Thresia Thomas

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications
    T Thomas
    Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick 08903, USA
    Cell Mol Life Sci 58:244-58. 2001
  2. ncbi Polyamine metabolism and cancer
    Thresia Thomas
    Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    J Cell Mol Med 7:113-26. 2003
  3. ncbi Estrogen receptors as targets for drug development for breast cancer, osteoporosis and cardiovascular diseases
    Thresia Thomas
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway New Brunswick, NJ 08903, USA
    Curr Cancer Drug Targets 4:483-99. 2004
  4. ncbi Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2
    Joan S Lewis
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, NJ 08903, USA
    Oncol Res 15:113-28. 2005
  5. ncbi Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine
    Sandhya K Nair
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Cancer Lett 250:311-22. 2007
  6. ncbi Bending of the estrogen response element by polyamines and estrogen receptors alpha and beta: a fluorescence resonance energy transfer study
    Veena Vijayanathan
    Department of Medicine, University of Medicine and Dentistry of New Jersey--Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Int J Biochem Cell Biol 38:1191-1206. 2006
  7. ncbi A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells
    Irina Nayvelt
    Department of Medicine and Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Amino Acids 42:899-911. 2012
  8. ncbi Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells
    Veena Vijayanathan
    Department of Medicine, Environmental and Occupational Health Sciences Institute and The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Clin Cancer Res 12:2038-48. 2006
  9. ncbi Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells
    Srivani Balabhadrapathruni
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Oncol Rep 13:101-8. 2005
  10. ncbi Regulation of estrogenic effects by beclin 1 in breast cancer cells
    Shali John
    Departments of Medicine, Environmental and Occupational Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Cancer Res 68:7855-63. 2008

Research Grants

  1. ROLE OF POLYAMINES IN ESTROGEN FUNCTION IN BREAST CANCER
    Thresia Thomas; Fiscal Year: 1992
  2. POLYAMINES AND ESTROGEN FUNCTION AND BREAST CANCER
    Thresia Thomas; Fiscal Year: 2001
  3. ROLE OF POLYAMINES IN ESTROGEN FUNCTION IN BREAST CANCER
    Thresia Thomas; Fiscal Year: 1993
  4. ROLE OF POLYAMINES IN ESTROGEN FUNCTION IN BREAST CANCER
    Thresia Thomas; Fiscal Year: 2006

Collaborators

  • Mervi T Hyvonen
  • Chris Albanese
  • Norma J Greenfield
  • Leonard H Sigal
  • BAO T ZHU
  • Leena Alhonen
  • Veena Vijayanathan
  • Irina Nayvelt
  • Akira Shirahata
  • Michael A Gallo
  • Sandhya K Nair
  • Joan S Lewis
  • Shali John
  • Sripriya Venkiteswaran
  • Latha M Santhakumaran
  • Rajesh Patel
  • Tuomo A Keinänen
  • PingAr Yang
  • Hui Chen Hsu
  • Wensheng Liu
  • Arti Verma
  • Srivani Balabhadrapathruni
  • Richard G Pestell
  • M Saminathan
  • GOKUL DAS
  • Ipsit Pandya
  • Jouko Vepsalainen
  • Alex R Khomutov
  • Gokul M Das
  • T C Chou
  • Valentyn V Tyulmenkov
  • Margarita M Ivanova
  • Carolyn M Klinge
  • Jasleen Lyall
  • Thomas Antony
  • C K S Pillai

Detail Information

Publications22

  1. ncbi Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications
    T Thomas
    Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick 08903, USA
    Cell Mol Life Sci 58:244-58. 2001
    ..Inhibitors of biosynthesis, polyamine analogues as well as oligonucleotide/polyamine analogue combinations are promising drug candidates for chemoprevention and/or treatment of cancer...
  2. ncbi Polyamine metabolism and cancer
    Thresia Thomas
    Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    J Cell Mol Med 7:113-26. 2003
    ....
  3. ncbi Estrogen receptors as targets for drug development for breast cancer, osteoporosis and cardiovascular diseases
    Thresia Thomas
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway New Brunswick, NJ 08903, USA
    Curr Cancer Drug Targets 4:483-99. 2004
    ..Current research on SERMs points toward accomplishing this goal by exploiting ER as a versatile target against multiple diseases...
  4. ncbi Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2
    Joan S Lewis
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, NJ 08903, USA
    Oncol Res 15:113-28. 2005
    ..These results indicate that spermine can enhance E2-induced cell signaling and cyclin D1 transcription by activation of the p38 MAP kinase and phosphorylation of ATF-2, contributing to breast cancer cell proliferation...
  5. ncbi Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine
    Sandhya K Nair
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Cancer Lett 250:311-22. 2007
    ..Our results suggest an important strategy to induce apoptosis of breast cancer cells, with potential applications in therapy...
  6. ncbi Bending of the estrogen response element by polyamines and estrogen receptors alpha and beta: a fluorescence resonance energy transfer study
    Veena Vijayanathan
    Department of Medicine, University of Medicine and Dentistry of New Jersey--Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Int J Biochem Cell Biol 38:1191-1206. 2006
    ..Our results suggest that polyamine-induced bending of the ERE might be a mechanism for enhancing ERalpha-ERE binding affinity and thereby fine-tuning the transcriptional response of estrogen-responsive genes...
  7. ncbi A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells
    Irina Nayvelt
    Department of Medicine and Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Amino Acids 42:899-911. 2012
    ....
  8. ncbi Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells
    Veena Vijayanathan
    Department of Medicine, Environmental and Occupational Health Sciences Institute and The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Clin Cancer Res 12:2038-48. 2006
    ..The intriguing growth-stimulatory and growth-inhibitory effects of 2ME on breast cancer cells suggests the need for its selective use in patients...
  9. ncbi Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells
    Srivani Balabhadrapathruni
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Oncol Rep 13:101-8. 2005
    ..These studies indicate a potentially effective combination strategy for breast cancer treatment. Our results also link the down-regulation of polyamine pathway to apoptotic cell death and regulation of mediators of cell death...
  10. ncbi Regulation of estrogenic effects by beclin 1 in breast cancer cells
    Shali John
    Departments of Medicine, Environmental and Occupational Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Cancer Res 68:7855-63. 2008
    ..This observation might be useful to define and overcome antiestrogen resistance of breast cancer...
  11. ncbi Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta
    Veena Vijayanathan
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 125 Paterson Street, NB, NJ 08903, USA
    Biochem Cell Biol 85:1-10. 2007
    ..The increased thermal stability of HT-ERbeta-ERE was associated with reduced specificity of ERbeta-ERE recognition, illustrating profound differences in conformational states of ERbeta induced by E2 and HT...
  12. ncbi Ionic, structural, and temperature effects on DNA nanoparticles formed by natural and synthetic polyamines
    Veena Vijayanathan
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Biomacromolecules 6:1097-103. 2005
    ..A possible mechanism for the differential effects of temperature on DNA nanoparticles might involve different modes of DNA-polyamine interactions...
  13. ncbi Formation of DNA nanoparticles in the presence of novel polyamine analogues: a laser light scattering and atomic force microscopic study
    Veena Vijayanathan
    Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 125 Paterson Street, CAB7090, New Brunswick, NJ 08903, USA
    Nucleic Acids Res 32:127-34. 2004
    ..These studies might help to develop novel nonviral gene delivery vehicles...
  14. ncbi Development of polyamine analogs as cancer therapeutic agents
    Thresia Thomas
    Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Oncol Res 13:123-35. 2002
    ..In either case, further research into the action of polyamine analogs will open up new opportunities in the fight against cancer...
  15. ncbi DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage
    Irina Nayvelt
    University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Biomacromolecules 11:97-105. 2010
    ..Our findings indicate that Me(2)Spm stereoisomers are efficient DNA packaging agents with potential applications in gene delivery. Our study also reveals stereospecificity in DNA interaction and protection against cellular stress...
  16. ncbi Antisense recognition of the HER-2 mRNA: effects of phosphorothioate substitution and polyamines on DNA.RNA, RNA.RNA, and DNA.DNA duplex stability
    Sripriya Venkiteswaran
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Biochemistry 44:303-12. 2005
    ..These data help us to understand the role of endogenous polyamines in DNA.RNA hybrid stabilization, and provide information for designing novel polyamines to facilitate the use of antisense ODNs for controlling HER-2 gene expression...
  17. ncbi DNA nanoparticles and development of DNA delivery vehicles for gene therapy
    Veena Vijayanathan
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Biochemistry 41:14085-94. 2002
    ..Future studies aimed at defining the mechanism(s) of DNA compaction and structural features of DNA nanoparticles might aid in the development of novel gene delivery vehicles...
  18. ncbi Mechanistic differences in DNA nanoparticle formation in the presence of oligolysines and poly-L-lysine
    Irina Nayvelt
    Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA
    Biomacromolecules 8:477-84. 2007
    ..The DNA melting temperature increased with oligolysine concentration. These results indicate distinct differences in the mechanism(s) by which oligolysines and PLL provoke DNA condensation to nanoparticles...
  19. ncbi Enhanced cellular uptake of a triplex-forming oligonucleotide by nanoparticle formation in the presence of polypropylenimine dendrimers
    Latha M Santhakumaran
    Department of Medicine, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Nucleic Acids Res 32:2102-12. 2004
    ..Taken together, our results indicate that polypropylenimine dendrimers might be useful vehicles for delivering therapeutic oligonucleotides in cancer cells...
  20. ncbi Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells
    Joan S Lewis
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    J Mol Endocrinol 34:91-105. 2005
    ..The binding of ATF-2 was inhibited by the presence of 2-ME2. These results show that 2-ME2 can downregulate cyclin D1 and thereby cell cycle progression by a mechanism involving the disruption of ATF-2 binding to cyclin D1 promoter...
  21. ncbi Polyamine structural effects on the induction and stabilization of liquid crystalline DNA: potential applications to DNA packaging, gene therapy and polyamine therapeutics
    M Saminathan
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Nucleic Acids Res 30:3722-31. 2002
    ..These data show a structural specificity effect of polyamines on liquid crystalline phase transitions of DNA and suggest a possible physiological function of natural polyamines...
  22. ncbi Direct measurement of the association constant of HER2/neu antisense oligonucleotide to its target RNA sequence using a molecular beacon
    Veena Vijayanathan
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903, USA
    Antisense Nucleic Acid Drug Dev 12:225-33. 2002
    ..The information generated through this new approach for thermodynamic measurements might be useful for the design of oligonucleotides for antisense therapeutics...

Research Grants28

  1. ROLE OF POLYAMINES IN ESTROGEN FUNCTION IN BREAST CANCER
    Thresia Thomas; Fiscal Year: 1992
    ..These studies will also provide significant information for the development of novel therapeutic approaches involving polyamine inhibitors in combination with antiestrogens/antitumor drugs...
  2. POLYAMINES AND ESTROGEN FUNCTION AND BREAST CANCER
    Thresia Thomas; Fiscal Year: 2001
    ..Results of these studies will provide new insights into the mechanism of action of polyamines in estrogen function in breast cancer and contribute to the identification and design of novel therapeutic agents. ..
  3. ROLE OF POLYAMINES IN ESTROGEN FUNCTION IN BREAST CANCER
    Thresia Thomas; Fiscal Year: 1993
    ..This information is important to the development of novel strategies for the treatment of breast cancer...
  4. ROLE OF POLYAMINES IN ESTROGEN FUNCTION IN BREAST CANCER
    Thresia Thomas; Fiscal Year: 2006
    ..Our studies will generate information on polyamine function in vitro and in vivo and advance development new therapies for breast cancer. ..