H L Weiner

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors
    H L Weiner
    Division of Pediatric Neurosurgery, New York University School of Medicine, New York 10016, USA
    Neurosurgery 47:1400-9. 2000
  2. ncbi request reprint Multistage epilepsy surgery: safety, efficacy, and utility of a novel approach in pediatric extratemporal epilepsy
    Joel A Bauman
    New York University Comprehensive Epilepsy Center, and Department of Neurology, New York University Medical Center, New York, New York, USA
    Neurosurgery 56:318-34. 2005
  3. ncbi request reprint Tuberous sclerosis and multiple tubers: localizing the epileptogenic zone
    Howard L Weiner
    Division of Pediatric Neurosurgery, Department of Neurosurgery, Comprehensive Epilepsy Center, New York University Medical Center, New York, New York 10016, USA
    Epilepsia 45:41-2. 2004
  4. ncbi request reprint Epilepsy surgery for children with tuberous sclerosis complex
    Howard L Weiner
    Division of Pediatric Neurosurgery, Department of Neurosurgery, New York University Medical Center, New York, NY 10016, USA
    J Child Neurol 19:687-9. 2004
  5. ncbi request reprint Epilepsy surgery in young children with tuberous sclerosis: results of a novel approach
    Howard L Weiner
    Division of Pediatric Neurosurgery, Department of Neurosurgery, New York University Medical Center, New York, New York 10016, USA
    Pediatrics 117:1494-502. 2006
  6. ncbi request reprint Delayed surgical resection of central nervous system germ cell tumors
    Howard L Weiner
    Department of Neurosurgery, New York University Medical Center, New York Presbyterian Hospital, New York, New York 10016, USA
    Neurosurgery 50:727-33; discussion 733-4. 2002
  7. ncbi request reprint Intrathecal baclofen in X-linked adrenoleukodystrophy
    M L Chu
    The Center for Children, Hospital for Joint Diseases and New York University Hospitals Center, New York, NY 10003, USA
    Pediatr Neurol 24:156-8. 2001
  8. ncbi request reprint Comparison of frameless stereotactic systems: accuracy, precision, and applications
    E A Benardete
    Department of Neurosurgery, New York University Medical Center, New York, New York 10016, USA
    Neurosurgery 49:1409-15; discussion 1415-6. 2001
  9. ncbi request reprint Bilateral resective epilepsy surgery in a child with tuberous sclerosis: case report
    P Romanelli
    Department of Neurosurgery, New York University-Mount Sinai Comprehensive Epilepsy Center, New York University Medical Center, New York 10016, USA
    Neurosurgery 49:732-4; discussion 735. 2001
  10. ncbi request reprint Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome
    H L Weiner
    Department of Neurosurgery, New York University Medical Center, New York
    Neurosurgery 35:1001-10; discussion 1010-1. 1994

Research Grants

  1. Hedgehog, Patched, and Gli in Medulloblastoma
    Howard Weiner; Fiscal Year: 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors
    H L Weiner
    Division of Pediatric Neurosurgery, New York University School of Medicine, New York 10016, USA
    Neurosurgery 47:1400-9. 2000
    ..Here, we analyze the cellular origin and distribution of DDR1 expression in human brain tumors and its expression in tumor cells relative to surrounding brain...
  2. ncbi request reprint Multistage epilepsy surgery: safety, efficacy, and utility of a novel approach in pediatric extratemporal epilepsy
    Joel A Bauman
    New York University Comprehensive Epilepsy Center, and Department of Neurology, New York University Medical Center, New York, New York, USA
    Neurosurgery 56:318-34. 2005
    ....
  3. ncbi request reprint Tuberous sclerosis and multiple tubers: localizing the epileptogenic zone
    Howard L Weiner
    Division of Pediatric Neurosurgery, Department of Neurosurgery, Comprehensive Epilepsy Center, New York University Medical Center, New York, New York 10016, USA
    Epilepsia 45:41-2. 2004
    ..Long-term follow-up will determine whether this approach has durable effects. We await better methods for identifying the epileptogenic zone, both noninvasive and invasive...
  4. ncbi request reprint Epilepsy surgery for children with tuberous sclerosis complex
    Howard L Weiner
    Division of Pediatric Neurosurgery, Department of Neurosurgery, New York University Medical Center, New York, NY 10016, USA
    J Child Neurol 19:687-9. 2004
    ..Long-term follow-up will determine whether this approach has durable effects. We await better methods for identifying the epileptogenic zone, both noninvasive and invasive...
  5. ncbi request reprint Epilepsy surgery in young children with tuberous sclerosis: results of a novel approach
    Howard L Weiner
    Division of Pediatric Neurosurgery, Department of Neurosurgery, New York University Medical Center, New York, New York 10016, USA
    Pediatrics 117:1494-502. 2006
    ..To identify patients who might benefit from surgery and to maximize outcome, we used a novel surgical approach in young children that consists of invasive intracranial monitoring, which is typically 3-staged and often bilateral...
  6. ncbi request reprint Delayed surgical resection of central nervous system germ cell tumors
    Howard L Weiner
    Department of Neurosurgery, New York University Medical Center, New York Presbyterian Hospital, New York, New York 10016, USA
    Neurosurgery 50:727-33; discussion 733-4. 2002
    ....
  7. ncbi request reprint Intrathecal baclofen in X-linked adrenoleukodystrophy
    M L Chu
    The Center for Children, Hospital for Joint Diseases and New York University Hospitals Center, New York, NY 10003, USA
    Pediatr Neurol 24:156-8. 2001
    ....
  8. ncbi request reprint Comparison of frameless stereotactic systems: accuracy, precision, and applications
    E A Benardete
    Department of Neurosurgery, New York University Medical Center, New York, New York 10016, USA
    Neurosurgery 49:1409-15; discussion 1415-6. 2001
    ..Each system uses a different method of spatial localization, i.e., mechanical linkage (ISG system), magnetic field digitization (Cygnus system), or optical technology (SMN system)...
  9. ncbi request reprint Bilateral resective epilepsy surgery in a child with tuberous sclerosis: case report
    P Romanelli
    Department of Neurosurgery, New York University-Mount Sinai Comprehensive Epilepsy Center, New York University Medical Center, New York 10016, USA
    Neurosurgery 49:732-4; discussion 735. 2001
    ..CONCLUSION: In selected patients with bilateral seizure foci involving separate lobes, aggressive bilateral surgery can be safe and effective...
  10. ncbi request reprint Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome
    H L Weiner
    Department of Neurosurgery, New York University Medical Center, New York
    Neurosurgery 35:1001-10; discussion 1010-1. 1994
    ..3) Contrary to prior hypotheses, brain invasion in totally resected tumors does not predict higher recurrence. 4) GTR is associated with a significantly lower recurrence rate and can be achieved without sacrificing functional outcome...
  11. pmc Long-term quality of life and neuropsychologic functioning for patients with CNS germ-cell tumors: from the First International CNS Germ-Cell Tumor Study
    S A Sands
    Department of Psychiatry, New York University School of Medicine, NY 10016, USA
    Neuro Oncol 3:174-83. 2001
    ....
  12. ncbi request reprint Subfascial implantation of intrathecal baclofen pumps in children: technical note
    B H Kopell
    Department of Neurosurgery, New York University School of Medicine, New York 10016, USA
    Neurosurgery 49:753-6; discussion 756-7. 2001
    ..CONCLUSION: At this early follow-up, the subfascial implantation technique was associated with a reduced rate of local wound and pump infections and provided optimal cosmetic results as compared with that observed in retrospective cases...
  13. ncbi request reprint Transient syringomyelia leading to acute neurological deterioration after repair of a lipomyelomeningocele: case report
    Nicholas H Post
    Division of Pediatric Neurosurgery, Department of Neurosurgery, New York University School of Medicine, New York, New York, USA
    Neurosurgery 61:E426; discussion E426. 2007
    ..We present the unique case of a patient who developed transient paraplegia 48 hours after lipomyelomeningocele repair attributable to the acute development of a thoracic syrinx...
  14. ncbi request reprint Local epileptogenic networks in tuberous sclerosis complex: a case review
    Deepak Madhavan
    New York University Comprehensive Epilepsy Center, 403 East 34th Street, Fourth Floor, New York, NY 10016, USA
    Epilepsy Behav 11:140-6. 2007
    ..This article describes three patients with TSC who underwent three-stage epilepsy surgery at our center, with the intention of examining local electrophysiological changes after each stage of the procedure...
  15. ncbi request reprint Surgical outcome in tuberous sclerosis complex: a multicenter survey
    Deepak Madhavan
    Comprehensive Epilepsy Center, Department of Neurology, NYU Medical Center, 403 East 34th Street, New York, NY 10016, U S A
    Epilepsia 48:1625-8. 2007
    ..01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant...
  16. ncbi request reprint Developmental outcome of epilepsy surgery in tuberous sclerosis complex
    Charles M Zaroff
    Clinical Neuropsychology, NYU Comprehensive Epilepsy Center, New York 10016, USA
    Epileptic Disord 7:321-6. 2005
    ..Age estimates of developmental level indicated developmental progress in the majority of subjects in the current sample, and may yield greater clinical information for individuals with developmental delay than do standard scores...
  17. doi request reprint Tuberous sclerosis: a primary pathology of astrocytes?
    Alexander A Sosunov
    Neurological Surgery, Columbia University, New York, New York 10032, USA
    Epilepsia 49:53-62. 2008
    ..We hypothesize that the development of astrogliosis in cortical tubers constitutes a primary pathology of astrocytes and is directly related to TSC 1/2 mutations...
  18. ncbi request reprint Markers of cellular proliferation are expressed in cortical tubers
    Allana Lee
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Ann Neurol 53:668-73. 2003
    ..Tubers and SEGAs exhibit a heterogeneous profile of differentiation and may share a common cellular lineage. Tubers may contain a subpopulation of newly generated cells...
  19. doi request reprint Glioma-like proliferation within tissues excised as tubers in patients with tuberous sclerosis complex
    Ingeborg Fischer
    Department of Pathology, New York University School of Medicine, New York, NY, USA
    Acta Neuropathol 116:67-77. 2008
    ..Genomic analysis with SNP arrays revealed copy number changes which may be associated with the pathogenesis of such infiltrates...
  20. ncbi request reprint Hung span method of scaphocephaly reconstruction in patients with elevated intracranial pressure
    Joseph G McCarthy
    Institute of Plastic and Reconstructive Surgery and the Department of Neurosurgery, New York University Medical Center, New York, NY, USA
    Plast Reconstr Surg 109:2009-18. 2002
  21. ncbi request reprint Epilepsy surgery in tuberous sclerosis: multistage procedures with bilateral or multilobar foci
    Pantaleo Romanelli
    Department of Neurosurgery, Stanford University Medical Center, California, USA
    J Child Neurol 17:689-92. 2002
    ..This multistage approach permitted resection of epileptogenic foci that would traditionally have been considered inoperable...
  22. pmc Membrane bound IL-15 is increased on CD14 monocytes in early stages of MS
    Adi Vaknin-Dembinsky
    Center for Neurological Diseases, Brigham and Women s Hospital, Harvard Medical, School, Boston Massachusetts 02115, United States
    J Neuroimmunol 195:135-9. 2008
    ..Thus, IL-15 may be an important cytokine that drives Th1 responses early in the course of the disease and could serve as a target for immunotherapy and as an early marker in the immunologic staging of MS...
  23. ncbi request reprint MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals
    Francois Cotton
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurology 60:640-6. 2003
    ..For practical reasons, few serial MRI studies of patients with MS have been performed at intervals shorter than 4 weeks...
  24. ncbi request reprint The importance of cell-mediated immunity in the course and severity of autoimmune anti-glomerular basement membrane disease in mice
    Helmut Hopfer
    Program in Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Dana 514, Boston Massachusetts 02215, USA
    FASEB J 17:860-8. 2003
    ..Our in vivo and in vitro results provide direct evidence that the balance between Th1 and Th2 responses associates with the outcome of anti-GBM disease in mice...
  25. ncbi request reprint Immunosuppressive treatment in multiple sclerosis
    Howard L Weiner
    Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Neurol Sci 223:1-11. 2004
    ..Cyclophosphamide and mitoxantrone are the most common immunosuppressive drugs used in patients with rapidly worsening MS whose disease is not controlled by beta-interferon or glatiramer acetate...
  26. ncbi request reprint Tuberous sclerosis complex: molecular pathogenesis and animal models
    Leandro R Piedimonte
    Division of Pediatric Neurosurgery, Department of Neurosurgery, New York University School of Medicine, New York, New York 10016, USA
    Neurosurg Focus 20:E4. 2006
    ..In the future, these animals will be invaluable preclinical models for the development of highly specific and efficacious treatments for children affected with TSC...
  27. ncbi request reprint Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas
    Dennis J Kuo
    Department of Pediatrics, New York University, New York, USA
    J Pediatr Hematol Oncol 25:372-8. 2003
    ..To assess the activity and tolerability of temozolomide in children with progressive low-grade gliomas (LGGs)...
  28. ncbi request reprint Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke
    Dan Frenkel
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Neurol Sci 233:125-32. 2005
    ..Based on these results, modulation of cerebral inflammation by mucosal tolerance to myelin antigens may have applicability both as prophylactic therapy and treatment following ischemia attacks...
  29. ncbi request reprint Immunotherapeutic approaches to Alzheimer's disease
    Alon Monsonego
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 302:834-8. 2003
    ..We will also discuss how these approaches affect microglia activation, which plays a key role in therapy of such diseases...
  30. ncbi request reprint Skull deformities
    Emily B Ridgway
    Department of Neurological Surgery, New York University School of Medicine, 317 East 34 th Street, New York, NY 10016, USA
    Pediatr Clin North Am 51:359-87. 2004
    ..Because the most common causes of distortion or asymmetry are craniosynostosis or deformation, these abnormalities are the primary subjects of this article...
  31. ncbi request reprint IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis
    Robyn S Klein
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital East, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    J Immunol 172:550-9. 2004
    ..Our data demonstrated that IP-10 was not required for the trafficking of pathogenic T cells into the CNS in EAE but played an unexpected role in determining the threshold of disease susceptibility in the periphery...

Research Grants1

  1. Hedgehog, Patched, and Gli in Medulloblastoma
    Howard Weiner; Fiscal Year: 2007
    ..This system provides a unique opportunity to investigate an in vivo animal model of childhood medulloblastoma, and to determine the roles of Ptc and Gli in tumorigenesis. ..