Research Topics
| Sunil WimalawansaSummaryAffiliation: New Jersey Country: USA Publications
Research Grants
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Detail Information
Publications
Vitamin D: an essential component for skeletal healthSunil J Wimalawansa
Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, and UMDNJ, Robert Wood Johnson Medical School, Physiology and Integrative Biology, Graduate School of Biomedical Sciences, New Brunswick, New Jersey 08903 0019, USA
Ann N Y Acad Sci 1240:E1-12. 2011..Additional research is needed to clarify the relationship between vitamin D and the nonskeletal systems, nonclassic functions, and targets of vitamin D...- Vitamin D in the new millenniumSunil J Wimalawansa
Physiology and Integrative Biology, Endocrinology, Metabolism and Nutrition, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Curr Osteoporos Rep 10:4-15. 2012..Other vulnerable patients, such as the obese, those who have undergone bariatric surgery, and those with gastrointestinal malabsorption syndromes, may require higher doses of vitamin D to maintain normal serum levels and be healthy... - Nitric oxide and boneSunil J Wimalawansa
Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Ann N Y Acad Sci 1192:391-403. 2010..Large numbers of animal studies and human pilot studies support the concept of using NO donors for preventing bone loss. Administration of exogenous NO or prolonging endogenous NO activity are practical ways to supplement NO... 
Transdermal nitroglycerin therapy may not prevent early postmenopausal bone lossSunil J Wimalawansa
Division of Endocrinology, Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903 0019, USA
J Clin Endocrinol Metab 94:3356-64. 2009..Osteoporosis is common among postmenopausal women; animal studies and human pilot studies support the concept of nitric oxide (NO) donors reducing bone mineral density loss...
Bisphosphonate-associated osteomyelitis of the jaw: guidelines for practicing cliniciansSunil J Wimalawansa
Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903 0019, USA
Endocr Pract 14:1150-68. 2008..To evaluate the literature and discuss the risk factors, mechanisms, pathophysiologic aspects, and recommended management of bisphosphonate-associated osteomyelitis of the jaw (BAOMJ)...- Nitric oxide: novel therapy for osteoporosisSunil J Wimalawansa
Regional Osteoporosis Center, Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
Expert Opin Pharmacother 9:3025-44. 2008..Excess or inappropriate local production of NO aggravates bone destruction in some diseases such as septic shock, rheumatoid and other inflammatory arthropathies... - Nitric oxide: new evidence for novel therapeutic indicationsSunil J Wimalawansa
Robert Wood Johnson Medical School, Department of Medicine, New Brunswick, NJ 08903, USA
Expert Opin Pharmacother 9:1935-54. 2008..NO donor therapies are indicated in these conditions... - Insight into bisphosphonate-associated osteomyelitis of the jaw: pathophysiology, mechanisms and clinical managementSunil J Wimalawansa
Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
Expert Opin Drug Saf 7:491-512. 2008..Bisphosphonate-associated osteomyelitis of the jaw (BAOMJ) affects 1 per 100,000 patients-treated years for non-cancer bone diseases and approximately 1 - 2% of cancer patients treated with bisphosphonates... - Rationale for using nitric oxide donor therapy for prevention of bone loss and treatment of osteoporosis in humansSunil J Wimalawansa
Division of Endocrinology and Metabolism, Robert Wood Johnson Medical School, 372 MEB, New Brunswick, NJ 08903 0019, USA
Ann N Y Acad Sci 1117:283-97. 2007..If results of this study confirm our hypothesis, it is plausible that nitroglycerine therapy may supplant estrogen replacement and SERMs in preventing and treating postmenopausal osteoporosis... - Breastfeeding and postmenopausal osteoporosisJulia P Grimes
Division of Endocrinology, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, One Robert Wood Johnson Place 372 MEB, PO Box 19, New Brunswick, NJ 08903 0019, USA
Curr Womens Health Rep 3:193-8. 2003..Better understanding of this relationship will provide new opportunities for early intervention and ultimately help in the prevention of bone loss in postmenopausal women... - Bones and nutrition: common sense supplementation for osteoporosisSonoo Advani
Division of Endocrinology, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, One Robert Wood Johnson Place 372 MEB, PO Box 19, New Brunswick, NJ 08903 0019, USA
Curr Womens Health Rep 3:187-92. 2003..In this article, the roles of diet and nutritional supplementation in preventing and treating osteoporosis are reviewed... - The efficacy of acute administration of pamidronate on the conservation of bone mass following severe burn injury in children: a double-blind, randomized, controlled studyGordon L Klein
Children s Hospital, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas, TX 77555 0352, USA
Osteoporos Int 16:631-5. 2005..In summary, acute intravenous pamidronate administration following burns may help to preserve bone mass, perhaps by inhibiting the glucocorticoid-induced apoptosis of osteoblasts and osteocytes... - Model for bone strength and osteoporotic fracturesGemunu H Gunaratne
Department of Physics, University of Houston, Houston, Texas 77204, USA
Phys Rev Lett 88:068101. 2002..The "stress backbones" and histograms of stress distributions for healthy and weak networks are shown to be qualitatively different. A hereto untested relationship between bone density and bone strength is presented... - Testing two predictions for fracture load using computer models of trabecular boneMichael A K Liebschner
Department of Bioengineering, Rice University, Houston, Texas, USA
Biophys J 89:759-67. 2005..Since Gamma can be computed from a vibrational assessment of bone, we argue that the latter can be used to introduce new surrogates for bone strength and hence diagnostic tools for osteoporosis... - Adrenomedullin antagonist treatment during early gestation in rats causes fetoplacental growth restriction through apoptosisJosthna Penchalaneni
Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555, USA
Biol Reprod 71:1475-83. 2004..In conclusion, these findings show that antagonism of AM in rats during early pregnancy caused fetoplacental growth restriction through the activation of mitochondrial apoptotic pathways... - An expression relating breaking stress and density of trabecular boneChamith S Rajapakse
Department of Physics, University of Houston, Houston, TX 77204, USA
J Biomech 37:1241-9. 2004..In addition, changes caused by trabecular thinning and anisotropy can be modeled by the expression... - Adrenomedullin requires an intact nitric oxide system to function as an endogenous vasodilator in rat gestationAndrea G Witlin
Obstetrics and Gynecology Department, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 1066, USA
Hypertens Pregnancy 22:9-24. 2003....
Research Grants
- Prevention of Postmenopausal Bone Loss with Nitric OxideSunil Wimalawansa; Fiscal Year: 2006..The study will also pave the way for the future for providing more acceptable affordable and cost-effective therapies for the prevention of postmenopausal osteoporosis. ..
- Prevention of Postmenopausal Bone Loss with Nitric OxideSunil Wimalawansa; Fiscal Year: 2007..The study will also pave the way for the future, for providing more acceptable, affordable and cost- effective therapies for the prevention of postmenopausalosteoporosis. ..