STEVE S ZALCMAN
Affiliation: New Jersey
- Pharmacokinetics and modeling of immune cell trafficking: quantifying differential influences of target tissues versus lymphocytes in SJL and lipopolysaccharide-treated miceWilliam A Banks
GRECC, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
J Neuroinflammation 9:231. 2012..Immune cell trafficking into the CNS and other tissues plays important roles in health and disease. Rapid quantitative methods are not available that could be used to study many of the dynamic aspects of immune cell-tissue interactions...
- Interleukin-6 increases sensitivity to the locomotor-stimulating effects of amphetamine in ratsS Zalcman
Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada
Brain Res 847:276-83. 1999..The fact that IL-6 caused a lasting change in responsiveness to amphetamine implies a mechanism by which immunogenic stimuli can alter brain circuitry, changing its sensitivity to seemingly unrelated subsequent stimuli or events...
- Interleukin-2 potentiates novelty- and GBR 12909-induced exploratory activityS S Zalcman
Department of Psychiatry and Rutgers UMDNJ Integrative Neuroscience Program, UMD New Jersey Medical School, Medical Science Building, E 503, 185 S Orange Ave, Newark, NJ 07103 2714, USA
Brain Res 899:1-9. 2001..847 (1999) 276-283), it is suggested that cytokines can influence the development of behavioral abnormalities that are characteristic of aberrant mesolimbic dopamine activity via sensitization-like processes...
- Interleukin-2-induced increases in climbing behavior: inhibition by dopamine D-1 and D-2 receptor antagonistsSteven S Zalcman
UMD New Jersey Medical School, Department of Psychiatry and Rutgers UMDNJ Integrative Neuroscience Program, Newark, NJ 07103, USA
Brain Res 944:157-64. 2002..These findings could shed light on the mechanisms by which IL-2 increases vulnerability to psychiatric abnormalities associated with aberrations in central dopaminergic processes...
- The neurobiology of aggression and rage: role of cytokinesSteven S Zalcman
Department of Psychiatry, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Brain Behav Immun 20:507-14. 2006..Present research is designed to further delineate the roles of cytokines in aggressive behavior and to begin to unravel the possible signaling pathways involved this process...
- Kainate-activated currents in the ventral tegmental area of neonatal rats are modulated by interleukin-2Jiang Hong Ye
Department of Anesthesiology, New Jersey Medical School UMDNJ, Newark, NJ 07103 2714, USA
Brain Res 1049:227-33. 2005..IL-2 might thus be required for normal cell development in the mesolimbic and mesostriatal systems...
- Role of IL-1 beta and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in catSuresh Bhatt
Department of Neurology and Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
Brain Behav Immun 22:224-33. 2008..The present study demonstrates that IL-beta in the dorsal PAG, similar to the medial hypothalamus, potentiates defensive rage behavior and is mediated through a 5-HT(2C) receptor mechanism...
- Permeability of the mouse blood-brain barrier to murine interleukin-2: predominance of a saturable efflux systemWilliam A Banks
Division of Geriatrics, Department of Internal Medicine, GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, 915 N Grand Blvd, St Louis, MO 63106, USA
Brain Behav Immun 18:434-42. 2004..This is the first description of a saturable CNS-to-blood efflux system for a cytokine. We postulate that this efflux system may protect the brain from circulating IL-2...