Genomes and Genes
Cristina C Teixeira
Affiliation: New York University
- Biphasic calcium phosphate: a scaffold for growth plate chondrocyte maturationCristina C Teixeira
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York 10010, USA
Tissue Eng 12:2283-9. 2006..These results demonstrated for the first time the proliferation, maturation of chondrocytes, and matrix deposition on MBCP, suggesting the potential for such scaffold in tissue engineering via the endochondral bone formation mechanism...
- Apoptosis of growth plate chondrocytes occurs through a mitochondrial pathwayCristina C Teixeira
Department of Orthodontics and Department of Basic Sciences, New York University College of Dentistry, New York, NY 10010, USA
Angle Orthod 77:129-34. 2007..To determine the role of mitochondria in chondrocyte apoptosis induced by inorganic phosphate (Pi)...
- Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossificationCristina C Teixeira
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA
Dev Biol 319:171-8. 2008..This review summarizes our knowledge of the roles and mechanisms of NO, CNP and cGKII signaling in cartilage and endochondral bone development...
- Nitric oxide-nitric oxide synthase regulates key maturational events during chondrocyte terminal differentiationCristina C Teixeira
Department of Basic Science and Craniofacial Biology, and Department of Orthodontics, College of Dentistry, New York University, 345 East 24th Street, New York, NY 10010, USA
Bone 37:37-45. 2005..Since expression of these two determinants was blocked by inhibitors of the cGMP pathway, it is concluded that NO metabolism is required for development of the mature chondrocyte phenotype...
- F-spondin regulates chondrocyte terminal differentiation and endochondral bone formationGlyn D Palmer
Division of Rheumatology, New York University School of Medicine, Hospital for Joint Diseases, New York, New York, USA
J Orthop Res 28:1323-9. 2010..Our findings indicate that F-spondin is expressed in embryonic cartilage, where it has the capacity to enhance chondrocyte terminal differentiation and mineralization via interactions in its TSR domain and TGF-β dependent pathways...
- F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activationMukundan G Attur
Division of Rheumatology, New York University School of Medicine, New York University Hospital for Joint Diseases, 301 E 17th St, New York, NY 10003, USA
FASEB J 23:79-89. 2009..05). Together these studies identify F-spondin as a novel protein in OA cartilage, where it may act in situ at lesional areas to activate latent TGF-beta and induce cartilage degradation via pathways that involve production of PGE2...
- Maturation-dependent thiol loss increases chondrocyte susceptibility to apoptosisCristina C Teixeira
Department of Basic Science and Craniofacial Biology and Department of Orthodontics, New York University, College of Dentistry, New York, New York 10010, USA
J Bone Miner Res 18:662-8. 2003..It was concluded that the loss of thiol reserve is not only linked to the expression of the hypertrophic phenotype but also influenced chondrocyte survival, linking chondrocyte maturation and the activation of the apoptotic pathway...
- Changes in matrix protein gene expression associated with mineralization in the differentiating chick limb-bud micromass culture systemCristina C Teixeira
New York University, College of Dentistry, New York, New York, USA
J Cell Biochem 112:607-13. 2011..MMP-13, and alkaline phosphatase, along with matrix protein genes (type X collagen, bone sialoprotein, and osteopontin) usually associated with initiation of mineralization are discussed...
- Foxo1, a novel regulator of osteoblast differentiation and skeletogenesisCristina C Teixeira
Department of Orthodontics, New York University College of Dentistry, New York, New York 10010, USA
J Biol Chem 285:31055-65. 2010..In conclusion, our in vitro, ex vivo, and in vivo results strongly support the notion that Foxo1 is an early molecular regulator in the differentiation of mesenchymal cells into osteoblast...