CHARLES STIER

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. ncbi request reprint Stress triggered rise in plasma aldosterone is lessened by chronic nicotine infusion
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Eur J Pharmacol 495:167-70. 2004
  2. ncbi request reprint Osteopontin in patients with primary aldosteronism
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, New York, USA
    Am J Hypertens 19:298-9. 2006
  3. ncbi request reprint Effect of aldosterone and MR blockade on the brain and the kidney
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Heart Fail Rev 10:53-62. 2005
  4. ncbi request reprint Estrogen promotes microvascular pathology in female stroke-prone spontaneously hypertensive rats
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla 10595, USA
    Am J Physiol Endocrinol Metab 285:E232-9. 2003
  5. ncbi request reprint Aldosterone and aldosterone antagonism in cardiovascular disease: focus on eplerenone (Inspra)
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Heart Dis 5:102-18. 2003
  6. ncbi request reprint Eplerenone: a selective aldosterone blocker
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Cardiovasc Drug Rev 21:169-84. 2003
  7. ncbi request reprint Aldosterone as a mediator in cardiovascular injury
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Cardiol Rev 10:97-107. 2002
  8. ncbi request reprint Amiloride reduces stroke and renalinjury in stroke-prone hypertensive rats
    Reza Sepehrdad
    Department of Pharmacology, New York Medical College, Valhalla 10595, USA
    Am J Hypertens 16:312-8. 2003
  9. ncbi request reprint Sodium transport antagonism reduces thrombotic microangiopathy in stroke-prone spontaneously hypertensive rats
    Reza Sepehrdad
    Dept of Pharmacology, Basic Science Bldg New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 286:F1185-92. 2004
  10. pmc TNFR1-deficient mice display altered blood pressure and renal responses to ANG II infusion
    Chun Cheng Andy Chen
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 299:F1141-50. 2010

Research Grants

  1. PREVENTION OF STROKE & KIDNEY DYSFUNCTION
    CHARLES STIER; Fiscal Year: 1991
  2. PREVENTION OF STROKE DYSFUNCTION BY ACE INHIBITION
    CHARLES STIER; Fiscal Year: 2003

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Stress triggered rise in plasma aldosterone is lessened by chronic nicotine infusion
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Eur J Pharmacol 495:167-70. 2004
    ..Nicotine infusion attenuated the rise in aldosterone with restraint and cold stress, but not immobilization. These results reveal that nicotine infusion can attenuate the aldosterone response, depending on the type of stress...
  2. ncbi request reprint Osteopontin in patients with primary aldosteronism
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, New York, USA
    Am J Hypertens 19:298-9. 2006
  3. ncbi request reprint Effect of aldosterone and MR blockade on the brain and the kidney
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Heart Fail Rev 10:53-62. 2005
    ..The specific blockade of aldosterone action should prove to be of great therapeutic value in the prevention of cerebral and renal vascular disease and associated end-organ damage...
  4. ncbi request reprint Estrogen promotes microvascular pathology in female stroke-prone spontaneously hypertensive rats
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla 10595, USA
    Am J Physiol Endocrinol Metab 285:E232-9. 2003
    ..kg-1.wk-1) prolonged survival by >2 wk compared with controls (P < 0.01). The data indicate that estrogen promotes microangiopathy in the kidney and stroke in saline-drinking SHRSP...
  5. ncbi request reprint Aldosterone and aldosterone antagonism in cardiovascular disease: focus on eplerenone (Inspra)
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Heart Dis 5:102-18. 2003
    ..Eplerenone has already been approved for the treatment of systemic hypertension, and several clinical trials are currently underway to identify other therapeutic uses for this agent in cardiovascular disease management...
  6. ncbi request reprint Eplerenone: a selective aldosterone blocker
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Cardiovasc Drug Rev 21:169-84. 2003
    ..The advent of selective aldosterone blockers, such as eplerenone, should prove to be of great therapeutic value in hypertension control and prevention of cardiovascular disease and associated end-organ damage...
  7. ncbi request reprint Aldosterone as a mediator in cardiovascular injury
    Charles T Stier
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Cardiol Rev 10:97-107. 2002
    ..The advent of selective aldosterone receptor antagonists such as eplerenone should prove of great therapeutic value in the prevention of cardiovascular disease and associated end-organ damage...
  8. ncbi request reprint Amiloride reduces stroke and renalinjury in stroke-prone hypertensive rats
    Reza Sepehrdad
    Department of Pharmacology, New York Medical College, Valhalla 10595, USA
    Am J Hypertens 16:312-8. 2003
    ..Presently, we examined whether amiloride, an epithelial sodium channel blocker, would also protect against pathology in these rats...
  9. ncbi request reprint Sodium transport antagonism reduces thrombotic microangiopathy in stroke-prone spontaneously hypertensive rats
    Reza Sepehrdad
    Dept of Pharmacology, Basic Science Bldg New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 286:F1185-92. 2004
    ....
  10. pmc TNFR1-deficient mice display altered blood pressure and renal responses to ANG II infusion
    Chun Cheng Andy Chen
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 299:F1141-50. 2010
    ..These findings indicate deletion of TNFR1 is associated with an exacerbated SBP response, decrease in HR, and altered renal function in ANG II-dependent hypertension...
  11. pmc Kinetics and persistence of cardiovascular and locomotor effects of immobilization stress and influence of ACTH treatment
    Esther L Sabban
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, N Y 10595, USA
    Neuroendocrinology 89:98-108. 2009
    ..In addition, prior exposure to ACTH delayed recovery in cardiovascular and locomotor functions following cessation of stress...
  12. ncbi request reprint Aldosterone and aldosterone antagonism in systemic hypertension
    William H Frishman
    Department of Medicine, New York Medical College, Munger Pavilion 263, Valhalla, NY 10595, USA
    Curr Hypertens Rep 6:195-200. 2004
    ..Hyperkalemia remains a potential problem with all aldosterone antagonists...
  13. ncbi request reprint Aldosterone plays a pivotal role in the pathogenesis of thrombotic microangiopathy in SHRSP
    Praveen N Chander
    Departments of Pathology, New York Medical College, Valhalla, New York, USA
    J Am Soc Nephrol 14:1990-7. 2003
    ..These results demonstrate a pivotal role for aldosterone in the development of thrombotic microangiopathy, independent of hypertension...
  14. ncbi request reprint Male gender and not the severity of hypertension is associated with end-organ damage in aged stroke-prone spontaneously hypertensive rats
    Sreeharsha N Masineni
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Am J Hypertens 18:878-84. 2005
    ..In the present study, we examined arterial blood pressure (BP), proteinuria, and end-organ damage in male and female retired breeders from our colony of stroke-prone spontaneously hypertensive rats (SHRSP)...
  15. ncbi request reprint Increase in heme oxygenase-1 levels ameliorates renovascular hypertension
    Fady T Botros
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Kidney Int 68:2745-55. 2005
    ..We examined whether HO-1 overexpression, as a prophylactic approach, would attenuate renovascular hypertension and evaluated potential mechanisms that may account for its effect...
  16. ncbi request reprint Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension
    Jing Li
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Front Biosci 13:3480-7. 2008
    ..sEH inhibition may provide a therapeutic strategy for treating salt-sensitive hypertension and its sequelae...
  17. pmc Inhibition of the adenosine2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensive
    Elvira L Liclican
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Hypertension 54:1284-90. 2009
    ..1+/-1 mEq/L), reflecting a diminished natriuretic capacity. These data support a role for the A(2A)R-EET pathway in the adaptive natriuretic response to modulate blood pressure during salt loading...
  18. ncbi request reprint Direct inhibition of renin as a cardiovascular pharmacotherapy: focus on aliskiren
    Reza Sepehrdad
    Department of Internal Medicine, UC Davis Medical Center, Sacramento, California, USA
    Cardiol Rev 15:242-56. 2007
    ....
  19. pmc Aldosterone, but not angiotensin II, increases profibrotic factors in kidney of adrenalectomized stroke-prone spontaneously hypertensive rats
    Tae Yon Chun
    Department of Medicine, Indiana University School of Medicine, 1481 West 10th St, Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Am J Physiol Endocrinol Metab 295:E305-12. 2008
    ..In summary, in the saline-drinking SHRSP, Aldo increased renal profibrotic factors and produced renal injury whereas ANG II in the absence of the adrenals had no effect...
  20. ncbi request reprint Protective effects of dietary potassium chloride on hemodynamics of Dahl salt-sensitive rats in response to chronic administration of sodium chloride
    William M Manger
    Department of Medicine, New York University, NY, USA
    J Hypertens 21:2305-13. 2003
    ..Dietary potassium supplementation decreases blood pressure and prevents strokes in humans, and prevents strokes and renal damage in Dahl salt-sensitive (DSS) rats...
  21. ncbi request reprint Microarray analysis of gene expression in vascular smooth muscle cells from spontaneously hypertensive rats at an early age
    Charles T Stier
    J Hypertens 20:1259-61. 2002
  22. ncbi request reprint Mineralocorticoid receptor blockade: new insights into the mechanism of action in patients with cardiovascular disease
    Bertram Pitt
    Division of Cardiology, University of Michigan, USA
    J Renin Angiotensin Aldosterone Syst 4:164-8. 2003
    ..This hypothesis will, however, require further prospective evaluation...

Research Grants13

  1. PREVENTION OF STROKE & KIDNEY DYSFUNCTION
    CHARLES STIER; Fiscal Year: 1991
    ..Stroke is currently the nation's third largest killer (over 150,000 Americans/year). Our studies will provide important information in an area relevant to the therapy of hypertension, kidney dysfunction and stroke...
  2. PREVENTION OF STROKE DYSFUNCTION BY ACE INHIBITION
    CHARLES STIER; Fiscal Year: 2003
    ..abstract_text> ..