Yajaira Suarez

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. pmc Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation
    Yajaira Suarez
    Department of Immunobiology and Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    J Immunol 184:21-5. 2010
  2. pmc MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function
    Sebastian Albinsson
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 30:1118-26. 2010
  3. pmc Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
    Yajaira Suarez
    Department of Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, Amistad Research Building, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 105:14082-7. 2008
  4. pmc Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis
    Carlos Fernandez-Hernando
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Metab 10:48-54. 2009
  5. pmc Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair
    Jun Yu
    Department of Pharmacology, Amistad Research Building, Yale University School of Medicine, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 106:17511-6. 2009
  6. pmc Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
    Michael Schleicher
    Department of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 180:101-12. 2008
  7. pmc MicroRNAs as novel regulators of angiogenesis
    Yajaira Suarez
    Vascular Biology and Therapuetics Program corrected Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA
    Circ Res 104:442-54. 2009
  8. pmc miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish
    Carlos Stahlhut
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
    Development 139:4356-64. 2012
  9. pmc microRNAs and cholesterol metabolism
    Kathryn J Moore
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Trends Endocrinol Metab 21:699-706. 2010
  10. pmc MicroRNAs in lipid metabolism
    Carlos Fernandez-Hernando
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    Curr Opin Lipidol 22:86-92. 2011

Collaborators

Detail Information

Publications16

  1. pmc Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation
    Yajaira Suarez
    Department of Immunobiology and Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    J Immunol 184:21-5. 2010
    ..Conversely, transfections with mimics of these miRNAs decreased neutrophil adhesion to endothelial cells. These data suggest that miRNAs provide negative feedback control of inflammation...
  2. pmc MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function
    Sebastian Albinsson
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 30:1118-26. 2010
    ..Here, we investigated the role of miRNAs in VSM by deleting the rate-limiting enzyme in miRNA synthesis, Dicer...
  3. pmc Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
    Yajaira Suarez
    Department of Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, Amistad Research Building, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 105:14082-7. 2008
    ..Thus, endothelial miRNAs regulate postnatal angiogenesis and VEGF induces the expression of miRNAs implicated in the regulation of an integrated angiogenic response...
  4. pmc Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis
    Carlos Fernandez-Hernando
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Metab 10:48-54. 2009
    ..In summary, this unique model provides physiological evidence supporting the important role of endothelial Cav-1 expression in regulating the entry of LDL into the vessel wall and the initiation of atherosclerosis...
  5. pmc Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair
    Jun Yu
    Department of Pharmacology, Amistad Research Building, Yale University School of Medicine, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 106:17511-6. 2009
    ..Thus, endogenous Nogo coordinates macrophage-mediated inflammation with arteriogenesis, wound healing, and blood flow control...
  6. pmc Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
    Michael Schleicher
    Department of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 180:101-12. 2008
    ..Collectively, our results provide evidence that PHB1 is important for mitochondrial function and prevents reactive oxygen species-induced senescence and thereby maintains the angiogenic capacity of endothelial cells...
  7. pmc MicroRNAs as novel regulators of angiogenesis
    Yajaira Suarez
    Vascular Biology and Therapuetics Program corrected Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA
    Circ Res 104:442-54. 2009
    ....
  8. pmc miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish
    Carlos Stahlhut
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
    Development 139:4356-64. 2012
    ..These findings uncover a novel function for miR-1/206 in the control of developmental angiogenesis through the regulation of VegfA, and identify a key role for miRNAs as regulators of cross-tissue signaling...
  9. pmc microRNAs and cholesterol metabolism
    Kathryn J Moore
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Trends Endocrinol Metab 21:699-706. 2010
    ..These new data suggest important roles of microRNAs in the epigenetic regulation of cholesterol metabolism and have opened new avenues for the treatment of dyslipidemias...
  10. pmc MicroRNAs in lipid metabolism
    Carlos Fernandez-Hernando
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    Curr Opin Lipidol 22:86-92. 2011
    ..This review summarizes the evidence for a critical role of miRNAs in regulating lipid metabolism...
  11. pmc The role of microRNAs in cholesterol efflux and hepatic lipid metabolism
    Kathryn J Moore
    Departments of Medicine and Cell Biology, Leon H Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA
    Annu Rev Nutr 31:49-63. 2011
    ..These findings have highlighted the complexity of lipid homeostasis and the important role that miRNAs play in these processes, potentially opening new avenues for the treatment of dyslipidemias...
  12. pmc Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking
    Kenneth D Harrison
    Department of Pharmacology and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Metab 10:208-18. 2009
    ..These data identify NgBR as an NPC2-interacting protein and provide evidence of a role for NgBR in intracellular cholesterol trafficking...
  13. pmc Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease
    Carlos Fernandez-Hernando
    Department of Pharmacology and Vascular Biology and Therapeutics, Amistad Building, 10 Amistad St, Yale University School of Medicine, New Haven, CT 06511, USA
    Cell Metab 6:446-57. 2007
    ..The presence of coronary lesions in ApoE(-/-)Akt1(-/-) mice provides a new model for studying the mechanisms of acute coronary syndrome in humans...
  14. ncbi request reprint Alloimmunity to human endothelial cells derived from cord blood progenitors
    Yajaira Suarez
    Department of Immunobiology, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:7488-96. 2007
    ..These findings have significant implications for the use of cord blood EPCs in regenerative medicine or tissue engineering...
  15. ncbi request reprint Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells
    Yajaira Suarez
    Department of Pathology, Yale University School of Medicine, New Haven, Conn 06536, USA
    Circ Res 100:1164-73. 2007
    ..Collectively, these results indicate that maintenance and regulation of endogenous miRNA levels via Dicer mediated processing is critical for EC gene expression and functions in vitro...
  16. ncbi request reprint Vascularization and engraftment of a human skin substitute using circulating progenitor cell-derived endothelial cells
    Benjamin R Shepherd
    Department of Pathology, Yale University School of Medicine, 295 Congress Ave, Boyer Center for Molecular Medicine Rm 454, New Haven, Connecticut 06510, USA
    FASEB J 20:1739-41. 2006
    ..We conclude that EC differentiated from circulating progenitors can be utilized to vascularize human skin substitutes even in the setting of compromised host angiogenesis/vasculogenesis...