G P Wormser

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. ncbi request reprint Duration of antibiotic therapy for early Lyme disease. A randomized, double-blind, placebo-controlled trial
    Gary P Wormser
    Division of Infectious Diseases, New York Medical College, Room 245, Munger Pavilion, Valhalla, New York 10595, USA
    Ann Intern Med 138:697-704. 2003
  2. pmc Microbiologic evaluation of patients from Missouri with erythema migrans
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 40:423-8. 2005
  3. pmc Failure of topical antibiotics to prevent disseminated Borrelia burgdorferi infection following a tick bite in C3H/HeJ mice
    Gary P Wormser
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Infect Dis 205:991-4. 2012
  4. doi request reprint Utility of serodiagnostics designed for use in the United States for detection of Lyme borreliosis acquired in Europe and vice versa
    Gary P Wormser
    Division of Infectious Diseases, New York Medical College, Valhalla, NY, 10595, USA
    Med Microbiol Immunol 203:65-71. 2014
  5. pmc Differences and similarities between culture-confirmed human granulocytic anaplasmosis and early lyme disease
    Gary P Wormser
    Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA
    J Clin Microbiol 51:954-8. 2013
  6. doi request reprint Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA
    Diagn Microbiol Infect Dis 75:9-15. 2013
  7. pmc Critical analysis of treatment trials of rhesus macaques infected with Borrelia burgdorferi reveals important flaws in experimental design
    Gary P Wormser
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Vector Borne Zoonotic Dis 12:535-8. 2012
  8. doi request reprint The amber theory of Lyme arthritis: initial description and clinical implications
    Gary P Wormser
    Division of Infectious Diseases of the Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Rheumatol 31:989-94. 2012
  9. ncbi request reprint Duration of treatment for Lyme borreliosis: time for a critical reappraisal
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine of New York Medical College, Westchester Medical Center, Valhalla, New York, USA
    Wien Klin Wochenschr 114:613-5. 2002
  10. ncbi request reprint Brief communication: hematogenous dissemination in early Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, New York Medical College, Valhalla, New York 10595, USA
    Ann Intern Med 142:751-5. 2005

Research Grants

  1. Subjective Symptoms after Treatment of Lyme Disease
    Gary P Wormser; Fiscal Year: 2010
  2. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007

Detail Information

Publications98

  1. ncbi request reprint Duration of antibiotic therapy for early Lyme disease. A randomized, double-blind, placebo-controlled trial
    Gary P Wormser
    Division of Infectious Diseases, New York Medical College, Room 245, Munger Pavilion, Valhalla, New York 10595, USA
    Ann Intern Med 138:697-704. 2003
    ..Treatment of patients with early Lyme disease has trended toward longer duration despite the absence of supporting clinical trials...
  2. pmc Microbiologic evaluation of patients from Missouri with erythema migrans
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 40:423-8. 2005
    ..Therefore, B. lonestari is considered to be a leading candidate for the etiologic agent of EM in this region...
  3. pmc Failure of topical antibiotics to prevent disseminated Borrelia burgdorferi infection following a tick bite in C3H/HeJ mice
    Gary P Wormser
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Infect Dis 205:991-4. 2012
    ..burgdorferi from the tick bite site or in preventing dissemination to other tissues. Reasons for the discrepant findings are discussed...
  4. doi request reprint Utility of serodiagnostics designed for use in the United States for detection of Lyme borreliosis acquired in Europe and vice versa
    Gary P Wormser
    Division of Infectious Diseases, New York Medical College, Valhalla, NY, 10595, USA
    Med Microbiol Immunol 203:65-71. 2014
    ..First-tier testing with an assay such as the C6 ELISA should be considered as a stand-alone diagnostic strategy in such cases. ..
  5. pmc Differences and similarities between culture-confirmed human granulocytic anaplasmosis and early lyme disease
    Gary P Wormser
    Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA
    J Clin Microbiol 51:954-8. 2013
    ..389, P = 0.009) was observed for HGA patients but not for patients with Lyme disease. In conclusion, although there are overlapping features, culture-confirmed HGA is a more severe illness than early Lyme disease...
  6. doi request reprint Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA
    Diagn Microbiol Infect Dis 75:9-15. 2013
    ..The C6 ELISA had slightly decreased specificity. Future studies should evaluate the performance of the C6 ELISA compared with 2-tier testing in routine clinical practice...
  7. pmc Critical analysis of treatment trials of rhesus macaques infected with Borrelia burgdorferi reveals important flaws in experimental design
    Gary P Wormser
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Vector Borne Zoonotic Dis 12:535-8. 2012
    ..Consequently, it is impossible to conclude that the findings have validity in judging the efficacy of doxycycline or ceftriaxone for the treatment of Borrelia burgdorferi in this animal model...
  8. doi request reprint The amber theory of Lyme arthritis: initial description and clinical implications
    Gary P Wormser
    Division of Infectious Diseases of the Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Rheumatol 31:989-94. 2012
    ..This "amber" hypothesis can account for the clinical and laboratory features of Lyme arthritis and is amenable to experimental validation. Validation would directly impact the clinical management of patients with Lyme arthritis...
  9. ncbi request reprint Duration of treatment for Lyme borreliosis: time for a critical reappraisal
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine of New York Medical College, Westchester Medical Center, Valhalla, New York, USA
    Wien Klin Wochenschr 114:613-5. 2002
    ..Recommendations on duration of treatment of early Lyme borreliosis deserve critical reappraisal...
  10. ncbi request reprint Brief communication: hematogenous dissemination in early Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, New York Medical College, Valhalla, New York 10595, USA
    Ann Intern Med 142:751-5. 2005
    ..Bloodstream invasion in Lyme disease has been difficult to study because until recently blood culture methods were too insensitive to detect spirochetemia...
  11. ncbi request reprint Babesiosis as a cause of fever in patients undergoing a splenectomy
    Gary P Wormser
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Am Surg 77:345-7. 2011
    ..The third patient underwent splenectomy for trauma and acquired babesiosis postoperatively from a blood transfusion. Our cases demonstrate the need to be vigilant for babesiosis in patients undergoing splenectomy...
  12. ncbi request reprint Prevention of Lyme borreliosis
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
    Wien Klin Wochenschr 117:385-91. 2005
    ..A safe, effective, inexpensive and well-accepted vaccine would be welcome...
  13. doi request reprint Treatment of infection caused by Borrelia burgdorferi sensu lato
    Gary P Wormser
    New York Medical College, Division of Infectious Diseases, Munger Pavilion Room 245, Valhalla, NY 10595, USA
    Expert Rev Anti Infect Ther 9:245-60. 2011
    ..The clinical outcome with 10-28 days of antibiotic treatment is generally excellent, but in view of the experience with other infections, future studies might address whether the duration of antibiotic therapy could be shortened...
  14. ncbi request reprint Prospective clinical evaluation of patients from Missouri and New York with erythema migrans-like skin lesions
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla 10595, USA
    Clin Infect Dis 41:958-65. 2005
    ..An illness associated with an EM-like skin lesion, but which is not caused by B. burgdorferi, occurs in many southern states in the United States (southern tick-associated rash illness [STARI], also known as Masters disease)...
  15. pmc Impact of clinical variables on Borrelia burgdorferi-specific antibody seropositivity in acute-phase sera from patients in North America with culture-confirmed early Lyme disease
    Gary P Wormser
    Department of Medicine, Division of Infectious Diseases, Munger Pavilion Room 245, New York Medical College, Valhalla, NY 10595, USA
    Clin Vaccine Immunol 15:1519-22. 2008
    ..Thus, in patients with erythema migrans, certain clinical variables such as the duration and number of skin lesions had a profound impact on seropositivity rates, irrespective of the serologic assay performed...
  16. ncbi request reprint Dissociation between inhibition and killing by levofloxacin in human granulocytic anaplasmosis
    Gary P Wormser
    Division of Infectious Diseases, Depatment of Medicine, New York Medical College, Westcheser Medical Center, Valhalla, New York, USA
    Vector Borne Zoonotic Dis 6:388-94. 2006
    ..Relapse of infection after levofloxacin therapy was reproduced in a severe combined immune-deficient (SCID) mouse infection model. Quinolone therapy should not be considered curative of HGA...
  17. ncbi request reprint Hematogenous dissemination in early Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine of New York Medical College, Valhalla, NY 10595, USA
    Wien Klin Wochenschr 118:634-7. 2006
    ..The high rate, early onset and prolonged duration of risk of spirochetemia probably explain why untreated patients with erythema migrans may develop objective clinical manifestations at a distant anatomic site...
  18. ncbi request reprint The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 43:1089-134. 2006
    ..Tables list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided. A definition of post-Lyme disease syndrome is proposed...
  19. pmc Antibiotic treatment of animals infected with Borrelia burgdorferi
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, York Medical College, Munger Pavilion Room 245, Valhalla, NY 10595, USA
    Clin Microbiol Rev 22:387-95. 2009
    ..We conclude that there is no scientific evidence to support the hypothesis that such spirochetes, should they exist in humans, are the cause of post-Lyme disease syndrome...
  20. ncbi request reprint Clinical practice. Early Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    N Engl J Med 354:2794-801. 2006
  21. pmc Comparison of the yields of blood cultures using serum or plasma from patients with early Lyme disease
    G P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    J Clin Microbiol 38:1648-50. 2000
    ..The rate of recovery from plasma cultures was significantly greater than that from serum cultures (P < 0.001)...
  22. pmc Implications of gender in chronic Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Munger Pavilion Room 245, Valhalla, NY 10595, USA
    J Womens Health (Larchmt) 18:831-4. 2009
    ..Chronic Lyme disease" is a vaguely defined term that has been applied to patients with unexplained prolonged subjective symptoms, whether or not there was or is evidence of B. burgdorferi infection...
  23. doi request reprint Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection
    Gary P Wormser
    Divisions of 1Infectious Diseases, Departments of Medicine and 3Pathology, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 50:381-6. 2010
    ..microti...
  24. pmc Association between human leukocyte antigen class II alleles and genotype of Borrelia burgdorferi in patients with early lyme disease
    Gary P Wormser
    Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA
    J Infect Dis 192:2020-6. 2005
    ..RST1 strains are the most pathogenic, and RST3 strains are the least pathogenic...
  25. pmc Effect of Borrelia burgdorferi genotype on the sensitivity of C6 and 2-tier testing in North American patients with culture-confirmed Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 47:910-4. 2008
    ..This is a particular concern for the C6 test, which is based on reactivity to a single peptide...
  26. pmc Effects of OspA vaccination on Lyme disease serologic testing
    M E Aguero-Rosenfeld
    Department of Pathology, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    J Clin Microbiol 37:3718-21. 1999
    ..Furthermore, OspA reactivity did not interfere with interpretation of immunoblots with sera from patients who developed early Lyme disease despite vaccination...
  27. ncbi request reprint Laboratory diagnostic techniques for patients with early Lyme disease associated with erythema migrans: a comparison of different techniques
    J Nowakowski
    Division of Infectious Diseases and Department of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY, 10595, USA
    Clin Infect Dis 33:2023-7. 2001
    ..burgdorferi infection. No single diagnostic modality is suitable for detection of B. burgdorferi in every patient with erythema migrans...
  28. pmc Impact of genotypic variation of Borrelia burgdorferi sensu stricto on kinetics of dissemination and severity of disease in C3H/HeJ mice
    G Wang
    Department of Biochemistry and Molecular Biology, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Infect Immun 69:4303-12. 2001
    ..burgdorferi, suggesting that genotypic differences in the infecting spirochetes play a key role in the pathogenesis and development of clinical disease...
  29. doi request reprint Quantitation of cell-associated borrelial DNA in the blood of Lyme disease patients with erythema migrans
    D Liveris
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Eur J Clin Microbiol Infect Dis 31:791-5. 2012
    ..For reasons discussed, we suggest caution in extrapolating an estimate of the number of viable Borrelia in plasma from the observed number of flaB copies...
  30. ncbi request reprint Failure of treatment with cephalexin for Lyme disease
    J Nowakowski
    Division of Infectious Diseases, Westchester Medical Center, New York Medical College, Valhalla, USA
    Arch Fam Med 9:563-7. 2000
    ..The first-generation cephalosporin, cephalexin monohydrate, is effective for treating bacterial cellulitis but has not been recommended or studied for treating Lyme disease because of poor in vitro activity...
  31. ncbi request reprint Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite
    R B Nadelman
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    N Engl J Med 345:79-84. 2001
    ..02). CONCLUSIONS: A single 200-mg dose of doxycycline given within 72 hours after an I. scapularis tick bite can prevent the development of Lyme disease...
  32. pmc Characterization of Borrelia burgdorferi isolated from erythema migrans lesions: interrelationship of three molecular typing methods
    R Iyer
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    J Clin Microbiol 39:2954-7. 2001
    ..001). The association between distinct chromosomal and plasmid markers implies a clonal origin for each genotype...
  33. ncbi request reprint Long-term follow-up of patients with culture-confirmed Lyme disease
    John Nowakowski
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York, USA
    Am J Med 115:91-6. 2003
    ..To determine the long-term outcome of patients with culture-confirmed Lyme disease...
  34. pmc Serology of culture-confirmed cases of human granulocytic ehrlichiosis
    M E Aguero-Rosenfeld
    Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10505, USA
    J Clin Microbiol 38:635-8. 2000
    ..Antibodies reach high titers during the first month and remain detectable in about one-half of patients at 1 year after onset of symptoms...
  35. ncbi request reprint Yield of large-volume blood cultures in patients with early Lyme disease
    G P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York, NY, USA
    J Infect Dis 184:1070-2. 2001
    ..Our findings suggest that, if further improvements in the yield of blood cultures are possible, they probably will depend on enhancing the sensitivity of the culture method rather than increasing the volume of material cultured...
  36. ncbi request reprint Efficacy of antibiotic prophylaxis for prevention of Lyme disease
    S Warshafsky
    Department of Medicine, New York Medical College, Valhalia 10595, USA
    J Gen Intern Med 11:329-33. 1996
    ..A larger randomized trial is needed to demonstrate definitively that prophylaxis is more effective than placebo in reducing the risk of early Lyme disease in endemic areas...
  37. ncbi request reprint Asymptomatic Borrelia burgdorferi infection
    G P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York, USA
    Med Hypotheses 57:435-8. 2001
    ..Theoretically, a serologic testing method could be devised which would distinguish infection with invasive versus non-invasive strains of B. burgdorferi, and allow testing of the second hypothesis...
  38. doi request reprint High frequency of false positive IgM immunoblots for Borrelia burgdorferi in clinical practice
    V Seriburi
    Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA
    Clin Microbiol Infect 18:1236-40. 2012
    ..False positive results were not restricted to any single commercial laboratory. Research on alternative testing strategies that eliminate the IgM immunoblot entirely is warranted...
  39. ncbi request reprint A first-tier rapid assay for the serodiagnosis of Borrelia burgdorferi infection
    M J Gomes-Solecki
    Brook Biotechnologies, Inc, Stony Brook, NY, USA
    Arch Intern Med 161:2015-20. 2001
    ..CONCLUSION: This sensitive and specific rapid assay, which is suited for the physician's office, streamlines the 2-tier system by allowing the physician to determine if a Western blot is necessary at the time of the initial office visit...
  40. pmc Antimicrobial susceptibility of Ehrlichia phagocytophila
    H W Horowitz
    Division of Infectious Diseases and Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 45:786-8. 2001
    ..For one strain, the MBC of chloramphenicol was < or =8 microg/ml. These data suggest that quinolone antibiotics and rifampin may be alternative agents for patients with intolerance to tetracyclines...
  41. pmc Quantitative detection of Borrelia burgdorferi in 2-millimeter skin samples of erythema migrans lesions: correlation of results with clinical and laboratory findings
    Dionysios Liveris
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    J Clin Microbiol 40:1249-53. 2002
    ..burgdorferi (P = 0.008) but not with the number or severity of symptoms. Skin culture positivity was significantly associated with skin lesions containing larger numbers of spirochetes (P = 0.019)...
  42. doi request reprint Pharmacodynamics of doxycycline for chemoprophylaxis of Lyme disease: preliminary findings and possible implications for other antimicrobials
    Jooyun Lee
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Int J Antimicrob Agents 31:235-9. 2008
    ..Additional experimental studies are needed to clarify more precisely the pharmacodynamic properties of doxycycline and to validate the accuracy of this hypothesis...
  43. ncbi request reprint Abnormalities of blood selenium and glutathione peroxidase activity in patients with acquired immunodeficiency syndrome and aids-related complex
    B M Dworkin
    Sarah C Upham Division of Gastroenterology, New York Medical College, Valhalla 10595
    Biol Trace Elem Res 15:167-77. 1988
    ..These abnormalities are most marked in patients with AIDS, but are also present in patients with AIDS-related complex. Selenium deficiency has important implications for the progression and pathogenesis of clinical disease in AIDS...
  44. doi request reprint Blood cultures for patients with extracutaneous manifestations of Lyme disease in the United States
    John Nowakowski
    Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York 10595, USA
    Clin Infect Dis 49:1733-5. 2009
    ..2%; 95% confidence interval, 6.6%-39.4%) of 26 untreated adult patients with extracutaneous manifestations but only for patients with clinical evidence for a short duration of infection...
  45. doi request reprint Persistent and relapsing babesiosis in immunocompromised patients
    Peter J Krause
    Division of Infectious Diseases, Connecticut Children s Medical Center, and Department of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut 06106, USA
    Clin Infect Dis 46:370-6. 2008
    ..Although patients experiencing babesiosis that is unresponsive to standard antimicrobial therapy have been described, the pathogenesis, clinical course, and optimal treatment regimen of such cases remain uncertain...
  46. ncbi request reprint Reinfection in patients with Lyme disease
    Robert B Nadelman
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 45:1032-8. 2007
    ..Because patients with early Lyme disease continue to remain at high risk for reinfection, this population should be targeted for education about prevention of Lyme disease...
  47. pmc Borrelia burgdorferi sensu stricto is clonal in patients with early Lyme borreliosis
    Klára Hanincová
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Appl Environ Microbiol 74:5008-14. 2008
    ..The strong linkage observed between the chromosome-located rrs-rrlA and plasmid-borne ospC genes suggests a clonal structure of B. burgdorferi in these isolates, despite evidence of recombination at ospC...
  48. pmc Seroprevalence of antibodies that react with Anaplasma phagocytophila, the agent of human granulocytic ehrlichiosis, in different populations in Westchester County, New York
    Maria E Aguero-Rosenfeld
    Division of Infectious Diseases, Department of Medicine, New York Medical College and Westchester Medical Center, Valhalla, New York 10595, USA
    J Clin Microbiol 40:2612-5. 2002
    ..phagocytophila antibodies when the conventional cutoff titer of 80 is used in the IFA. This information must be considered in interpretation of test results...
  49. pmc Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Infect Dis 198:1358-64. 2008
    ..burgdorferi recovered from patients from suburban New York City with early Lyme disease associated with erythema migrans; it is the largest number of borrelial strains from North America ever to be investigated...
  50. pmc Efficacy of short-course ceftriaxone therapy for Borrelia burgdorferi infection in C3H mice
    Charles Pavia
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 46:132-4. 2002
    ..These experiments suggest that shorter courses of antibiotics than those currently recommended should be considered for study in patients with early uncomplicated Lyme disease...
  51. pmc Disease severity in a murine model of lyme borreliosis is associated with the genotype of the infecting Borrelia burgdorferi sensu stricto strain
    Guiqing Wang
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    J Infect Dis 186:782-91. 2002
    ..burgdorferi isolate. The RST1 genotype is genetically homogeneous and thus may represent a recently evolved clonal lineage that is highly pathogenic in humans and animals...
  52. pmc Use of Peptide library screening to detect a previously unknown linear diagnostic epitope: proof of principle by use of lyme disease sera
    Carl V Hamby
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Clin Diagn Lab Immunol 12:801-7. 2005
    ....
  53. pmc Diagnosis of lyme borreliosis
    Maria E Aguero-Rosenfeld
    Department of Pathology, Division of Infectious Diseases, New York Medical College, Valhalla, NY, USA
    Clin Microbiol Rev 18:484-509. 2005
    ..Evaluation of these assays is currently being done, and there is evidence that certain of these antigens may be broadly cross-reactive with the B. burgdorferi sensu lato species causing LB in Europe...
  54. ncbi request reprint Poly-ticks: Blue State versus Red State for Lyme disease
    Robert B Nadelman
    Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA
    Lancet 365:280. 2005
  55. ncbi request reprint A comparison of two treatment regimens of ceftriaxone in late Lyme disease
    Raymond J Dattwyler
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Wien Klin Wochenschr 117:393-7. 2005
    ..The optimal duration of treatment for patients with late Lyme disease is unresolved...
  56. pmc Variations in Barbour-Stoenner-Kelly culture medium modulate infectivity and pathogenicity of Borrelia burgdorferi clinical isolates
    Guiqing Wang
    Department of Microbiology and Immunology, New York Medical College, Valhalla 10595, USA
    Infect Immun 72:6702-6. 2004
    ..The data suggest that variations in BSK medium have a significant impact on the infectivity and pathogenicity of B. burgdorferi clinical isolates...
  57. ncbi request reprint Costs and savings associated with infection control measures that reduced transmission of vancomycin-resistant enterococci in an endemic setting
    M A Montecalvo
    Division of Infectious Diseases, New York Medical College, Valhalla 10595, USA
    Infect Control Hosp Epidemiol 22:437-42. 2001
    ....
  58. ncbi request reprint Tuberculin skin test conversion in hospital employees vaccinated with bacille Calmette-Guérin: recent Mycobacterium tuberculosis infection or booster effect?
    H W Horowitz
    Department of Medicine, Westchester County Medical Center, New York Medical College, Valhalla 10595, USA
    Am J Infect Control 23:181-7. 1995
    ..We focused on the effect of bacille Calmette-Guérin (BCG) vaccination on PPD skin test conversion because of changes in employee health service policies in 1990 regarding testing of persons who had received BCG vaccination...
  59. ncbi request reprint Hepatitis C in the health care setting. II. Seroprevalence among hemodialysis staff and patients in suburban New York City
    G Forseter
    Division of Infectious Diseases, New York Medical College, Valhalla
    Am J Infect Control 21:5-8. 1993
    ..CONCLUSIONS: In contrast to the experience with hepatitis B virus infection, hemodialysis nurses appear to be at low risk for occupationally acquired HCV infection...
  60. pmc Comparative genome hybridization reveals substantial variation among clinical isolates of Borrelia burgdorferi sensu stricto with different pathogenic properties
    Darya Terekhova
    Department of Microbiology and Immunology, New York Medical College, BSB Room 308, Valhalla, NY 10595, USA
    J Bacteriol 188:6124-34. 2006
    ..Because there is substantially less variation in the chromosomal and circular plasmid portions of the genome, the major differences in open reading frame content and genomic diversity among isolates are linear plasmid driven...
  61. pmc Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptoms
    Abhishek Chandra
    Department of Neurology and Neuroscience, Cornell University, New York, NY 10065, USA
    Brain Behav Immun 24:1018-24. 2010
    ..The results provide evidence for the existence of a differential immune system response in PLS, offering new clues about the etiopathogenesis of the disease that may prove useful in devising more effective treatment strategies...
  62. ncbi request reprint Ecthyma gangrenosum in patients with acquired immunodeficiency syndrome
    M O Khan
    Department of Medicine, New York Medical College, Valhalla, USA
    Cutis 66:121-3. 2000
    ..To describe the reoccurrence of ecthyma gangrenosum (EG) in two patients with acquired immunodeficiency syndromes (AIDS)...
  63. ncbi request reprint Use of mycobacterial smears in the diagnosis of pulmonary tuberculosis in AIDS/ARC patients
    N C Klein
    Department of Medicine, Metropolitan Hospital Center, New York, New York
    Chest 95:1190-2. 1989
    ..We conclude that acid-fast smears on sputum specimens are a relatively insensitive test for pulmonary tuberculosis in AIDS/ARC patients...
  64. ncbi request reprint SI units and the clinical practice of infectious diseases: application to the usage of antimicrobial agents
    H L Quentzel
    Department of Medicine, New York Medical College, Valhalla 10595
    Rev Infect Dis 11:122-7. 1989
    ..A table is presented to facilitate conversion of metric units to SI units and vice versa...
  65. doi request reprint Epidemiology of an outbreak of antibiotic-resistant Klebsiella pneumoniae at a tertiary care medical center
    Alina Filozov
    Division of Infectious Diseases, New York Medical College, Valhalla, NY, USA
    Am J Infect Control 37:723-8. 2009
    ..In 2004, a 650-bed, tertiary care medical center experienced an outbreak of multiple antibiotic-resistant Klebsiella pneumoniae (MR-KP) that included extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing strains...
  66. pmc Erythromycin resistance in Borrelia burgdorferi
    Darya Terekhova
    Departments of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 46:3637-40. 2002
    ....
  67. ncbi request reprint Factors influencing the utilization of Lyme disease-prevention behaviors in a high-risk population
    Donna McKenna
    Lyme Disease Diagnostic Center LDDC, Westchester Medical Center, USA
    J Am Acad Nurse Pract 16:24-30. 2004
    ..To evaluate factors motivating high-risk individuals to implement Lyme disease-prevention behaviors...
  68. ncbi request reprint Dietary intake in patients with acquired immunodeficiency syndrome (AIDS), patients with AIDS-related complex, and serologically positive human immunodeficiency virus patients: correlations with nutritional status
    B M Dworkin
    New York Medical College, Sarah C Upham Division of Gastroenterology, Valhalla 10595
    JPEN J Parenter Enteral Nutr 14:605-9. 1990
    ..9 +/- 2.5 in HIV-seropositive-only cases (p less than 0.05 AIDS vs ARC). There were no significant correlations between specific anthropometric measurements and dietary intakes of protein or fat.(ABSTRACT TRUNCATED AT 250 WORDS)..
  69. pmc In vivo and in vitro studies on Anaplasma phagocytophilum infection of the myeloid cells of a patient with chronic myelogenous leukaemia and human granulocytic ehrlichiosis
    M Bayard-Mc Neeley
    Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
    J Clin Pathol 57:499-503. 2004
    ....
  70. ncbi request reprint Dexamethasone inhibits CD4 T cell deletion mediated by macrophages from human immunodeficiency virus-infected persons
    T W Orlikowsky
    Department of Microbiology and Immunology, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA
    J Infect Dis 184:1328-30. 2001
    ..Dexamethasone inhibits the macrophage-mediated deletion of CD4 lymphocytes in HIV-infected persons...
  71. doi request reprint Cryptococcal infection presenting as cellulitis in a renal transplant recipient
    J Orsini
    Department of Medicine, Division of Infectious Diseases, New York Medical College and Westchester Medical Center, Valhalla, New York 10595, USA
    Transpl Infect Dis 11:68-71. 2009
    ..Tissue sampling for histological and microbiological evaluation is usually necessary to establish a diagnosis...
  72. ncbi request reprint Hepatitis C infection in the health care setting. I. Low risk from parenteral exposure to blood of human immunodeficiency virus-infected patients
    G P Wormser
    Department of Medicine, New York Medical College, Valhalla 10595
    Am J Infect Control 19:237-42. 1991
    ..We conclude that parenteral exposure to blood of HIV-infected patients in the health care setting is rarely associated with the development of hepatitis C infection...
  73. doi request reprint Relationship between population density of attorneys and prevalence of methicillin-resistant Staphylococcus aureus: is medical-legal pressure on physicians a driving force behind the development of antibiotic resistance?
    George Sakoulas
    Division of Infectious Diseases, Department of Medicine, School of Public Health, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA
    Am J Ther 16:e1-6. 2009
    ..aureus, with global implications on the ethics of the delivery of quality health care to all members of society...
  74. pmc Borrelia burgdorferi BmpA, BmpB, and BmpD proteins are expressed in human infection and contribute to P39 immunoblot reactivity in patients with Lyme disease
    Anton V Bryksin
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Clin Diagn Lab Immunol 12:935-40. 2005
    ..This suggests that at least three of the four Bmp proteins are expressed by B. burgdorferi in infected patients and that specific antibodies to them are likely to be present in the P39 band in some patients...
  75. pmc Bacterial contamination of ophthalmic solutions used in an extended care facility
    Danny H Kauffmann Jokl
    Department of Ophthalmology, Westchester Medical Center, New York Medical College, New York, USA
    Br J Ophthalmol 91:1308-10. 2007
    ..To assess the frequency of contamination of ophthalmic solutions in a long-term care facility and to describe the characteristics of contaminated solutions...
  76. doi request reprint Scientific evidence and best patient care practices should guide the ethics of Lyme disease activism
    Paul G Auwaerter
    Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Med Ethics 37:68-73. 2011
    ..It is the responsibility of all physicians and medical scientists to stand up to antiscientific, baseless and unethical attacks on those who support an evidence-based approach to caring for patients...
  77. pmc Improving the yield of blood cultures from patients with early Lyme disease
    Dionysios Liveris
    Department of Microbiology and Immunology, Division of Infectious Diseases, New York Medical College, Valhalla, New York 10595, USA
    J Clin Microbiol 49:2166-8. 2011
    ..Patients with multiple erythema migrans were almost uniformly culture positive by this technique...
  78. doi request reprint Efficacy of antibiotic prophylaxis for the prevention of Lyme disease: an updated systematic review and meta-analysis
    Stephen Warshafsky
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Antimicrob Chemother 65:1137-44. 2010
    ..Our objective was to update our prior meta-analysis on antibiotic prophylaxis for the prevention of Lyme disease, to obtain a more precise estimate of treatment effect...
  79. ncbi request reprint Natural history of colonization with vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus, and resistant gram-negative bacilli among long-term-care facility residents
    Glenn A Pacio
    Division of Infectious Diseases, New York Medical College, Valhalla 10595, USA
    Infect Control Hosp Epidemiol 24:246-50. 2003
    ..To determine the natural history of colonization with vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and resistant gram-negative bacilli among long-term-care facility (LTCF) residents...
  80. doi request reprint Hepatitis in association with rickettsialpox
    Gul Madison
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Vector Borne Zoonotic Dis 8:111-5. 2008
    ..In this report, we describe two patients with rickettsialpox who had acute hepatitis that resolved completely. In the appropriate clinical setting, rickettsialpox should be considered in the differential diagnosis of hepatitis...
  81. ncbi request reprint Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates
    Rendi Murphree Bacon
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    J Infect Dis 187:1187-99. 2003
    ..burgdorferi in patients with acute erythema migrans. In later stages of Lyme disease, the sensitivities of the in parallel tests and 2-tiered testing were high and statistically equivalent...
  82. ncbi request reprint A skin lesion in a patient from Kentucky
    Fadi A Haddad
    Center for Infectious Diseases, T J Samson Community Hospital, Glasgow, Kentucky 42141, USA
    Clin Infect Dis 40:429, 475-6. 2005
  83. pmc Analysis of sequences and loci of p44 homologs expressed by Anaplasma phagocytophila in acutely infected patients
    Quan Lin
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA
    J Clin Microbiol 40:2981-8. 2002
    ..Furthermore, several p44 genes are not hypermutatable in nature, based on the conservation of gene sequences and loci among isolates obtained 5 years apart...
  84. ncbi request reprint Advances in the treatment and prevention of Lyme borreliosis
    Gary P Wormser
    Wien Klin Wochenschr 117:381-4. 2005
  85. pmc Recombinant assay for serodiagnosis of Lyme disease regardless of OspA vaccination status
    Maria J C Gomes-Solecki
    Brook Biotechnologies, Inc, Stony Brook, New York 11790 3350, USA
    J Clin Microbiol 40:193-7. 2002
    ..05). Our data demonstrate that this new sensitive rNon-OspA ELISA can be used for the laboratory detection of B. burgdorferi antibodies regardless of vaccination status and could replace existing serologic assays for Lyme disease...
  86. ncbi request reprint Impressions of the IX Conference on Lyme Borreliosis and Other Tick-Borne Diseases, August 18-22, 2002
    Gary P Wormser
    Vector Borne Zoonotic Dis 2:201-7. 2002
  87. pmc MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi
    Gabriele Margos
    Departments of Biology and Biochemistry and Mathematical Sciences, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 105:8730-5. 2008
    ..burgdorferi correspond to genetically distinct populations. Importantly, the MLST data suggest that B. burgdorferi originated in Europe rather than in North America as proposed previously...
  88. pmc The propensity of different Borrelia burgdorferi sensu stricto genotypes to cause disseminated infections in humans
    Daniel E Dykhuizen
    Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
    Am J Trop Med Hyg 78:806-10. 2008
    ..Our results demonstrate that only some genotypes of B. burgdorferi present in ticks have a high propensity to disseminate in humans...
  89. doi request reprint Anti-tumor necrosis factor-alpha activation of Borrelia burgdorferi spirochetes in antibiotic-treated murine Lyme borreliosis: an unproven conclusion
    Gary P Wormser
    J Infect Dis 196:1865-6; author reply 1866-7. 2007
  90. pmc Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis
    Utpal Pal
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 205:133-41. 2008
    ..These data delineate a role for differentially produced B. burgdorferi antigens in spirochete colonization of mouse joints, and suggest new strategies for the treatment of Lyme arthritis...
  91. ncbi request reprint A critical appraisal of "chronic Lyme disease"
    Henry M Feder
    Department of Family Medicine and Pediatrics, Connecticut Children s Medical Center, Hartford, CT, USA
    N Engl J Med 357:1422-30. 2007
  92. ncbi request reprint Single-dose prophylaxis against Lyme disease
    Gary P Wormser
    Lancet Infect Dis 7:371-3. 2007
  93. pmc Borrelia burgdorferi spirochetes that harbor only a portion of the lp28-1 plasmid elicit antibody responses detectable with the C6 test for Lyme disease
    Monica E Embers
    Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Clin Vaccine Immunol 14:90-3. 2007
    ..These findings demonstrate that diagnosis by C6 ELISA remains effective for infection with all B. burgdorferi genotypes, including those with incomplete lp28-1 plasmids...
  94. pmc Serologic evaluation of patients from Missouri with erythema migrans-like skin lesions with the C6 Lyme test
    Mario T Philipp
    Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Clin Vaccine Immunol 13:1170-1. 2006
    ..The C6 test is negative in patients with STARI, providing further evidence that B. burgdorferi is not the etiologic agent of this disease...
  95. ncbi request reprint Response to meta-analysis of Lyme borreliosis symptoms
    Eugene D Shapiro
    Int J Epidemiol 34:1437-9; author reply 1440-3. 2005
  96. pmc A decline in C6 antibody titer occurs in successfully treated patients with culture-confirmed early localized or early disseminated Lyme Borreliosis
    Mario T Philipp
    Department of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    Clin Diagn Lab Immunol 12:1069-74. 2005
    ..0001). These results indicate that a decline in anti-C(6) antibody titer coincides with effective antimicrobial therapy in patients with early localized or early disseminated Lyme borreliosis...
  97. ncbi request reprint Recognition and treatment of erythema migrans: are we off target?
    Robert B Nadelman
    Ann Intern Med 136:477-9. 2002
  98. doi request reprint Oral doxycycline for neuroborreliosis
    Gary P Wormser
    Lancet Neurol 7:665-6. 2008

Research Grants2

  1. Subjective Symptoms after Treatment of Lyme Disease
    Gary P Wormser; Fiscal Year: 2010
    ..In a different group of patients, we will describe for the first time the outcome of patients with early Lyme disease more than 10 years after diagnosis and treatment. ..
  2. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ....