Xue ru Wu

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins
    Marcia R Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, USA
    BMC Cancer 7:204. 2007
  2. ncbi request reprint Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, Veterans Affairs Medical Center in Manhattan, 423 E23 St, Rm 18064S, New York, NY 10010, USA
    Am J Physiol Renal Physiol 293:F1935-43. 2007
  3. pmc Uroplakins in urothelial biology, function, and disease
    Xue ru Wu
    Department of Urology, New York University Langone Medical Center, New York, USA
    Kidney Int 75:1153-65. 2009
  4. pmc Biology of urothelial tumorigenesis: insights from genetically engineered mice
    Xue ru Wu
    Department of Urology and Pathology, New York University School of Medicine, New York, NY 10016, USA
    Cancer Metastasis Rev 28:281-90. 2009
  5. ncbi request reprint Urothelial tumorigenesis: a tale of divergent pathways
    Xue ru Wu
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    Nat Rev Cancer 5:713-25. 2005
  6. ncbi request reprint Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, 423 East 23 St, 18th Floor, Rm 18064 South, New York, NY 10010, USA
    Am J Physiol Renal Physiol 286:F795-802. 2004
  7. pmc E3 ligase activity of XIAP RING domain is required for XIAP-mediated cancer cell migration, but not for its RhoGDI binding activity
    Jinyi Liu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
    PLoS ONE 7:e35682. 2012
  8. pmc Temporally and spatially controllable gene expression and knockout in mouse urothelium
    Haiping Zhou
    Departments of Urology, New York Univ School of Medicine, New York, 10010, USA
    Am J Physiol Renal Physiol 299:F387-95. 2010
  9. pmc RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility
    Jianxiu Yu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Biol Chem 287:13752-60. 2012
  10. ncbi request reprint Allelic loss of p53 gene is associated with genesis and maintenance, but not invasion, of mouse carcinoma in situ of the bladder
    Jin Cheng
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Cancer Res 63:179-85. 2003

Collaborators

Detail Information

Publications50

  1. pmc Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins
    Marcia R Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, USA
    BMC Cancer 7:204. 2007
    ..The objective of this study was to determine differentially expressed genes in the mouse bladder following repeated intravesical BCG therapy...
  2. ncbi request reprint Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, Veterans Affairs Medical Center in Manhattan, 423 E23 St, Rm 18064S, New York, NY 10010, USA
    Am J Physiol Renal Physiol 293:F1935-43. 2007
    ....
  3. pmc Uroplakins in urothelial biology, function, and disease
    Xue ru Wu
    Department of Urology, New York University Langone Medical Center, New York, USA
    Kidney Int 75:1153-65. 2009
    ..We also call attention to important areas where greater investigative efforts are warranted...
  4. pmc Biology of urothelial tumorigenesis: insights from genetically engineered mice
    Xue ru Wu
    Department of Urology and Pathology, New York University School of Medicine, New York, NY 10016, USA
    Cancer Metastasis Rev 28:281-90. 2009
    ....
  5. ncbi request reprint Urothelial tumorigenesis: a tale of divergent pathways
    Xue ru Wu
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    Nat Rev Cancer 5:713-25. 2005
    ..Correcting pathway-specific defects represents an attractive strategy for the molecular therapy of urothelial carcinomas...
  6. ncbi request reprint Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, 423 East 23 St, 18th Floor, Rm 18064 South, New York, NY 10010, USA
    Am J Physiol Renal Physiol 286:F795-802. 2004
    ..The generation of THP-deficient mice established the role of THP as a first line of urinary defense and should help elucidate other potential functions of this major protein in urinary tract physiology and diseases...
  7. pmc E3 ligase activity of XIAP RING domain is required for XIAP-mediated cancer cell migration, but not for its RhoGDI binding activity
    Jinyi Liu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
    PLoS ONE 7:e35682. 2012
    ..Although E3 ligase activity of RING domain contributed to cell migration, it was not involved in RhoGDI binding nor its ubiquitinational modification...
  8. pmc Temporally and spatially controllable gene expression and knockout in mouse urothelium
    Haiping Zhou
    Departments of Urology, New York Univ School of Medicine, New York, 10010, USA
    Am J Physiol Renal Physiol 299:F387-95. 2010
    ....
  9. pmc RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility
    Jianxiu Yu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Biol Chem 287:13752-60. 2012
    ..The physiological regulation of RhoGDI SUMOylation by the RING domain of XIAP may account for modulation of cancer cell invasion and metastasis by XIAP...
  10. ncbi request reprint Allelic loss of p53 gene is associated with genesis and maintenance, but not invasion, of mouse carcinoma in situ of the bladder
    Jin Cheng
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Cancer Res 63:179-85. 2003
    ..On the basis of our current and previous transgenic studies, we have proposed an integrated pathway progression model of bladder cancer...
  11. ncbi request reprint Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growth
    Jin Cheng
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Cancer Res 62:4157-63. 2002
    ....
  12. ncbi request reprint p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis
    Jing Gao
    Veterans Affairs Medical Center in New York, NY 10010, USA
    Oncogene 23:687-96. 2004
    ....
  13. ncbi request reprint Isolation of mouse THP gene promoter and demonstration of its kidney-specific activity in transgenic mice
    Xinhua Zhu
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016, USA
    Am J Physiol Renal Physiol 282:F608-17. 2002
    ....
  14. ncbi request reprint Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation
    Lan Mo
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10010, USA
    Kidney Int 66:1159-66. 2004
    ..Here we examined the role of Tamm-Horsfall protein (THP), the principal urinary protein, in urinary defense against renal calcium crystal formation, using a THP knockout model that we recently developed...
  15. ncbi request reprint Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior
    Antonio Garcia-Espana
    Department of Pathology, New York University Cancer Institute, New York, USA
    Cancer Res 65:1150-7. 2005
    ..Our results indicate that the transgenic mouse models can be used not only for studying tumorigenesis but also for evaluating therapeutic strategies that target specific cell cycle regulators...
  16. ncbi request reprint Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder
    Jose A Karam
    Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Clin Cancer Res 13:4400-6. 2007
    ..Little is known about the expression of this gene in urothelial carcinoma of the bladder (UCB). We profiled DOC-2/DAB2 expression in mouse and human normal and neoplastic urothelia...
  17. pmc Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis
    Lan Mo
    Department of Urology, New York University Cancer Institute, New York University School of Medicine, New York, New York, USA
    J Clin Invest 117:314-25. 2007
    ....
  18. pmc Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein
    Yan Liu
    Dept of Urology, New York Univ School of Medicine, NY 10010, USA
    Am J Physiol Renal Physiol 299:F469-78. 2010
    ....
  19. ncbi request reprint The prostatic utricle is not a Müllerian duct remnant: immunohistochemical evidence for a distinct urogenital sinus origin
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York, USA
    J Urol 172:1753-6; discussion 1756. 2004
    ..Others propose that the urogenital sinus (UGS) contributes either partially or totally to the development of this structure. Using immunohistochemical probes, we provide strong evidence that the utricle is of UGS origin only...
  20. pmc Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis
    Hsiang Tsui Wang
    Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo Park, New York 10987, USA
    Carcinogenesis 34:220-7. 2013
    ..These results indicate that both CpG sequence context and the chemical nature of the carcinogens are crucial factors for determining the effect of CpG methylation on mutagenesis...
  21. pmc Deficiency of pRb family proteins and p53 in invasive urothelial tumorigenesis
    Feng He
    Department of Urology, New York University School of Medicine, Veterans Affairs Medical Center in Manhattan, New York, NY 10010, USA
    Cancer Res 69:9413-21. 2009
    ....
  22. ncbi request reprint Immunolocalization of androgen receptor and estrogen receptors alpha and beta in human fetal testis and epididymis
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Urol 174:1695-8; discussion 1698. 2005
    ..Expression and cellular localization of the androgen receptor (AR) and estrogen receptor (ER) isoforms were determined using antibodies specific to these receptors and to specific cell types...
  23. pmc Persistent uroplakin expression in advanced urothelial carcinomas: implications in urothelial tumor progression and clinical outcome
    Hong Ying Huang
    Department of Urology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Hum Pathol 38:1703-13. 2007
    ..Our results also suggest that UP-positive and -negative carcinomas have different clonal origins or may be derived from different cancer stem cells...
  24. ncbi request reprint Renal tubule-specific expression and urinary secretion of human growth hormone: a kidney-based transgenic bioreactor growth
    Xinhua Zhu
    Department of Urology, New York University School of Medicine, New York, NY 10016, USA
    Transgenic Res 12:155-62. 2003
    ....
  25. ncbi request reprint Gene deletion in urothelium by specific expression of Cre recombinase
    Lan Mo
    Dept of Urology, New York University Cancer Institute, New York Univ School of Medicine, New York, New York, USA
    Am J Physiol Renal Physiol 289:F562-8. 2005
    ..These results demonstrate for the first time the feasibility and potentially wide applicability of the UPII-Cre transgenic mice to inactivate any genes of interest in the urothelium...
  26. ncbi request reprint Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity
    Songshan Jiang
    Epithelial Biology Unit, Ronald O Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University Medical School, New York, New York, USA
    Kidney Int 66:10-9. 2004
    ..Recent studies indicate that genetic ablation of mouse uroplakin (UP) III gene, which encodes a 47 kD urothelial-specific integral membrane protein forming urothelial plaques, causes VUR and hydronephrosis...
  27. pmc The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP
    Yong Fang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Biol Chem 287:35234-43. 2012
    ..cleistostachyum by down-regulation of XIAP expression and induction of apoptosis through specific targeting of a SP1 pathway, and cast new light on the treatment of the cancer patients with XIAP overexpression...
  28. pmc Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies
    Haiping Zhou
    Department of Urology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 33:770-80. 2012
    ....
  29. ncbi request reprint Acrolein- and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells
    Hyun Wook Lee
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo Park, New York
    Oncotarget 5:3526-40. 2014
    ....
  30. pmc Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap
    Yan Liu
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 287:16365-78. 2012
    ..Based on these and other data, we present a unifying model that underscores the role of THP as a major regulator of renal and systemic immunity...
  31. pmc Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration
    Dongyun Zhang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    J Cell Sci 127:2920-33. 2014
    ..Collectively, our data strongly indicate that p27 plays a crucial negative role in cell migration by inhibiting MnSOD expression in a STAT3-dependent manner. ..
  32. ncbi request reprint New concepts on the development of the vagina
    Ellen Shapiro
    Department of Urology, 150 East 32nd Street, 2nd Floor, New York, NY 10016, USA
    Adv Exp Med Biol 545:173-85. 2004
  33. pmc Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperones
    Lijie Ma
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 287:1290-305. 2012
    ..Our results reveal intricate mechanistic details that may underlie THP-associated diseases and suggest that novel therapeutics enhancing the refolding of THP mutants may be of important value in therapy...
  34. pmc Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility
    Hsiang Tsui Wang
    Department of Environmental Medicine, New York University School of Medicine, New York, New York 10987, USA
    J Biol Chem 287:12379-86. 2012
    ..We propose that these two detrimental effects contribute to Acr mutagenicity and carcinogenicity...
  35. pmc SNX31: A Novel Sorting Nexin Associated with the Uroplakin-Degrading Multivesicular Bodies in Terminally Differentiated Urothelial Cells
    Neide Vieira
    Department of Cell Biology, NYU Cancer Institute, NYU Langone Medical Center, New York, New York, United States of America
    PLoS ONE 9:e99644. 2014
    ....
  36. ncbi request reprint Detection of circulating cancer cells expressing uroplakins and epidermal growth factor receptor in bladder cancer patients
    Iman Osman
    Kaplan Comprehensive Cancer Center, New York, NY, USA
    Int J Cancer 111:934-9. 2004
    ..Further efforts are under way to confirm the potential predictive value of these markers in a prospectively designed study of a larger cohort of patients...
  37. ncbi request reprint Immunolocalization of estrogen receptor alpha and beta in human fetal prostate
    Ellen Shapiro
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Urol 174:2051-3. 2005
    ..We examined the immunolocalization of estrogen receptor (ER)alpha and ERbeta in the human fetal prostate...
  38. pmc The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo
    Michael T Buckley
    Urology, New York University School of Medicine, New York, USA
    J Transl Med 5:49. 2007
    ....
  39. pmc X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton
    Jinyi Liu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Biol Chem 286:15630-40. 2011
    ....
  40. ncbi request reprint The human prostate expresses sonic hedgehog during fetal development
    Daniel H Barnett
    Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, USA
    J Urol 168:2206-10. 2002
    ..Studies in mice have shown that budding requires the signaling peptide, which is expressed in the epithelium of the prostatic anlagen. We report our characterization of (SHH) expression in the human fetal prostate...
  41. doi request reprint Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression
    Tarek M El-Achkar
    Department of Medicine, Saint Louis University and St Louis Veterans Affairs Medical Center, St Louis, MO, USA
    Am J Physiol Renal Physiol 295:F534-44. 2008
    ..Our data suggest that THP stabilizes the outer medulla in the face of injury by decreasing inflammation, possibly through an effect on TLR4...
  42. pmc VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation
    Marcia R Saban
    Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Am J Physiol Renal Physiol 295:F60-72. 2008
    ....
  43. ncbi request reprint A survivin gene signature predicts aggressive tumor behavior
    Whitney Salz
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 65:3531-4. 2005
    ..Detection of survivin or its associated gene signature may provide an early biomarker of aggressive tumor behavior before the appearance of tissue abnormalities...
  44. pmc Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement
    Feng Xia Liang
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology
    J Cell Biol 171:835-44. 2005
    ....
  45. pmc Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha
    Marcia R Saban
    College of Medicine, Department of Physiology, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    BMC Immunol 9:4. 2008
    ..In addition, the transcriptome was precipitated with an antibody against RNA polymerase II and real-time polymerase chain reaction assay (Q-PCR) was used to confirm some of the BCG-specific transcripts...
  46. ncbi request reprint Variation of high mannose chains of Tamm-Horsfall glycoprotein confers differential binding to type 1-fimbriated Escherichia coli
    Daniela Cavallone
    Department of Experimental Pathology, University of Bologna, Bologna 40126, Italy
    J Biol Chem 279:216-22. 2004
    ..coli and that the differences in high mannose processing may reflect species-specific adaptation of urinary defenses against E. coli infections...
  47. ncbi request reprint Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia
    Bo Xie
    Mass Spectrometry Resource, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
    J Biol Chem 281:14644-53. 2006
    ..Results from this study shed light on the molecular pathogenesis of urinary tract infections and may aid in the design of glyco-mimetic inhibitors for preventing and treating this disease...
  48. pmc Lymphatic vessel density and function in experimental bladder cancer
    Marcia R Saban
    Department of Physiology, College of Medicine, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    BMC Cancer 7:219. 2007
    ..Both cancer and inflammation are known to induce lymphangiogenesis. However, little is known about bladder lymphatic vessels and their involvement in cancer formation and progression...
  49. ncbi request reprint Early detection and measurement of urothelial tumors in mice
    Aimee M Johnson
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Urology 67:1309-14. 2006
    ..To establish reliable noninvasive in vivo methods to detect, measure, and monitor experimentally induced urothelial tumors in mice...
  50. ncbi request reprint Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder?
    Ina Riedel
    Institute of Pathology, Philipp University, D 35033 Marburg, Germany
    Eur J Cell Biol 84:393-405. 2005
    ..Additional studies are needed to distinguish these two possibilities and to elucidate the physiological and pathological significance of the observed urothelial and uroplakin heterogeneity...

Research Grants15

  1. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2000
    ..These studies should lead to a better understanding of the physiological function of THP, the molecular pathogenesis of urinary tract infections, and the host defense mechanisms of the urinary tract. ..
  2. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2010
    ..Results from these studies will shed new light on the molecular pathogenesis and intervention strategies for important urinary tract diseases such as urolithiasis, which afflicts millions of people annually in the United States alone. ..
  3. Bladder-specific Knockout and Gene Expression
    Xue ru Wu; Fiscal Year: 2009
    ..These studies will generate powerful experimental tools for studying bladder biology and diseases and offer molecular insights regarding urothelial growth and tumorigenesis. ..
  4. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2009
    ..Results from these studies will shed new light on the molecular pathogenesis and intervention strategies for important urinary tract diseases such as urolithiasis, which afflicts millions of people annually in the United States alone. ..
  5. Bladder-specific Knockout and Gene Expression
    Xue ru Wu; Fiscal Year: 2007
    ..These studies will generate powerful experimental tools for studying bladder biology and diseases and offer molecular insights regarding urothelial growth and tumorigenesis. ..
  6. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2007
    ..Results from these studies will shed new light on the molecular pathogenesis and intervention strategies for important urinary tract diseases such as urolithiasis, which afflicts millions of people annually in the United States alone. ..
  7. Bladder-specific Knockout and Gene Expression
    Xue ru Wu; Fiscal Year: 2006
    ..These studies will generate powerful experimental tools for studying bladder biology and diseases and offer molecular insights regarding urothelial growth and tumorigenesis. ..
  8. Role of Tamm-Horsfall Protein in Urinary Track Defense
    Xue ru Wu; Fiscal Year: 2006
    ..Results from these studies will shed new light on the molecular pathogenesis and intervention strategies for important urinary tract diseases such as urolithiasis, which afflicts millions of people annually in the United States alone. ..
  9. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2004
    ..These studies should lead to a better understanding of the physiological function of THP, the molecular pathogenesis of urinary tract infections, and the host defense mechanisms of the urinary tract. ..
  10. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2003
    ..These studies should lead to a better understanding of the physiological function of THP, the molecular pathogenesis of urinary tract infections, and the host defense mechanisms of the urinary tract. ..
  11. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2002
    ..These studies should lead to a better understanding of the physiological function of THP, the molecular pathogenesis of urinary tract infections, and the host defense mechanisms of the urinary tract. ..
  12. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2001
    ..These studies should lead to a better understanding of the physiological function of THP, the molecular pathogenesis of urinary tract infections, and the host defense mechanisms of the urinary tract. ..
  13. Role of Tamm-Horsfall Protein in Urinary Track Defense
    Xue ru Wu; Fiscal Year: 2009
    ..Results from these studies will shed new light on the molecular pathogenesis and intervention strategies for important urinary tract diseases such as urolithiasis, which afflicts millions of people annually in the United States alone. ..