Jiang H Ye


Affiliation: New Jersey
Country: USA


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    Ye J, Schaefer R, Wu W, Liu P, Zbuzek V, McArdle J. Inhibitory effect of ondansetron on glycine response of dissociated rat hippocampal neurons. J Pharmacol Exp Ther. 1999;290:104-11 pubmed
    ..The data suggest that ondansetron competitively inhibits the glycine receptor. ..
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    Ye J, Mui W, Ren J, Hunt T, Wu W, Zbuzek V. Ondansetron exhibits the properties of a local anesthetic. Anesth Analg. 1997;85:1116-21 pubmed
    ..We found that it also causes numbness when injected under the skin. This new action may contribute to its role in "calming the stomach." We studied the effect of ondansetron on the isolated brain cells of live rats. ..
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    Ye J, Hunt T, Wu W, McArdle J. Ondansetron modulates GABA(A) current of rat central nervous system neurons. Eur J Pharmacol. 1997;337:87-94 pubmed
    ..The present data suggest that ondansetron's suppression of GABA-activated current may be the molecular basis of ondansetron-induced seizures observed in vivo. ..
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    Ye J, Ponnudurai R, Schaefer R. Ondansetron: a selective 5-HT(3) receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 2001;7:199-213 pubmed
    ..In addition, new discoveries relating to the effects of ondansetron on other receptors/channels and their possible therapeutic applications are presented. ..
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    Ye J, Zhang J, Xiao C, Kong J. Patch-clamp studies in the CNS illustrate a simple new method for obtaining viable neurons in rat brain slices: glycerol replacement of NaCl protects CNS neurons. J Neurosci Methods. 2006;158:251-9 pubmed
    ..Due to the increase in the number of viable neurons, the new ACSF increases the productivity of experiments. Based on our data, we propose that this glycerol-based solution may protect CNS neurons. ..
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    Ye J, Wang F, Krnjevic K, Wang W, Xiong Z, Zhang J. Presynaptic glycine receptors on GABAergic terminals facilitate discharge of dopaminergic neurons in ventral tegmental area. J Neurosci. 2004;24:8961-74 pubmed
    ..Furthermore, glycine (1-3 microm) reduced the amplitude of eIPSCs and the frequency of sIPSCs. Hence, the overall effect of the presynaptic action of glycine is to enhance the firing of DA cells, both in very young and older rats. ..
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    Ye J. Regulation of excitation by glycine receptors. Results Probl Cell Differ. 2008;44:123-43 pubmed
    ..This chapter is an overview of selective studies on the newly discovered roles of GlyRs in regulating neuronal excitation, and inhibition, particularly in the upper brain areas. ..
  8. Ye J, Sokol K, Bhavsar U. Glycine receptors contribute to hypnosis induced by ethanol. Alcohol Clin Exp Res. 2009;33:1069-74 pubmed publisher
    ..Given that hypnosis is caused by neuronal depression in upper brain areas, we therefore conclude that brain GlyRs contribute at least in part to the hypnosis induced by ethanol. ..
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    Ye J, McArdle J. 2,3-Butanedione monoxime modifies the glycine-gated chloride current of acutely isolated murine hypothalamic neurons. Brain Res. 1996;735:20-9 pubmed
    ..These findings suggest that BDM alters protein kinase activity and acts as a phosphatase to regulate the activity of the glycine receptor/channel complex. ..

More Information


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    Ye J, Tao L, Zhu L, Krnjevic K, McArdle J. Ethanol inhibition of glycine-activated responses in neurons of ventral tegmental area of neonatal rats. J Neurophysiol. 2001;86:2426-34 pubmed
    ..In conclusion, by altering VTA neuronal function, ethanol-induced changes in glycine receptors may contribute to neurobehavioral manifestations of the fetal alcohol syndrome...