J Vilcek

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor
    R Kamijo
    Department of Microbiology, New York University Medical Center, NY 10016
    Proc Natl Acad Sci U S A 90:6626-30. 1993
  2. ncbi Historical review: Cytokines as therapeutics and targets of therapeutics
    Jan Vilcek
    New York University School of Medicine, Department of Microbiology, 550 First Avenue, New York, NY 10016, USA
    Trends Pharmacol Sci 25:201-9. 2004
  3. ncbi Fifty years of interferon research: aiming at a moving target
    Jan Vilcek
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Immunity 25:343-8. 2006
  4. ncbi My fifty years with interferon
    Jan Vilcek
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Interferon Cytokine Res 27:535-42. 2007
  5. ncbi Interferon research BC (before cloning)
    J Vilcek
    Department of Microbiology, New York University School of Medicine, 550 First Ave, New York, NY 10021, USA
    Curr Top Microbiol Immunol 316:9-22. 2007
  6. ncbi A prize for the foreign-born
    Jan Vilcek
    Department of Microbiology, NYU School of Medicine, New York, New York, USA
    FASEB J 20:1281-3. 2006
  7. ncbi Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide
    R Kamijo
    Department of Microbiology, Kaplan Cancer Center, New York University Medical Center, New York 10016
    J Exp Med 178:1435-40. 1993
  8. ncbi Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein
    T H Lee
    Department of Microbiology, New York University Medical Center, New York 10016
    J Biol Chem 268:6154-60. 1993
  9. ncbi Up-regulation of cyclooxygenase-2 expression by TSG-6 protein in macrophage cell line
    Catalin Mindrescu
    Department of Microbiology, New York University School of Medicine, New York, USA
    Biochem Biophys Res Commun 330:737-45. 2005
  10. ncbi Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14
    Hans Georg Wisniewski
    Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Cytokine Growth Factor Rev 15:129-46. 2004

Collaborators

Detail Information

Publications20

  1. ncbi Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor
    R Kamijo
    Department of Microbiology, New York University Medical Center, NY 10016
    Proc Natl Acad Sci U S A 90:6626-30. 1993
    ..The inability of other cytokines to substitute fully for IFN-gamma in macrophage activation helps to explain the earlier observed decreased resistance of IFN-gamma R0/0 mice to some infections...
  2. ncbi Historical review: Cytokines as therapeutics and targets of therapeutics
    Jan Vilcek
    New York University School of Medicine, Department of Microbiology, 550 First Avenue, New York, NY 10016, USA
    Trends Pharmacol Sci 25:201-9. 2004
    ..In this article, we highlight some of the studies that have been responsible for the introduction of cytokine and anti-cytokine therapies, with emphasis on the development of interferons and anti-TNF agents...
  3. ncbi Fifty years of interferon research: aiming at a moving target
    Jan Vilcek
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Immunity 25:343-8. 2006
    ..This commentary introduces the four accompanying review articles on type I IFN research and attempts to relate how the field of IFN research has been changing during its history...
  4. ncbi My fifty years with interferon
    Jan Vilcek
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Interferon Cytokine Res 27:535-42. 2007
  5. ncbi Interferon research BC (before cloning)
    J Vilcek
    Department of Microbiology, New York University School of Medicine, 550 First Ave, New York, NY 10021, USA
    Curr Top Microbiol Immunol 316:9-22. 2007
    ..I also recount some of the early work that led to the identification of IFN-alpha and IFN-beta as the two major type I interferon species...
  6. ncbi A prize for the foreign-born
    Jan Vilcek
    Department of Microbiology, NYU School of Medicine, New York, New York, USA
    FASEB J 20:1281-3. 2006
  7. ncbi Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide
    R Kamijo
    Department of Microbiology, Kaplan Cancer Center, New York University Medical Center, New York 10016
    J Exp Med 178:1435-40. 1993
    ....
  8. ncbi Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein
    T H Lee
    Department of Microbiology, New York University Medical Center, New York 10016
    J Biol Chem 268:6154-60. 1993
    ..The results suggest that TSG6 gene expression is regulated by an interplay of positively and negatively acting transactivating factors...
  9. ncbi Up-regulation of cyclooxygenase-2 expression by TSG-6 protein in macrophage cell line
    Catalin Mindrescu
    Department of Microbiology, New York University School of Medicine, New York, USA
    Biochem Biophys Res Commun 330:737-45. 2005
    ..As the PGD2 metabolite, 15-deoxy-Delta12,14-PGJ2, can act as a negative regulator of inflammation, these TSG-6 actions may explain, at least in part, the anti-inflammatory effect of TSG-6 observed in the intact organism...
  10. ncbi Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14
    Hans Georg Wisniewski
    Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Cytokine Growth Factor Rev 15:129-46. 2004
    ..Female mice with a targeted disruption of either the TSG-6 or PTX3 gene show severe defects in fertility...
  11. ncbi TSG-6 protein binding to glycosaminoglycans: formation of stable complexes with hyaluronan and binding to chondroitin sulfates
    Hans Georg Wisniewski
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 280:14476-84. 2005
    ..These interactions may contribute to the localization of TSG-6 in cartilage and to its chondroprotective and anti-inflammatory effects in models of arthritis...
  12. ncbi NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1
    L Klampfer
    Department of Microbiology, New York University Medical Center, New York 10016
    Mol Cell Biol 14:6561-9. 1994
    ..Thus, the functionally distinct NF-IL6 isoforms cooperate with Fos and Jun to positively and negatively regulate the native TSG-6 promoter by TNF-alpha and IL-1...
  13. ncbi TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo
    H G Wisniewski
    Department of Microbiology, Kaplan Cancer Center, New York University Medical Center, NY 10016, USA
    J Immunol 156:1609-15. 1996
    ....
  14. ncbi Biological functions of IFN-gamma and IFN-alpha/beta: lessons from studies in gene knockout mice
    R Kamijo
    Department of Microbiology, Kaplan Cancer Center, New York University Medical Center, NY 10016
    Hokkaido Igaku Zasshi 69:1332-8. 1994
    ..The greatly reduced ability of BCG-infected IFN-gamma R0/0 mice to produce TNF-alpha may be an important factor in their inability to resist BCG infection.(ABSTRACT TRUNCATED AT 250 WORDS)..
  15. ncbi Inhibition of glucocorticoid receptor-mediated transcriptional activation by p38 mitogen-activated protein (MAP) kinase
    Zoltán Szatmáry
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 279:43708-15. 2004
    ..Suppression of GR function by activated p38 and JNK MAP kinases may be physiologically important as a mechanism of resistance to glucocorticoids seen in many patients with chronic inflammatory conditions...
  16. ncbi Reassessing the usual suspects causing a commotion in the blood (and vessels?)
    Jedd D Wolchok
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Biol Ther 3:124-5. 2004
  17. ncbi First demonstration of the role of TNF in the pathogenesis of disease
    Jan Vilcek
    New York University School of Medicine, New York, NY 10021, USA
    J Immunol 181:5-6. 2008
  18. ncbi Why are rabbits uniquely sensitive to myxoma virus? Cherchez l'interferon!
    Jan Vilcek
    Nat Immunol 5:1205-6. 2004
  19. ncbi Boosting p53 with interferon and viruses
    Jan Vilcek
    Nat Immunol 4:825-6. 2003
  20. ncbi Novel interferons
    Jan Vilcek
    Nat Immunol 4:8-9. 2003