    A S Doane
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 25:3994-4008. 2006
    ..This subset of BCs, characterized by a hormonally regulated transcriptional program and response to androgen, suggests the potential for therapeutic strategies targeting the androgen signaling pathway...
  18. ncbi request reprint Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma
    P Okunieff
    Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Clin Oncol 24:491-5. 2001
    ..The results suggest that KGFs could be safely used to prevent radiation toxicity of the abdomen or pelvis and may in fact improve tumor response to radiation...
  19. doi request reprint Hepatic inflammatory cytokine mRNA expression in hepatitis C virus-human immunodeficiency virus co-infection
    S A Gonzalez
    Center for the Study of Hepatitis C and Division of Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, NY 10065 4896, USA
    J Viral Hepat 15:331-8. 2008
    ..Further studies are needed to assess whether decreased IFN-gamma secretion by HCV-specific CD4+ cells may account for accelerated fibrogenesis in these patients...
  20. pmc A human Raf-responsive zinc-finger protein that binds to divergent sequences
    L Zhang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Nucleic Acids Res 27:2947-56. 1999
    ..The ability of transcription factors such as RREB1/LZ321 to bind diverse sequences gives them the potential to regulate previously unsuspected genes...
  21. ncbi request reprint Evidence that Gal11 protein is a target of the Gal4 activation domain in the mediator
    C J Jeong
    Department of Internal Medicine, Ryburn Center for Molecular Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8573, USA
    Biochemistry 40:9421-7. 2001
    ....
  22. pmc DNA-binding activity and subunit interaction of the mariner transposase
    L Zhang
    Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, UK
    Nucleic Acids Res 29:3566-75. 2001
    ..This mutant enzyme allows insertion at dinucleotides other than TA, including sequences with GC base pairs. This is the first example of a mariner/Tc1 transposase with altered target specificity...
  23. pmc Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1
    L Zhang
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 90:2851-5. 1993
    ..This suggests that the regulatory domain acts by preventing dimerization of HAP1 in the absence of heme. Consistent with this view is an in vivo assay that also reveals that heme promotes HAP1 dimerization in yeast cells...
  24. pmc TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion
    M Sacher
    Howard Hughes Medical Institute and the Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    EMBO J 17:2494-503. 1998
    ..TRAPP contains at least nine other constituents, five of which have been identified and shown to be highly conserved novel proteins...
  25. ncbi request reprint Analysis of heat-shock transcription factor-DNA binding in Arabidopsis suspension cultures by UV laser crosslinking
    L Zhang
    ZMBP-Allgemeine Genetik, , Auf der Morgenstelle 28, , Germany
    Plant J 28:217-23. 2001
    ..In addition, methods for immunoprecipitation and detection of the co-immunoprecipitated DNA are reported. Our results suggest that Arabidopsis HSFs immunoreactive for HSF1 antibodies bind constitutively to the HSP18.2 gene...
  26. pmc A high copy suppressor screen reveals genetic interactions between BET3 and a new gene. Evidence for a novel complex in ER-to-Golgi transport
    Y Jiang
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Genetics 149:833-41. 1998
    ..The identification of mammalian homologues of Bet3p and Bet5p implies that the Bet3p/Bet5p complex is highly conserved in evolution...
  27. ncbi request reprint Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6
    P W Chiang
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor 48109, USA
    Genomics 47:426-8. 1998
  28. ncbi request reprint HAP1 is nuclear but is bound to a cellular factor in the absence of heme
    L Zhang
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Biol Chem 269:14643-7. 1994
    ..Deletion of the heme domain prevents sequestration of HAP1 in the high molecular weight complex. We discuss these findings in a model that postulates that the heme domain of HAP1 can interact with other cellular factors to regulate HAP1...
  29. ncbi request reprint Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma
    R F Niu
    Central Laboratory of Oncology, Cancer Hospital, Tianjin Medical University, Tianjin, China
    J Exp Clin Cancer Res 26:385-94. 2007
    ..Our results demonstrate that Twist may play an important role in the angiogenesis and metastasis of HCC. Twist expression may become a potential novel prognostic factor for the disease survival of HCC...
  30. ncbi request reprint Niobium oxide-supported platinum ultra-low amount electrocatalysts for oxygen reduction
    K Sasaki
    Department of Chemistry, Center for Functional Nanomaterials Brookhaven National Laboratory, Upton, NY 11973, USA
    Phys Chem Chem Phys 10:159-67. 2008
    ..6 V to 1.1 V). These findings demonstrate that niobium-oxide (NbO(2)) nanoparticles can be adequate supports for Pt and facilitate further reducing the noble metal content in electrocatalysts for the oxygen reduction reaction...
  31. ncbi request reprint Highly efficient expression of rabbit neutrophil peptide-1 gene in Chlorella ellipsoidea cells
    Y Chen
    Group 603, Institute of Genetics, Chinese Academy of Sciences, Beijing, PR China
    Curr Genet 39:365-70. 2001
    ..Integration of the gene for NP-1 into the Chlorella genome was confirmed by PCR and Southern blot analysis. In, vitro anti-microbial testes demonstrated the expression of biologically active NP-1 by the transgenic Chlorella cells...
  32. ncbi request reprint [Identification of Mortieralla isabellina M6-22 delta 6-fatty acid desaturase by heterologous expression in Saccharomyces cerevisiae]
    L Liu
    Department of Microbiology, Nankai University, Tianjin 300071, China
    Wei Sheng Wu Xue Bao 41:397-401. 2001
    ..69% of the total yeast fatty acid by GC-MS detection. It is the first report about expression of M. isabellina D6D gene in S. cerevisiae...
  33. doi request reprint Inhibition of sulfide generation by dosing formaldehyde and its derivatives in sewage under anaerobic conditions
    L Zhang
    Laboratory of Microbial Ecology and Technology LabMET, Gent University, Coupure Links 653, B 9000 Ghent, Belgium
    Water Sci Technol 57:915-9. 2008
    ..The impact of 19 mg L(-1) formaldehyde on activated sludge system was negligible in terms of COD removal, nitrification rate and oxygen uptake rate...
  34. doi request reprint Treatment of low and medium strength sewage in a lab-scale gradual concentric chambers (GCC) reactor
    L Mendoza
    Experimental Reproduction Centre CEYSA, Agricultural Faculty, Technical University of Cotopaxi, Latacunga, Ecuador
    Water Sci Technol 57:1155-60. 2008
    ..For the low strength domestic wastewater, a highest removal efficiency of 85% was observed, producing a final effluent with 22 mg COD/L. Changes in the nutrient concentration levels were followed for both reactors...
  35. ncbi request reprint The nuclear localization signal of zebrafish terra is located within the DM domain
    L Zhang
    Institute of Cellular and Developmental Biology, Department of Biological Sciences and Biotechnology, National Laboratory of Protein Sciences of MOE, Tsinghua University, 100084, Beijing, China
    FEBS Lett 503:25-9. 2001
    ..Sequence comparison discloses that the NLS of Terra is also present in the other known members of the DM family, indicating the conservative nature of the NLS of this family during evolution...
  36. pmc Ski can negatively regulates macrophage differentiation through its interaction with PU.1
    N Ueki
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, USA
    Oncogene 27:300-7. 2008
    ..1 is closely related to the development of myeloid leukemia and Ski strongly inhibits PU.1 function, we propose that aberrant Ski expression in certain types of myeloid cell lineages might contribute to leukemogenesis...
  37. ncbi request reprint Activation of the c-myc p1 promoter in Burkitt's lymphoma by the hs3 immunoglobulin heavy-chain gene enhancer
    H M Hu
    Center for Molecular Biology in Medicine, Veterans Affairs Palo Alto Health Care System, Stanford, CA, USA
    Leukemia 21:747-53. 2007
    ..Mutation of the major active sites (nuclear factor-kappa B and YY1) in the enhancers prevented c-myc activation...
  38. pmc Identification of a new class of PAX3-FKHR target promoters: a role of the Pax3 paired box DNA binding domain
    L Zhang
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, Chicago, IL 60612, USA
    Oncogene 26:1595-605. 2007
    ..We demonstrate that PAX3-FKHR could induce myogenin expression in undifferentiated myoblasts by a MyoD independent pathway, and that PAX3-FKHR is directly involved in myogenin expression in aRMS cells...
  39. pmc F-box protein Skp2: a novel transcriptional target of E2F
    L Zhang
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, Chicago, IL 60612, USA
    Oncogene 25:2615-27. 2006
    ..These results reveal Skp2 as a novel target for E2F regulation that is disrupted in several human tumor cell lines...
  40. ncbi request reprint Adenoviral delivery of human CDC5 promotes G2/M progression and cell division in neonatal ventricular cardiomyocytes
    S D Williams
    Cardiovascular Research Institute, University of California, San Francisco, CA 92121, USA
    Gene Ther 13:837-43. 2006
    ....
  41. ncbi request reprint Vulvar squamous cell carcinoma in young women: a clinicopathologic study of 21 cases
    A al-Ghamdi
    Department of Pathology, University of British Columbia and British Columbia Cancer Agency, Vancouver, British Columbia V6T 2B5, Canada
    Gynecol Oncol 84:94-101. 2002
    ..The aim of this study was to examine clinical and pathological features of ISCC presenting in women younger than 40 years of age...
  42. pmc Alterations in NF-kappaB and RBP-Jkappa by arenavirus infection of macrophages in vitro and in vivo
    S M Fennewald
    Department of Pathology and WHO Collaborating Center for Tropical Disease, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    J Virol 76:1154-62. 2002
    ..Taken together, these changes suggest that the attenuated viral strain induces an "activation" of macrophages, while the virulent form of the virus does not...
  43. ncbi request reprint The bone morphogenic protein antagonist gremlin regulates proximal-distal patterning of the lung
    M M Lu
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Dyn 222:667-80. 2001
    ..These data suggest that gremlin plays an important role in lung morphogenesis by regulating the proximal-distal patterning of the lung during development...
  44. pmc Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha
    M Buck
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 20:6712-23. 2001
    ..Treatment of TNF-alpha mice with antioxidants or NOS inhibitors prevented phosphorylation of C/EBPbeta on Ser239 and its nuclear export, and rescued the abnormal albumin gene expression...
  45. ncbi request reprint 5'-sulfhydryl-modified RNA: initiator synthesis, in vitro transcription, and enzymatic incorporation
    L Zhang
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Bioconjug Chem 12:939-48. 2001
    ..This is an efficient method to incorporate enzymatically a thiol group into the 5'-end of RNA...
  46. ncbi request reprint Biochemical studies of Saccharomyces cerevisiae myristoyl-coenzyme A:protein N-myristoyltransferase mutants
    L Zhang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:33131-40. 1996
    ..The ts growth arrest produced by nmt1 alleles correlates with a reduction in myristoyl-Arf1p to </=50% of total cellular Arf1p...
  47. ncbi request reprint PUMA induces the rapid apoptosis of colorectal cancer cells
    J Yu
    The Johns Hopkins Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Mol Cell 7:673-82. 2001
    ..Based on its unique expression patterns, p53 dependence, and biochemical properties, PUMA may be a direct mediator of p53-associated apoptosis...
  48. pmc Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element
    L Zhang
    Skin Biology Technical Resourse Center, Johnson and Johnson, Consumer Products World Wide, 199 Grandview Road, Skillman, NJ 08558, USA
    Biochem J 357:183-93. 2001
    ..These studies indicate that CCAAT-box-binding proteins activate SCD transcription in cultured keratinocytes and that fatty acids modulate transcription, most likely through the conserved PUFA response element...
  49. ncbi request reprint Structure and organization of the human reduced folate carrier gene
    L Zhang
    Experimental and Clinical Therapeutics Program, Karmanos Cancer Institute, 110 E Warren Ave, Detroit, MI 48201, USA
    Biochim Biophys Acta 1442:389-93. 1998
    ..The presence of consensus splice donor and acceptor elements in the deleted KS1 isoform suggested that this form was likely a splice variant; however, KS32 likely arose during reverse transcription rather than by alternative splicing...
  50. pmc Comparison of murine Supt4h and a nearly identical expressed, processed gene: evidence of sequence conservation through gene conversion extending into the untranslated regions
    P W Chiang
    University of Michigan Medical Center, Department of Pediatrics and Department of Human Genetics, 1150 West Medical Center Drive, 3520 MSRB I, Ann Arbor, MI 48109 0650, USA
    Nucleic Acids Res 26:4960-4. 1998
    ..This illustrates another potential complexity of the mammalian genome, i.e. the use of a processed gene under the control of a different promoter region than the spliced gene...
  51. ncbi request reprint A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein
    T Megidish
    Pacific Northwest Research Institute, Seattle, Washington 98122 and Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 273:21834-45. 1998
    ....
  52. ncbi request reprint Genomic organization, chromosomal localization, and expression of the murine thromboxane synthase gene
    L Zhang
    Department of Obstetrics, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA
    Genomics 45:519-28. 1997
    ..These studies provide the genetic tools and information for TS research in mice, which should expedite understanding of the genetic contribution of TS in normal physiology as well as in disease states...
  53. pmc IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency
    L Zhang
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599 7295, USA
    Mol Cell Biol 17:5748-57. 1997
    ..The identification of a functional viral ISRE and association of IRF-7 with type III latency may be relevant to the mechanism of regulation of Qp...
  54. ncbi request reprint Characterization of the yeast transcriptome
    V E Velculescu
    Program in Human Genetics and Molecular Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cell 88:243-51. 1997
    ..These studies provide insight into global patterns of gene expression in yeast and demonstrate the feasibility of genome-wide expression studies in eukaryotes...
  55. pmc Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia
    F Melet
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 16:2708-18. 1996
    ....
  56. pmc An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes
    L Zhang
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 15:6961-70. 1995
    ..Thus, H-2Kk-Fli-1 transgenic mice may serve as a murine model for autoimmune disease in humans, such as systemic lupus erythematosus...
  57. ncbi request reprint The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members
    L Zhang
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Oncogene 8:1621-30. 1993
    ..Furthermore, we have identified an octanucleotide core sequence that is required in vitro for optimal binding of Fli-1 to the Drosophila E74 target and the promoter sequence of the human GPIIB gene...
  58. ncbi request reprint Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis
    S M Baker
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201 3098, USA
    Cell 82:309-19. 1995
    ..These observations suggest links among mismatch repair, genetic recombination, and chromosome synapsis in meiosis...
  59. ncbi request reprint Sequence analysis of sarcosine oxidase and nearby genes reveals homologies with key enzymes of folate one-carbon metabolism
    L J Chlumsky
    Department of Biological Chemistry, Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 270:18252-9. 1995
    ..The results suggest that the alpha subunit and dimethylglycine dehydrogenase contain an NH2-terminal domain that binds noncovalent or covalent FAD, respectively, and a carboxyl-terminal H4folate-binding domain...
  60. pmc cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1
    C B Thompson
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109
    Mol Cell Biol 12:1043-53. 1992
    ..Taken together, these results demonstrate that multiple Ets family members with apparently distinct DNA binding specificities regulate differential gene expression in resting and activated T cells...
  61. ncbi request reprint Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1
    J Zhang
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla 10595, USA
    Biochemistry 37:16728-34. 1998
    ..These characteristics are shared by the previously described protein phosphatase-1 inhibitor-2 and inhibitor-1 proteins...
  62. ncbi request reprint Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18
    A I Fletcher
    Departments of Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:4027-35. 1999
    ..Our data suggest a model whereby Cdk5 acts to regulate Munc18a interaction with syntaxin 1a and thereby modulates the level of vesicle SNARE interaction with syntaxin 1a and secretory responsiveness...
  63. ncbi request reprint Myogenic determination and differentiation of the mouse palatal muscle in relation to the developing mandibular nerve
    L Zhang
    Department of Oral and Maxillofacial Surgery, Shimane Medical University, Izumo, Japan
    J Dent Res 78:1417-25. 1999
    ....
  64. ncbi request reprint Adenovirus-mediated gene transfer of dominant-negative Smad4 blocks TGF-beta signaling in pancreatic acinar cells
    L Zhang
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1247-53. 2001
    ..AddnSmad4 also inhibited TGF-beta-induced expression of the TGF-beta-responsive luciferase reporter 3TP-Lux. These results show that Smad4 is essential in TGF-beta-mediated signaling in pancreatic acinar cells...
  65. ncbi request reprint Multiple mechanisms regulate expression of low temperature responsive (LOT) genes in Saccharomyces cerevisiae
    L Zhang
    Department of Biotechnology, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan
    Biochem Biophys Res Commun 283:531-5. 2001
    ..The data indicate that multiple mechanisms, including translational functionality may be involved in the regulation of LOT gene expression in yeast...
  66. ncbi request reprint Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure
    L Zhang
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 276:19214-9. 2001
    ..Disulfide cross-linked SP-D oligomers are required for the regulation of surfactant phospholipid homeostasis and the prevention of emphysema and foamy macrophages in vivo...
  67. ncbi request reprint Structure-function of the putative I-domain within the integrin beta 2 subunit
    Y M Xiong
    Department of Vascular Biology, American Red Cross Holland Laboratory, Rockville, Maryland 20855, USA
    J Biol Chem 276:19340-9. 2001
    ..Finally, both the conformation of the beta(2)I-domain and C3bi binding activity of alpha(M)beta(2) were dependent on a high affinity Ca(2+) binding site (K(d) = 105 microm), which is most likely located within this region of beta(2)...
  68. ncbi request reprint Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways
    R Kapur
    The Section of Pediatric Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Blood 97:1975-81. 2001
    ..Blood. 2001;97:1975-1981)..
  69. ncbi request reprint Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function
    D I Simon
    Cardiovascular, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:10228-34. 2000
    ....
  70. ncbi request reprint Function of Rx, but not Pax6, is essential for the formation of retinal progenitor cells in mice
    L Zhang
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 28:135-42. 2000
    ....
  71. ncbi request reprint NF-kappa B activity is required for the deregulation of c-myc expression by the immunoglobulin heavy chain enhancer
    K Kanda
    Center for Molecular Biology in Medicine, Veterans Affairs Palo Alto Health Care System and the Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 275:32338-46. 2000
    ....
  72. ncbi request reprint Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi
    R L Tarleton
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    J Immunol 165:1520-5. 2000
    ..These data suggest that type 1 T cells are required for the development of immune control to T. cruzi, but that type 2 T cells contribute to parasite persistence and increased severity of disease...
  73. pmc Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
    D I Simon
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Exp Med 192:193-204. 2000
    ..These observations provide a molecular target for disrupting leukocyte-platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis...
  74. pmc The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
    J Peng
    Lawson Research Institute, St Joseph s Health Center, Departments of Pediatrics and Biochemistry, University of Western Ontario, London, ON, Canada N6A 4V2
    Proc Natl Acad Sci U S A 97:8386-91. 2000
    ..Our results suggest that EPAS-1 plays an important role at postvasculogenesis stages and is required for the remodeling of the primary vascular network into a mature hierarchy pattern...
  75. ncbi request reprint Molecular cloning, expression, and characterization of rat homolog of human AP-2alpha that stimulates neuropeptide Y transcription activity in response to nerve growth factor
    B S Li
    Laboratory of Neurochemistry, NINDS, National Institutes of Health Bethesda, Maryland 20892 4130, USA
    Mol Endocrinol 14:837-47. 2000
    ....
  76. ncbi request reprint The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor
    H Kuster
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Disease, Rockville, Maryland 20852
    J Biol Chem 267:12782-7. 1992
    ....