John H Siegel
Affiliation: New Jersey
- Oxygen debt criteria quantify the effectiveness of early partial resuscitation after hypovolemic hemorrhagic shockJohn H Siegel
Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, 07101 1709, USA
J Trauma 54:862-80; discussion 880. 2003..The effectiveness of partial resuscitation after hypovolemic hemorrhagic shock with deferment of full resuscitation is critical to successful hypotensive resuscitation...
- Change in velocity and energy dissipation on impact in motor vehicle crashes as a function of the direction of crash: key factors in the production of thoracic aortic injuries, their pattern of associated injuries and patient survival. A Crash Injury ReseJohn H Siegel
Department of Cell Biology and Molecular Medicine, New Jersey Medical School UMDNJ, Newark, New Jersey 07107 1709, USA
J Trauma 57:760-77; discussion 777-8. 2004..Comparison of 80 AI and 796 non-AI patients of AIS=3...
- Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shockDieter Rixen
Department of Trauma Orthopedic Surgery, University of Witten Herdecke at the Hospital Merheim, Cologne, Germany
Crit Care 9:441-53. 2005..The data examined in this review indicate that estimates of oxygen debt and its metabolic correlates should be included in studies of experimental shock and in the management of patients suffering from hemorrhagic shock...
- Analysis of the mechanism of lateral impact aortic isthmus disruption in real-life motor vehicle crashes using a computer-based finite element numeric model: with simulation of prevention strategiesJohn H Siegel
New Jersey Medical School UMDNJ, Newark, New Jersey, USA
J Trauma 68:1375-95. 2010..Of the 34 AIs due to lateral impact MVCs (LMVC), 91% had an aortic isthmus laceration. Computer simulation is used to study the cause of LMVC AI...
- Computer simulation and validation of the Archimedes Lever hypothesis as a mechanism for aortic isthmus disruption in a case of lateral impact motor vehicle crash: a Crash Injury Research Engineering Network (CIREN) studyJohn H Siegel
Department of Cell Biology and Molecular Medicine, New Jersey Medical School, NJ 07631, USA
J Trauma 60:1072-82. 2006....
- Spine and spinal cord injury in motor vehicle crashes: a function of change in velocity and energy dissipation on impact with respect to the direction of crashJoyce A Smith
New Jersey Crash Injury Research Engineering Network Center, New Jersey Medical School, Newark, NJ 07107, USA
J Trauma 59:117-31. 2005..Comparison of 214 patients with SF or SCI with 938 patients who did not have SF or SCI...
- Deceleration energy and change in velocity on impact: key factors in fatal versus potentially survivable motor vehicle crash (mvc) aortic injuries (AI): the role of associated injuries as determinants of outcomeJohn H Siegel
CIREN NHTSA, New Jersey Medical School UMDNJ, Newark, NJ, USA
Annu Proc Assoc Adv Automot Med 46:315-38. 2002..To examine the difference in force mechanisms between fatal and potentially survivable MVC aortic injuries (AI) compared to non-AI severe thoracic injuries (ST)...
- Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patientsZoltan Spolarics
Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
Crit Care Med 31:1722-9. 2003....
- Attenuated monocyte IL-10 production in glucose-6-phosphate dehydrogenase-deficient trauma patientsAmy M Liese
Department of Cell Biology and Injury Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
Shock 18:18-23. 2002..An attenuated IL-10 production may be a contributing mechanism in the previously observed augmented inflammatory response in severely injured G6PD-deficient compared with non-deficient trauma patients...
- The septic abscess wall: a cytokine-generating organ associated with portal venous cytokinemia, hepatic outflow fibrosis, sinusoidal congestion, inflammatory cell sequestration, hepatocellular lipid deposition, and focal cell deathAdil Ceydeli
Department of Cell Biology, New Jersey Medical School UMDNJ, 30 Bergen Street, Newark, NJ 07101, USA
Shock 20:74-84. 2003..There is also increased hepatocellular lipid deposition and apoptosis. Thus, the cytokine production of the abscess wall itself appears to be a major mediator of the septic hepatic response...
- Use of hemorrhagic shock model based on the endpoints of oxygen debtJohn H Siegel
J Trauma 56:454-5; author reply 455-6. 2004
- Patterns of correlation of plasma ceruloplasmin in sepsisCarlo Chiarla
IASI CNR Center for Pathophysiology of Shock, Catholic University School of Medicine, Rome, Italy
J Surg Res 144:107-10. 2008..However, there is poor knowledge of the patterns of increase and correlation with changes in other biochemical variables, and our study has been performed to investigate this aspect...