Research Topics
| CHARLES STIERSummaryAffiliation: New York Medical College Country: USA Publications
Research Grants
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Detail Information
Publications
Stress triggered rise in plasma aldosterone is lessened by chronic nicotine infusionCharles T Stier
Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
Eur J Pharmacol 495:167-70. 2004..Nicotine infusion attenuated the rise in aldosterone with restraint and cold stress, but not immobilization. These results reveal that nicotine infusion can attenuate the aldosterone response, depending on the type of stress...- Osteopontin in patients with primary aldosteronismCharles T Stier
Department of Pharmacology, New York Medical College, Valhalla, New York, USA
Am J Hypertens 19:298-9. 2006 - Effect of aldosterone and MR blockade on the brain and the kidneyCharles T Stier
Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
Heart Fail Rev 10:53-62. 2005..The specific blockade of aldosterone action should prove to be of great therapeutic value in the prevention of cerebral and renal vascular disease and associated end-organ damage... - Estrogen promotes microvascular pathology in female stroke-prone spontaneously hypertensive ratsCharles T Stier
Department of Pharmacology, New York Medical College, Valhalla 10595, USA
Am J Physiol Endocrinol Metab 285:E232-9. 2003..kg-1.wk-1) prolonged survival by >2 wk compared with controls (P < 0.01). The data indicate that estrogen promotes microangiopathy in the kidney and stroke in saline-drinking SHRSP... - Aldosterone and aldosterone antagonism in cardiovascular disease: focus on eplerenone (Inspra)Charles T Stier
Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
Heart Dis 5:102-18. 2003..Eplerenone has already been approved for the treatment of systemic hypertension, and several clinical trials are currently underway to identify other therapeutic uses for this agent in cardiovascular disease management... - Eplerenone: a selective aldosterone blockerCharles T Stier
Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
Cardiovasc Drug Rev 21:169-84. 2003..The advent of selective aldosterone blockers, such as eplerenone, should prove to be of great therapeutic value in hypertension control and prevention of cardiovascular disease and associated end-organ damage... - Aldosterone as a mediator in cardiovascular injuryCharles T Stier
Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
Cardiol Rev 10:97-107. 2002..The advent of selective aldosterone receptor antagonists such as eplerenone should prove of great therapeutic value in the prevention of cardiovascular disease and associated end-organ damage... - Amiloride reduces stroke and renalinjury in stroke-prone hypertensive ratsReza Sepehrdad
Department of Pharmacology, New York Medical College, Valhalla 10595, USA
Am J Hypertens 16:312-8. 2003.... - Sodium transport antagonism reduces thrombotic microangiopathy in stroke-prone spontaneously hypertensive ratsReza Sepehrdad
Dept. of Pharmacology, Basic Science Bldg. New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Renal Physiol 286:F1185-92. 2004.... 
TNFR1-deficient mice display altered blood pressure and renal responses to ANG II infusionChun Cheng Andy Chen
Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Renal Physiol 299:F1141-50. 2010..These findings indicate deletion of TNFR1 is associated with an exacerbated SBP response, decrease in HR, and altered renal function in ANG II-dependent hypertension...- Kinetics and persistence of cardiovascular and locomotor effects of immobilization stress and influence of ACTH treatmentEsther L Sabban
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, N Y 10595, USA
Neuroendocrinology 89:98-108. 2009..In addition, prior exposure to ACTH delayed recovery in cardiovascular and locomotor functions following cessation of stress... - Aldosterone and aldosterone antagonism in systemic hypertensionWilliam H Frishman
Department of Medicine, New York Medical College, Munger Pavilion 263, Valhalla, NY 10595, USA
Curr Hypertens Rep 6:195-200. 2004..Hyperkalemia remains a potential problem with all aldosterone antagonists... - Aldosterone plays a pivotal role in the pathogenesis of thrombotic microangiopathy in SHRSPPraveen N Chander
Departments of Pathology, New York Medical College, Valhalla, New York, USA
J Am Soc Nephrol 14:1990-7. 2003..These results demonstrate a pivotal role for aldosterone in the development of thrombotic microangiopathy, independent of hypertension... - Male gender and not the severity of hypertension is associated with end-organ damage in aged stroke-prone spontaneously hypertensive ratsSreeharsha N Masineni
Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
Am J Hypertens 18:878-84. 2005..CONCLUSIONS: These findings demonstrate that male gender is a major risk factor for multisystem end-organ damage associated with aging and hypertension in SHRSP, despite comparable degrees of hypertension among males and females... - Increase in heme oxygenase-1 levels ameliorates renovascular hypertensionFady T Botros
Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
Kidney Int 68:2745-55. 2005..We examined whether HO-1 overexpression, as a prophylactic approach, would attenuate renovascular hypertension and evaluated potential mechanisms that may account for its effect... - Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertensionJing Li
Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
Front Biosci 13:3480-7. 2008..sEH inhibition may provide a therapeutic strategy for treating salt-sensitive hypertension and its sequelae... - Inhibition of the adenosine2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensiveElvira L Liclican
Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
Hypertension 54:1284-90. 2009..1+/-1 mEq/L), reflecting a diminished natriuretic capacity. These data support a role for the A(2A)R-EET pathway in the adaptive natriuretic response to modulate blood pressure during salt loading... - Direct inhibition of renin as a cardiovascular pharmacotherapy: focus on aliskirenReza Sepehrdad
Department of Internal Medicine, UC Davis Medical Center, Sacramento, California, USA
Cardiol Rev 15:242-56. 2007.... - Aldosterone, but not angiotensin II, increases profibrotic factors in kidney of adrenalectomized stroke-prone spontaneously hypertensive ratsTae Yon Chun
Department of Medicine, Indiana University School of Medicine, 1481 West 10th St, Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
Am J Physiol Endocrinol Metab 295:E305-12. 2008..In summary, in the saline-drinking SHRSP, Aldo increased renal profibrotic factors and produced renal injury whereas ANG II in the absence of the adrenals had no effect... - Protective effects of dietary potassium chloride on hemodynamics of Dahl salt-sensitive rats in response to chronic administration of sodium chlorideWilliam M Manger
Department of Medicine, New York University, NY, USA
J Hypertens 21:2305-13. 2003..CONCLUSION: 'Optimal' dietary KCl (2.6%) prevents hypertension and preserves cerebral and renal hemodynamics in DSS rats fed a diet containing 1% NaCl for 8 months, which causes hypertension when dietary KCl is limited or excessive... - Microarray analysis of gene expression in vascular smooth muscle cells from spontaneously hypertensive rats at an early ageCharles T Stier
J Hypertens 20:1259-61. 2002 - Mineralocorticoid receptor blockade: new insights into the mechanism of action in patients with cardiovascular diseaseBertram Pitt
Division of Cardiology, University of Michigan, USA
J Renin Angiotensin Aldosterone Syst 4:164-8. 2003..This hypothesis will, however, require further prospective evaluation...
Research Grants
- PREVENTION OF STROKE & KIDNEY DYSFUNCTIONCHARLES STIER; Fiscal Year: 1991..Stroke is currently the nation's third largest killer (over 150,000 Americans/year). Our studies will provide important information in an area relevant to the therapy of hypertension, kidney dysfunction and stroke...
- PREVENTION OF STROKE DYSFUNCTION BY ACE INHIBITIONCHARLES STIER; Fiscal Year: 2003..abstract_text> ..