Toshiki Tanaka

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. pmc ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke
    Toshiki Tanaka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    BMC Cell Biol 8:26. 2007
  2. ncbi request reprint Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis
    Xuan Huang
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10532, USA
    Cytometry A 69:222-9. 2006
  3. ncbi request reprint Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine
    Xuan Huang
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cancer Biol Ther 5:959-64. 2006
  4. ncbi request reprint Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase
    Toshiki Tanaka
    Brander Cancer Research Institute, Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 6:371-6. 2007
  5. ncbi request reprint Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes
    Hong Zhao
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 71:905-14. 2007
  6. ncbi request reprint Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis
    Akira Kurose
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York, USA
    Cytometry A 69:212-21. 2006
  7. ncbi request reprint Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents
    Toshiki Tanaka
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 71:648-61. 2007
  8. pmc Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage
    Dorota Halicka
    Branch Cancer Reearch Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Pharmacol Rep 60:93-100. 2008
  9. pmc Protective effect of hyaluronate on oxidative DNA damage in WI-38 and A549 cells
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 32:1159-67. 2008
  10. ncbi request reprint Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation and apoptosis preferentially in S-phase cells: involvement of reactive oxygen species
    Toshiki Tanaka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York, USA
    Cell Cycle 5:1669-74. 2006

Collaborators

Detail Information

Publications19

  1. pmc ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke
    Toshiki Tanaka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    BMC Cell Biol 8:26. 2007
    ..We have recently reported that brief exposure of human pulmonary adenocarcinoma A549 cells or normal human bronchial epithelial cells (NHBE) to cigarette smoke (CS) induced phosphorylation of H2AX...
  2. ncbi request reprint Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis
    Xuan Huang
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10532, USA
    Cytometry A 69:222-9. 2006
    ....
  3. ncbi request reprint Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine
    Xuan Huang
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cancer Biol Ther 5:959-64. 2006
    ....
  4. ncbi request reprint Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase
    Toshiki Tanaka
    Brander Cancer Research Institute, Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 6:371-6. 2007
    ..mitoxantrone, may contribute to formation of DSBs and to triggering of apoptosis...
  5. ncbi request reprint Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes
    Hong Zhao
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 71:905-14. 2007
    ..Cytometric analysis of CHP and CAA provides the means to measure the effectiveness of exogenous factors, which either through lowering aerobic metabolism or neutralizing radicals may protect DNA from such damage...
  6. ncbi request reprint Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis
    Akira Kurose
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York, USA
    Cytometry A 69:212-21. 2006
    ..The present study was undertaken to reveal whether H2AX is phosphorylated in cells exposed to HU or APH and whether its phosphorylation is mediated by ATM...
  7. ncbi request reprint Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents
    Toshiki Tanaka
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 71:648-61. 2007
    ....
  8. pmc Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage
    Dorota Halicka
    Branch Cancer Reearch Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Pharmacol Rep 60:93-100. 2008
    ..3 microM CEP for 24 h. The data strongly suggest that the scavenging properties of CEP provide a protection of DNA from the radicals generated endogenously during oxidative metabolism...
  9. pmc Protective effect of hyaluronate on oxidative DNA damage in WI-38 and A549 cells
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 32:1159-67. 2008
    ..Since no significant degradation of HA upon its exposure in tissue culture medium to H2O2 was detected the scavenging may occur intracellularly...
  10. ncbi request reprint Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation and apoptosis preferentially in S-phase cells: involvement of reactive oxygen species
    Toshiki Tanaka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York, USA
    Cell Cycle 5:1669-74. 2006
    ..Because neither induction of H2AX phosphorylation nor apoptosis were observed at equimolar concentrations of ASA, the NO moiety attached to ASA appeared to mediate these effects...
  11. ncbi request reprint Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes
    Toshiki Tanaka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 5:2671-5. 2006
    ..The observed H2AX phosphorylation in lymphocytes may reflect their DNA damage by the superoxide ions propagating from the neighboring granulocytes and/or monocytes...
  12. ncbi request reprint 2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX
    Toshiki Tanaka
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10532, USA
    Cell Cycle 5:878-82. 2006
    ..Therefore, the assay of CHP by multiparameter cytometry provides the means to measure effects of antioxidants and metabolic inhibitors on endogenous oxidative DNA damage in relation to cell cycle phase...
  13. pmc Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants
    Toshiki Tanaka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 5:1940-5. 2006
    ....
  14. ncbi request reprint Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species
    Xuan Huang
    Brander Cancer Research Institute, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 29:495-501. 2006
    ....
  15. ncbi request reprint Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis
    Akira Kurose
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10532, USA
    Cytometry A 68:1-9. 2005
    ....
  16. pmc Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis
    Xuan Huang
    Brander Cancer Research Institute, New York Medical College, Valhalla, NY 10532, USA
    Cell Prolif 38:223-43. 2005
    ..Detection of DNA damage in tumour cells during radio- or chemotherapy may provide an early marker predictive of response to treatment...
  17. pmc Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines
    Masamichi Ita
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cancer Biol Ther 7:1104-8. 2008
    ..The data suggest that the combination of these two drugs, that individually express a low toxic profile, may have strong antitumor potential...
  18. doi request reprint Cytometric assessment of DNA damage induced by DNA topoisomerase inhibitors
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute, New York Medical College, Valhalla, NY, USA
    Methods Mol Biol 582:145-53. 2009
    ..Examples where DNA damage was induced by topotecan (topo I) and etoposide (topo II) inhibitors are provided...
  19. ncbi request reprint Activating an enzyme by an engineered coiled coil switch
    Satoshi Yuzawa
    Graduate School of Material Science, Nagoya Institute of Technology, Gokiso cho, Nagoya 466 8555, Japan
    Chemistry 12:7345-52. 2006
    ..The formation of the trimeric coiled coil structure should bring the cleaved sites of RNaseT1 close enough to refold the RNaseT1 domain spontaneously...