Eileen White

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
    Kevin Bray
    The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America
    PLoS ONE 7:e41831. 2012
  2. pmc Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma
    Xiaoqi Xie
    The Cancer Institute of New Jersey, New Brunswick, NJ, USA
    PLoS ONE 8:e55096. 2013
  3. pmc Deconvoluting the context-dependent role for autophagy in cancer
    Eileen White
    The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08903, USA
    Nat Rev Cancer 12:401-10. 2012
  4. pmc Role of autophagy in suppression of inflammation and cancer
    Eileen White
    The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Curr Opin Cell Biol 22:212-7. 2010
  5. pmc Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    Kurt Degenhardt
    Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey 08854, USA
    Cancer Cell 10:51-64. 2006
  6. pmc Autophagy suppresses tumor progression by limiting chromosomal instability
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 21:1367-81. 2007
  7. pmc Effect of dual inhibition of apoptosis and autophagy in prostate cancer
    Ahamed Saleem
    The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
    Prostate 72:1374-81. 2012
  8. pmc Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    Vassiliki Karantza-Wadsworth
    Division of Medical Oncology, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Genes Dev 21:1621-35. 2007
  9. pmc Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
    Jessie Yanxiang Guo
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 25:460-70. 2011
  10. pmc Bcl-2 modulation to activate apoptosis in prostate cancer
    Kevin Bray
    The Cancer Institute of New Jersey, New Brunswick, NJ 08903 2681, USA
    Mol Cancer Res 7:1487-96. 2009

Collaborators

Detail Information

Publications62

  1. pmc Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
    Kevin Bray
    The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America
    PLoS ONE 7:e41831. 2012
    ..Thus, coordinate mTOR and autophagy inhibition leads to an imbalance between ROS production and defense, causing necroptosis that may enhance cancer treatment efficacy...
  2. pmc Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma
    Xiaoqi Xie
    The Cancer Institute of New Jersey, New Brunswick, NJ, USA
    PLoS ONE 8:e55096. 2013
    ..These data suggest that coordinate inhibition of the mTOR and autophagy pathways promotes apoptosis and could be a new therapeutic paradigm for the treatment of melanoma...
  3. pmc Deconvoluting the context-dependent role for autophagy in cancer
    Eileen White
    The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08903, USA
    Nat Rev Cancer 12:401-10. 2012
    ..Therefore, defining the context-specific role for autophagy in cancer and the mechanisms involved will be important to guide autophagy-based therapeutic intervention...
  4. pmc Role of autophagy in suppression of inflammation and cancer
    Eileen White
    The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Curr Opin Cell Biol 22:212-7. 2010
    ..Thus, cellular damage mitigation through autophagy is a novel mechanism of tumor suppression...
  5. pmc Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    Kurt Degenhardt
    Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey 08854, USA
    Cancer Cell 10:51-64. 2006
    ..Thus, autophagy may function in tumor suppression by mitigating metabolic stress and, in concert with apoptosis, by preventing death by necrosis...
  6. pmc Autophagy suppresses tumor progression by limiting chromosomal instability
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 21:1367-81. 2007
    ..Identification of this novel role of autophagy may be important for rational chemotherapy and therapeutic exploitation of autophagy inducers as potential chemopreventive agents...
  7. pmc Effect of dual inhibition of apoptosis and autophagy in prostate cancer
    Ahamed Saleem
    The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
    Prostate 72:1374-81. 2012
    ....
  8. pmc Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    Vassiliki Karantza-Wadsworth
    Division of Medical Oncology, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Genes Dev 21:1621-35. 2007
    ..Therefore, we propose that autophagy limits metabolic stress to protect the genome, and that defective autophagy increases DNA damage and genomic instability that ultimately facilitate breast cancer progression...
  9. pmc Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
    Jessie Yanxiang Guo
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 25:460-70. 2011
    ..As cancers with Ras mutations have a poor prognosis, this "autophagy addiction" suggests that targeting autophagy and mitochondrial metabolism are valuable new approaches to treat these aggressive cancers...
  10. pmc Bcl-2 modulation to activate apoptosis in prostate cancer
    Kevin Bray
    The Cancer Institute of New Jersey, New Brunswick, NJ 08903 2681, USA
    Mol Cancer Res 7:1487-96. 2009
    ..Thus, rational targeting of both the Bcl-2 and Mcl-1 mechanisms of apoptosis resistance may be therapeutically advantageous for advanced prostate cancer...
  11. pmc Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer
    Yanying Huo
    Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Cancer Discov 3:894-907. 2013
    ..These results indicate that, in the face of DNA damage and oxidative stress elicited by PALB2 loss, p53 is a barrier to cancer development, whereas autophagy facilitates cell survival and tumorigenesis. ..
  12. pmc Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
    Jessie Yanxiang Guo
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 27:1447-61. 2013
    ..Moreover, cancers require autophagy for distinct roles in metabolism that are oncogene- and tumor suppressor gene-specific. ..
  13. pmc Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression
    Cristina M Karp
    Department of Molecular Biology and Biochemistry, Center for Advanced Biotechnology and Medicine, Rutgers University, NJ 08854, USA
    Cancer Res 68:4105-15. 2008
    ..These findings suggest a role for mammalian polarity determinants in suppressing tumorigenesis that may be analogous to the well-studied polarity tumor suppressor mechanisms in Drosophila...
  14. pmc Role of autophagy in cancer
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nat Rev Cancer 7:961-7. 2007
    ..Recent evidence suggests that autophagy provides a protective function to limit tumour necrosis and inflammation, and to mitigate genome damage in tumour cells in response to metabolic stress...
  15. doi Immortalized mouse epithelial cell models to study the role of apoptosis in cancer
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Methods Enzymol 446:77-106. 2008
    ..Applying this technology to other mouse models can provide insight into additional aspects of oncogenesis...
  16. pmc Role of autophagy in breast cancer
    Vassiliki Karantza-Wadsworth
    Division of Medical Oncology, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Autophagy 3:610-3. 2007
    ....
  17. pmc Metabolic catastrophe as a means to cancer cell death
    Shengkan Jin
    Department of Pharmacology, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Cell Sci 120:379-83. 2007
    ..The challenge now is to induce metabolic catastrophe therapeutically as an approach to killing the unkillable cells...
  18. pmc Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma
    Gaofeng Fan
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School, Piscataway, USA
    Blood 115:3559-69. 2010
    ..Furthermore, because bfl-1 is up-regulated in many human hematopoietic tumors, this finding suggests that strategies to promote Bfl-1 ubiquitination may improve therapy...
  19. ncbi Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling
    Ramya Sundararajan
    Rutgers University, 679 Hoes Lane, Room 140, Piscataway, NJ 08854, USA
    Oncogene 24:4908-20. 2005
    ..DBC-1, like its homolog cell cycle and apoptosis regulatory protein-1 (CARP-1), may function in the regulation of apoptosis...
  20. ncbi Autophagy is required for glucose homeostasis and lung tumor maintenance
    Gizem Karsli-Uzunbas
    Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey
    Cancer Discov 4:914-27. 2014
    ..This antitumor activity occurred before destruction of normal tissues, suggesting that acute autophagy inhibition may be therapeutically beneficial in cancer...
  21. pmc Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8521, USA
    J Nat Prod 74:842-6. 2011
    ..To our knowledge, this is the first report of secondary metabolites from the marine hydrothermal vent mussel B. thermophilus...
  22. doi Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies
    Mark Stein
    Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08901, USA
    Prostate 70:1388-94. 2010
    ....
  23. pmc Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    Mar Drugs 10:2300-11. 2012
    ..To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans...
  24. ncbi Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity
    Sylvain Lesne
    UMR CNRS 6185, Universite de Caen, Bd H Becquerel BP5229, 14074 Caen, France and Howard Hughes Medical Institute, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:24941-7. 2005
    ..Together, these findings demonstrate that NT-3 signaling counters Abeta-dependent neuronal cell death and may represent an innovative therapeutic intervention to limit neuronal death in Alzheimer disease...
  25. pmc Autophagy suppresses tumorigenesis through elimination of p62
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell 137:1062-75. 2009
    ....
  26. ncbi Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
    Ting Ting Tan
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
    Cancer Cell 7:227-38. 2005
    ....
  27. pmc Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
    Jing Fan
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    Mol Syst Biol 9:712. 2013
    ..Thus, glutamine-driven oxidative phosphorylation is a major means of ATP production even in hypoxic cancer cells. ..
  28. pmc A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899
    Robert S DiPaola
    Department of Medicine, The Cancer Institute of New Jersey, UMDNJ RWJMS, New Brunswick NJ, USA
    J Transl Med 8:20. 2010
    ....
  29. pmc Rationally designed treatment for solid tumors with MAPK pathway activation: a phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach
    Janice M Mehnert
    Department of Medicine, Division of Medical Oncology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Mol Cancer Ther 10:1509-19. 2011
    ....
  30. ncbi A novel proteomic coculture model of prostate cancer cell growth
    Dmitri Dvorzhinski
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08901, USA
    Proteomics 4:3268-75. 2004
    ..These data, therefore, demonstrate a novel coculture model for further study of agents that target proteins in pathways of paracrine or autocrine stimulated cell growth...
  31. pmc Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy
    Robert S DiPaola
    Department of Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Prostate 68:1743-52. 2008
    ..The understanding of autophagy, as either a mechanism of resistance to therapies that induce metabolic stress, or as a means to cell death, is rapidly expanding and supportive of a new paradigm of therapeutic starvation...
  32. pmc Production of membrane proteins for NMR studies using the condensed single protein (cSPP) production system
    Lili Mao
    New York Center on Membrane Protein Structure, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA
    J Struct Funct Genomics 10:281-9. 2009
    ....
  33. pmc Hypoxia and defective apoptosis drive genomic instability and tumorigenesis
    Deirdre A Nelson
    Howard Hughes Medical Institute, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 18:2095-107. 2004
    ....
  34. pmc Assessing metabolic stress and autophagy status in epithelial tumors
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Methods Enzymol 453:53-81. 2009
    ..Additionally these cell lines provide an efficient way to perform biochemical analyses, and high throughput screening for modulators of autophagy for potential use in cancer therapy and prevention...
  35. pmc NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition
    Tsutomu Shimazu
    Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 21:929-41. 2007
    ..Although NBK/BIK is dispensable for development, it is the BH3-only protein targeted for inactivation by viruses, suggesting that it plays a role in pathogen/toxin response through apoptosis activation...
  36. pmc Mode of Action of Diterpene and Characterization of Related Metabolites from the Soft Coral, Xenia elongata
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    Mar Drugs 12:1102-15. 2014
    ..Compound (3) inhibits selectively HDAC6 in high micromolar concentrations. ..
  37. pmc A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression
    Vassiliki Karantza-Wadsworth
    Division of Medical Oncology, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Methods Enzymol 446:61-76. 2008
    ....
  38. ncbi Therapeutic targeting of death pathways in cancer: mechanisms for activating cell death in cancer cells
    Ting Ting Tan
    Center for Advanced Biotechnology and Medicine and Rutgers University, Piscataway, NJ 08854, USA
    Adv Exp Med Biol 615:81-104. 2008
    ..This chapter summarizes the current knowledge of the apoptotic pathways and provides a selective review on the development of drugs that target the apoptotic machinery...
  39. ncbi BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis
    Celine Gelinas
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 19:1263-8. 2005
  40. pmc Induction of apoptosis by diterpenes from the soft coral Xenia elongata
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08901 8521, USA
    J Nat Prod 70:1551-7. 2007
    ..The diterpenes induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by marine diterpenes in xenicane skeletons...
  41. pmc The double-edged sword of autophagy modulation in cancer
    Eileen White
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Clin Cancer Res 15:5308-16. 2009
    ..This is especially critical as many current cancer therapeutics activate autophagy. Therefore, efforts to understand and modulate the autophagy pathway will provide new approaches to cancer therapy and prevention...
  42. ncbi A mouse model system to genetically dissect the molecular mechanisms regulating tumorigenesis
    Kurt Degenhardt
    Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854 and Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
    Clin Cancer Res 12:5298-304. 2006
    ..We have applied this model to establish the role of apoptosis in epithelial solid tumor progression and in treatment response, which has provided novel opportunities for cancer therapies in humans...
  43. ncbi A sesquiterpenelactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylation
    Mohamed M Rafi
    Department of Food Science, New Jersey Agricultural Experimentation Station, Cook College, Rutgers University, New Brunswick, New Jersey 08901 8520, USA
    Anticancer Res 25:313-8. 2005
    ..Although initially active in clinical studies, current anti-microtubule agents are only temporarily effective and the discovery of new agents is warranted...
  44. pmc Apoptosis-inducing galactolipids from a cultured marine diatom, Phaeodactylum tricornutum
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8521, USA
    J Nat Prod 71:1197-201. 2008
    ..The galactolipids induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by galactolipids...
  45. pmc Autophagy-mediated tumor promotion
    Jessie Yanxiang Guo
    Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Cell 155:1216-9. 2013
    ..Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas. ..
  46. pmc Tumor suppression by autophagy through the management of metabolic stress
    Shengkan Jin
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Autophagy 4:563-6. 2008
    ..Furthermore, we need to be able to identify human tumors with deficient autophagy, and to develop rational cancer therapies that take advantage of the altered metabolic state and stress responses inherent to this autophagy defect...
  47. pmc Role of autophagy in cancer: management of metabolic stress
    Shengkan Jin
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Newark, NJ 08854, USA
    Autophagy 3:28-31. 2007
    ....
  48. ncbi Grm5 expression is not required for the oncogenic role of Grm1 in melanocytes
    YARI E MARIN
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, 213, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Neuropharmacology 49:70-9. 2005
    ..Taken together, these results indicate that Grm1 can act as an oncogene in melanocytes independently of Grm5 expression...
  49. pmc Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors
    Sameera Kongara
    Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Mol Cancer Res 8:873-84. 2010
    ..High phospho(Ser73)-K8 expression may be a marker of autophagy functional status in breast tumors and, as such, could have therapeutic implications for breast cancer patients...
  50. pmc Why sick cells produce tumors: the protective role of autophagy
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Autophagy 3:502-5. 2007
    ..The protective role of autophagy may be exploited in developing novel autophagy modulators as rational chemotherapeutic as well as chemopreventive agents...
  51. doi Eating to exit: autophagy-enabled senescence revealed
    Eileen White
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 23:784-7. 2009
    ..Knowing now that these two pathways are functionally intertwined sets the stage for establishing how they function cooperatively in the cancer setting...
  52. pmc Exploiting the bad eating habits of Ras-driven cancers
    Eileen White
    Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    Genes Dev 27:2065-71. 2013
    ..Targeting these distinct features of Ras-driven cancers provides novel approaches to cancer therapy. ..
  53. ncbi Exploiting different ways to die
    Deirdre A Nelson
    Howard Hughes Medical Institute and Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 18:1223-6. 2004
  54. pmc Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night
    Robin Mathew
    The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Curr Opin Genet Dev 21:113-9. 2011
    ..A better understanding of how autophagy modulates cell metabolism under various cellular stresses and the consequences of this on tumorigenesis will help develop better therapeutic strategies against cancer prevention and treatment...
  55. pmc Role of autophagy in cancer prevention
    Hsin Yi Chen
    The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Cancer Prev Res (Phila) 4:973-83. 2011
    ..These findings revealed the concept that aggressive cancers can be addicted to autophagy for survival. In this setting, autophagy inhibition is a therapeutic strategy for established cancers...
  56. ncbi Bax and Bak independently promote cytochrome C release from mitochondria
    Kurt Degenhardt
    Department of Molecular Biology, The Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 277:14127-34. 2002
    ..Thus, either Bax or Bak is required for death signaling through mitochondria in response to TNF-alpha, but both are dispensable for p53-dependent transformation inhibition...
  57. ncbi Epothilone induced cytotoxicity is dependent on p53 status in prostate cells
    Margarita L Ioffe
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School UMDNJ, New Brunswick, New Jersey 08901, USA
    Prostate 61:243-7. 2004
    ..We hypothesized that epothilone induced cytotoxicity would be influenced by the status of p53 in prostate cells...
  58. pmc Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers
    Saurabh V Laddha
    Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903 2681
    Mol Cancer Res 12:485-90. 2014
    ..Visual Overview: http://mcr.aacrjournals.org/content/early/2014/04/01/1541-7786.MCR-13-0614/F1.large.jpg. Mol Cancer Res; 12(4); 485-90. ©2014 AACR. ..
  59. pmc Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes
    Huimei Lu
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
    PLoS Genet 7:e1002291. 2011
    ..In addition, BCCIP deficiency causes excessive spontaneous chromatin bridges via the formation of SCU, which can subsequently impair chromosome segregations in mitosis and cell division...
  60. ncbi FLIPping the balance between apoptosis and proliferation in thyroid cancer
    Robin Mathew
    Center for Advanced Biotechnology and Medicine, Rutgers University, USA
    Clin Cancer Res 12:3648-51. 2006
  61. ncbi The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines
    Eileen White
    Howard Hughes Medical Institute, Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 17:1813-6. 2003
  62. pmc DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
    Andrea Cuconati
    Howard Hughes Medical Institute, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 17:2922-32. 2003
    ....