Julian M Stewart

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. pmc Middle cerebral O₂ delivery during the modified Oxford maneuver increases with sodium nitroprusside and decreases during phenylephrine
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, NY, USA
    Am J Physiol Heart Circ Physiol 304:H1576-83. 2013
  2. pmc Common syndromes of orthostatic intolerance
    Julian M Stewart
    Departments of Pediatrics, Physiology, and Medicine, The Maria Fareri Children s Hospital, NY, USA
    Pediatrics 131:968-80. 2013
  3. pmc Mechanisms of sympathetic regulation in orthostatic intolerance
    Julian M Stewart
    Departments of Physiology, Pediatrics and Medicine, New York Medical College, Valhalla, NY, USA mail
    J Appl Physiol 113:1659-68. 2012
  4. doi request reprint Update on the theory and management of orthostatic intolerance and related syndromes in adolescents and children
    Julian M Stewart
    Departments of Pediatrics, Physiology and Medicine, The Maria Fareri Childrens Hospital and New York Medical College, Valhalla, NY, USA
    Expert Rev Cardiovasc Ther 10:1387-99. 2012
  5. pmc Postural neurocognitive and neuronal activated cerebral blood flow deficits in young chronic fatigue syndrome patients with postural tachycardia syndrome
    Julian M Stewart
    Departments of Physiology, New York Medical College, Valhalla, New York USA
    Am J Physiol Heart Circ Physiol 302:H1185-94. 2012
  6. pmc Cutaneous constitutive nitric oxide synthase activation in postural tachycardia syndrome with splanchnic hyperemia
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, New York, New York, USA
    Am J Physiol Heart Circ Physiol 301:H704-11. 2011
  7. pmc Ascorbate improves circulation in postural tachycardia syndrome
    Julian M Stewart
    Department of Physiology, New York Medical College, Valhalla, New York 10532, USA
    Am J Physiol Heart Circ Physiol 301:H1033-42. 2011
  8. pmc Ventilatory baroreflex sensitivity in humans is not modulated by chemoreflex activation
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, USA
    Am J Physiol Heart Circ Physiol 300:H1492-500. 2011
  9. pmc Intradermal angiotensin II administration attenuates the local cutaneous vasodilator heating response
    Julian M Stewart
    New York Medical College, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 295:H327-34. 2008
  10. ncbi request reprint Angiotensin II type 1 receptor blockade corrects cutaneous nitric oxide deficit in postural tachycardia syndrome
    Julian M Stewart
    The Center for Pediatric Hypotension, New York Medical College, 19 Bradhurst Avenue, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 294:H466-73. 2008

Collaborators

Detail Information

Publications62

  1. pmc Middle cerebral O₂ delivery during the modified Oxford maneuver increases with sodium nitroprusside and decreases during phenylephrine
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, NY, USA
    Am J Physiol Heart Circ Physiol 304:H1576-83. 2013
    ..PE decreased ΔQa by 0.27 ± .2 μmol·kg(-1)·s(-1) (16.2 μmol·kg(-1)·min(-1)), whereas CBFv increased to 75 ± 3 cm/s. These results are consistent with dilation of the MCA by SNP and constriction by PE...
  2. pmc Common syndromes of orthostatic intolerance
    Julian M Stewart
    Departments of Pediatrics, Physiology, and Medicine, The Maria Fareri Children s Hospital, NY, USA
    Pediatrics 131:968-80. 2013
    ..In this article, mechanisms for OI having components of adrenergic hypofunction, adrenergic hyperfunction, hyperpnea, and regional blood volume redistribution are discussed. Therapeutic strategies to cope with OI are proposed...
  3. pmc Mechanisms of sympathetic regulation in orthostatic intolerance
    Julian M Stewart
    Departments of Physiology, Pediatrics and Medicine, New York Medical College, Valhalla, NY, USA mail
    J Appl Physiol 113:1659-68. 2012
    ..Potential mechanisms for OI are discussed including forms of sympathetic hypofunction, forms of sympathetic hyperfunction, and OI that results from regional blood volume redistribution attributable to regional adrenergic hypofunction...
  4. doi request reprint Update on the theory and management of orthostatic intolerance and related syndromes in adolescents and children
    Julian M Stewart
    Departments of Pediatrics, Physiology and Medicine, The Maria Fareri Childrens Hospital and New York Medical College, Valhalla, NY, USA
    Expert Rev Cardiovasc Ther 10:1387-99. 2012
    ..General and specific treatment options are proposed...
  5. pmc Postural neurocognitive and neuronal activated cerebral blood flow deficits in young chronic fatigue syndrome patients with postural tachycardia syndrome
    Julian M Stewart
    Departments of Physiology, New York Medical College, Valhalla, New York USA
    Am J Physiol Heart Circ Physiol 302:H1185-94. 2012
    ..CBFV activation, normally tightly linked to cognitive neuronal activity, is unrelated to cognitive performance in CFS subjects; the increased CCP and vasomotor tone may indicate an uncoupling of the neurovascular unit during orthostasis...
  6. pmc Cutaneous constitutive nitric oxide synthase activation in postural tachycardia syndrome with splanchnic hyperemia
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, New York, New York, USA
    Am J Physiol Heart Circ Physiol 301:H704-11. 2011
    ..Aminoguanidine was without effect. This is consistent with increased endothelial and neuronal NOS activity in normal-flow POTS...
  7. pmc Ascorbate improves circulation in postural tachycardia syndrome
    Julian M Stewart
    Department of Physiology, New York Medical College, Valhalla, New York 10532, USA
    Am J Physiol Heart Circ Physiol 301:H1033-42. 2011
    ..These data provide experimental support for the concept that oxidative stress and reduced NO possibly contribute to vasoconstriction and venoconstriction of LFP...
  8. pmc Ventilatory baroreflex sensitivity in humans is not modulated by chemoreflex activation
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, USA
    Am J Physiol Heart Circ Physiol 300:H1492-500. 2011
    ..Tidal volume is primarily increased. Ventilatory baroreflex sensitivity is unaffected by chemoreflex activation, although the operating point is shifted with hypoxia and hypercapnia...
  9. pmc Intradermal angiotensin II administration attenuates the local cutaneous vasodilator heating response
    Julian M Stewart
    New York Medical College, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 295:H327-34. 2008
    ..ANG II mediates the AT(1)R blunting of local heating, which is not exclusively NO dependent, and is improved by antioxidant supplementation...
  10. ncbi request reprint Angiotensin II type 1 receptor blockade corrects cutaneous nitric oxide deficit in postural tachycardia syndrome
    Julian M Stewart
    The Center for Pediatric Hypotension, New York Medical College, 19 Bradhurst Avenue, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 294:H466-73. 2008
    ..53 +/- 2 %CVC(max)). The data suggest that the reduction in cutaneous NO-dependent vasodilation in low-flow POTS is corrected by AT(1)R blockade...
  11. ncbi request reprint Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome
    Julian M Stewart
    The Center for Pediatric Hypotension, New York Medical College, Ste 3050, 19 Bradhurst Ave, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 293:H2161-7. 2007
    ..The data suggest that nNO activity but not NO of endothelial NOS origin is reduced in low-flow POTS...
  12. pmc Increased vasoconstriction predisposes to hyperpnea and postural faint
    Indu Taneja
    Department of Pediatrics, New York Medical College, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 295:H372-81. 2008
    ..Hyperpnea and pulmonary stretch may contribute to the sympathoinhibition that occurs at the time of faint...
  13. pmc Increased phase synchronization and decreased cerebral autoregulation during fainting in the young
    Anthony J Ocon
    Department of Physiology, The Center for Hypotension, New York Medical College, 19 Bradhurst Ave, Suite 1600S, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 297:H2084-95. 2009
    ..Thus, a sudden period of highly efficient cerebral autoregulation precedes the virtual loss of autoregulation, which continued during and after the faint...
  14. ncbi request reprint Reduced central blood volume and cardiac output and increased vascular resistance during static handgrip exercise in postural tachycardia syndrome
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 293:H1908-17. 2007
    ..While increased cardiac output and central blood volume characterizes controls, increased peripheral resistance with blunted or eliminated in central blood volume increments characterizes POTS and may contribute to exercise intolerance...
  15. ncbi request reprint Persistent splanchnic hyperemia during upright tilt in postural tachycardia syndrome
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, NY, USA
    Am J Physiol Heart Circ Physiol 290:H665-73. 2006
    ..Lower body vasoconstriction in high-flow POTS was abnormal, and vasoconstriction in low-flow POTS was sustained at initially elevated supine levels...
  16. ncbi request reprint Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume
    Julian M Stewart
    Center for Pediatric Hypotension, New York Medical College, Valhalla, NY 10595, USA
    Clin Sci (Lond) 110:255-63. 2006
    ..The data suggest that plasma Ang II is increased in low-flow POTS patients with hypovolaemia, which may contribute to local blood flow dysregulation and reduced NO bioavailability...
  17. ncbi request reprint Reduced body mass index is associated with increased angiotensin II in young women with postural tachycardia syndrome
    Julian M Stewart
    Center for Pediatric Hypotension, New York Medical College, Valhalla, NY 10595, USA
    Clin Sci (Lond) 113:449-57. 2007
    ..Patients with low-flow POTS had decreased body mass, but decreased body mass alone cannot account for findings of peripheral vasoconstriction. In conclusion, the findings suggest that reduced body mass relates to increased plasma AngII...
  18. pmc Reactive oxygen species (ROS) from NADPH and xanthine oxidase modulate the cutaneous local heating response in healthy humans
    Marvin S Medow
    Department of Pediatrics, New York Medical College, The Center for Hypotension, 19 Bradhurst Ave, Suite 1600S, Hawthorne, NY 10532, USA
    J Appl Physiol 111:20-6. 2011
    ..This suggests that ROS, produced by ANG II via NADPH and xanthine oxidase pathways, modulates the response of skin to the application of heat, and thus contributes to the control of local cutaneous blood flow...
  19. ncbi request reprint Regional blood volume and peripheral blood flow in postural tachycardia syndrome
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 287:H1319-27. 2004
    ..The data demonstrate enhanced thoracic hypovolemia during upright tilt and confirm that POTS is related to inadequate cardiac venous return during orthostasis...
  20. ncbi request reprint Microvascular filtration is increased in postural tachycardia syndrome
    Julian M Stewart
    Department of Pediatrics and Physiology, New York Medical College, Valhalla, NY 10595, USA
    Circulation 107:2816-22. 2003
    ..Postural tachycardia syndrome (POTS) is related to defective peripheral vasoconstriction of dependent extremities with redistributive hypovolemia...
  21. ncbi request reprint Contrasting neurovascular findings in chronic orthostatic intolerance and neurocardiogenic syncope
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, NY 10595, U S A
    Clin Sci (Lond) 104:329-40. 2003
    ..We conclude that peripheral vascular physiology in patients with POTS is abnormal, in contrast with normal peripheral vascular physiology in neurocardiogenic syncope...
  22. pmc Postural change alters autonomic responses to breath-holding
    Indu Taneja
    Department of Pediatrics, New York Medical College, Valhalla, NY, USA
    Clin Auton Res 20:65-72. 2010
    ..We used breath-holding during inspiration as a model to study the effect of pulmonary stretch on sympathetic nerve activity...
  23. pmc Modulation of the axon-reflex response to local heat by reactive oxygen species in subjects with chronic fatigue syndrome
    Marvin S Medow
    Department of Pediatrics, New York Medical College and The Center for Pediatric Hypotension, Hawthorne, New York 10532, USA
    J Appl Physiol 114:45-51. 2013
    ..None of these agents changed the response to local heat in control subjects. Thus the response to heat may be altered by local levels of ROS, particularly H(2)O(2) in CFS subjects, and may be related to their hyperesthesia/hyperalgesia...
  24. ncbi request reprint Splanchnic hyperemia and hypervolemia during Valsalva maneuver in postural tachycardia syndrome
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, NY, USA
    Am J Physiol Heart Circ Physiol 289:H1951-9. 2005
    ..Thus splanchnic hyperemia and hypervolemia are related to excessive phase II blood pressure reduction in POTS despite intense peripheral vasoconstriction. Factors other than autonomic dysfunction may play a role in POTS...
  25. pmc Decreased upright cerebral blood flow and cerebral autoregulation in normocapnic postural tachycardia syndrome
    Anthony J Ocon
    Department of Physiology, The Center for Hypotension, New York Medical College, Valhalla, New York 10532, USA
    Am J Physiol Heart Circ Physiol 297:H664-73. 2009
    ..We conclude that dynamic and static autoregulation of CBF are less effective in POTS patients compared with control subjects during orthostatic challenge...
  26. ncbi request reprint Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flow
    Julian M Stewart
    Department of Pediatrics, Research Division and Hypotension Laboratory, New York Medical College, Suite 3050, 19 Bradhurst Ave, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 291:H904-13. 2006
    ..Variability indexes suggested enhanced sympathetic activation in POTS(HC) compared with other subjects. The data suggest enhanced cardiac and peripheral sympathetic excitation in POTS(HC)...
  27. pmc Respiration drives phase synchronization between blood pressure and RR interval following loss of cardiovagal baroreflex during vasovagal syncope
    Anthony J Ocon
    Department of Physiology, New York Medical College, The Center for Hypotension, 19 Bradhurst Ave, Ste 1600S, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 300:H527-40. 2011
    ..Cardiovagal baroreflex is lost before syncope and supplanted by respiratory reflexes, producing hypotension and bradycardia...
  28. ncbi request reprint Clinical and physiological effects of an acute alpha-1 adrenergic agonist and a beta-1 adrenergic antagonist in chronic orthostatic intolerance
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, NY 10595, USA
    Circulation 106:2946-54. 2002
    ..POTS may be associated with increased limb blood flow ("high flow") and defective orthostatic vasoconstriction or decreased limb blood flow ("low flow") and potentially with small blood volume...
  29. ncbi request reprint Pooling in chronic orthostatic intolerance: arterial vasoconstrictive but not venous compliance defects
    Julian M Stewart
    Department of Pediatrics and Physiology, New York Medical College, Valhalla, NY 10595, USA
    Circulation 105:2274-81. 2002
    ..My colleagues and I tested the hypothesis that pooling results from increased venous compliance in POTS patients...
  30. ncbi request reprint Plantar vibration improves leg fluid flow in perimenopausal women
    Julian M Stewart
    Depts of Pediatrics and Physiology, The Center for Pediatric Hypotension and Division of Pediatric Cardiology, Suite 618, Munger Pavilion, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Regul Integr Comp Physiol 288:R623-9. 2005
    ....
  31. pmc Initial orthostatic hypotension in the young is attenuated by static handgrip
    Debbie A Clarke
    Department of Pediatrics, The Center for Hypotension, New York Medical College, Valhalla, NY, USA
    J Pediatr 156:1019-22, 1022.e1. 2010
    ..We show that in 14 subjects with initial orthostatic hypotension, isometric handgrip coupled with standing abolished symptoms of initial orthostatic hypotension and minimized decreases in blood pressure and cardiac output with standing...
  32. pmc Nitric oxide and prostaglandin inhibition during acetylcholine-mediated cutaneous vasodilation in humans
    Marvin S Medow
    Department of Pediatrics, New York Medical College, Valhalla, New York 10532, USA
    Microcirculation 15:569-79. 2008
    ..These data suggest that cutaneous acetylcholine-mediated endothelium-dependent vasodilation is highly NO-dependent and is also strongly related to the interactions of NO with prostaglandins...
  33. pmc Increased pulsatile cerebral blood flow, cerebral vasodilation, and postsyncopal headache in adolescents
    Anthony J Ocon
    Department of Physiology, Center for Hypotension, New York Medical College, Valhalla, NY, USA
    J Pediatr 159:656-62.e1. 2011
    ....
  34. ncbi request reprint Noninvasive measure of microvascular nitric oxide function in humans using very low-frequency cutaneous laser Doppler flow spectra
    Julian M Stewart
    New York Medical College, Valhalla, New York, USA
    Microcirculation 14:169-80. 2007
    ..0095-0.021 Hz) do not. The authors investigated whether VLF LDF power is nitric oxide (NO) specific...
  35. ncbi request reprint Local vascular responses affecting blood flow in postural tachycardia syndrome
    Julian M Stewart
    Department of Pediatrics, Center for Pediatric Hypotension and Division of Pediatric Cardiology, Suite 618, Munger Pavilion, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 285:H2749-56. 2003
    ..29 +/- 4 and 28 +/- 4 s; cutaneous time constant = 60 +/- 25 vs. 149 +/- 53 s in controls). Local blood flow regulation in low-flow POTS is impaired...
  36. ncbi request reprint Differential effects of lower body negative pressure and upright tilt on splanchnic blood volume
    Indu Taneja
    Department of Pediatrics, New York Medical College, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 292:H1420-6. 2007
    ..Splanchnic emptying in LBNP models regional vascular changes during hemorrhage. Splanchnic filling may limit the ability of the splanchnic bed to respond to thoracic hypovolemia during upright posture...
  37. ncbi request reprint Changes in regional blood volume and blood flow during static handgrip
    Julian M Stewart
    Professor of Pediatrics and Physiology, Research Division and Hypotension Laboratory, New York Medical College, Suite 3050, 19 Bradhurst Ave, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 292:H215-23. 2007
    ..We conclude that the exercise pressor reflex is associated with reduced baroreflex cardiovagal regulation and driven by increased cardiac output related to enhanced preload, cardiac contractility, and splanchnic blood mobilization...
  38. pmc Baroreceptor unloading in postural tachycardia syndrome augments peripheral chemoreceptor sensitivity and decreases central chemoreceptor sensitivity
    Indu Taneja
    The Center for Pediatric Hypotension, Ste 1600S, 19 Bradhurst Ave, New York Medical College, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 301:H173-9. 2011
    ..The interactions between orthostatic baroreflex unloading and altered chemoreflex sensitivities may explain the hyperventilation in POTS patients...
  39. ncbi request reprint Decreased microvascular nitric oxide-dependent vasodilation in postural tachycardia syndrome
    Marvin S Medow
    New York Medical College, Valhalla, NY, USA
    Circulation 112:2611-8. 2005
    ..One variant of postural tachycardia syndrome (POTS), designated low-flow POTS, is associated with decreased peripheral blood flow related to impaired local vascular regulation...
  40. ncbi request reprint Decreased skeletal muscle pump activity in patients with postural tachycardia syndrome and low peripheral blood flow
    Julian M Stewart
    Center for Pediatric Hypotension and Division of Pediatric Cardiology, Suite 618, Munger Pavilion, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 286:H1216-22. 2004
    ..Decreased calf blood flow may reduce calf size in POTS and thereby impair the upright ejective ability of the skeletal muscle pump and further contribute to overall reduced blood flow and orthostatic intolerance in these patients...
  41. pmc Multiresolution wavelet analysis of time-dependent physiological responses in syncopal youths
    Jennifer A Nowak
    Pediatrics, Physiology, and Medicine, The Center for Hypotension, New York Medical College, Hawthorne, New York 10532, USA
    Am J Physiol Heart Circ Physiol 296:H171-9. 2009
    ..The data imply a rapid reduction in time-dependent sympathetic baroreflex activity in fainters but not control subjects during HUT...
  42. ncbi request reprint Relation of postural vasovagal syncope to splanchnic hypervolemia in adolescents
    Julian M Stewart
    Department of Pediatrics, The Center for Pediatric Hypotension, Suite 618, Munger Pavilion, New York Medical College, Valhalla, NY 10595, USA
    Circulation 110:2575-81. 2004
    ..The mechanisms of simple faint remain elusive. We propose that postural fainting is related to excessive thoracic hypovolemia and splanchnic hypervolemia during orthostasis compared with healthy subjects...
  43. pmc Spontaneous fluctuation indices of the cardiovagal baroreflex accurately measure the baroreflex sensitivity at the operating point during upright tilt
    Christopher E Schwartz
    Department of Pediatrics, New York Medical College, Valhalla, NY, USA
    Am J Physiol Regul Integr Comp Physiol 304:R1107-13. 2013
    ..In conclusion, spontaneous measurements of cardiovagal baroreflex function accurately estimate the slope near operating points in both supine and upright position...
  44. ncbi request reprint The postural tachycardia syndrome
    Marvin S Medow
    Department of Pediatrics, New York Medical College, Valhalla, New York 10598, USA
    Cardiol Rev 15:67-75. 2007
    ..Treatments have resulted in varying degrees of success and are often used in combination with each other...
  45. pmc Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome
    Anthony J Ocon
    Department of Physiology, New York Medical College, Valhalla, NY, USA
    Clin Sci (Lond) 122:227-38. 2012
    ..Individuals with CFS/POTS should be aware that orthostatic stress may impair their neurocognitive abilities...
  46. ncbi request reprint Reciprocal splanchnic-thoracic blood volume changes during the Valsalva maneuver
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 288:H752-8. 2005
    ..Changes in baseline splanchnic vascular properties may account for variability in thoracic blood volume changes during the Valsalva maneuver...
  47. pmc Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome
    Julian M Stewart
    The Center for Pediatric Hypotension, Suite 1600 S, 19 Bradhurst Ave, New York Medical College, Hawthorne, NY 10532, USA
    Hypertension 53:767-74. 2009
    ..Data imply impaired catabolism of Ang II through the ACE2 pathway. Vasoconstriction in POTS may result from a reduction in Ang-(1-7) and an increase in Ang II...
  48. ncbi request reprint Transient orthostatic hypotension is common in adolescents
    Julian M Stewart
    Department of Pediatric, The Center for Pediatric Hypotension, New York Medical College, Valhalla 10595, USA
    J Pediatr 140:418-24. 2002
    ..We hypothesized that transient hypotension associated with the symptom of lightheadedness with standing is a common phenomenon in healthy adolescents but may be mistaken for orthostatic intolerance...
  49. doi request reprint Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology
    Dikoma C Shungu
    Department of Radiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    NMR Biomed 25:1073-87. 2012
    ..Collectively, the results of this third independent study support a pathophysiological model of CFS in which increased oxidative stress may play a key role in CFS etiopathophysiology...
  50. ncbi request reprint Chronic orthostatic intolerance and the postural tachycardia syndrome (POTS)
    Julian M Stewart
    Department of Pediatrics and Physiology, New York Medical College Valhalla, New York, USA
    J Pediatr 145:725-30. 2004
  51. ncbi request reprint Effect of plantar micromechanical stimulation on cardiovascular responses to immobility
    Guruprasad Madhavan
    Clinical Sciences Research Center, Department of Bioengineering, Thomas J Watson School of Engineering and Applied Science, State University of New York, Binghamton, New York, USA
    Am J Phys Med Rehabil 84:338-45. 2005
    ..We investigated the cardiovascular responses of adult women to the influence of extended quiet sitting and the extent to which these responses may be reversed by micromechanical stimulation of the plantar surface...
  52. doi request reprint Anorectal motility abnormalities in children with encopresis and chronic constipation
    Neeraj Raghunath
    Department of Pediatrics, Division of Gastroenterology and Nutrition, New York Medical College, Valhalla, NY 10532, USA
    J Pediatr 158:293-6. 2011
    ..To evaluate the response to rectal distension in children with chronic constipation and children with chronic constipation and encopresis...
  53. ncbi request reprint Orthostatic intolerance in pediatrics
    Julian M Stewart
    Department of Pediatrics and Physiology, The Center for Pediatric Hypotension, New York Medical College, Valhalla 10595, USA
    J Pediatr 140:404-11. 2002
  54. ncbi request reprint Effects of thoracic blood volume on Valsalva maneuver
    Julian M Stewart
    Department of Pediatrics, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H798-804. 2004
    ..The VM depends on vascular as well as autonomic activation, which broadens its utility but complicates its analysis...
  55. ncbi request reprint Cyclooxygenase and nitric oxide synthase dependence of cutaneous reactive hyperemia in humans
    Marvin S Medow
    Department of Pediatrics, The Center for Pediatric Hypotension, New York Medical College, 19 Bradhurst Avenue, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 293:H425-32. 2007
    ..Low-dose NLA + SNP duplicates the Keto response. Isoproterenol increased baseline and peak reactive flow. These results suggest that COX inhibition unmasks NO dependence of reactive hyperemia in human cutaneous circulation...
  56. ncbi request reprint Pathophysiology, diagnosis, and treatment of orthostatic hypotension and vasovagal syncope
    Marvin S Medow
    Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
    Cardiol Rev 16:4-20. 2008
    ..Treatment for recurrent vasovagal syncope includes increased salt and water intake and various drug treatments, most of which are still under investigation...
  57. doi request reprint Chronic fatigue syndrome: comments on deconditioning, blood volume and resulting cardiac function
    Julian M Stewart
    Department of Pediatrics and Physiology, New York Medical College, Hawthorne, NY 10532, USA
    Clin Sci (Lond) 118:121-3. 2010
    ..The circulatory consequences of reduced cardiac output may help to account for many of the findings of the syndrome...
  58. pmc The arterial baroreflex resets with orthostasis
    Christopher E Schwartz
    Department of Physiology, The Center for Hypotension, New York Medical College Valhalla, NY, USA Department of Pediatrics, The Center for Hypotension, New York Medical College Valhalla, NY, USA
    Front Physiol 3:461. 2012
    ..This difference is likely selective for exercising muscle and may represent the actions of functional sympatholysis by which exercise metabolites interfere with adrenergic vasoconstriction...
  59. ncbi request reprint Orthostatic hypotension in pediatrics
    Julian M Stewart
    Department of Pediatrics and Physiology, The Center for Pediatric Hypotension, New York Medical College Children s Hospital at Westchester Medical Center, Valhalla, New York 10595, USA
    Heart Dis 4:33-9. 2002
    ..However, persistent orthostatic hypotension and chronic symptoms of orthostatic intolerance indicate postural tachycardia syndrome...
  60. pmc Reduced iron stores and its effect on vasovagal syncope (simple faint)
    Julian M Stewart
    J Pediatr 153:9-11. 2008
  61. ncbi request reprint Cardiovascular systemic regulation by plantar surface stimulation
    Guruprasad Madhavan
    Department of Orthopaedics, School of Medicine, Health Sciences Center, State University of New York, Stony Brook, USA
    Biomed Instrum Technol 40:78-84. 2006
    ..Here, we investigate the potential of low-magnitude vibration, applied at the plantar surface, to inhibit the cardiovascular responses of adult women to the orthostatic stress associated with quiet sitting...
  62. ncbi request reprint Midodrine for the treatment of vasovagal syncope (simple faint)
    Julian M Stewart
    J Pediatr 149:740-2. 2006