Dorothy Vatner

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. doi request reprint Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway
    Lo Lai
    Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Circulation 127:1692-701. 2013
  2. ncbi request reprint Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress
    Stephen F Vatner
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School Newark, NJ 07103, USA
    Circ J 73:195-200. 2009
  3. pmc Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window
    Christophe Depre
    Dept of Cell Biology and Molecular Medicine, Univ of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, MSB G 609, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 299:H752-62. 2010
  4. ncbi request reprint Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals
    Atsuko Yatani
    Cardiovascular Research Institute, Dept of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, 185 South Orange Avenue G609, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 286:H2219-28. 2004
  5. ncbi request reprint Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms
    Song Jung Kim
    Cardiovascular Research Institute, Department of Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, PO Box 1709, 185 S Orange Ave MSB G 609, Newark, NJ 07101 1709, USA
    Circ Res 92:1233-9. 2003
  6. pmc The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
    Junichi Sadoshima
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    J Clin Invest 110:271-9. 2002
  7. pmc Preemptive conditioning of the swine heart by H11 kinase/Hsp22 provides cardiac protection through inducible nitric oxide synthase
    Li Chen
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, 07103, USA
    Am J Physiol Heart Circ Physiol 300:H1303-10. 2011
  8. pmc Apoptosis in severe, compensated pressure overload predominates in nonmyocytes and is related to the hypertrophy but not function
    Ricardo J Gelpi
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Am J Physiol Heart Circ Physiol 300:H1062-8. 2011
  9. pmc An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p
    Shweta Rane
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Cell Signal 22:1054-62. 2010
  10. ncbi request reprint Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs
    Raymond K Kudej
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, Newark 07103, USA
    Circ Res 99:1270-6. 2006

Collaborators

Detail Information

Publications36

  1. doi request reprint Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway
    Lo Lai
    Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Circulation 127:1692-701. 2013
    ..To reconcile this controversy we examined the cardiomyopathy induced by chronic isoproterenol in AC5 transgenic (Tg) mice and the signaling mechanisms involved...
  2. ncbi request reprint Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress
    Stephen F Vatner
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School Newark, NJ 07103, USA
    Circ J 73:195-200. 2009
    ..Accordingly, inhibition of this molecule should be considered as a new therapeutic modality for heart failure...
  3. pmc Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window
    Christophe Depre
    Dept of Cell Biology and Molecular Medicine, Univ of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, MSB G 609, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 299:H752-62. 2010
    ..These findings illustrate new cardioprotective mechanisms developed by repetitive IPC, which are potentially more relevant to patients with chronic ischemic heart disease, who are subjected to repetitive episodes of ischemia...
  4. ncbi request reprint Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals
    Atsuko Yatani
    Cardiovascular Research Institute, Dept of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, 185 South Orange Avenue G609, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 286:H2219-28. 2004
    ..These changes may account for natural resistance to Ca2+ overload-related ventricular dysfunction and point to an important cardioprotective mechanism during true hibernation...
  5. ncbi request reprint Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms
    Song Jung Kim
    Cardiovascular Research Institute, Department of Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, PO Box 1709, 185 S Orange Ave MSB G 609, Newark, NJ 07101 1709, USA
    Circ Res 92:1233-9. 2003
    ..These hemodynamic/metabolic adjustments could facilitate survival of hibernating myocardium...
  6. pmc The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
    Junichi Sadoshima
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    J Clin Invest 110:271-9. 2002
    ..MEKK1 also prevents apoptosis and inflammation, thereby protecting against heart failure and sudden death following cardiac pressure overload...
  7. pmc Preemptive conditioning of the swine heart by H11 kinase/Hsp22 provides cardiac protection through inducible nitric oxide synthase
    Li Chen
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, 07103, USA
    Am J Physiol Heart Circ Physiol 300:H1303-10. 2011
    ..Therefore, short-term, prophylactic conditioning by Hsp22 provides NO-dependent cardioprotection that reproduces the signaling of SWOP, placing Hsp22 as a potential alternative for preemptive treatment of myocardial ischemia...
  8. pmc Apoptosis in severe, compensated pressure overload predominates in nonmyocytes and is related to the hypertrophy but not function
    Ricardo J Gelpi
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Am J Physiol Heart Circ Physiol 300:H1062-8. 2011
    ..The extent of apoptosis was linearly related to the amount of LV hypertrophy, but not to LV function...
  9. pmc An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p
    Shweta Rane
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Cell Signal 22:1054-62. 2010
    ..Thus, activation of beta-adrenergic signaling counteracts the survival effects of the AKT pathway via upregulating miR-199a-5p...
  10. ncbi request reprint Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs
    Raymond K Kudej
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, Newark 07103, USA
    Circ Res 99:1270-6. 2006
    ..Thus, the mechanism of protection during the second window, but not the first window, appears to be dependent on cardiac nerves and alpha(1)-AR stimulation...
  11. ncbi request reprint Paradoxical cellular Ca2+ signaling in severe but compensated canine left ventricular hypertrophy
    Long Sheng Song
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Circ Res 97:457-64. 2005
    ..We conclude that severe LVH with compensation masks cellular and subcellular Ca2+ defects that remain likely contributors to the limited contractile reserve of LVH...
  12. ncbi request reprint Program of cell survival underlying human and experimental hibernating myocardium
    Christophe Depre
    Department of Cell Biology and Molecular Medicine and The Cardiovascular Research Institute, University of Medicine and Dentistry New Jersey, Newark 07103, USA
    Circ Res 95:433-40. 2004
    ..Potentially, promoting such a program offers a novel opportunity to salvage postmitotic tissues in conditions of ischemia...
  13. pmc Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes
    Carmine Morisco
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, UMDNJ, New Jersey Medical School, 185 South Orange Avenue, MSB G 609, Newark, NJ 07103, USA
    Cardiovasc Res 78:36-44. 2008
    ..Cardiac hypertrophy by activation of the beta-adrenergic receptor (beta AR) is mediated more efficiently by the beta1-AR than by the beta2-AR. We investigated the signalling mechanism by which the beta1-AR mediates cardiac hypertrophy...
  14. ncbi request reprint Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha
    Takao Nishizawa
    Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, MSB G609, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 292:H971-5. 2007
    ..The impaired reflex control was generalized, not only affecting the high-pressure arterial baroreflex but also the low-pressure Bezold-Jarisch reflex and the nasopharyngeal reflex...
  15. pmc Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload
    Satoshi Okumura
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine and Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07101 1709, USA
    Proc Natl Acad Sci U S A 100:9986-90. 2003
    ..Our findings suggest that limiting type 5 AC plays a protective role in response to pressure overload and the development of heart failure, potentially through limiting the incidence of myocardial apoptosis...
  16. pmc Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy
    Shimako Yamamoto
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, and Department of Gynecology, Obstetrics and Women s Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA
    J Clin Invest 111:1463-74. 2003
    ..These results show that Mst1 works as both an essential initiator of apoptosis and an inhibitor of hypertrophy in cardiac myocytes, resulting in a previously unrecognized form of cardiomyopathy...
  17. ncbi request reprint Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation
    Satoshi Okumura
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07101 1709, USA
    Circ Res 93:364-71. 2003
    ....
  18. ncbi request reprint Type 5 adenylyl cyclase disruption increases longevity and protects against stress
    Lin Yan
    Department of Cell Biology and Molecular Medicine and Cardiovascular Research Institute, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Cell 130:247-58. 2007
    ..Fibroblasts isolated from AC5 KO mice exhibited ERK-dependent resistance to oxidative stress. These results suggest that AC is a fundamentally important mechanism regulating lifespan and stress resistance...
  19. ncbi request reprint Mechanism of gender-specific differences in aortic stiffness with aging in nonhuman primates
    Hongyu Qiu
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 S Orange Ave, Newark, NJ 07103, USA
    Circulation 116:669-76. 2007
    ..Our hypothesis was that the changes in vascular properties responsible for aortic stiffness with aging would be greater in old male monkeys than old female monkeys...
  20. pmc Increased apoptosis and myocyte enlargement with decreased cardiac mass; distinctive features of the aging male, but not female, monkey heart
    Xiao ping Zhang
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, 185 S Orange Avenue, MSB G 609, Newark, NJ 07103, USA
    J Mol Cell Cardiol 43:487-91. 2007
    ..The old male hearts demonstrated increased apoptosis, which more than offset the myocyte hypertrophy. Interestingly, the hypertrophy was not uniform and there was no significant increase in myocyte proliferation...
  21. ncbi request reprint Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress
    Satoshi Okumura
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Circulation 116:1776-83. 2007
    ..Molecular mechanisms of desensitization have been well studied at the level of adrenergic receptors but less so at the level of the effector enzyme, adenylyl cyclase (AC)...
  22. pmc Characterization of a novel cardiac isoform of the cell cycle-related kinase that is regulated during heart failure
    Hongyu Qiu
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    J Biol Chem 283:22157-65. 2008
    ....
  23. pmc Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism
    Samuel C Lieber
    Dept of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, 185 South Orange Ave, MSB G 609, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 295:H860-6. 2008
    ..3-fold), whereas intact desmin decreased by 51%. Thus the cardiomyopathy of aging in old, conscious rats may be due not only to increases in collagen but also to alterations in cytoskeletal proteins...
  24. ncbi request reprint Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy
    Christophe Depre
    Department of Cell Biology and Molecular Medicine, UMDNJ, Newark, NJ 07103, USA
    Circulation 114:1821-8. 2006
    ....
  25. ncbi request reprint Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain
    Stefan E Hardt
    Cardiovascular Research Institute, Department of Cell Biology, University of Medicine and Dentistry New Jersey, New Jersey Medical School, Newark, USA
    Circulation 105:614-20. 2002
    ....
  26. ncbi request reprint Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates
    Mingyi Wang
    National Institute on Aging, Intramural Research Program, Gerontology Research Center, National Institutes of Health, 5600 Nathan Shock Dr, Baltimore, MD, USA
    Hypertension 41:1308-16. 2003
    ..This might explain, in part, the dramatically exaggerated prevalence and severity of vascular diseases with aging...
  27. ncbi request reprint Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart
    Jing Liu
    Department of Cell Biology and Molecular Medicine, and Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07101, USA
    Am J Physiol Heart Circ Physiol 285:H2587-91. 2003
    ..Myocardial LV collagen solubility (%) increased significantly after treatment with ALT-711. These data suggest that an AGE cross-link breaker may have a therapeutic role in aged patients with DM...
  28. ncbi request reprint Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt
    Young Kwon Kim
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry New Jersey, New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    J Biol Chem 278:47622-8. 2003
    ....
  29. ncbi request reprint Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy
    Joan Li
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Medical Science Building, 185 South Orange Avenue, Newark, NJ 07101, USA
    Cardiovasc Res 59:649-57. 2003
    ..The calcineurin pathway has been involved in the development of cardiac hypertrophy, yet it remains unknown whether calcineurin activity can be regulated in myocardium independently from hypertrophy and cardiac load...
  30. ncbi request reprint Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure
    Vijaya Karoor
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, The University of Medicine and Dentistry of New Jersey, New Jersey Medical School, P O Box 1709, 185 South Orange Avenue, MSB G 609, Newark, NJ 07101 1709, USA
    J Mol Cell Cardiol 36:305-12. 2004
    ....
  31. pmc Autophagy in chronically ischemic myocardium
    Lin Yan
    Cardiovascular Research Institute and Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 102:13807-12. 2005
    ..Thus, autophagy, triggered by ischemia, could be a homeostatic mechanism, by which apoptosis is inhibited and the deleterious effects of chronic ischemia are limited...
  32. pmc Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice
    Peiyong Zhai
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Clin Invest 115:3045-56. 2005
    ..Thus, the AT1 receptor mediates downstream signaling mechanisms through G(alpha)q/G(alpha)i-dependent and -independent mechanisms, which induce hypertrophy with a distinct phenotype...
  33. ncbi request reprint Overexpressed cardiac Gsalpha in rabbits
    Takao Nishizawa
    Cardiovascular Research Institute and Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, and Children s Hospital Medical Center, Cincinnati, OH, USA
    J Mol Cell Cardiol 41:44-50. 2006
    ..Although both TG mice and rabbits with overexpressed cardiac Gsalpha exhibited enhanced heart rate and contractility, the TG rabbit does not develop cardiomyopathy, potentially due to a compensatory increase in Gialpha...
  34. ncbi request reprint Autophagy: a novel protective mechanism in chronic ischemia
    Lin Yan
    Department of Cell Biology and Molecular Medicine and Cardiovascular Research Institute, UMDNJ New Jersey Medical School, Newark, New Jersey, USA
    Cell Cycle 5:1175-7. 2006
    ..Our study provided insight into understanding of the protective mechanism of autophagy in chronic ischemia...
  35. ncbi request reprint Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition
    Jing Liu
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue MSB G609, Newark, NJ 07103, USA
    J Mol Cell Cardiol 41:680-8. 2006
    ....
  36. ncbi request reprint Altered excitation-contraction coupling in myocytes from remodeled myocardium after chronic myocardial infarction
    Young Kwon Kim
    Cardiovascular Research Institute, Department of Medicine, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Mol Cell Cardiol 34:63-73. 2002
    ..Hypertrophy is implicated as the mechanism, since these changes were noted at 8 weeks, but not at 1 week after MI...

Research Grants16

  1. Age and Gender Differences in Apoptosis and Stem Cells
    Dorothy Vatner; Fiscal Year: 2007
    ..In summary, this proposal will provide new conceptual information on gender differences with regard to compensatory adaptive mechanisms in the aging heart in a novel primate model. ..
  2. Oxidative Stress and ERK Signaling in AC-5 KO Longevity
    Dorothy Vatner; Fiscal Year: 2006
    ..Finding molecular switches, such as the one described in this project, could ameliorate disability with aging and would be a major step forward. ..
  3. TRANSMURAL SR REGULATION IN LV HYPERTROPHY
    Dorothy Vatner; Fiscal Year: 2003
    ..abstract_text> ..
  4. BETA-ADRENERGIC SIGNALING, DENERVATION AND HEART FAILURE
    Dorothy Vatner; Fiscal Year: 2002
    ..Secondly, no study has systematically examined catecholamine desensitization mechanisms using a combination of in vivo studies and isolated myocytes for transmural physiology, biochemistry and molecular biology. ..
  5. Rescue of Beta-Adrenergic Cardiomyopathy by Inhibition of Adenylyl Cyclase
    Dorothy E Vatner; Fiscal Year: 2010
    ....