Research Topics
Genomes and Genes | Xue ru WuSummaryAffiliation: New York University Country: USA Publications
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Publications
Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakinsMarcia R Saban
Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, USA
BMC Cancer 7:204. 2007..The objective of this study was to determine differentially expressed genes in the mouse bladder following repeated intravesical BCG therapy...
Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coliLan Mo
Dept of Urology, New York Univ School of Medicine, 423 East 23 St, 18th Floor, Rm 18064 South, New York, NY 10010, USA
Am J Physiol Renal Physiol 286:F795-802. 2004..The generation of THP-deficient mice established the role of THP as a first line of urinary defense and should help elucidate other potential functions of this major protein in urinary tract physiology and diseases...- Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or bothLan Mo
Dept of Urology, New York Univ School of Medicine, Veterans Affairs Medical Center in Manhattan, 423 E23 St, Rm 18064S, New York, NY 10010, USA
Am J Physiol Renal Physiol 293:F1935-43. 2007.... 
Uroplakins in urothelial biology, function, and diseaseXue ru Wu
Department of Urology, New York University Langone Medical Center, New York, USA
Kidney Int 75:1153-65. 2009..We also call attention to important areas where greater investigative efforts are warranted...- Biology of urothelial tumorigenesis: insights from genetically engineered miceXue ru Wu
Department of Urology and Pathology, New York University School of Medicine, New York, NY 10016, USA
Cancer Metastasis Rev 28:281-90. 2009.... - Urothelial tumorigenesis: a tale of divergent pathwaysXue ru Wu
Department of Urology, New York University School of Medicine, New York, New York 10016, USA
Nat Rev Cancer 5:713-25. 2005..Correcting pathway-specific defects represents an attractive strategy for the molecular therapy of urothelial carcinomas... - E3 ligase activity of XIAP RING domain is required for XIAP-mediated cancer cell migration, but not for its RhoGDI binding activityJinyi Liu
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
PLoS ONE 7:e35682. 2012..Although E3 ligase activity of RING domain contributed to cell migration, it was not involved in RhoGDI binding nor its ubiquitinational modification... - Temporally and spatially controllable gene expression and knockout in mouse urotheliumHaiping Zhou
Departments of Urology, New York Univ School of Medicine, New York, 10010, USA
Am J Physiol Renal Physiol 299:F387-95. 2010.... - Allelic loss of p53 gene is associated with genesis and maintenance, but not invasion, of mouse carcinoma in situ of the bladderJin Cheng
Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
Cancer Res 63:179-85. 2003..On the basis of our current and previous transgenic studies, we have proposed an integrated pathway progression model of bladder cancer... - RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motilityJianxiu Yu
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
J Biol Chem 287:13752-60. 2012..The physiological regulation of RhoGDI SUMOylation by the RING domain of XIAP may account for modulation of cancer cell invasion and metastasis by XIAP... - Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formationLan Mo
Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10010, USA
Kidney Int 66:1159-66. 2004..Here we examined the role of Tamm-Horsfall protein (THP), the principal urinary protein, in urinary defense against renal calcium crystal formation, using a THP knockout model that we recently developed... - Isolation of mouse THP gene promoter and demonstration of its kidney-specific activity in transgenic miceXinhua Zhu
Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016, USA
Am J Physiol Renal Physiol 282:F608-17. 2002.... - Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behaviorAntonio Garcia-Espana
Department of Pathology, New York University Cancer Institute, New York, USA
Cancer Res 65:1150-7. 2005..Our results indicate that the transgenic mouse models can be used not only for studying tumorigenesis but also for evaluating therapeutic strategies that target specific cell cycle regulators... - Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesisLan Mo
Department of Urology, New York University Cancer Institute, New York University School of Medicine, New York, New York, USA
J Clin Invest 117:314-25. 2007.... - p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesisJing Gao
Veterans Affairs Medical Center in New York, NY 10010, USA
Oncogene 23:687-96. 2004.... - Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall proteinYan Liu
Dept of Urology, New York Univ School of Medicine, NY 10010, USA
Am J Physiol Renal Physiol 299:F469-78. 2010.... - Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneitySongshan Jiang
Epithelial Biology Unit, Ronald O Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University Medical School, New York, New York, USA
Kidney Int 66:10-9. 2004..Recent studies indicate that genetic ablation of mouse uroplakin (UP) III gene, which encodes a 47 kD urothelial-specific integral membrane protein forming urothelial plaques, causes VUR and hydronephrosis... - Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladderJose A Karam
Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Clin Cancer Res 13:4400-6. 2007..Little is known about the expression of this gene in urothelial carcinoma of the bladder (UCB). We profiled DOC-2/DAB2 expression in mouse and human normal and neoplastic urothelia... - Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesisHsiang Tsui Wang
Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo Park, New York 10987, USA
Carcinogenesis 34:220-7. 2013..These results indicate that both CpG sequence context and the chemical nature of the carcinogens are crucial factors for determining the effect of CpG methylation on mutagenesis... - Deficiency of pRb family proteins and p53 in invasive urothelial tumorigenesisFeng He
Department of Urology, New York University School of Medicine, Veterans Affairs Medical Center in Manhattan, New York, NY 10010, USA
Cancer Res 69:9413-21. 2009.... - Gene deletion in urothelium by specific expression of Cre recombinaseLan Mo
Dept of Urology, New York University Cancer Institute, New York Univ School of Medicine, New York, New York, USA
Am J Physiol Renal Physiol 289:F562-8. 2005..These results demonstrate for the first time the feasibility and potentially wide applicability of the UPII-Cre transgenic mice to inactivate any genes of interest in the urothelium... - The prostatic utricle is not a Müllerian duct remnant: immunohistochemical evidence for a distinct urogenital sinus originEllen Shapiro
Department of Urology, New York University School of Medicine, New York, New York, USA
J Urol 172:1753-6; discussion 1756. 2004..Others propose that the urogenital sinus (UGS) contributes either partially or totally to the development of this structure. Using immunohistochemical probes, we provide strong evidence that the utricle is of UGS origin only... - Immunolocalization of androgen receptor and estrogen receptors alpha and beta in human fetal testis and epididymisEllen Shapiro
Department of Urology, New York University School of Medicine, New York, New York 10016, USA
J Urol 174:1695-8; discussion 1698. 2005..Expression and cellular localization of the androgen receptor (AR) and estrogen receptor (ER) isoforms were determined using antibodies specific to these receptors and to specific cell types... - Persistent uroplakin expression in advanced urothelial carcinomas: implications in urothelial tumor progression and clinical outcomeHong Ying Huang
Department of Urology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
Hum Pathol 38:1703-13. 2007..Our results also suggest that UP-positive and -negative carcinomas have different clonal origins or may be derived from different cancer stem cells... - Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapiesHaiping Zhou
Department of Urology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
Carcinogenesis 33:770-80. 2012.... - Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trapYan Liu
Department of Urology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 287:16365-78. 2012..Based on these and other data, we present a unifying model that underscores the role of THP as a major regulator of renal and systemic immunity... - Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperonesLijie Ma
Department of Urology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 287:1290-305. 2012..Our results reveal intricate mechanistic details that may underlie THP-associated diseases and suggest that novel therapeutics enhancing the refolding of THP mutants may be of important value in therapy... - Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibilityHsiang Tsui Wang
Department of Environmental Medicine, New York University School of Medicine, New York, New York 10987, USA
J Biol Chem 287:12379-86. 2012..We propose that these two detrimental effects contribute to Acr mutagenicity and carcinogenicity... - Detection of circulating cancer cells expressing uroplakins and epidermal growth factor receptor in bladder cancer patientsIman Osman
Kaplan Comprehensive Cancer Center, New York, NY, USA
Int J Cancer 111:934-9. 2004..Further efforts are under way to confirm the potential predictive value of these markers in a prospectively designed study of a larger cohort of patients... - Immunolocalization of estrogen receptor alpha and beta in human fetal prostateEllen Shapiro
Department of Urology, New York University School of Medicine, New York, New York 10016, USA
J Urol 174:2051-3. 2005..We examined the immunolocalization of estrogen receptor (ER)alpha and ERbeta in the human fetal prostate... - Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growthJin Cheng
Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
Cancer Res 62:4157-63. 2002.... - The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivoMichael T Buckley
Urology, New York University School of Medicine, New York, USA
J Transl Med 5:49. 2007.... - X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeletonJinyi Liu
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
J Biol Chem 286:15630-40. 2011.... - New concepts on the development of the vaginaEllen Shapiro
Department of Urology, 150 East 32nd Street, 2nd Floor, New York, NY 10016, USA
Adv Exp Med Biol 545:173-85. 2004 - Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expressionTarek M El-Achkar
Department of Medicine, Saint Louis University and St Louis Veterans Affairs Medical Center, St Louis, MO, USA
Am J Physiol Renal Physiol 295:F534-44. 2008..Our data suggest that THP stabilizes the outer medulla in the face of injury by decreasing inflammation, possibly through an effect on TLR4... - The human prostate expresses sonic hedgehog during fetal developmentDaniel H Barnett
Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, USA
J Urol 168:2206-10. 2002..Studies in mice have shown that budding requires the signaling peptide, which is expressed in the epithelium of the prostatic anlagen. We report our characterization of (SHH) expression in the human fetal prostate... - A survivin gene signature predicts aggressive tumor behaviorWhitney Salz
Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Cancer Res 65:3531-4. 2005..Detection of survivin or its associated gene signature may provide an early biomarker of aggressive tumor behavior before the appearance of tissue abnormalities... - Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder?Ina Riedel
Institute of Pathology, Philipp University, D 35033 Marburg, Germany
Eur J Cell Biol 84:393-405. 2005..Additional studies are needed to distinguish these two possibilities and to elucidate the physiological and pathological significance of the observed urothelial and uroplakin heterogeneity... - Lymphatic vessel density and function in experimental bladder cancerMarcia R Saban
Department of Physiology, College of Medicine, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
BMC Cancer 7:219. 2007..Both cancer and inflammation are known to induce lymphangiogenesis. However, little is known about bladder lymphatic vessels and their involvement in cancer formation and progression... - Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacementFeng-xia Liang
Epithelial Biology Unit, The Ronald O. Perelman Department of Dermatology
J Cell Biol 171:835-44. 2005.... - Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin IaBo Xie
Mass Spectrometry Resource, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
J Biol Chem 281:14644-53. 2006..Results from this study shed light on the molecular pathogenesis of urinary tract infections and may aid in the design of glyco-mimetic inhibitors for preventing and treating this disease... - Variation of high mannose chains of Tamm-Horsfall glycoprotein confers differential binding to type 1-fimbriated Escherichia coliDaniela Cavallone
Department of Experimental Pathology, University of Bologna, Bologna 40126, Italy
J Biol Chem 279:216-22. 2004..coli and that the differences in high mannose processing may reflect species-specific adaptation of urinary defenses against E. coli infections... - Early detection and measurement of urothelial tumors in miceAimee M Johnson
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
Urology 67:1309-14. 2006..This approach could provide an important alternative to serial sacrifice experimental designs, while refining statistical power and reducing animal use... - VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammationMarcia R Saban
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Am J Physiol Renal Physiol 295:F60-72. 2008.... - Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alphaMarcia R Saban
College of Medicine, Department of Physiology, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
BMC Immunol 9:4. 2008..In addition, the transcriptome was precipitated with an antibody against RNA polymerase II and real-time polymerase chain reaction assay (Q-PCR) was used to confirm some of the BCG-specific transcripts...
Research Grants
- ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSEXue ru Wu; Fiscal Year: 2010..Results from these studies will shed new light on the molecular pathogenesis and intervention strategies for important urinary tract diseases such as urolithiasis, which afflicts millions of people annually in the United States alone. ..
- Bladder-specific Knockout and Gene ExpressionXue ru Wu; Fiscal Year: 2009..These studies will generate powerful experimental tools for studying bladder biology and diseases and offer molecular insights regarding urothelial growth and tumorigenesis. ..
- Bladder-specific Knockout and Gene ExpressionXue ru Wu; Fiscal Year: 2007..These studies will generate powerful experimental tools for studying bladder biology and diseases and offer molecular insights regarding urothelial growth and tumorigenesis. ..
- ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSEXue ru Wu; Fiscal Year: 2004..These studies should lead to a better understanding of the physiological function of THP, the molecular pathogenesis of urinary tract infections, and the host defense mechanisms of the urinary tract. ..
- Role of Tamm-Horsfall Protein in Urinary Track DefenseXue ru Wu; Fiscal Year: 2009..Results from these studies will shed new light on the molecular pathogenesis and intervention strategies for important urinary tract diseases such as urolithiasis, which afflicts millions of people annually in the United States alone. ..