Research Topics
| Z UngvariSummaryAffiliation: New York Medical College Country: USA Publications
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Detail Information
Publications
Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activationZsuzsanna Orosz
Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 292:H130-9. 2007..NAD(P)H oxidase-derived H(2)O(2) activates NF-kappaB, leading to proinflammatory alterations in vascular phenotype, which likely promotes development of atherosclerosis, especially if other risk factors are also present...- Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling?Zoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, 10595, USA
Antioxid Redox Signal 8:1121-9. 2006.... - Resveratrol increases vascular oxidative stress resistanceZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 292:H2417-24. 2007..We propose that the antioxidant and antiapoptotic effects of resveratrol, together with its previously described anti-inflammatory actions, are responsible, at least in part, for its cardioprotective effects... - Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteriesZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 293:H37-47. 2007..g., calorie restriction mimetics) will exert significant anti-inflammatory and vasoprotective effects... 
Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged ratsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 294:H2121-8. 2008..We posit that impaired mitochondrial biogenesis and downregulation of COX may contribute to the increased mitochondrial oxidative stress in aged endothelial cells...- Oxidative stress in vascular senescence: lessons from successfully aging speciesZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Front Biosci 13:5056-70. 2008.... - Can simvastatin promote tumor growth by inducing angiogenesis similar to VEGF?Z Ungvari
Department of Pathophysiology, Semmelweis University, Budapest, Hungary
Med Hypotheses 58:85-6. 2002..Thus, it can be hypothesized that chronic systemic treatment of elderly patients with a drug that induces angiogenesis by a VEGF-like manner will also promote tumor growth... 
Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiencyZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY, 10595, USA
Age (Dordr) 30:121-33. 2008..leucopus cells toward oxidative stress-induced apoptosis. The link between these three pathways and species longevity is discussed...- Vascular aging in the longest-living rodent, the naked mole ratAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 293:H919-27. 2007..Thus long-living NMRs can maintain a youthful vascular function and cellular oxidant-antioxidant phenotype relatively longer and are better protected against aging-induced oxidative stress than shorter-living rats... - Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cellsAnna Csiszar
Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Physiol Heart Circ Physiol 295:H569-77. 2008..The vascular bed-specific endothelial effects of BMP-4 are likely to contribute to its differential pathophysiological role in the systemic and pulmonary circulation... - Bone morphogenetic protein-2 induces proinflammatory endothelial phenotypeAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Pathol 168:629-38. 2006..Thus, the proinflammatory effects of BMP-2 may play a role in vascular pathophysiology... - Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) miceAnna Buday
Institute of Pathophysiology, Dept of Medicine, Semmelweis Univ, Budapest, 1089 Nagyvárad tér 4, Hungary
Am J Physiol Heart Circ Physiol 299:H386-95. 2010..These findings may provide a mechanism explaining accelerated atherosclerosis in patients with elevated plasma TGFbeta(1)... - Endothelin and prostaglandin H(2)/thromboxane A(2) enhance myogenic constriction in hypertension by increasing Ca(2+) sensitivity of arteriolar smooth muscleZ Ungvari
Institute of Pathophysiology, Semmelweis University of Medicine, Budapest, Hungary
Hypertension 36:856-61. 2000.... - Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf miceAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 295:H1882-94. 2008..Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress... - Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressureAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circulation 111:2364-72. 2005..We tested the hypothesis that BMP-2 expression in endothelial cells is governed by an H2O2 and nuclear factor (NF)-kappaBeta-dependent pathway that can be activated by both proinflammatory and mechanical stimuli... - Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopusNazar Labinskyy
Department of Physiology, New York Medical College, Valhalla, New York, USA
Am J Physiol Heart Circ Physiol 296:H946-56. 2009..leucopus is associated with decreased cellular ROS generation and increased resistance to prooxidant and proinflammatory effects of metabolic stress, which accord with predictions of the oxidative stress hypothesis of aging... - Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1Anna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Mech Ageing Dev 130:518-27. 2009..CR exerts anti-oxidant and anti-inflammatory vascular effects, which are likely mediated by circulating factors, in part, via a SIRT1-dependent pathway... - Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and miceNazar Labinskyy
Dept. of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 291:H2698-704. 2006.... - High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidaseZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circulation 108:1253-8. 2003.... - Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cellsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York, USA
Am J Physiol Heart Circ Physiol 297:H1876-81. 2009.... - Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin systemZoltan Ungvari
Department of Physiology, Basic Sciences Building, New York Medical College, Valhalla, NY 10595, USA
Am J Pathol 165:219-26. 2004.... - The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approachFrancesco Addabbo
Department of Medicine, Renal Research Institute, Division of Nephrology, New York Medical College, Valhalla, NY 10595, USA
Am J Pathol 174:34-43. 2009..These findings may contribute to an early preclinical diagnosis of endothelial dysfunction... - Role of endothelial [Ca2+]i in activation of eNOS in pressurized arterioles by agonists and wall shear stressZ Ungvari
Department of Pathophysiology, Semmelweis University of Medicine, H-1445 Budapest, Hungary
Am J Physiol Heart Circ Physiol 281:H606-12. 2001.... - Speculations on difference between tricyclic and selective serotonin reuptake inhibitor antidepressants on their cardiac effects. Is there any?P Pacher
Department of Pharmacology, Semmelweis University of Medicine, P O Box 370, Budapest, H l445, Hungary
Curr Med Chem 6:469-80. 1999..This paper also summarizes the recently observed effects of fluoxetine apparently not related to the blockage of 5-HT transporter based on literature... - Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A(2) mediationZ Bagi
Department of Pathophysiology, Semmelweis University, Budapest, Hungary
Arterioscler Thromb Vasc Biol 21:233-7. 2001.... - The aging kidney: role of endothelial oxidative stress and inflammationA Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Acta Physiol Hung 94:107-15. 2007.... - Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthaseZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Arterioscler Thromb Vasc Biol 23:418-24. 2003..Thus, TNF-alpha induces a proinflammatory vascular phenotype in HHcy that potentially contributes to the development of coronary atherosclerosis... - Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidaseMuhammad T Zia
Pediatrics, Maria Fareri Children s Hospital at Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 40:2191-8. 2009.... - Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar functionAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY, USA
Circ Res 90:1159-66. 2002..Thus, aging induces changes in the phenotype of coronary arterioles that could contribute to the development of oxidative stress, which impairs NO-mediated dilations... - Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Physiol Genomics 17:21-30. 2004.... - Homocysteine reduces smooth muscle [Ca2+]i and constrictor responses of isolated arteriolesZ Ungvari
Institute of Pathophysiology, Semmelweis University of Medicine, Budapest, Hungary
J Cardiovasc Pharmacol 37:705-12. 2001..These data suggest that in isolated arterioles homocysteine decreases pressure-induced tone and responses to vasoconstrictor agents, likely by altering Ca2+ signaling of arteriolar smooth muscle... - Effect of hyperoxic resuscitation on propensity of germinal matrix haemorrhage and cerebral injuryC O Chua
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York, USA
Neuropathol Appl Neurobiol 36:448-58. 2010..Therefore, we asked whether hyperoxia during neonatal resuscitation increased the incidence and severity of IVH and cerebral injury in premature newborns... - Selected contribution: NO released to flow reduces myogenic tone of skeletal muscle arterioles by decreasing smooth muscle Ca(2+) sensitivityZ Ungvari
Department of Pathophysiology, Semmelweis University, H-1089 Budapest, Hungary
J Appl Physiol 91:522-7; discussion 504-5. 2001.... - Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathwayAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Arterioscler Thromb Vasc Biol 27:776-82. 2007..Recent studies suggested that atheroprotective levels of shear stress control endothelial BMP-4 expression; however, the underlying mechanisms remained unknown... - Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesityAttila Feher
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Cardiovasc Res 87:732-9. 2010..We investigated the role of Cav-1 in modulating BK(Ca) channel-mediated, endothelium-derived hyperpolarizing factor (EDHF)-dependent arteriolar dilation in normal condition and in an experimental model of obesity... - Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formationZoltan Ungvari
Department of Pathophysiology, Semmelweis University, Budapest, Hungary
Am J Pathol 161:145-53. 2002..The reduced bioavailability of NO impairs flow-induced dilations of coronary arteries, which may contribute to the development of coronary atherosclerosis and ischemic heart disease... - Resveratrol induces mitochondrial biogenesis in endothelial cellsAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 297:H13-20. 2009..Resveratrol induced mitochondrial biogenesis in the aortas of type 2 diabetic mice, suggesting the potential for new treatment approaches targeting endothelial mitochondria in metabolic diseases... - Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterationsAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 294:H2721-35. 2008..The vasoprotective effects of resveratrol will likely contribute to its antiaging action in mammals and may be especially beneficial in pathophysiological conditions associated with accelerated vascular aging... - Aging-induced proinflammatory shift in cytokine expression profile in coronary arteriesAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
FASEB J 17:1183-5. 2003..Thus, a proinflammatory shift in the profile of vascular cytokine expression may contribute to the aging-induced phenotypic changes in coronary arteries, promoting the development of ischemic heart disease in the elderly... - Pentose phosphate pathway coordinates multiple redox-controlled relaxing mechanisms in bovine coronary arteriesSachin A Gupte
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 285:H2316-26. 2003..Thus PPP inhibition oxidizes NADPH and GSH and appears to activate a novel coordination of redox-controlled relaxing mechanisms in BCAs mediated primarily through decreasing intracellular Ca2+... - Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogenNazar Labinskyy
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Curr Med Chem 13:989-96. 2006..This review focuses on the role of oxidative stress and inflammation in cardiovascular dysfunction in aging, and on emerging anti-aging therapeutic strategies offered by resveratrol and other polyphenol compounds... - Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, 10595, USA
Curr Vasc Pharmacol 3:285-91. 2005.... - Inflammation and endothelial dysfunction during aging: role of NF-kappaBAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
J Appl Physiol 105:1333-41. 2008..We also discuss the possibility that nucleophosmin (NPM or nuclear phosphoprotein B23), a known modulator of the cellular oxidative stress response, may also regulate NF-kappaB activity in endothelial cells... - Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibitionAnna Csiszar
Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 291:H1694-9. 2006..We propose that these anti-inflammatory actions of resveratrol are responsible, at least in part, for its cardioprotective effects... - Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevityAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Aging Cell 6:783-97. 2007..Thus, increased lifespan potential in P. leucopus is associated with a decreased cellular ROS generation and increased oxidative stress resistance, which accords with the prediction of the oxidative stress hypothesis of aging... - Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Pathol 170:388-98. 2007..Thus, we propose that anti-TNF-alpha treatment exerts anti-aging vasculoprotective effects... - Increases in endothelial Ca(2+) activate K(Ca) channels and elicit EDHF-type arteriolar dilation via gap junctionsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Physiol Heart Circ Physiol 282:H1760-7. 2002.... - Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitriteZsolt Bagi
Department of Pathophysiology, Semmelweis University, H-1445, Budapest, Hungary
Arterioscler Thromb Vasc Biol 22:28-33. 2002..Thus, we suggest that in HHcy, xanthine oxidase-derived superoxide scavenges NO released to flow, forming peroxynitrite, which promotes release of thromboxane A(2), resulting in arteriolar constriction... - Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extractsZhirong Wang
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
Biochem Biophys Res Commun 346:367-76. 2006..These results indicate that distinct mechanisms are involved in the regulation of HASMC growth and gene expression by SGE and resveratrol... - Increased NO-mediated and reduced TxA2-dependent responses in skeletal muscle arterioles in pregnancyZoltan Ungvari
Department of Pulmonology and Pathophysiology, Semmelweis University, Budapest, Hungary
Hypertens Pregnancy 21:135-46. 2002..These changes in the local regulation of microvascular tone are likely to favor a dilated state of skeletal muscle arterioles, which may contribute to the decreased peripheral vascular resistance during normal pregnancy... - Oxidative stress and accelerated vascular aging: implications for cigarette smokingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Front Biosci 14:3128-44. 2009..The potential pathogenetic role of peroxynitrite formation, and downstream mechanisms including poly(ADP-ribose) polymerase (PARP) activation in cardiovascular complications in smokers are also discussed... - Mediation of EDHF-induced reduction of smooth muscle [Ca(2+)](i) and arteriolar dilation by K(+) channels, 5,6-EET, and gap junctionsZ Ungvari
Department of Pathophysiology, Semmelweis University of Medicine, Budapest, Hungary
Microcirculation 8:265-74. 2001.... - Oxidative stress-induced isoprostane formation may contribute to aspirin resistance in plateletsA Csiszar
Department of Pathophysiology, Semmelweis University, Budapest, Hungary
Prostaglandins Leukot Essent Fatty Acids 66:557-8. 2002.... - Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscleP Pacher
Institute of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
Can J Physiol Pharmacol 79:580-4. 2001..5-30 mM). These data suggest that fluoxetine and citalopram elicit relaxation of intestinal smooth muscle, likely by inhibiting Ca2+ channel(s). This effect may be of clinical importance... - Altered mitochondrial energy metabolism may play a role in vascular agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Med Hypotheses 67:904-8. 2006.... - Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular agingZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, USA
Circ Res 102:519-28. 2008.... - Different roles of PKC and MAP kinases in arteriolar constrictions to pressure and agonistsMichael P Massett
Department of Physiology, New York Medical College, Valhalla 10595, USA
Am J Physiol Heart Circ Physiol 283:H2282-7. 2002.... - Consequences of intraventricular hemorrhage in a rabbit pup modelCaroline O Chua
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 40:3369-77. 2009..We asked whether induction of moderate-to-severe IVH in premature rabbit pups would produce long-term sequelae of cerebral palsy, posthemorrhagic hydrocephalus, reduced myelination, and gliosis... - Vascular inflammation in agingZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla 10595, USA
Herz 29:733-40. 2004.... - Effect of prenatal glucocorticoids on cerebral vasculature of the developing brainGovindaiah Vinukonda
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 41:1766-73. 2010..Therefore, we asked whether glucocorticoid treatment would suppress angiogenesis and enhance periendothelial coverage by pericytes and glial fibrillary acidic protein-positive end feet in the germinal matrix microvasculature... - Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathyMartino Pepe
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circ Res 106:1893-903. 2010..Vascular endothelial growth factor (VEGF)-B selectively binds VEGF receptor (VEGFR)-1, a receptor that does not mediate angiogenesis, and is emerging as a major cytoprotective factor... - Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibitionGovindaiah Vinukonda
Department of Paediatrics, New York Medical College Westchester Medical Centre, Valhalla, NY 10595, USA
Brain 133:2264-80. 2010.... - Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expressionAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York, USA
Antioxid Redox Signal 11:1683-97. 2009..This review considers how hemodynamic forces regulate BMP-2/4 expression and explores the role of mechanosensitive generation of reactive oxygen species by NAD(P)H oxidases in the control of BMP signaling... - Angiogenic inhibition reduces germinal matrix hemorrhagePraveen Ballabh
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
Nat Med 13:477-85. 2007..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants... - Synergistic effects of vascular IL-17 and TNFalpha may promote coronary artery diseaseAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Med Hypotheses 63:696-8. 2004..We propose that increased vascular IL-17 and TNFalpha levels can act synergistically to create a pro-inflammatory microenvironment promoting the development of atherosclerotic vascular disease... - CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesionMohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
Am J Physiol Heart Circ Physiol 293:H2210-8. 2007.... - Nrf2 mediates cancer protection but not prolongevity induced by caloric restrictionKevin J Pearson
Laboratories of Experimental Gerontology, Clinical Investigation, and Immunology and Research Resources Branch, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 105:2325-30. 2008..However, CR extended lifespan and increased insulin sensitivity similarly in KO and WT mice. These findings identify a molecular pathway that dissociates the prolongevity and anticarcinogenic effects of CR... - Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanKevin J Pearson
Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Cell Metab 8:157-68. 2008..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife... - Endothelial dysfunction and vascular inflammation in type 2 diabetes: interaction of AGE/RAGE and TNF-alpha signalingAnna Csiszar
Am J Physiol Heart Circ Physiol 295:H475-6. 2008 - Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistanceGyorgyi Stef
State Hospital for Cardiology, Balatonfured, Hungary
J Cardiovasc Pharmacol 48:1-5. 2006..Collectively, resveratrol effectively inhibited collagen- and epinephrine-induced aggregation of platelets from ASA-R patients, which may contribute to its cardioprotective effects in high-risk cardiac patients... - Inhibition of NAD(P)H oxidase attenuates aggregation of platelets from high-risk cardiac patients with aspirin resistanceGyorgyi Stef
State Hospital for Cardiology, Balatonfured 8230, Hungary
Pharmacol Rep 59:428-36. 2007....