Isaac Wirgin

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. pmc Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River
    Isaac Wirgin
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Science 331:1322-5. 2011
  2. doi request reprint Polymorphisms in RAD51, XRCC2, and XRCC3 are not related to breast cancer risk
    Jennifer Brooks
    Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016 3240, USA
    Cancer Epidemiol Biomarkers Prev 17:1016-9. 2008
  3. pmc Evidence of spatially extensive resistance to PCBs in an anadromous fish of the Hudson River
    Zhanpeng Yuan
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Environ Health Perspect 114:77-84. 2006
  4. ncbi request reprint Comparison of hepatic and extra hepatic induction of cytochrome P4501A by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations
    Zhanpeng Yuan
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, 10987, USA
    Aquat Toxicol 76:306-20. 2006
  5. doi request reprint Polymorphisms in XPC and ERCC2 genes, smoking and breast cancer risk
    Roy E Shore
    Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Int J Cancer 122:2101-5. 2008
  6. doi request reprint Development and use of real-time reverse transcription-polymerase chain reaction assay to quantify cytochrome P4501A1 expression in American mink
    Nirmal K Roy
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Arch Environ Contam Toxicol 57:608-15. 2009
  7. pmc Characterization and expression of cytochrome P4501A in Atlantic sturgeon and shortnose sturgeon experimentally exposed to coplanar PCB 126 and TCDD
    Nirmal K Roy
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Aquat Toxicol 104:23-31. 2011
  8. pmc DNA methylation in pre-diagnostic serum samples of breast cancer cases: results of a nested case-control study
    Jennifer D Brooks
    Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, United States
    Cancer Epidemiol 34:717-23. 2010
  9. ncbi request reprint Resistance to contaminants in North American fish populations
    Isaac Wirgin
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 552:73-100. 2004
  10. pmc Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer
    Tess V Clendenen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cancer Lett 260:209-15. 2008

Collaborators

Detail Information

Publications11

  1. pmc Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River
    Isaac Wirgin
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Science 331:1322-5. 2011
    ..This mechanistic basis of resistance in a vertebrate population provides evidence of evolutionary change due to selective pressure at a single locus...
  2. doi request reprint Polymorphisms in RAD51, XRCC2, and XRCC3 are not related to breast cancer risk
    Jennifer Brooks
    Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016 3240, USA
    Cancer Epidemiol Biomarkers Prev 17:1016-9. 2008
  3. pmc Evidence of spatially extensive resistance to PCBs in an anadromous fish of the Hudson River
    Zhanpeng Yuan
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Environ Health Perspect 114:77-84. 2006
    ..Tomcod from the Hudson River may represent the most geographically expansive population of vertebrates with resistance to chemical pollutants that has been characterized...
  4. ncbi request reprint Comparison of hepatic and extra hepatic induction of cytochrome P4501A by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations
    Zhanpeng Yuan
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, 10987, USA
    Aquat Toxicol 76:306-20. 2006
    ..Our results also indicate that CYP1A mRNA levels in environmentally exposed fish may not reflect additive tissue burdens of PCB congeners...
  5. doi request reprint Polymorphisms in XPC and ERCC2 genes, smoking and breast cancer risk
    Roy E Shore
    Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
    Int J Cancer 122:2101-5. 2008
    ..Further study of the XPC haplotypes and their interactions with smoking in relation to breast cancer risk is needed...
  6. doi request reprint Development and use of real-time reverse transcription-polymerase chain reaction assay to quantify cytochrome P4501A1 expression in American mink
    Nirmal K Roy
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Arch Environ Contam Toxicol 57:608-15. 2009
    ..This study demonstrates that hepatic CYP1A1 mRNA may be a sensitive biomarker of exposure of mink to environmentally relevant levels of PCBs and may be predictive of their effects in natural populations...
  7. pmc Characterization and expression of cytochrome P4501A in Atlantic sturgeon and shortnose sturgeon experimentally exposed to coplanar PCB 126 and TCDD
    Nirmal K Roy
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Aquat Toxicol 104:23-31. 2011
    ....
  8. pmc DNA methylation in pre-diagnostic serum samples of breast cancer cases: results of a nested case-control study
    Jennifer D Brooks
    Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, United States
    Cancer Epidemiol 34:717-23. 2010
    ..This suggests the potential for these serum markers to be used for breast cancer detection...
  9. ncbi request reprint Resistance to contaminants in North American fish populations
    Isaac Wirgin
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 552:73-100. 2004
    ..Open-ended microarray and proteomic approaches may provide additional resolution in determining the molecular mechanisms of resistance. Also, studies that evaluate the prevalence and ecosystem cost of resistance are needed...
  10. pmc Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer
    Tess V Clendenen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cancer Lett 260:209-15. 2008
    ..These observations do not support a role for BSMI, APAI, TAQI, and FOKI polymorphisms in epithelial ovarian cancer in a predominantly Caucasian population...
  11. ncbi request reprint Cytochrome P4501A1 is induced by PCB 77 and benzo[a]pyrene treatment but not by exposure to the Hudson River environment in Atlantic tomcod (Microgadus tomcod) post-yolk sac larvae
    Nirmal K Roy
    Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Biomarkers 7:162-73. 2002
    ....