Affiliation: New York University
Witkovsky P. Dopamine and retinal function. Doc Ophthalmol. 2004;108:17-40 pubmed
..Some diseases affecting photoreceptor function also diminish day/night differences in dopamine release and turnover. A reduction in retinal dopamine, as occurs in Parkinsonian patients, results in reduced visual contrast sensitivity. ..
Witkovsky P, Veisenberger E, Haycock J, Akopian A, Garcia Espana A, Meller E. Activity-dependent phosphorylation of tyrosine hydroxylase in dopaminergic neurons of the rat retina. J Neurosci. 2004;24:4242-9 pubmed
..Collectively, these data indicate that, in the retina, dopamine synthesis in varicosities is affected by the spiking activity of retinal neurons, possibly including that of the DA neurons themselves. ..
Witkovsky P, Patel J, Lee C, Rice M. Immunocytochemical identification of proteins involved in dopamine release from the somatodendritic compartment of nigral dopaminergic neurons. Neuroscience. 2009;164:488-96 pubmed publisher
Witkovsky P, Svenningsson P, Yan L, Bateup H, Silver R. Cellular localization and function of DARPP-32 in the rodent retina. Eur J Neurosci. 2007;25:3233-42 pubmed
..We also tested for a possible circadian rhythm of Thr 34- and Thr 75-DARPP-32 and Ser 845-GluR1 expression. No significant circadian rhythm of either DARPP-32 or GluR1 phosphorylation was found. ..
Witkovsky P, Veisenberger E, LeSauter J, Yan L, Johnson M, Zhang D, et al
. Cellular location and circadian rhythm of expression of the biological clock gene Period 1 in the mouse retina. J Neurosci. 2003;23:7670-6 pubmed
..Our results are the first to demonstrate a circadian rhythm of a biological clock component in identified neurons of a mammalian retina. ..
Witkovsky P, Shen C, McRory J. Differential distribution of voltage-gated calcium channels in dopaminergic neurons of the rat retina. J Comp Neurol. 2006;497:384-96 pubmed
..Our findings are consistent with the available pharmacological data indicating that alpha1A and alpha1B calcium channels control the major fraction of dopamine release in the rat retina. ..
Witkovsky P, Stell W, Ishida A. Circuits and properties of signal transmission in the retina. J Neurophysiol. 2006;96:509-11 pubmed
..J. Neurophysiol 36: 619-633, 1973. Naka K-I, Marmarelis PZ, and Chan RY. Morphological and functional identifications of catfish retinal neurons. III. Functional identification. J. Neurophysiol 38: 92-131, 1975...
Witkovsky P, G briel R, Krizaj D. Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinas. J Comp Neurol. 2008;510:158-74 pubmed publisher
..Outer retinal varicosities of this putative GABAergic IPC did colocalize synaptic vesicle protein 2a, suggesting they possessed a conventional vesicular release mechanism...