Jiri Zavadil

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity
    Jiri Zavadil
    Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Cells Tissues Organs 185:157-61. 2007
  2. pmc Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP
    Paolo Mita
    Department of Urology, New York University School of Medicine, 550 First Avenue, MSB424, New York, NY 10016, USA
    Mol Cell Biol 31:3639-52. 2011
  3. pmc Wild type N-ras displays anti-malignant properties, in part by downregulating decorin
    Marta Benet
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    J Cell Physiol 227:2341-51. 2012
  4. pmc Histology-specific microRNA alterations in melanoma
    Laura Poliseno
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA
    J Invest Dermatol 132:1860-8. 2012
  5. pmc Comparison of gene expression profiles in chromate transformed BEAS-2B cells
    Hong Sun
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
    PLoS ONE 6:e17982. 2011
  6. pmc Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres
    Olga Mendez
    Microvascular and Molecular Neuro Oncology Laboratory, New York University School of Medicine, New York University Langone Medical Center, New York, NY, USA
    Mol Cancer 9:133. 2010
  7. pmc A novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block
    David Alvarez
    New York University Medical Center, New York, New York 10016, USA
    J Biol Chem 286:30444-54. 2011
  8. pmc chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila
    Maria Sol Flaherty
    Pharmacology Department, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 18:556-68. 2010
  9. pmc The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy
    Olga Zhdanova
    Skirball Institute for Biomolecular Medicine, New York University Langone Medical Center, New York, New York, USA
    Kidney Int 80:719-30. 2011
  10. pmc Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer
    Hailey A Clancy
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Department of Environmental Health Sciences, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Metallomics 4:784-93. 2012

Detail Information

Publications46

  1. ncbi request reprint Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity
    Jiri Zavadil
    Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Cells Tissues Organs 185:157-61. 2007
    ....
  2. pmc Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP
    Paolo Mita
    Department of Urology, New York University School of Medicine, 550 First Avenue, MSB424, New York, NY 10016, USA
    Mol Cell Biol 31:3639-52. 2011
    ..1 promoter. While Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes...
  3. pmc Wild type N-ras displays anti-malignant properties, in part by downregulating decorin
    Marta Benet
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    J Cell Physiol 227:2341-51. 2012
    ..The components of the pathways modulated by wt N-ras mediating its anti-malignant effects are potential targets for therapeutic intervention in cancer...
  4. pmc Histology-specific microRNA alterations in melanoma
    Laura Poliseno
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA
    J Invest Dermatol 132:1860-8. 2012
    ..Our data support a molecular classification in which SSM and NM are two molecularly distinct phenotypes. Therapeutic strategies that take into account subtype-specific alterations might improve the outcome of melanoma patients...
  5. pmc Comparison of gene expression profiles in chromate transformed BEAS-2B cells
    Hong Sun
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
    PLoS ONE 6:e17982. 2011
    ....
  6. pmc Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres
    Olga Mendez
    Microvascular and Molecular Neuro Oncology Laboratory, New York University School of Medicine, New York University Langone Medical Center, New York, NY, USA
    Mol Cancer 9:133. 2010
    ..GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1 (HIF-1) play a key role in glioma invasion...
  7. pmc A novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block
    David Alvarez
    New York University Medical Center, New York, New York 10016, USA
    J Biol Chem 286:30444-54. 2011
    ..In conclusion, these data support a novel role of ET-1 in linking TLR7 inflammatory signaling to subsequent fibrosis and provide new insight in considering therapeutics for CHB...
  8. pmc chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila
    Maria Sol Flaherty
    Pharmacology Department, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 18:556-68. 2010
    ..Like hyperactivated Stat92E, Chinmo misexpression in CySCs is sufficient to maintain GSCs nonautonomously. Chinmo is therefore a key effector of JAK/STAT signaling in a variety of developmental and pathological contexts...
  9. pmc The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy
    Olga Zhdanova
    Skirball Institute for Biomolecular Medicine, New York University Langone Medical Center, New York, New York, USA
    Kidney Int 80:719-30. 2011
    ..Identifying these miRNAs may provide new insight into disease pathogenesis and novel therapeutic targets in various podocytopathies...
  10. pmc Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer
    Hailey A Clancy
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Department of Environmental Health Sciences, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Metallomics 4:784-93. 2012
    ....
  11. pmc Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis
    Ding Wang
    Department of Medicine, New York University School of Medicine, 550 1st Avenue, New York, New York 10016, USA
    Mol Cell Biol 31:3670-80. 2011
    ..These data indicate that NMD inhibition by the tumor microenvironment is also an important mechanism to dynamically regulate genes critical for the response to cellular stress and tumorigenesis...
  12. pmc Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression
    Amy E Rose
    Department of Dermatology, New York University School of Medicine, New York, New York, USA
    Cancer Res 71:2561-71. 2011
    ..Furthermore, our data suggest a role for altered regulation of metabolism-related genes as a possible cause of the different clinical behavior of SSM and NM...
  13. pmc Insulin acts through FOXO3a to activate transcription of plasminogen activator inhibitor type 1
    Ushma R Jag
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Endocrinol 23:1587-602. 2009
    ..Finally, chromatin immunoprecipitation assays confirm the presence of FoxO3a on the PAI-1 promoter. These results suggest that FoxO3a mediates insulin-increased PAI-1 gene expression...
  14. pmc Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
    Raphael Margueron
    Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, NY 10016, USA
    Mol Cell 32:503-18. 2008
    ..These results might reflect subfunctionalization of a PcG protein during evolution...
  15. pmc Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage
    Eunjeong Seo
    Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA
    Mol Cell Biol 31:4593-608. 2011
    ..Our results establish a connection between Sox2 and BMI-1 in maintaining self-renewal and identify BMI-1 as a key mediator of Sox2 function...
  16. pmc Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila
    Andrea L Zamparini
    HHMI and Kimmel Center for Biology and Medicine at Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 138:4039-50. 2011
    ..We propose that Vret plays an essential role in transposon regulation at an early stage of primary piRNA processing...
  17. pmc DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs
    Michelle Badura
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 109:18767-72. 2012
    ..Increased expression of eIF4G1 therefore promotes specialized translation of survival, growth arrest, and DDR mRNAs that are important in cell survival and DNA repair following genotoxic DNA damage...
  18. doi request reprint Comprehensive transcriptional profiling of human epidermis, reconstituted epidermal equivalents, and cultured keratinocytes using DNA microarray chips
    Ding Dar Lee
    Department of Dermatology, The NYU Cancer Institute, New York University School of Medicine, New York, NY, USA
    Methods Mol Biol 585:193-223. 2010
    ..The work can be a primer for researchers embarking on skinomics, the comprehensive analysis of transcriptional changes in the skin...
  19. pmc miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis
    Avital Gaziel-Sovran
    Department of Pathology, New York University Medical Center, NY 10016, USA
    Cancer Cell 20:104-18. 2011
    ..These data support a key role of miR-30b/30d and GalNAc transferases in metastasis, by simultaneously promoting cellular invasion and immunosuppression...
  20. pmc Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop
    Jun An Chen
    Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 69:721-35. 2011
    ....
  21. doi request reprint Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144
    Cristina M Ramírez
    Leon H Charney Division of Cardiology, Departments of Medicine and Cell Biology, New York University School of Medicine, New York, New York, USA
    Circ Res 112:1592-601. 2013
    ..Increasing evidence supports the role of microRNA (miRNAs) in regulating cholesterol metabolism through ABC transporters...
  22. pmc Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas
    Jiri Zavadil
    Department of Pathology, School of Medicine, New York University, New York, New York, United States of America
    PLoS ONE 5:e12362. 2010
    ..In order to identify microRNA::mRNA associations relevant to ULM pathogenesis, we examined global correlation patterns between the altered microRNA expression and the predicted target genes in ULMs and matched myometria...
  23. ncbi request reprint Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition
    Miroslav Blumenberg
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    Cells Tissues Organs 185:162-74. 2007
    ..3B. Finally, we discuss the potential significance of this scenario for EMT in the light of recent findings on gene regulation by histone modifications and chromatin structure changes...
  24. pmc Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase
    Xue Zhou
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 70:4214-21. 2010
    ..Thus, these results indicate that hypoxia might target JARID1A activity, which in turn increases H3K4me3 at both the global and gene-specific levels, leading to the altered programs of gene expression and tumor progression...
  25. pmc Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
    Kelly Moran-Crusio
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, NY 10016, USA
    Cancer Cell 20:11-24. 2011
    ..In addition, Tet2(+/-) mice also displayed increased stem cell self-renewal and extramedullary hematopoiesis, suggesting that Tet2 haploinsufficiency contributes to hematopoietic transformation in vivo...
  26. pmc Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway
    Maria Sol Flaherty
    Pharmacology Department, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 238:2235-53. 2009
    ..These data suggest that this study will be a useful resource for the identification of additional Stat92E targets...
  27. ncbi request reprint TGF-beta and epithelial-to-mesenchymal transitions
    Jiri Zavadil
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 24:5764-74. 2005
    ..Here we will review the distinct physiological contexts of EMT and the underlying molecular signaling networks controlled by TGF-beta...
  28. pmc Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling
    Maria V Guijarro
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Am J Pathol 182:2015-27. 2013
    ..Our results highlight the importance of molecularly subclassifying patients with high-grade sarcoma for targeted treatments...
  29. pmc Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggression
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University Langone Medical Center, New York, NY, USA
    Brain Struct Funct 216:347-56. 2011
    ..Additional molecular and cellular characterization of COMT, TH, and other potential targets is warranted within this animal model of aggression...
  30. pmc Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival
    Dusan Bogunovic
    Cancer Institute and Department of Pathology, New York University Langone Medical Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 106:20429-34. 2009
    ....
  31. pmc Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type
    David H Nguyen
    Department of Radiation Oncology, New York University School of Medicine, New York, NY 10016, USA
    Cancer Cell 19:640-51. 2011
    ..This effect was TGFβ independent and linked to mammary stem cell activity. Thus, the irradiated microenvironment affects latency and clinically relevant features of cancer through distinct and unexpected mechanisms...
  32. pmc Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development
    Ines Carrera
    Skirball Institute 4 9, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mol Cell Biol 28:5238-50. 2008
    ..Finally, we generated mutants lacking Bap170, Bap180, and Osa in the germ line to demonstrate that the core Brahma complex can function in oogenesis without any of these accessory subunits...
  33. pmc Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer
    Roy Blum
    Department of Cell Biology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 4:e5722. 2009
    ..The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer...
  34. pmc In TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways
    Stephen J Lynch
    Department of Pathology, New York University Langone School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e63193. 2013
    ....
  35. pmc Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia
    Julia A Meyer
    New York University Cancer Institute, New York University Langone Medical Center, New York, New York, USA
    Nat Genet 45:290-4. 2013
    ..Clinically, all individuals who harbored NT5C2 mutations relapsed early, within 36 months of initial diagnosis (P = 0.03). These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in ALL...
  36. pmc Antibiotics in early life alter the murine colonic microbiome and adiposity
    Ilseung Cho
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nature 488:621-6. 2012
    ..In this model, we demonstrate the alteration of early-life murine metabolic homeostasis through antibiotic manipulation...
  37. ncbi request reprint Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block
    Robert M Clancy
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Arthritis Rheum 56:4120-31. 2007
    ..Accordingly, this study was carried out to explore the hypothesis that hypoxia potentiates a profibrosing phenotype of the fetal cardiac fibroblast...
  38. pmc eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy
    Francisco Ramírez-Valle
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 181:293-307. 2008
    ..These results suggest that the high levels of eIF4GI observed in many breast cancers might act to specifically increase proliferation, prevent autophagy, and release tumor cells from control by nutrient sensing...
  39. pmc Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex
    Linsey Reavie
    Howard Hughes Medical Institute and Department of Pathology, New York, New York, USA
    Nat Immunol 11:207-15. 2010
    ..Our studies show that a ubiquitin ligase-substrate pair can orchestrate the molecular program of HSC differentiation...
  40. pmc Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult
    Sumanta Goswami
    Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Invest Ophthalmol Vis Sci 44:2084-93. 2003
    ..Oxidative stress (OS) is believed to be a major contributor to age-related cataract and other age-related diseases...
  41. pmc Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
    Jiri Zavadil
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    EMBO J 23:1155-65. 2004
    ....
  42. ncbi request reprint Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:6278-88. 2002
    ..We conclude that aligning cell behavior in vivo with patterns of gene expression can lead to new insights into the microenvironment of carcinoma cells in the primary tumor and the molecular mechanisms behind cell behavior...
  43. ncbi request reprint Inhibition of Smad5 in human hematopoietic progenitors blocks erythroid differentiation induced by BMP4
    Ota Fuchs
    Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Blood Cells Mol Dis 28:221-33. 2002
    ..We propose that the BMP4/Smad5 signal transduction pathway activates hematopoietic differentiation programs that may be impaired in anemia manifestations in MDS and AML patients with Smad5 haploinsufficiency...
  44. pmc Hierarchical model of gene regulation by transforming growth factor beta
    Yaw Ching Yang
    Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 100:10269-74. 2003
    ....
  45. ncbi request reprint Nicotine-induced sensitization in mice: changes in locomotor activity and mesencephalic gene expression
    Mariko Saito
    Laboratory of Neurobehavioral Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurochem Res 30:1027-35. 2005
    ..Down-regulation of GABA-A receptors induced by repeated nicotine exposure may facilitate dopaminergic neuronal transmission and may contribute to increased locomotor activity...
  46. ncbi request reprint RNA labeling and hybridization of DNA microarrays
    Erwin P Bottinger
    Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
    Methods Mol Med 86:275-84. 2003