Hiroko Yano

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Mechanisms of neurotrophin receptor vesicular transport
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    J Neurobiol 58:244-57. 2004
  2. ncbi request reprint Biochemical characterization of intracellular membranes bearing Trk neurotrophin receptors
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Neurochem Res 30:767-77. 2005
  3. ncbi request reprint Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation
    Juan Carlos Arevalo
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, NY 10016, USA
    J Biol Chem 281:1001-7. 2006
  4. pmc Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 29:14790-802. 2009
  5. pmc The ARMS/Kidins220 scaffold protein modulates synaptic transmission
    Juan Carlos Arevalo
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell Neurosci 45:92-100. 2010
  6. ncbi request reprint BDNF-mediated neurotransmission relies upon a myosin VI motor complex
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 9:1009-18. 2006
  7. ncbi request reprint Akt1 regulates a JNK scaffold during excitotoxic apoptosis
    Albert H Kim
    Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Neuron 35:697-709. 2002
  8. pmc A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein
    Juan Carlos Arevalo
    Molecular Neurobiology Program, Departments of Cell Biology, Physiology and Neuroscience, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    EMBO J 23:2358-68. 2004
  9. pmc Neuregulin-1 type III determines the ensheathment fate of axons
    Carla Taveggia
    Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:681-94. 2005

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Mechanisms of neurotrophin receptor vesicular transport
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    J Neurobiol 58:244-57. 2004
    ..In particular, the molecules that may direct Trk receptor trafficking in the axon will be discussed. Finally, potential mechanisms by which receptor-containing vesicles link to molecular cytoskeletal motors will be presented...
  2. ncbi request reprint Biochemical characterization of intracellular membranes bearing Trk neurotrophin receptors
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Neurochem Res 30:767-77. 2005
    ..Taken together, these biochemical approaches allowed separation of distinct Trk-bearing membrane pools, which may be involved in different functions of neurotrophin receptor signaling and trafficking...
  3. ncbi request reprint Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation
    Juan Carlos Arevalo
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, NY 10016, USA
    J Biol Chem 281:1001-7. 2006
    ..Therefore, Trk receptor signaling involves an inducible switch mechanism through an unconventional substrate that distinguishes neurotrophin action from other growth factor receptors...
  4. pmc Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 29:14790-802. 2009
    ..Together, these results raise the intriguing possibility that dysregulation of proneurotrophin processing/release by innervated targets can be deleterious to the neurons projecting to these sites...
  5. pmc The ARMS/Kidins220 scaffold protein modulates synaptic transmission
    Juan Carlos Arevalo
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell Neurosci 45:92-100. 2010
    ..These results provide evidence that modulation of ARMS/Kidins220 levels can regulate basal synaptic strength in a specific manner in hippocampal neurons...
  6. ncbi request reprint BDNF-mediated neurotransmission relies upon a myosin VI motor complex
    Hiroko Yano
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 9:1009-18. 2006
    ..Together, these results define an important role for the Myo6-GIPC1 motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic plasticity...
  7. ncbi request reprint Akt1 regulates a JNK scaffold during excitotoxic apoptosis
    Albert H Kim
    Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Neuron 35:697-709. 2002
    ..Overexpression of Akt1 mutants that bind JIP1 reduced excitotoxic apoptosis. These results suggest that Akt1 binding to JIP1 acts as a regulatory gate preventing JNK activation, which is released under conditions of excitotoxic injury...
  8. pmc A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein
    Juan Carlos Arevalo
    Molecular Neurobiology Program, Departments of Cell Biology, Physiology and Neuroscience, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    EMBO J 23:2358-68. 2004
    ..These findings suggest that ARMS acts as a major and neuronal-specific platform for prolonged MAP kinase signaling by neurotrophins...
  9. pmc Neuregulin-1 type III determines the ensheathment fate of axons
    Carla Taveggia
    Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:681-94. 2005
    ..These results indicate that levels of NRG1 type III, independent of axon diameter, provide a key instructive signal that determines the ensheathment fate of axons...