George Tzertzinis

Summary

Affiliation: New England Biolabs
Country: USA

Publications

  1. doi request reprint Selection of a mimotope peptide of S-adenosyl-L-homocysteine and its application in immunoassays
    Chun Wu
    Health Research Institute, AIST, 1 8 31 Midorigaoka, Ikeda 563 8577, Osaka, Japan
    Molecules 18:13020-6. 2013
  2. pmc Molecular evidence for a functional ecdysone signaling system in Brugia malayi
    George Tzertzinis
    New England Biolabs, Ipswich, Massachusetts, USA
    PLoS Negl Trop Dis 4:e625. 2010
  3. doi request reprint An EcR homolog from the filarial parasite, Dirofilaria immitis requires a ligand-activated partner for transactivation
    Cathy Shea
    New England Biolabs, 240 County Road, Ipswich, MA 01839, USA
    Mol Biochem Parasitol 171:55-63. 2010
  4. ncbi request reprint An rxr/usp homolog from the parasitic nematode, Dirofilaria immitis
    Cathy Shea
    New England Biolabs, 32 Tozer Road, Beverly, MA 01915, USA
    Gene 324:171-82. 2004
  5. pmc E. coli RNase III(E38A) generates discrete-sized products from long dsRNA
    Jianping Xiao
    New England Biolabs, Ipswich, Massachusetts 01938, USA
    RNA 15:984-91. 2009
  6. pmc Controlled expression of functional miR-122 with a ligand inducible expression system
    Cathy M Shea
    RNA Biology Division, New England Biolabs, 240 County Road, Ipswich, MA, USA
    BMC Biotechnol 10:76. 2010
  7. pmc Substrate cooperativity in marine luciferases
    George Tzertzinis
    New England Biolabs, Inc, Ipswich, Massachusetts, United States of America
    PLoS ONE 7:e40099. 2012
  8. ncbi request reprint Determination of silencing potency of synthetic and RNase III-generated siRNA using a secreted luciferase assay
    Jean Etienne Morlighem
    New England Biolabs, Ipswich, MA 01938, USA
    Biotechniques 42:599-600, 602, 604-6. 2007

Collaborators

Detail Information

Publications8

  1. doi request reprint Selection of a mimotope peptide of S-adenosyl-L-homocysteine and its application in immunoassays
    Chun Wu
    Health Research Institute, AIST, 1 8 31 Midorigaoka, Ikeda 563 8577, Osaka, Japan
    Molecules 18:13020-6. 2013
    ..The linear range of the assay for SAH was 0.4-6.4 µM, in good correlation to the conventional assay using an SAH-conjugated plate. Our results show that the mimotope peptide has potential to substitute for SAH in immunoassays...
  2. pmc Molecular evidence for a functional ecdysone signaling system in Brugia malayi
    George Tzertzinis
    New England Biolabs, Ipswich, Massachusetts, USA
    PLoS Negl Trop Dis 4:e625. 2010
    ..In insects, ecdysone triggers molting through the activation of the ecdysone receptor: a heterodimer of EcR (ecdysone receptor) and USP (Ultraspiracle)...
  3. doi request reprint An EcR homolog from the filarial parasite, Dirofilaria immitis requires a ligand-activated partner for transactivation
    Cathy Shea
    New England Biolabs, 240 County Road, Ipswich, MA 01839, USA
    Mol Biochem Parasitol 171:55-63. 2010
    ..However, unlike most insect EcRs, DiEcR requires a ligand-activated RXR partner to exhibit ligand-dependent transcriptional activation of a reporter gene in tissue culture...
  4. ncbi request reprint An rxr/usp homolog from the parasitic nematode, Dirofilaria immitis
    Cathy Shea
    New England Biolabs, 32 Tozer Road, Beverly, MA 01915, USA
    Gene 324:171-82. 2004
    ..By Northern blot analysis, Di-rxr-1 mRNA is detected in adult females, but not in males. This is the first characterization of a nematode rxr/usp...
  5. pmc E. coli RNase III(E38A) generates discrete-sized products from long dsRNA
    Jianping Xiao
    New England Biolabs, Ipswich, Massachusetts 01938, USA
    RNA 15:984-91. 2009
    ..The RNA interference activity suggests that the 23-bp dsRNA product has typical 2-nucleotide 3' overhangs and behaves as siRNA thereby making it a useful tool in RNA interference experiments...
  6. pmc Controlled expression of functional miR-122 with a ligand inducible expression system
    Cathy M Shea
    RNA Biology Division, New England Biolabs, 240 County Road, Ipswich, MA, USA
    BMC Biotechnol 10:76. 2010
    ..Systems employing constitutive RNA polymerase II promoters have been used to express miRNAs. However, for many experimental systems these methods do not offer sufficient control over expression...
  7. pmc Substrate cooperativity in marine luciferases
    George Tzertzinis
    New England Biolabs, Inc, Ipswich, Massachusetts, United States of America
    PLoS ONE 7:e40099. 2012
    ..The consequences of these enzyme responses are discussed...
  8. ncbi request reprint Determination of silencing potency of synthetic and RNase III-generated siRNA using a secreted luciferase assay
    Jean Etienne Morlighem
    New England Biolabs, Ipswich, MA 01938, USA
    Biotechniques 42:599-600, 602, 604-6. 2007
    ..These results suggest that one advantage of using enzymatic complex siRNA mixtures for RNAi is that, unlike single synthetic siRNAs, selecting a target region is not important to ensure potency...