Zoltan Spolarics

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint Tumor necrosis factor alpha augments the expression of glucose-6-phosphate dehydrogenase in rat hepatic endothelial and Kupffer cells
    Z Spolarics
    Department of Anatomy, Cell Biology and Injury Sciences, University of Medicine and Dentistry of New Jersey, Newark, USA
    Life Sci 60:565-71. 1997
  2. ncbi request reprint Red blood cell dysfunction in septic glucose-6-phosphate dehydrogenase-deficient mice
    Zoltan Spolarics
    Dept of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Ave, MSB G 626, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 286:H2118-26. 2004
  3. ncbi request reprint Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients
    Zoltan Spolarics
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
    Crit Care Med 31:1722-9. 2003
  4. ncbi request reprint The X-files of inflammation: cellular mosaicism of X-linked polymorphic genes and the female advantage in the host response to injury and infection
    Zoltan Spolarics
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 27:597-604. 2007
  5. ncbi request reprint Endotoxemia, pentose cycle, and the oxidant/antioxidant balance in the hepatic sinusoid
    Z Spolarics
    Department of Anatomy, Cell Biology and Injury Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    J Leukoc Biol 63:534-41. 1998
  6. ncbi request reprint Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients
    Z Spolarics
    Department of Anatomy Cell Biology, New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 29:728-36. 2001
  7. ncbi request reprint Augmented resistance to oxidative stress in fatty rat livers induced by a short-term sucrose-rich diet
    Z Spolarics
    Department of Anatomy, Cell Biology and Injury Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Biochim Biophys Acta 1487:190-200. 2000
  8. pmc Female X-chromosome mosaicism for NOX2 deficiency presents unique inflammatory phenotype and improves outcome in polymicrobial sepsis
    Rachna Chandra
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 186:6465-73. 2011
  9. ncbi request reprint Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages
    Jeanette Wilmanski
    Graduate School of Biomedical Sciences, UMDNJ New Jersey Medical School, Newark, 07103, USA
    J Leukoc Biol 78:85-94. 2005
  10. pmc A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation
    Balázs Csóka
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 185:542-50. 2010

Research Grants

  1. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2009
  2. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2007
  3. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2006
  4. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2005
  5. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2004
  6. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2004
  7. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2003
  8. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2002
  9. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2001
  10. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Tumor necrosis factor alpha augments the expression of glucose-6-phosphate dehydrogenase in rat hepatic endothelial and Kupffer cells
    Z Spolarics
    Department of Anatomy, Cell Biology and Injury Sciences, University of Medicine and Dentistry of New Jersey, Newark, USA
    Life Sci 60:565-71. 1997
    ..These data indicate that the proinflammatory cytokine TNF alpha plays an important role in the regulation of cellular G6PD expression in hepatic immune competent cells...
  2. ncbi request reprint Red blood cell dysfunction in septic glucose-6-phosphate dehydrogenase-deficient mice
    Zoltan Spolarics
    Dept of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Ave, MSB G 626, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 286:H2118-26. 2004
    ....
  3. ncbi request reprint Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients
    Zoltan Spolarics
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
    Crit Care Med 31:1722-9. 2003
    ....
  4. ncbi request reprint The X-files of inflammation: cellular mosaicism of X-linked polymorphic genes and the female advantage in the host response to injury and infection
    Zoltan Spolarics
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 27:597-604. 2007
    ..The unique inheritance pattern of X-linked polymorphisms and their potential confounding effects in clinical trials are also discussed; furthermore, we present potential biomarkers for studying mosaic cell populations of innate immunity...
  5. ncbi request reprint Endotoxemia, pentose cycle, and the oxidant/antioxidant balance in the hepatic sinusoid
    Z Spolarics
    Department of Anatomy, Cell Biology and Injury Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    J Leukoc Biol 63:534-41. 1998
    ....
  6. ncbi request reprint Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients
    Z Spolarics
    Department of Anatomy Cell Biology, New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 29:728-36. 2001
    ....
  7. ncbi request reprint Augmented resistance to oxidative stress in fatty rat livers induced by a short-term sucrose-rich diet
    Z Spolarics
    Department of Anatomy, Cell Biology and Injury Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Biochim Biophys Acta 1487:190-200. 2000
    ....
  8. pmc Female X-chromosome mosaicism for NOX2 deficiency presents unique inflammatory phenotype and improves outcome in polymicrobial sepsis
    Rachna Chandra
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 186:6465-73. 2011
    ..This study suggests that mice mosaic for gp91phox expression have multiple advantages compared with WT and deficient mice during the septic course...
  9. ncbi request reprint Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages
    Jeanette Wilmanski
    Graduate School of Biomedical Sciences, UMDNJ New Jersey Medical School, Newark, 07103, USA
    J Leukoc Biol 78:85-94. 2005
    ..Alterations in signaling pathways and associated changes in cytokine production may play a role in modulating the inflammatory responses following bacterial or malarial infections in G6PD deficiency...
  10. pmc A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation
    Balázs Csóka
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 185:542-50. 2010
    ..These results indicate that A(2B) receptor activation may offer a new therapeutic approach for the management of sepsis...
  11. pmc Cellular mosaicism for X-linked polymorphisms and IRAK1 expression presents a distinct phenotype and improves survival following sepsis
    Rachna Chandra
    1 Rutgers New Jersey Medical School, 185 South Orange Ave, MSB G 578, Newark, NJ 07103, USA
    J Leukoc Biol 95:497-507. 2014
    ..Mosaicism for IRAK1 expression is accompanied by skewing toward deficient immune cell populations, producing a phenotype that is preconditioned for improved sepsis outcome similar to that observed in IRAK1 deficiency. ..
  12. ncbi request reprint Attenuated monocyte IL-10 production in glucose-6-phosphate dehydrogenase-deficient trauma patients
    Amy M Liese
    Department of Cell Biology and Injury Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    Shock 18:18-23. 2002
    ..An attenuated IL-10 production may be a contributing mechanism in the previously observed augmented inflammatory response in severely injured G6PD-deficient compared with non-deficient trauma patients...
  13. ncbi request reprint Effect of trauma-hemorrhagic shock on red blood cell deformability and shape
    Sergey B Zaets
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    Shock 19:268-73. 2003
    ..Additionally, a direct relationship appears to exist between the magnitude of the physiologic insult and the degree of RBC damage...
  14. pmc Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function
    Balázs Csóka
    Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Ave, University Heights, Newark, NJ 07103, USA
    FASEB J 22:3491-9. 2008
    ..In summary, these data demonstrate that A(2A) receptor activation has strong inhibitory actions during early developmental, as well as late effector, stages of Th1- and Th2-cell responses...
  15. pmc Female X-chromosome mosaicism for gp91phox expression diversifies leukocyte responses during endotoxemia
    Rachna Chandra
    Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 38:2003-10. 2010
    ..This is in contrast with the conditions in males who carry exclusively the maternal X chromosome...
  16. pmc CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis
    Balázs Csóka
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 4:e6409. 2009
    ..Here we examined the role of CB(2) receptors in regulating the host's response to sepsis...
  17. doi request reprint Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: the effect of G6PD deficiency
    Rachna Chandra
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Leukoc Biol 83:1541-50. 2008
    ..LPS-induced down-regulation of B cell production contributes to the generalized lymphopenia and lymphocyte dysfunction observed following nonspecific immune challenges...
  18. pmc Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis
    Gyorgy Hasko
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 187:4256-67. 2011
    ..Pharmacological inactivation of CD73 in WT mice using α, β-methylene ADP augmented cytokine levels in the blood and peritoneal lavage fluid. These findings suggest that CD73-derived adenosine may be beneficial in sepsis...
  19. ncbi request reprint Mesenteric lymph duct ligation decreases red blood cell alterations caused by acute pancreatitis
    Tamara L Berezina
    University of Medicine and Dentistry of New Jersey New Jersey Medical School, MSB, Room G 507, 185 S Orange Ave, Newark, NJ 07103, USA
    Am J Surg 190:800-4. 2005
    ..The mechanisms by which AP induces RBC injury are unknown. The purpose of this study was to test the hypothesis that factors carried in the mesenteric lymph after an attack of AP significantly contribute to the RBC injury observed in AP...
  20. ncbi request reprint Appearance of an erythrocyte population with decreased deformability and hemoglobin content following sepsis
    Michael R Condon
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
    Am J Physiol Heart Circ Physiol 284:H2177-84. 2003
    ..Increased rigidity together with decreased corpuscular hemoglobin content in these cells may contribute to microcirculatory dysfunction and immune modulation during sepsis...
  21. ncbi request reprint Glucose-6-phosphate dehydrogenase deficiency and the inflammatory response to endotoxin and polymicrobial sepsis
    Jeanette Wilmanski
    Graduate School of Biomedical Sciences and the Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Crit Care Med 35:510-8. 2007
    ..This study tested whether the deficiency is associated with altered cytokine responses in vitro and in vivo and affects survival after endotoxemia or polymicrobial sepsis (cecal ligation and puncture)...
  22. pmc Intravenous injection of mesenteric lymph produced during hemorrhagic shock decreases RBC deformability in the rat
    Michael Condon
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    J Trauma 70:489-95. 2011
    ....
  23. ncbi request reprint Dominance of high-producing interleukin 6 and low-producing interleukin 10 and interferon gamma alleles in glucose-6-phosphate dehydrogenase-deficient trauma patients
    Jeffrey S Upperman
    Division of Pediatric Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Shock 23:197-201. 2005
    ....
  24. ncbi request reprint Trauma-hemorrhagic shock-induced red blood cell damage leads to decreased microcirculatory blood flow
    George W Machiedo
    Department of Surgery, UMD New Jersey Medical School, Newark, New Jersey, USA
    Crit Care Med 37:1000-10. 2009
    ..To test the hypothesis that trauma-hemorrhagic shock (T/HS)-induced changes in red blood cells (RBC) contribute to the reduction of blood flow in distant organs...
  25. ncbi request reprint Red blood cell damage after trauma-hemorrhage is modulated by gender
    George W Machiedo
    Department of Surgery, UMD New Jersey Medical School, Newark, NJ 07103, USA
    J Trauma 56:837-44. 2004
    ..We hypothesize that female subjects are more resistant to adverse effects of T/HS on RBC deformability and shape than male subjects because of estrogen protection...
  26. doi request reprint Trauma-hemorrhagic shock induces a CD36-dependent RBC endothelial-adhesive phenotype
    Edwin A Deitch
    1Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 2Surgical Services, VA New Jersey Healthcare System, East Orange, NJ 3Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ
    Crit Care Med 42:e200-10. 2014
    ..Thus, we tested the hypothesis that trauma-hemorrhage induces RBC-endothelial cell adhesion...
  27. pmc IRAK1-dependent signaling mediates mortality in polymicrobial sepsis
    Rachna Chandra
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, MSB G 578, Newark, NJ, 07103, USA
    Inflammation 36:1503-12. 2013
    ..The delayed inflammatory response caused by the lack of IRAK1 expression is beneficial, as it manifests a marked increased chance of survival after polymicrobial sepsis...
  28. pmc Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis
    Zoltán H Németh
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Immunol 176:5616-26. 2006
    ..Similar to observations with A(2A)R KO mice, an A(2A)R antagonist increased survival even when administered in a delayed fashion. These studies demonstrate that A(2A)R blockade may be useful in the treatment of infection and sepsis...
  29. ncbi request reprint Influence of storage on red blood cell rheological properties
    Tamara L Berezina
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Surg Res 102:6-12. 2002
    ..We assumed that blood storage was accompanied by a progressive decrease of RBC deformability and rheological disorders. The degree of rheological disturbances should be directly proportional to the number of RBC with altered geometry...
  30. ncbi request reprint Methemoglobin is a potent activator of endothelial cells by stimulating IL-6 and IL-8 production and E-selectin membrane expression
    Xueying Liu
    Department of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G 626, Newark, NJ 07103, USA
    Am J Physiol Cell Physiol 285:C1036-46. 2003
    ..MHb-induced endothelial cell activation may have clinical significance after infections, hemolysis, or methemoglobinemia...
  31. ncbi request reprint Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism
    Kiyoshi Itagaki
    Department of Surgery, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Avenue, ST 8M10A, Boston, MA 02215, USA
    J Pharmacol Exp Ther 323:186-91. 2007
    ..Thus, the potential dual roles of endogenous and exogenous S1P on EC function need to be considered in pharmacological studies targeting sphingosine metabolism...
  32. ncbi request reprint Augmented TNF-alpha and IL-10 production by primed human monocytes following interaction with oxidatively modified autologous erythrocytes
    A M Liese
    Department of Anatomy, Cell Biology and Injury Sciences, and. Pediatrics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Leukoc Biol 70:289-96. 2001
    ..An augmented cytokine production by the mononuclear phagocyte system may adversely affect the clinical course of injury and infections especially in genetic or acquired RBC diseases or after transfusions...
  33. ncbi request reprint Relationship between oxidative burst activity and CD11b expression in neutrophils and monocytes from healthy individuals: effects of race and gender
    M Siddiqi
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Cytometry 46:243-6. 2001
    ..This needs consideration in clinical studies utilizing healthy volunteers with mixed gender and ethnic backgrounds...

Research Grants14

  1. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2009
    ..Better understanding of the protecting cellular mechanisms that are in effect during septic conditions could lead to advanced protocols in treating the critically ill. ..
  2. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2007
    ..Elucidation of macrophage and T-cell cytokine responses to infection in G6PD deficiency may also be important in providing a mechanism of malaria protection alternative to currently accepted notions. ..
  3. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2006
    ..Elucidation of macrophage and T-cell cytokine responses to infection in G6PD deficiency may also be important in providing a mechanism of malaria protection alternative to currently accepted notions. ..
  4. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2005
    ..Elucidation of macrophage and T-cell cytokine responses to infection in G6PD deficiency may also be important in providing a mechanism of malaria protection alternative to currently accepted notions. ..
  5. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2004
    ..Elucidation of macrophage and T-cell cytokine responses to infection in G6PD deficiency may also be important in providing a mechanism of malaria protection alternative to currently accepted notions. ..
  6. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2004
    ..abstract_text> ..
  7. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2003
    ..abstract_text> ..
  8. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2002
    ..abstract_text> ..
  9. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2001
    ..abstract_text> ..
  10. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2010
    ..Better understanding of the protecting cellular mechanisms that are in effect during septic conditions could lead to advanced protocols in treating the critically ill. ..