Joseph M Wu

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. pmc Anti-EGFR Therapy: Mechanism and Advances in Clinical Efficacy in Breast Cancer
    John F Flynn
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    J Oncol 2009:526963. 2009
  2. ncbi request reprint Resveratrol and its metabolites modulate cytokine-mediated induction of eotaxin-1 in human pulmonary artery endothelial cells
    Joseph M Wu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Ann N Y Acad Sci 1290:30-6. 2013
  3. pmc Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress
    J L Bruder
    Department of Biochemistry, New York Medical College, Valhalla, New York 10595, USA
    BMC Cell Biol 2:1. 2001
  4. doi request reprint Resveratrol: a cardioprotective substance
    Joseph M Wu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, 10595, USA
    Ann N Y Acad Sci 1215:16-21. 2011
  5. pmc Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Room 133, Valhalla, NY 10595, USA
    Carcinogenesis 33:670-7. 2012
  6. ncbi request reprint gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Anticancer Res 30:2869-74. 2010
  7. ncbi request reprint Ethanolic extracts of herbal supplement Equiguard suppress growth and control gene expression in CWR22Rv1 cells representing the transition of prostate cancer from androgen dependence to hormone refractory status
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 32:209-19. 2008
  8. pmc Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling
    H Dorota Halicka
    Brander Cancer Research Institute, Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Aging (Albany NY) 4:952-65. 2012
  9. doi request reprint Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin αvβ3
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Cancer 129:2732-43. 2011
  10. ncbi request reprint Differential regulation of proliferation, cell cycle control and gene expression in cultured human aortic and pulmonary artery endothelial cells by resveratrol
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Mol Med 26:743-9. 2010

Collaborators

Detail Information

Publications44

  1. pmc Anti-EGFR Therapy: Mechanism and Advances in Clinical Efficacy in Breast Cancer
    John F Flynn
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    J Oncol 2009:526963. 2009
    ....
  2. ncbi request reprint Resveratrol and its metabolites modulate cytokine-mediated induction of eotaxin-1 in human pulmonary artery endothelial cells
    Joseph M Wu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Ann N Y Acad Sci 1290:30-6. 2013
    ..Control of eotaxin-1 gene regulation may be considered an in vitro model to evaluate agents linking cardioprotection with endothelial cell damage and inflammation. ..
  3. pmc Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress
    J L Bruder
    Department of Biochemistry, New York Medical College, Valhalla, New York 10595, USA
    BMC Cell Biol 2:1. 2001
    ..We further test the possibility that resveratrol acts by modulating structural and functional changes in endothelial cells lining the blood vessel wall...
  4. doi request reprint Resveratrol: a cardioprotective substance
    Joseph M Wu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, 10595, USA
    Ann N Y Acad Sci 1215:16-21. 2011
    ..A mechanism encompassing nongenomic and genomic effects and a research roadmap is proposed as a framework for uncovering further insights on cardioprotection by resveratrol...
  5. pmc Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Room 133, Valhalla, NY 10595, USA
    Carcinogenesis 33:670-7. 2012
    ..Our results indicate a hitherto unreported role of NQO2 in the control of AKT/GSK-3β/cyclin D1 and highlight the involvement of NQO2 in degradation of cyclin D1, as part of mechanism of chemoprevention by resveratrol...
  6. ncbi request reprint gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Anticancer Res 30:2869-74. 2010
    ..Differential growth responses among different types of tocotrienols have been observed in breast cancer cells; however, specific bioactivity of each individual tocotrienol remains to be elucidated...
  7. ncbi request reprint Ethanolic extracts of herbal supplement Equiguard suppress growth and control gene expression in CWR22Rv1 cells representing the transition of prostate cancer from androgen dependence to hormone refractory status
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 32:209-19. 2008
    ..These results provide further support that Equiguard possess multiple, chemopreventive attributes capable of disrupting the transition of AD --> AI in clinically advanced CaP...
  8. pmc Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling
    H Dorota Halicka
    Brander Cancer Research Institute, Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Aging (Albany NY) 4:952-65. 2012
    ..The data suggest that combined assessment of constitutive γH2AX expression, mitochondrial activity (ROS, ΔΨm) and mTOR signaling provides an adequate gamut of cell responses to evaluate effectiveness of gero-suppressive agents...
  9. doi request reprint Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin αvβ3
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Cancer 129:2732-43. 2011
    ....
  10. ncbi request reprint Differential regulation of proliferation, cell cycle control and gene expression in cultured human aortic and pulmonary artery endothelial cells by resveratrol
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Mol Med 26:743-9. 2010
    ....
  11. pmc Identification of glutathione sulfotransferase-pi (GSTP1) as a new resveratrol targeting protein (RTP) and studies of resveratrol-responsive protein changes by resveratrol affinity chromatography
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Anticancer Res 28:29-36. 2008
    ..The bioactivities of resveratrol may be attributed to qualitative and quantitative differences in its cell-type-specific interaction and binding with its cellular targets, denoted as resveratrol targeting proteins (RTPs)...
  12. doi request reprint Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Mol Med 28:1065-9. 2011
    ....
  13. pmc Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Anticancer Res 29:4025-32. 2009
    ....
  14. ncbi request reprint Growth inhibition of human MDA-mB-231 breast cancer cells by delta-tocotrienol is associated with loss of cyclin D1/CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma tumor suppressor gene product
    Selvakumar Elangovan
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Anticancer Res 28:2641-7. 2008
    ....
  15. ncbi request reprint Differential control of growth, cell cycle progression, and gene expression in human estrogen receptor positive MCF-7 breast cancer cells by extracts derived from polysaccharopeptide I'm-Yunity and Danshen and their combination
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 29:1215-22. 2006
    ..Taken together, our results are consistent with the interpretation that interaction exists between Danshen and I'm-Yunity and that I'm-Yunity-Plus may have efficacy in the treatment of BCa, particularly for patients with ER+ status...
  16. ncbi request reprint Effects of herbal preparation Equiguard on hormone-responsive and hormone-refractory prostate carcinoma cells: mechanistic studies
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, Brander Cancer Research Institute, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 20:681-9. 2002
    ....
  17. ncbi request reprint Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol and gamma-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 33:851-9. 2008
    ....
  18. ncbi request reprint Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 334:223-30. 2005
    ..We propose that induction of NQO2 may relate to the observed increased expression of p53 that, in turn, contributes to the observed suppression of cell growth in both melanoma cell lines...
  19. ncbi request reprint Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts
    Zhirong Wang
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 346:367-76. 2006
    ..These results indicate that distinct mechanisms are involved in the regulation of HASMC growth and gene expression by SGE and resveratrol...
  20. ncbi request reprint Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 337:224-31. 2005
    ..Taken together, these results provide a mechanistic framework for the cellular effects of ponicidin and oridonin in different stage breast cancer cells...
  21. ncbi request reprint Effects of PC-SPES on proliferation and expression of AR/PSA in androgen-responsive LNCaP cells are independent of estradiol
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla 10595, USA
    Anticancer Res 22:2051-60. 2002
    ..These studies show that the antiproliferative and gene modulatory effects of PC-SPES in androgen-dependent human prostate cancer cells are mechanistically and functionally distinct from effects attributable to estradiol...
  22. pmc In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York, 10595
    Cytometry A 85:386-99. 2014
    ..Discussed is cytometric analysis of cell size and heterogeneity of size as a potential biomarker used to asses gero-suppressive agents and longevity...
  23. ncbi request reprint In silico and biochemical analyses identify quinone reductase 2 as a target of piceatannol
    Tze Chen Hsieh
    Research Associate Professor, Room 133, Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Curr Med Chem 20:4195-202. 2013
    ..These results show that NQO2 is an intracellular target for piceatannol, suggesting that CaP prevention by resveratrol may be partially attributed to its conversion to piceatannol. ..
  24. pmc Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity (PSP)
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    BMC Complement Altern Med 6:30. 2006
    ..We investigate the mechanisms by which I'm-Yunity (PSP) elicits these effects...
  25. ncbi request reprint Differential suppression of proliferation in MCF-7 and MDA-MB-231 breast cancer cells exposed to alpha-, gamma- and delta-tocotrienols is accompanied by altered expression of oxidative stress modulatory enzymes
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Anticancer Res 30:4169-76. 2010
    ....
  26. doi request reprint Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Carcinogenesis 32:93-101. 2011
    ..These results suggest that triacetyl-resveratrol and trimethoxy-resveratrol are active against different stage CaP cells, using overlapping and distinct mechanisms...
  27. pmc Resveratrol: Biological and pharmaceutical properties as anticancer molecule
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, USA
    Biofactors 36:360-9. 2010
    ..Our analysis of published data strengthen support that resveratrol displays novel roles in various cellular processes, and help to establish an expanded molecular framework for cancer prevention by resveratrol in vivo...
  28. ncbi request reprint Inhibition of proliferation and expression of AR/PSA by herbal supplement Equiguard in LNCaP cells cultured in androgen-proficient FBS and androgen-deficient charcoal-stripped FBS is correlated with increased serine-15 phosphorylation of the tumor suppres
    Xiaohua Lu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Anticancer Res 23:2489-98. 2003
    ..These results are consistent with the interpretation that the anti-proliferative and gene modulatory properties of Equiguard are largely independent of the status of androgens in the culture media...
  29. pmc The 2,6-disubstituted purine reversine induces growth arrest and polyploidy in human cancer cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 31:1293-300. 2007
    ..These results suggest that RV may induce polyploidy and increase in cell size by up-regulating p21(WAF1) and cyclin D3/CDK6, while simultaneously suppressing the expression of cyclin B and CDK1...
  30. doi request reprint Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by the combination of Coriolus versicolor and Ganoderma lucidum
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Mol Med 32:251-7. 2013
    ....
  31. ncbi request reprint Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Med Chem 2:275-85. 2006
    ....
  32. pmc Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography
    Zhirong Wang
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 323:743-9. 2004
    ..These results provide evidence for the existence of distinctive RTPs in mammalian cells and that RAC is a facile approach to identify and purify RTPs...
  33. pmc Biochemical and cellular evidence demonstrating AKT-1 as a binding partner for resveratrol targeting protein NQO2
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York, United States of America
    PLoS ONE 9:e101070. 2014
    ..Less is known regarding proteins that control AKT. We recently reported that quinone reductase 2 (NQO2) inhibited AKT activity, by unknown mechanisms...
  34. ncbi request reprint Equiguard suppresses androgen-dependent LNCaP prostate cancer cell proliferation by targeting cell cycle control via down regulation of the retinoblastoma protein Rb and induction of apoptosis via the release of cytochrome c
    Xiaohua Lu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 25:1801-7. 2004
    ..These results suggest that the ability to trigger apoptosis as one aspect of the control of cell growth by Equiguard is integrally linked to the release of cytochrome c, by a mechanism largely independent of the presence of androgens...
  35. ncbi request reprint Mechanism of action of herbal supplement PC-SPES: elucidation of effects of individual herbs of PC-SPES on proliferation and prostate specific gene expression in androgen-dependent LNCaP cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 20:583-8. 2002
    ..Lack of concordance between changes in prostate cell growth and prostate specific gene expression makes it unlikely that the activity of a single herb can account for the overall effects of PC-SPES...
  36. ncbi request reprint Prevention and management of prostate cancer using PC-SPES: a scientific perspective
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    J Nutr 132:3513S-3517S. 2002
    ..These studies provide the impetus for further evaluation of the composition herbs within PC-SPES and the precise characterization of their bioactive ingredients...
  37. pmc Control of eotaxin-1 expression and release by resveratrol and its metabolites in culture human pulmonary artery endothelial cells
    Ching Jen Yang
    Department of Biochemistry and Molecular Biology, New York Medical College Valhalla, New York 10595, USA
    Am J Cardiovasc Dis 1:16-30. 2011
    ....
  38. pmc AKT/mTOR as Novel Targets of Polyphenol Piceatannol Possibly Contributing to Inhibition of Proliferation of Cultured Prostate Cancer Cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    ISRN Urol 2012:272697. 2012
    ..We propose that the observed AKT and mTOR changes are new targets of piceatannol possibly contributing to its inhibitory activities on proliferation of CaP cells...
  39. ncbi request reprint Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells
    Yue Fu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 322:263-70. 2004
    ..These findings provide mechanistic explanation for LA activity and suggest that it may be considered as a chemopreventive agent and its anticancer properties should be further explored...
  40. ncbi request reprint Effects of extracts of Coriolus versicolor (I'm-Yunity) on cell-cycle progression and expression of interleukins-1 beta,-6, and -8 in promyelocytic HL-60 leukemic cells and mitogenically stimulated and nonstimulated human lymphocytes
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, USA
    J Altern Complement Med 8:591-602. 2002
    ..Kowloon, Hong Kong) prepared from strain Cov-1 of the mushroom Coriolus versicolor...
  41. ncbi request reprint Treatment of Jurkat acute T-lymphocytic leukemia cells by onconase (Ranpirnase) is accompanied by an altered nucleocytoplasmic distribution and reduced expression of transcription factor NF-kappaB
    Shwu Y Tsai
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 25:1745-52. 2004
    ..These results implicate NF-kappaB and its turnover as important determinants in the anti-proliferative/apoptotic effects of onconase in acute T-lymphocytic leukemia cells...
  42. pmc Crystal structure of quinone reductase 2 in complex with resveratrol
    Leonid Buryanovskyy
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Biochemistry 43:11417-26. 2004
    ....
  43. ncbi request reprint Interaction of a Mycobacterium tuberculosis repetitive DNA sequence with eukaryotic proteins
    Xinyan Liu
    Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 320:966-72. 2004
    ..These results suggest that mycobacterial nucleic acid fragments may interact specifically with eukaryotic regulatory proteins which might contribute to bacterial life-cycle maintenance...
  44. ncbi request reprint Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels
    Zhirong Wang
    Department of Cardiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, PR China
    Int J Mol Med 16:533-40. 2005
    ..The results also provide support for the notion that resveratrol and phytochemicals in red wine can suppress atherosclerosis without affecting plasma lipid levels...

Research Grants3

  1. Novel target proteins of resveratrol in chemoprevention
    Joseph Wu; Fiscal Year: 2005
    ..abstract_text> ..
  2. Functional synergism in prevention of hormone refractory CaP by phytochemicals
    Joseph Wu; Fiscal Year: 2006
    ..The data obtained will support the concept that combined diet-derived phytochemicals can offer easily compliant strategies for protection against HRPC. ..
  3. Functional synergism in prevention of hormone refractory CaP by phytochemicals
    Joseph Wu; Fiscal Year: 2007
    ..The data obtained will support the concept that combined diet-derived phytochemicals can offer easily compliant strategies for protection against HRPC. ..