PATRICIA SONSALLA

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease
    Patricia K Sonsalla
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Exp Neurol 234:482-7. 2012
  2. pmc The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance
    Patricia K Sonsalla
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Exp Neurol 221:329-34. 2010
  3. pmc Chronic intraventricular administration of 1-methyl-4-phenylpyridinium as a progressive model of Parkinson's disease
    Patricia K Sonsalla
    Department of Neurology, Robert Wood Johnson Medical School UMDNJ, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Parkinsonism Relat Disord 14:S116-8. 2008
  4. ncbi request reprint Protection of malonate-induced GABA but not dopamine loss by GABA transporter blockade in rat striatum
    Gail D Zeevalk
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Exp Neurol 176:193-202. 2002
  5. ncbi request reprint Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter
    Lily Y Moy
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Pharmacol Exp Ther 320:747-56. 2007
  6. ncbi request reprint Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively
    Peter D Alfinito
    Levine Neuroscience Laboratory, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 23:10982-7. 2003
  7. doi request reprint Na(+)/H(+) exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions
    Marcelo A Rocha
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurochem 106:231-43. 2008
  8. ncbi request reprint Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, C329, Boston, MA 02118, USA
    Prog Neurobiol 83:310-31. 2007
  9. ncbi request reprint 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism
    Jiang Fan Chen
    Department of Neurology, Molecular Neurobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Biol Chem 277:36040-4. 2002
  10. ncbi request reprint Dopamine depletion causes fragmented clustering of neurons in the sensorimotor striatum: evidence of lasting reorganization of corticostriatal input
    Jeiwon Cho
    Department of Psychology, Rutgers University, New Brunswick, New Jersey 08903, USA
    J Comp Neurol 452:24-37. 2002

Research Grants

  1. DOPAMINERGIC NEUROTOXINS AND AGING
    PATRICIA SONSALLA; Fiscal Year: 2004
  2. Dopamine Homeostasis, Vesicles & Neurodegeneration
    PATRICIA SONSALLA; Fiscal Year: 2004
  3. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    PATRICIA SONSALLA; Fiscal Year: 2005
  4. Adenosine, Glutamate and Neurodegeneration
    PATRICIA SONSALLA; Fiscal Year: 2007
  5. DOPAMINERGIC NEUROTOXINS AND AGING
    PATRICIA SONSALLA; Fiscal Year: 1992
  6. DOPAMINERGIC NEUROTOXINS AND AGING
    PATRICIA SONSALLA; Fiscal Year: 1999

Detail Information

Publications10

  1. pmc Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease
    Patricia K Sonsalla
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Exp Neurol 234:482-7. 2012
    ..Importantly, neuroprotection was still apparent when caffeine was introduced after the onset of the neurodegenerative process. These results add to the clinical relevance for adenosine receptors as a disease-modifying drug target for PD...
  2. pmc The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance
    Patricia K Sonsalla
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Exp Neurol 221:329-34. 2010
    ..The results also suggest that caution in its use may be necessary, especially when administered with other drugs, in the treatment of epilepsy or PD...
  3. pmc Chronic intraventricular administration of 1-methyl-4-phenylpyridinium as a progressive model of Parkinson's disease
    Patricia K Sonsalla
    Department of Neurology, Robert Wood Johnson Medical School UMDNJ, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Parkinsonism Relat Disord 14:S116-8. 2008
    ..We review features of this model that include loss of nigral DA neurons, swollen and abnormal mitochondria, striatal inclusion-like bodies and microgliosis. Advantages as well as limitations of the model are addressed...
  4. ncbi request reprint Protection of malonate-induced GABA but not dopamine loss by GABA transporter blockade in rat striatum
    Gail D Zeevalk
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Exp Neurol 176:193-202. 2002
    ..These findings also point to fundamental differences between immature and adult neurons in the downstream involvement of GABA receptors during metabolic insult...
  5. ncbi request reprint Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter
    Lily Y Moy
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Pharmacol Exp Ther 320:747-56. 2007
    ....
  6. ncbi request reprint Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively
    Peter D Alfinito
    Levine Neuroscience Laboratory, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 23:10982-7. 2003
    ..Interestingly, these effects are mediated by A1 and A2a receptors located in the substantia nigra for DAergic neurons and in the striatum for GABAergic neurons...
  7. doi request reprint Na(+)/H(+) exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions
    Marcelo A Rocha
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurochem 106:231-43. 2008
    ..The absence of NHE1 co-location on DAergic neurons suggests that the effects of HOE-642 on striatal DA overflow are either mediated via NHE1 located on other cell types or that HOE-642 is acting through multiple NHE isoforms...
  8. ncbi request reprint Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation
    Jiang Fan Chen
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, C329, Boston, MA 02118, USA
    Prog Neurobiol 83:310-31. 2007
    ....
  9. ncbi request reprint 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism
    Jiang Fan Chen
    Department of Neurology, Molecular Neurobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Biol Chem 277:36040-4. 2002
    ..Together, these data indicate that CSC possesses dual actions of MAO-B inhibition and A(2A) receptor antagonism, a unique combination suggesting a new class of compounds with the potential for enhanced neuroprotective properties...
  10. ncbi request reprint Dopamine depletion causes fragmented clustering of neurons in the sensorimotor striatum: evidence of lasting reorganization of corticostriatal input
    Jeiwon Cho
    Department of Psychology, Rutgers University, New Brunswick, New Jersey 08903, USA
    J Comp Neurol 452:24-37. 2002
    ..Switched signals could partially explain parkinsonian deficits in motor functions involving somatosensory guidance and their intractability to L-DOPA therapy-particularly if the switching involves sprouting...

Research Grants24

  1. DOPAMINERGIC NEUROTOXINS AND AGING
    PATRICIA SONSALLA; Fiscal Year: 2004
    ..These studies will provide novel and relevant Information as to the contribution of VMAT2-containing vesicles in neuroprotection as well as in neurodegeneration under conditions of a metabolic stress. ..
  2. Dopamine Homeostasis, Vesicles & Neurodegeneration
    PATRICIA SONSALLA; Fiscal Year: 2004
    ..Results from these studies will provide novel and relevant information as to the contribution of VMAT2 containing vesicles in neuroprotection as well as in neurodegeneration of DA neurons during metabolic stress. ..
  3. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    PATRICIA SONSALLA; Fiscal Year: 2005
    ..abstract_text> ..
  4. Adenosine, Glutamate and Neurodegeneration
    PATRICIA SONSALLA; Fiscal Year: 2007
    ....
  5. DOPAMINERGIC NEUROTOXINS AND AGING
    PATRICIA SONSALLA; Fiscal Year: 1992
    ..An overall goal underlying this entire project is to determine if there are similarities in the etiology of idiopathic Parkinson's Disease in humans...
  6. DOPAMINERGIC NEUROTOXINS AND AGING
    PATRICIA SONSALLA; Fiscal Year: 1999
    ..This in turn raises the question as to whether defects in vesicular function of monoaminergic neurons might contribute to the neurodegeneration seen in PD. ..